Apoptosis

Author: Victor R. Preedy
Publisher: CRC Press
ISBN: 1439845433
Format: PDF, Mobi
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Targeting the key active elements in the mechanism and application of apoptosis and its therapeutic implications, Apoptosis: Modern Insights into Disease from Molecules to Man covers apoptosis from A to Z. Comprehensive in scope, it explores a wide range of topics including various cancers, asthma, and multiple sclerosis as well as alcohol induced liver disease, chronic back pain, and cardiovascular health. With 40 chapters written by highly respected authorities, this single source reference provides researchers and scientists with the foundation they need.

Adhesion Molecules

Author: Victor R. Preedy
Publisher: CRC Press
ISBN: 1439840601
Format: PDF
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This book covers the structure and classification of adhesion molecules in relation to signaling pathways and gene expression. It discusses immunohistochemical localization, neutrophil migration, and junctional, functional, and inflammatory adhesion molecules in pathologies such as leukocyte decompression sickness and ischemia reperfusion injury. Highlighting the medical applications of current research, chapters cover diabetes, obesity, and metabolic syndrome; hypoxia; kidney disease; smoking, atrial fibrillation, and heart disease, the brain and dementia; and tumor proliferation. Finally, it looks at molecular imaging and bioinformatics, high-throughput technologies, and chemotherapy.

Molecular Exploitation of Apoptosis Pathways in Prostate Cancer

Author: Natasha Kyprianou
Publisher: World Scientific
ISBN: 1908978252
Format: PDF, Docs
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This book focuses on the functional significance of targeting apoptosis for the treatment of prostate cancer. New concepts on the challenges relating to the development of resistance by androgen-independent tumors are introduced, in terms of the contribution of anoikis and cross-talk of androgens with key growth factor signaling pathways. This volume also provides insightful discussion on the exploitation of the apoptotic and angiogenic synergism towards complete eradication of prostate tumors. Last but not least, it includes reflections on the drug development challenge based on the analysis of data from existing clinical trials. Contents:Introduction: Prostate CancerThe Prostate Gland DynamicsApoptosis Pathways Signaling Execution of Cancer CellsAndrogen Receptor-Mediated Apoptosis: Significance in Development of Castration-Resistant Prostate CancerAnoikis in Prostate Cancer MetastasisEpithelial–Mesenchymal Transition (EMT) in Prostate Cancer MetastasisNovel Molecular Therapeutics for Targeting Castration-Resistant Prostate CancerApoptotic-Based Molecular Markers of Therapeutic ResponseRole of Apoptosis in Prostate Cancer PreventionSummary and Future Directions Readership: Practising clinicians including urologists, pathologists, medical oncologists and scientists with an interest in cancer, especially prostate cancer. Keywords:Apoptosis;Prostrate CancerKey Features:Discusses apoptosis with respect to prostate cancer that exhibits distinct signaling responsesProvides updated evidence on the understanding of the molecular pathways that lead to apoptosisCovers new mechanisms and therapeutic urology

Programmed Cell Death in Protozoa

Author: Jose Perez-Martin
Publisher: Springer Science & Business Media
ISBN: 9780387767178
Format: PDF
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Under the name of programmed cell death (PCD) are included diverse molecular mechanisms of cell suicide which play an essential role in the development of multicellular organisms. The best known PCD mechanism in multicellular organisms is called apoptosis. However, recent studies indicate that PCD is also present in protozoa and unicellular eukaryotes. The eleven chapters of this book give the reader a comprehensive update of the progress in the understanding of the mechanisms of PCD in protozoa. The chapters have been written by experts in this field of research and are arranged following an evolutionary point of view.

Genomics in Endocrinology

Author: Stuart Handwerger
Publisher: Springer Science & Business Media
ISBN: 9781597453097
Format: PDF
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Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The text provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed include the methodology of DNA microarrays and general methods for the analysis of microarray data.

Kirk s Current Veterinary Therapy XV E Book

Author: John D. Bonagura
Publisher: Elsevier Health Sciences
ISBN: 0323227627
Format: PDF, ePub, Mobi
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Written by today s leading experts, Kirk's Current Veterinary Therapy, Volume XV keeps you completely current with the latest in disease management for dogs and cats. It uses a clear and practical approach to medical disorders; the typical chapter includes both a brief guide to diagnosis and a detailed discussion of therapy. You ll gain quick access to information such as critical care; infectious, toxicologic, and dermatologic disorders; and diseases of the gastrointestinal, cardiovascular, respiratory, urinary, reproductive, neurologic,and ophthalmologic systems. From editors John Bonagura and David Twedt plus hundreds of expert contributors, Kirk's Current Veterinary Therapy enhances your skills in evidence-based treatment planning. "For the practitioner who wants to keep abreast of current therapies for a wide range of topics, ... CVT is the perfect reference ." Reviewed by: Ryan Ong, WAVES Veterinary Hospital on behalf of Australian Veterinary Hospital, March 2015 Authoritative, easy-to-read coverage includes a brief approach to diagnosis with detailed discussions of the latest therapies. An organ-system organization and a convenient index make it easy to find solutions for specific disorders. Treatment algorithms help you manage patients with difficult medical problems. A handy Table of Common Drugs, updated by Dr. Mark Papich, offers a quick reference to dosage information. 365 illustrations depict the pathophysiologic basis for therapy or show the management of a defined condition. A companion website includes valuable information still relevant from CVT XIV, an index, and drug formulary, all fully searchable; a collection of 300 images; references that link to PubMed; and clinical references on laboratory test procedures and interpretation, normal reference ranges, conversion tables, and more. Concise chapters are only 2-5 pages in length, saving you time in finding essential information. Expert contributors and editors provide scientific, up-to-date coverage of clinically useful topics, including broad, traditional, and controversial subjects. References indicate related material from earlier volumes of Kirk’s Current Veterinary Therapy. NEW chapters cover the most important, emerging information on current diagnostic, treatment, and preventive challenges in today’s veterinary practice. A new section on feline and canine nutrition covers important issues in nutritional health. 50 new chapter authors join hundreds of expert international contributors, all of whom are leading authorities in their fields. NEW! Availability as Pageburst ebook allows you digital access to this volume along with your library of other Elsevier references.

Retinal Pharmacotherapy E Book

Author: Quan Dong Nguyen
Publisher: Elsevier Health Sciences
ISBN: 0702047406
Format: PDF, ePub
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Retinal Pharmacotherapy is the first comprehensive book devoted to pharmacologic agents and their rationale and mechanisms of action in selected retinal and uveitic diseases. Drs. Quan Dong Nguyen, Eduardo Buchele Rodrigues, Michel Eid Farah, and William F. Mieler lead an international team of expert contributors to present up-to-date knowledge of new drugs on the market, the science behind the drugs, evidence of how the drugs work, and the reasons why they are effective or not. This user-friendly, all-in-one reference provides you with easy access to practical information on the effective and appropriate use of pharmacologic agents in the management of retinal diseases. Covers all new and existing retinal drugs to keep you current in this expanding area of the treatment of retinal diseases. Discusses the background behind retinal drugs and the various pathways of how they work so you can make thoroughly informed clinical decisions. Presents 400 color photographs and line drawings that illustrate disease appearance before and after treatment and clarify difficult key concepts. Features contributors from Europe, North America, South America, the Middle East, Asia, and Australia for an international approach. Identifies and emphasizes key points clearly in each chapter to improve comprehension and make finding information easier.

Molecular Biology of the SARS Coronavirus

Author: Sunil K. Lal
Publisher: Springer Science & Business Media
ISBN: 9783642036835
Format: PDF, Mobi
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SARS was the ?rst new plague of the twenty-?rst century. Within months, it spread worldwide from its “birthplace” in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across ?ve continents. SARS exposed the vulnerability of our modern globalised world to the spread of a new emerging infection. SARS (or a similar new emerging disease) could neither have spread so rapidly nor had such a great global impact even 50 years ago, and arguably, it was itself a product of our global inter-connectedness. Increasing af?uence and a demand for wild-game as exotic food led to the development of large trade of live animal and game animal markets where many species of wild and domestic animals were co-housed, providing the ideal opportunities for inter-species tra- mission of viruses and other microbes. Once such a virus jumped species and attacked humans, the increased human mobility allowed the virus the opportunity for rapid spread. An infected patient from Guangdong who stayed for one day at a hotel in Hong Kong led to the transmission of the disease to 16 other guests who travelled on to seed outbreaks of the disease in Toronto, Singapore, and Vietnam, as well as within Hong Kong itself. The virus exploited the practices used in modern intensive care of patients with severe respiratory disease and the weakness in infection control practices within our health care systems to cause outbreaks within hospitals, further amplifying the spread of the disease. Health-care itself has become a two-edged sword.

Skeletal Biology and Medicine

Author: Mone Zaidi
Publisher: Wiley-Blackwell
ISBN:
Format: PDF, ePub, Docs
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As part of the Annals of the New York Academy of Sciences series, this volume examines mechanisms involved in bone development and restructuring, including cellular and mechanical triggers, receptors, and signalling pathways. This volume also examines other factors associated with bone and musculoskeletal health, including physiological systems and disease states such as the immune system, inflammation, diabetes, infection and cancer. This book is ideal for Graduate students, medical students, researchers and clinicians in with an interest in anatomy, physiology, developmental biology, immunology, and musculoskeletal health NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Fishman s Pulmonary Diseases and Disorders Fourth Edition

Author: Alfred P. Fishman
Publisher: McGraw Hill Professional
ISBN: 0071641092
Format: PDF
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A complete guide to the entire field of respiratory medicine-with all-new content and a streamlined new design First published in 1980, Fishman's Pulmonary Diseases & Disorders is the classic reference through which pulmonary physicians have gained a commanding look at the diagnosis and treatment of pulmonary diseases and disorders. Edited by the world's foremost authorities, Fishman's Pulmonary Diseases & Disorders covers exactly what you need to know about lung diseases and their management, including sleep-disordered breathing, COPD, emphysema, and lung cancer, as well as new technological advances and imaging techniques. This unparalleled two-volume resource begins with a compelling overview of up-to-date clinical perspectives, along with the scientific basis of lung function health and disease. It then provides turnkey information on everything from respiratory disease signs and symptoms, to obstructive lung diseases, occupational and environmental disorders, and specific respiratory conditions such as infections diseases of the lungs and acute respiratory failure. New to the 4th Edition: Information on recent advancements in many clinically relevant areas of pulmonary medicine Update to the infectious diseases chapters that reflect current practice guidelines and recent antimicrobial developments Clearer connection between fundamental science concepts and clinical applications, which reflect current scientific research Latest information on sleep disorders Review of recent recommendations of the American Thoracic Society and European Respiratory Society for the accurate interpretation of pulmonary function tests Appendices that include a respiratory questionnaire, normal values, and commonly used terms & symbols