Applied Missing Data Analysis in the Health Sciences

Author: Xiao-Hua Zhou
Publisher: John Wiley & Sons
ISBN: 1118573641
Format: PDF, ePub, Docs
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A modern and practical guide to the essential concepts andideas for analyzing data with missing observations in the field ofbiostatistics With an emphasis on hands-on applications, Applied MissingData Analysis in the Health Sciences outlines the variousmodern statistical methods for the analysis of missing data. Theauthors acknowledge the limitations of established techniques andprovide newly-developed methods with concrete applications in areassuch as causal inference methods and the field of diagnosticmedicine. Organized by types of data, chapter coverage begins with anoverall introduction to the existence and limitations of missingdata and continues into traditional techniques for missing datainference, including likelihood-based, weighted GEE, multipleimputation, and Bayesian methods. The book’s subsequentlycovers cross-sectional, longitudinal, hierarchical, survival data.In addition, Applied Missing Data Analysis in the HealthSciences features: Multiple data sets that can be replicated using the SAS®,Stata®, R, and WinBUGS software packages Numerous examples of case studies in the field of biostatisticsto illustrate real-world scenarios and demonstrate applications ofdiscussed methodologies Detailed appendices to guide readers through the use of thepresented data in various software environments Applied Missing Data Analysis in the Health Sciences isan excellent textbook for upper-undergraduate and graduate-levelbiostatistics courses as well as an ideal resource for healthscience researchers and applied statisticians.

Network Meta Analysis for Decision Making

Author: Sofia Dias
Publisher: John Wiley & Sons
ISBN: 1118647505
Format: PDF, ePub, Mobi
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A practical guide to network meta-analysis with examples and code In the evaluation of healthcare, rigorous methods of quantitative assessment are necessary to establish which interventions are effective and cost-effective. Often a single study will not provide the answers and it is desirable to synthesise evidence from multiple sources, usually randomised controlled trials. This book takes an approach to evidence synthesis that is specifically intended for decision making when there are two or more treatment alternatives being evaluated, and assumes that the purpose of every synthesis is to answer the question “for this pre-identified population of patients, which treatment is ‘best’?” A comprehensive, coherent framework for network meta-analysis (mixed treatment comparisons) is adopted and estimated using Bayesian Markov Chain Monte Carlo methods implemented in the freely available software WinBUGS. Each chapter contains worked examples, exercises, solutions and code that may be adapted by readers to apply to their own analyses. This book can be used as an introduction to evidence synthesis and network meta-analysis, its key properties and policy implications. Examples and advanced methods are also presented for the more experienced reader. Methods used throughout this book can be applied consistently: model critique and checking for evidence consistency are emphasised. Methods are based on technical support documents produced for NICE Decision Support Unit, which support the NICE Methods of Technology Appraisal. Code presented is also the basis for the code used by the ISPOR Task Force on Indirect Comparisons. Includes extensive carefully worked examples, with thorough explanations of how to set out data for use in WinBUGS and how to interpret the output. Network Meta-Analysis for Decision Making will be of interest to decision makers, medical statisticians, health economists, and anyone involved in Health Technology Assessment including the pharmaceutical industry.

Missing Data Analysis in Practice

Author: Trivellore Raghunathan
Publisher: CRC Press
ISBN: 1482211939
Format: PDF, Mobi
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Missing Data Analysis in Practice provides practical methods for analyzing missing data along with the heuristic reasoning for understanding the theoretical underpinnings. Drawing on his 25 years of experience researching, teaching, and consulting in quantitative areas, the author presents both frequentist and Bayesian perspectives. He describes easy-to-implement approaches, the underlying assumptions, and practical means for assessing these assumptions. Actual and simulated data sets illustrate important concepts, with the data sets and codes available online. The book underscores the development of missing data methods and their adaptation to practical problems. It mainly focuses on the traditional missing data problem. The author also shows how to use the missing data framework in many other statistical problems, such as measurement error, finite population inference, disclosure limitation, combing information from multiple data sources, and causal inference.

Methods and Applications of Statistics in the Life and Health Sciences

Author: N. Balakrishnan
Publisher: John Wiley & Sons
ISBN: 0470405090
Format: PDF, Docs
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"Data collection holds an essential part in dictating the future of health sciences and public health, as the compilation of statistics allows researchers and medical practitioners to monitor trends in health status, identify health problems, and evaluate the impact of health policies and programs. Methods and Applications of Statistics in the Life and Health Sciences serves as a single, one-of-a-kind resource on the wide range of statistical methods, techniques, and applications that are applied in modern life and health sciences in research. Specially designed to present encyclopedic content in an accessible and self-contained format, this book outlines thorough coverage of the underlying theory and standard applications to research in related disciplines such as biology, epidemiology, clinical trials, and public health. Uniquely combining established literature with cutting-edge research, this book contains classical works and more than twenty-five new articles and completely revised contributions from the acclaimed Encyclopedia of Statistical Sciences, Second Edition. The result is a compilation of more than eighty articles that explores classic methodology and new topics."--Publisher's description.

Applied Linear Regression

Author: Sanford Weisberg
Publisher: John Wiley & Sons
ISBN: 1118594851
Format: PDF, ePub, Docs
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Praise for the Third Edition "...this is an excellent book which could easily be used as acourse text..." —International Statistical Institute The Fourth Edition of Applied LinearRegression provides a thorough update of the basic theoryand methodology of linear regression modeling. Demonstrating thepractical applications of linear regression analysis techniques,the Fourth Edition uses interesting, real-worldexercises and examples. Stressing central concepts such as model building, understandingparameters, assessing fit and reliability, and drawing conclusions,the new edition illustrates how to develop estimation, confidence,and testing procedures primarily through the use of least squaresregression. While maintaining the accessible appeal of eachprevious edition,Applied Linear Regression, FourthEdition features: Graphical methods stressed in the initial exploratory phase,analysis phase, and summarization phase of an analysis In-depth coverage of parameter estimates in both simple andcomplex models, transformations, and regression diagnostics Newly added material on topics including testing, ANOVA, andvariance assumptions Updated methodology, such as bootstrapping, cross-validationbinomial and Poisson regression, and modern model selectionmethods Applied Linear Regression, Fourth Edition is anexcellent textbook for upper-undergraduate and graduate-levelstudents, as well as an appropriate reference guide forpractitioners and applied statisticians in engineering, businessadministration, economics, and the social sciences.

Longitudinal Data Analysis

Author: Donald Hedeker
Publisher: John Wiley & Sons
ISBN: 0470036478
Format: PDF, Docs
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Longitudinal data analysis for biomedical and behavioral sciences This innovative book sets forth and describes methods for the analysis of longitudinaldata, emphasizing applications to problems in the biomedical and behavioral sciences. Reflecting the growing importance and use of longitudinal data across many areas of research, the text is designed to help users of statistics better analyze and understand this type of data. Much of the material from the book grew out of a course taught by Dr. Hedeker on longitudinal data analysis. The material is, therefore, thoroughly classroom tested and includes a number of features designed to help readers better understand and apply the material. Statistical procedures featured within the text include: * Repeated measures analysis of variance * Multivariate analysis of variance for repeated measures * Random-effects regression models (RRM) * Covariance-pattern models * Generalized-estimating equations (GEE) models * Generalizations of RRM and GEE for categorical outcomes Practical in their approach, the authors emphasize the applications of the methods, using real-world examples for illustration. Some syntax examples are provided, although the authors do not generally focus on software in this book. Several datasets and computer syntax examples are posted on this title's companion Web site. The authors intend to keep the syntax examples current as new versions of the software programs emerge. This text is designed for both undergraduate and graduate courses in longitudinal data analysis. Instructors can take advantage of overheads and additional course materials available online for adopters. Applied statisticians in biomedicine and the social sciences can also use the book as a convenient reference.

Multivariate Statistics

Author: Yasunori Fujikoshi
Publisher: John Wiley & Sons
ISBN: 0470411694
Format: PDF, ePub
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A comprehensive examination of high-dimensional analysis ofmultivariate methods and their real-world applications Multivariate Statistics: High-Dimensional and Large-SampleApproximations is the first book of its kind to explore howclassical multivariate methods can be revised and used in place ofconventional statistical tools. Written by prominent researchers inthe field, the book focuses on high-dimensional and large-scaleapproximations and details the many basic multivariate methods usedto achieve high levels of accuracy. The authors begin with a fundamental presentation of the basictools and exact distributional results of multivariate statistics,and, in addition, the derivations of most distributional resultsare provided. Statistical methods for high-dimensional data, suchas curve data, spectra, images, and DNA microarrays, are discussed.Bootstrap approximations from a methodological point of view,theoretical accuracies in MANOVA tests, and model selectioncriteria are also presented. Subsequent chapters feature additionaltopical coverage including: High-dimensional approximations of various statistics High-dimensional statistical methods Approximations with computable error bound Selection of variables based on model selection approach Statistics with error bounds and their appearance indiscriminant analysis, growth curve models, generalized linearmodels, profile analysis, and multiple comparison Each chapter provides real-world applications and thoroughanalyses of the real data. In addition, approximation formulasfound throughout the book are a useful tool for both practical andtheoretical statisticians, and basic results on exact distributionsin multivariate analysis are included in a comprehensive, yetaccessible, format. Multivariate Statistics is an excellent book for courseson probability theory in statistics at the graduate level. It isalso an essential reference for both practical and theoreticalstatisticians who are interested in multivariate analysis and whowould benefit from learning the applications of analyticalprobabilistic methods in statistics.

Modes of Parametric Statistical Inference

Author: Seymour Geisser
Publisher: John Wiley & Sons
ISBN: 0471743127
Format: PDF, ePub
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A fascinating investigation into the foundations of statisticalinference This publication examines the distinct philosophical foundations ofdifferent statistical modes of parametric inference. Unlike manyother texts that focus on methodology and applications, this bookfocuses on a rather unique combination of theoretical andfoundational aspects that underlie the field of statisticalinference. Readers gain a deeper understanding of the evolution andunderlying logic of each mode as well as each mode's strengths andweaknesses. The book begins with fascinating highlights from the history ofstatistical inference. Readers are given historical examples ofstatistical reasoning used to address practical problems that arosethroughout the centuries. Next, the book goes on to scrutinize fourmajor modes of statistical inference: * Frequentist * Likelihood * Fiducial * Bayesian The author provides readers with specific examples andcounterexamples of situations and datasets where the modes yieldboth similar and dissimilar results, including a violation of thelikelihood principle in which Bayesian and likelihood methodsdiffer from frequentist methods. Each example is followed by adetailed discussion of why the results may have varied from onemode to another, helping the reader to gain a greater understandingof each mode and how it works. Moreover, the author providesconsiderable mathematical detail on certain points to highlight keyaspects of theoretical development. The author's writing style and use of examples make the text clearand engaging. This book is fundamental reading for graduate-levelstudents in statistics as well as anyone with an interest in thefoundations of statistics and the principles underlying statisticalinference, including students in mathematics and the philosophy ofscience. Readers with a background in theoretical statistics willfind the text both accessible and absorbing.

Longitudinal Data Analysis

Author: Jason Newsom
Publisher: Routledge
ISBN: 1136705473
Format: PDF, Mobi
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First Published in 2012. Routledge is an imprint of Taylor & Francis, an informa company.