Apoptosis

Author: Victor R. Preedy
Publisher: CRC Press
ISBN: 1439845433
Format: PDF, ePub, Docs
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Targeting the key active elements in the mechanism and application of apoptosis and its therapeutic implications, Apoptosis: Modern Insights into Disease from Molecules to Man covers apoptosis from A to Z. Comprehensive in scope, it explores a wide range of topics including various cancers, asthma, and multiple sclerosis as well as alcohol induced liver disease, chronic back pain, and cardiovascular health. With 40 chapters written by highly respected authorities, this single source reference provides researchers and scientists with the foundation they need.

Adhesion Molecules

Author: Victor R. Preedy
Publisher: CRC Press
ISBN: 1439840601
Format: PDF, Docs
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This book covers the structure and classification of adhesion molecules in relation to signaling pathways and gene expression. It discusses immunohistochemical localization, neutrophil migration, and junctional, functional, and inflammatory adhesion molecules in pathologies such as leukocyte decompression sickness and ischemia reperfusion injury. Highlighting the medical applications of current research, chapters cover diabetes, obesity, and metabolic syndrome; hypoxia; kidney disease; smoking, atrial fibrillation, and heart disease, the brain and dementia; and tumor proliferation. Finally, it looks at molecular imaging and bioinformatics, high-throughput technologies, and chemotherapy.

Cytokines

Author: Victor R. Preedy
Publisher: CRC Press
ISBN: 1439876207
Format: PDF, ePub
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Cytokines are a group of peptides secreted by cells of the immune system such as macrophages, lymphocytes, and T cells. They can be divided into functional families and have-wide ranging impacts that affect cells and molecular pathways to the whole individual. Written by distinguished scholars and experts, this book is a holistic reference to enable scientists and doctors to understand cytokines in specific or broad detail. The book is divided into sections that cover general and cellular aspects, lifestyle factors, immunology and infections, cancer, cardiovascular and metabolic disease, and organs and tissue systems.

Adipokines

Author: Victor R. Preedy
Publisher: CRC Press
ISBN: 1439879885
Format: PDF, Mobi
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Adipokines (also called adipocytokines) are a group of peptides secreted by adipose tissue. They have diverse roles, from functions in the individual cell to the whole body. This volume examines a wide range of specific adipokines as well as their general cellular aspects, including thermal stress and adipokine expression, central nervous system roles for adiponectin in neuroendocrine and autonomic function, and astroglial leptin receptors. It discusses related diseases and conditions such as nonalcoholic fatty liver disease, metabolic syndrome, heart and rheumatic diseases, and allergies and sleep disorders.

Molecular Exploitation of Apoptosis Pathways in Prostate Cancer

Author: Natasha Kyprianou
Publisher: World Scientific
ISBN: 1908978252
Format: PDF, Mobi
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This book focuses on the functional significance of targeting apoptosis for the treatment of prostate cancer. New concepts on the challenges relating to the development of resistance by androgen-independent tumors are introduced, in terms of the contribution of anoikis and cross-talk of androgens with key growth factor signaling pathways. This volume also provides insightful discussion on the exploitation of the apoptotic and angiogenic synergism towards complete eradication of prostate tumors. Last but not least, it includes reflections on the drug development challenge based on the analysis of data from existing clinical trials. Contents:Introduction: Prostate CancerThe Prostate Gland DynamicsApoptosis Pathways Signaling Execution of Cancer CellsAndrogen Receptor-Mediated Apoptosis: Significance in Development of Castration-Resistant Prostate CancerAnoikis in Prostate Cancer MetastasisEpithelial–Mesenchymal Transition (EMT) in Prostate Cancer MetastasisNovel Molecular Therapeutics for Targeting Castration-Resistant Prostate CancerApoptotic-Based Molecular Markers of Therapeutic ResponseRole of Apoptosis in Prostate Cancer PreventionSummary and Future Directions Readership: Practising clinicians including urologists, pathologists, medical oncologists and scientists with an interest in cancer, especially prostate cancer. Keywords:Apoptosis;Prostrate CancerKey Features:Discusses apoptosis with respect to prostate cancer that exhibits distinct signaling responsesProvides updated evidence on the understanding of the molecular pathways that lead to apoptosisCovers new mechanisms and therapeutic urology

Programmed Cell Death in Protozoa

Author: Jose Perez-Martin
Publisher: Springer Science & Business Media
ISBN: 9780387767178
Format: PDF, ePub, Mobi
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Under the name of programmed cell death (PCD) are included diverse molecular mechanisms of cell suicide which play an essential role in the development of multicellular organisms. The best known PCD mechanism in multicellular organisms is called apoptosis. However, recent studies indicate that PCD is also present in protozoa and unicellular eukaryotes. The eleven chapters of this book give the reader a comprehensive update of the progress in the understanding of the mechanisms of PCD in protozoa. The chapters have been written by experts in this field of research and are arranged following an evolutionary point of view.

Molecular Pathology

Author: William B. Coleman
Publisher: Academic Press
ISBN: 0128027878
Format: PDF, ePub
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As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase

Neurotrauma New Insights into Pathology and Treatment

Author: John T. Weber
Publisher: Elsevier
ISBN: 9780080548876
Format: PDF, Mobi
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Neurotrauma is the leading cause of death and disability in young adults, and the incidence in older patients is increasing. Neurotrauma is also a field in medicine with one of the highest unmet needs. Concentrated, focused and multidisciplinary efforts are required to combat this important disease. Exciting findings from basic research open opportunities for improving treatment results. This volume presents a unique and comprehensive overview of the latest findings and insights on translational research in neurotrauma. This book should be a must for any TBI or SCI researcher interested in translating their work to the clinic, as well as to clinicians interested in the latest research findings which could provide novel treatment strategies for their patients. • Integrates results from research on traumatic brain injury and spinal cord injury, bridging basic science and clinical research • Includes contributions from a worldwide panel of leading researchers and clinicians in the fields of TBI and SCI

Human Evolutionary Biology

Author: Michael P. Muehlenbein
Publisher: Cambridge University Press
ISBN: 0521879485
Format: PDF, ePub, Docs
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A wide-ranging and inclusive text focusing on topics in human evolution and the understanding of modern human variation and adaptability.

The Autoimmune Diseases

Author: Ian R. Mackay
Publisher: Academic Press
ISBN: 0123849306
Format: PDF, Mobi
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Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels and includes expanded coverage of autoinflammatory disease and autoimmune responses to tumors. Gives a thorough and an important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and therapy Provides thorough, up-to-date information on specific diseases, along with clinical applications, in an easily found reference for clinicians and researchers interested in certain diseases Keeps readers abreast of current trends and emerging areas in the field Ensures that content is not only up-to-date, but applicable and relevant