A Pharmacology Primer

Author: Terry Kenakin
Publisher: Elsevier
ISBN: 9780080465302
Format: PDF, ePub, Docs
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The Second Edition will continue this tradition of better preparing researchers in the basics of pharmacology. In addition, new human interest material including historical facts in pharmacology will be added. A new section on therapeutics will help readers identify with diseases and drug treatments. Over 30 new figures and tables More human interest information to provide readers with historical facts on pharmacology research New section on therapeutics to help identify diseaes and drug treatments New section on new biological concepts relevant to pharmacological research (i.e., systems biology) New study sections organized with ASPET and other international pharmacology organizations New coverage of pharmacokinetics and drug disposition

A Pharmacology Primer

Author: Terrence P. Kenakin
Publisher: Academic Press
ISBN: 9780123745859
Format: PDF, ePub
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This guide has been designed especially for scientists trained in molecular biology and related fields who now need to know more about the basic theories, principles and practical applications of pharmacology.

The Handbook of Medicinal Chemistry

Author: Andrew Davis
Publisher: Royal Society of Chemistry
ISBN: 1782621830
Format: PDF, Kindle
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Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book helps readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to enable medicinal chemists to apply their academic understanding to every aspect of drug discovery. Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development. A free iPad app has been created in collaboration with the editors of the book. The Medicinal Chemistry Toolkit provides a suite of resources to support the day to day work of a medicinal chemist. Search for "Medicinal Chemistry Toolkit."

Brody s Human Pharmacology E Book

Author: Stephanie Watts
Publisher: Elsevier Health Sciences
ISBN: 0323075754
Format: PDF, Docs
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Featuring the contributions of leading faculty, this new edition provides a succinct overview of the most important aspects of pharmacology necessary for a basic understanding of the subject. It reviews the concepts, clinical applications and side effects of pharmacology, placing an emphasis on practical applications of the material, whenever possible. More than 480 full-color illustrations explain important processes, while color-coded boxes for major drugs, therapeutic overviews, clinical problems, and trade names—as well as USMLE-style self-assessment questions with answers and rationales—reinforce your mastery of the information. A consistent style of writing—and more focused, concise content—provide for better learning of the essentials. Online access to Student Consult—where you’ll find 15 pharmacology animations...150 USMLE-style questions...and more—further enhances your study and prepares you for exams. Includes online access to Student Consult where you’ll find USMLE-style questions, animations showing the actions of various important toxins, and much more. Focuses on the essential aspects of pharmacology for a solid foundation of knowledge in the subject. Includes more than 480 full-color illustrations that explain key pharmacologic processes. Provides between 4 and 6 USMLE-style self-assessment questions at the end of each chapter—with answers and full explanations in the appendix—that help you prepare for exams and master the material. Uses a templated format that promotes more effective and efficient learning. Presents color-coded boxes in each chapter that emphasize key points. Features a clinical emphasis throughout on both the basic science of pharmacology and its clinical relevance. Includes new Gold Standard content on Student Consult with 200 Professional Drug Monographs for additional information on generic and brand names, mechanism of action, pharmacokinetics, indications and dosage, drug interactions, patient education and much more! Features a more consistent style of writing—as well as focused, concise content—for enhanced learning of the essentials. Presents chapters in a re-arranged order for a more logical approach to learning. Includes additional biochemistry and physiology information in the introduction for each section for greater understanding.

Elektrophorese Praktikum

Author: Reiner Westermeier
Publisher: Wiley-Blackwell
ISBN: 9783527281725
Format: PDF
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Die Elektrophorese ist eine bedeutende Methode der Instrumentellen Analyse und vor allem aus den Laboratorien der Biochemiker nicht mehr wegzudenken. Dieses Buch bietet eine umfassende Methodenübersicht für alle, die die verschiedenen Varianten der modernen Elektrophorese kennenlernen oder die ihre Kenntnisse ausbauen wollen. Der Autor erläutert zunächst die physikalisch-chemischen Zusammenhänge und gibt dann zahlreiche praktische, an Anwendungsbeispielen orientierte Hinweise. Gründliche Arbeitsanleitungen und ausführliche Problemlösungen geben dem Praktiker eine wertvolle Hilfe für seine tägliche Arbeit. Reiner Westermeier ist Mitarbeiter am Institut für Lebensmitteltechnologie der TU München und in der internationalen Firmengruppe Pharmacia LKB tätig. Zahlreiche Veröffentlichungen und eine umfangreiche Vortrags- und Seminartätigkeit haben den promovierten Ingenieur zu einem bekannten und vielgefragten Fachmann auf dem Gebiet der Elektrophorese gemacht.

Casarett Doulls Toxicology The Basic Science of Poisons 9 E

Author: Curtis D. Klaassen
Publisher: McGraw Hill Professional
ISBN: 1259863751
Format: PDF, ePub
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Toxicology’s gold-standard text --- completely updated to reflect the latest breakthroughs and discoveries Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition equips you with an unsurpassed understanding of modern toxicology, including the key principles, concepts, mechanisms, chemical-specific toxicity, and modes of thought that are the foundation of the discipline. This trusted classic not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date, revealing, and in-depth look at the systemic responses of toxic substance available anywhere. Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition is logically divided into seven sections:•General Principles of Toxicology•Disposition of Toxicants•Non-Organ Directed Toxicity•Target Organ Toxicity•Toxic Agents•Environmental Toxicology•Applications of Toxicology Many new contributors capture the progress made in toxicology over the past few years:This edition is markedly updated from the previous edition, with more than one-third of the chapters authored by scientists who have not made previous contributions to the book. Sharing their expertise, they deliver dynamic new coverage of the importance of apoptosis, autophagy, cytokines, growth factors, oncogenes, cell cycling, receptors, gene regulation, protective mechanisms, repair mechanisms, transcription factors, signaling pathways, transgenic mice, knock-out mice, humanized mice, polymorphisms, microarray technology, second-generation sequencing, genomics, proteomics, epigenetics, exposome, microbiota, read across, adverse outcome pathways, high-content screening, computational toxicology, innovative test methods, and organ-on-a-chip in understanding the mechanisms of toxicity and the regulation of chemicals. A true “essential”If you are in need of an up-to-date, all-in-one overview of the biomedical and environmental aspects of toxicology----written by experts, and presented in full color, your search ends here.

Dose Optimization in Drug Development

Author: Rajesh Krishna
Publisher: CRC Press
ISBN: 9781574448085
Format: PDF, ePub, Docs
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This reference provides a concise overview of the key principles in dose selection and optimization and demonstrates applicability to recent successful new drug applications. Compiling key issues and current research on safety, efficacy, and clinical pharmacology, and PK-PD, this volume critically highlights the multidisciplinary nature of drug development and spans the fields of pharmacokinetics, clinical pharmacology, biostatistics, and experimental medicine.