Biochemistry of Collagens Laminins and Elastin

Author: Morten Karsdal
Publisher: Academic Press
ISBN: 0128098996
Format: PDF
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Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides a comprehensive introduction to collagen and structural proteins Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes a chapter dedicated to the biomarkers of structural proteins Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states

Synthesis of Essential Drugs

Author: Ruben Vardanyan
Publisher: Elsevier
ISBN: 9780080462127
Format: PDF, Docs
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Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO’s Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types * Includes synonyms * Includes over 2300 references

Progress in Heritable Soft Connective Tissue Diseases

Author: Jaroslava Halper
Publisher: Springer Science & Business Media
ISBN: 9400778937
Format: PDF, Docs
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This volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scientists and for clinicians seeing patients. It is also a stepping stone for new investigations and studies that goes beyond the facts about the composition and biochemistry of the connective tissue and extracellular matrix, as the authors connect individual components to specific aspects of various soft tissue disorders and to the actual or potential treatment of them. Progress in Heritable Soft Connective Tissue Diseases features very prominent physicians and scientists as contributors who bring their most recent discoveries to the benefit of readers. Their expertise will help clinicians with proper diagnosis of sometimes elusive and uncommon heritable diseases of soft connective tissues. This book also offers an update on the pathophysiology of these diseases, including an emphasis on unifying aspects such as connections between embryonic development of the different types of connective tissues and systems, and the role of TGF-beta in development and physiology of soft tissues. This new set of data explains, at least in part, why many of these disorders are interconnected, though the primary pathophysiological events, such as gene mutations, may be different for each disorder.

Cosmeceuticals and Cosmetic Practice

Author: Patricia K. Farris
Publisher: John Wiley & Sons
ISBN: 1118384806
Format: PDF, Kindle
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Anti-aging skin care is an important part of dermatologic practice. The science behind the aging process has led to revolutionary changes in the treatment options available. Dermatologists can offer increasing numbers of combinations of pharmaceutical and cosmetic products. As choice increases so the possibility of confusion arises. Cosmeceuticals and Cosmetic Practice offers a no-nonsense guide to defusing this confusion. With an emphasis on practical applications, and with easy-access summary features, you can learn the secrets of successful cosmeceutical practice for your patients.

Nutritional Cosmetics

Author: Aaron Tabor
Publisher: William Andrew
ISBN: 0815520301
Format: PDF, ePub, Docs
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Nutritional cosmetics is an emerging area of intense research and marketing and encompasses the concept that orally consumed dietary products can support healthier and more beautiful skin. There are numerous dietary ingredients now being marketed for their potential skin health and beauty benefits and many of these are supported by growing scientific evidence. The purpose of this book is to compile the scientific evidence showing the potential benefits of some of the more extensively researched ingredients. As far as possible, information about the benefits of ingredients consumed orally for skin health is presented. The information contained in this book will help provide insights into an emerging research area and provide scientific background for the potential clinical effectiveness for some of the better researched nutricosmetic ingredients. ABOUT THE EDITORS Aaron Tabor, M.D. is the CEO of Physicians Pharmaceuticals and author of The Revival Slim & Beautiful Diet. A graduate of the Johns Hopkins School of Medicine, Dr. Tabor oversees all clinical research on the Revival Slim & Beautiful Diet plan, conducting randomized, double-blinded, placebo-controlled studies at leading hospitals in the U.S. Areas of note include weight loss, skin/hair/nail appearance, energy, menopause, PMS, cholesterol, memory, and diabetic health. He is also responsible for directing new Revival product development based on clinical research results. Robert M. Blair, Ph.D. is the Research Manager for Physicians Pharmaceuticals, Inc. and manages the daily activities of the Research and Nutrition departments. Dr. Blair received his Ph.D. from Oklahoma State University in the field of Reproductive Physiology. Before joining Physicians Pharmaceuticals, Inc., he worked as an Assistant Professor of Comparative Medicine at the Wake Forest University School of Medicine where he examined the effects of dietary soy on cardiovascular health and cognitive function. Reviews the most-popular and most-researched nutricosmetic ingredients Presents information specifically about the benefits of ingredients consumed orally for skin health Considers the benefits of whey protein, rosemary, soy – and green tea and milk thistle, specifically, for protection against sun damage and photocarcinogenesis Provides information on antioxidants, incl: potential benefits of botanical antioxidants; carotenoids; coenzyme Q10; healthy fruits; olive fruit; and natural enzymes

Biomedical Sciences

Author: Raymond Iles
Publisher: John Wiley & Sons
ISBN: 1119962412
Format: PDF, Kindle
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Biomedical Sciences is an indispensable, all encompassing core textbook for first/ second year biomedical science students that will support them throughout their undergraduate career. The book includes the key components of the IBMS accredited degree programmes, plus sections on actual practice in UK hospital laboratories (including the compilation of a reflective portfolio). The book is visually exciting, and written in an interesting and accessible manner while maintaining scientific rigour. Highlighted boxes within the text link the theory to actual clinical laboratory practice for example, the histopathology chapter includes a photographically illustrated flow chart of the progress of a specimen through the histopathology lab, so that students can actually see how the specimen reception/inking/cut-up/cassette/block/section/stain system works, with an emphasis on the safety procedures that ensure specimens are not confused).

Biological Physical and Technical Basics of Cell Engineering

Author: Gerhard M. Artmann
Publisher: Springer
ISBN: 9811079048
Format: PDF, ePub, Mobi
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This book presents and discusses recent scientific progress on Cell and Stem Cell Engineering. It predominantly focuses on Biological, Physical and Technical Basics, and features new trends of research reaching far into the 21st century.

The Diabetic Kidney

Author: Pedro Cortes
Publisher: Springer Science & Business Media
ISBN: 1597451533
Format: PDF, Kindle
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A comprehensive and authoritative survey of recent findings, ideas, and hypotheses about the causes and treatment of diabetic nephropathy. The authors cover both the basic pathogenic mechanisms of the disease, as well as many of its clinical aspects of identification, management, and new therapeutic approaches. Highlights include an entire section devoted to novel approaches to studying diabetic nephropathy with the most advanced molecular techniques, and complete descriptions of the most up-to-date views on the diagnosis and treatment of the disease. The Diabetic Kidney offers both researchers and practicing clinicians a clear understanding of the of the progress that has been made regarding the pathogenesis of diabetic nephropathy and of the therapeutic interventions needed to prevent its development or treat it.

Oxidants and Antioxidants in Cutaneous Biology

Author: Jens Thiele
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805571321
Format: PDF
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Are free radicals and reactive oxygen species relevant to dermatopathology? Do antioxidants protect against free-radical-mediated cutaneous diseases and aging? To these and further current questions in the rapidly progressing field of basic and applied skin research, this up-to-date volume provides a scientific basis. It presents state-of-the-art reviews on the progress in detection of free radicals and antioxidants and their responses to environmental oxidative stressors. Furthermore, several expert contributions focus on the exciting developments in oxidative DNA damage and UVB- and UVA-induced signal transduction in skin. Finally, information is given on new antioxidant protection strategies against skin carcinogenesis and skin aging which may be fundamental for the pharmaceutical or skin-care products of tomorrow. Due to its unique and up-to-date collection of state-of-the-art contributions by many of the world's leading scientists in the field, this book will be essential reading for dermatologists, cosmetologists, pharmacologists and environmental toxicologists.