Biotechnology Operations

Author: John M. Centanni
Publisher: CRC Press
ISBN: 1498758851
Format: PDF, Docs
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This book describes seven areas in the field of biotechnology operations as practiced by biopharmaceutical firms and nonprofit institutions. Revisions focus upon changes that have occurred in several areas over the past six years, with emphasis on regulatory, biomanufacturing, clinical and technical information, along with processes and guidlines that have added to the discipline. Examples are increased for new technical fields such as cell and tissue engineering. Further, illustrations or figures are added to each chapter to emphasize particular points.

Engineering Principles in Biotechnology

Author: Wei-Shou Hu
Publisher: John Wiley & Sons
ISBN: 1119159024
Format: PDF, Mobi
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This book is a short introduction to the engineering principles of harnessing the vast potential of microorganisms, and animal and plant cells in making biochemical products. It was written for scientists who have no background in engineering, and for engineers with minimal background in biology. The overall subject dealt with is process, but the coverage goes beyond the process of biomanufacturing in the bioreactor, and extends to the factory of cell's biosynthetic machinery. Starting with an overview of biotechnology and organism, engineers are eased into biochemical reactions and life scientists are exposed to the technology of production using cells. Subsequent chapters allow engineers to be acquainted with biochemical pathways, while life scientist learn about stoichiometric and kinetic principles of reactions and cell growth. This leads to the coverage of reactors, oxygen transfer and scale up. Following three chapters on biomanufacturing of current and future importance, i.e. cell culture, stem cells and synthetic biology, the topic switches to product purification, first with a conceptual coverage of operations used in bioseparation, and then a more detailed analysis to provide a conceptual understanding of chromatography, the modern workhorse of bioseparation. Drawing on principles from engineering and life sciences, this book is for practitioners in biotechnology and bioengineering. The author has used the material within this book for a course for advanced students in both engineering and life sciences. To this end, problems are provided at the end of each chapter.

Comprehensive Biotechnology

Author:
Publisher: Newnes
ISBN: 0080885047
Format: PDF
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The second edition of Comprehensive Biotechnology continues the tradition of the first inclusive work on this dynamic field with up-to-date and essential entries on the principles and practice of biotechnology. The integration of the latest relevant science and industry practice with fundamental biotechnology concepts is presented with entries from internationally recognized world leaders in their given fields. With two volumes covering basic fundamentals, and four volumes of applications, from environmental biotechnology and safety to medical biotechnology and healthcare, this work serves the needs of newcomers as well as established experts combining the latest relevant science and industry practice in a manageable format. It is a multi-authored work, written by experts and vetted by a prestigious advisory board and group of volume editors who are biotechnology innovators and educators with international influence. All six volumes are published at the same time, not as a series; this is not a conventional encyclopedia but a symbiotic integration of brief articles on established topics and longer chapters on new emerging areas. Hyperlinks provide sources of extensive additional related information; material authored and edited by world-renown experts in all aspects of the broad multidisciplinary field of biotechnology Scope and nature of the work are vetted by a prestigious International Advisory Board including three Nobel laureates Each article carries a glossary and a professional summary of the authors indicating their appropriate credentials An extensive index for the entire publication gives a complete list of the many topics treated in the increasingly expanding field

Centrifugal Separations in Biotechnology

Author: Wallace Woon-Fong Leung
Publisher: Elsevier
ISBN: 0080549721
Format: PDF
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This book is the first devoted to centrifugal separation in biotechnology. It is of value to professionals in the chemical, bioprocess, and biotech sectors, and all those concerned with bioseparation, bioprocessing, unit-operations and process engineering. Key topics covered include a full introduction to centrifugation, sedimentation and separation; detailed coverage of centrifuge types, including batch and semi-batch centrifuges, disk-stack and tubular decanter centrifuges; methods for increasing solids concentration; laboratory and pilot testing of centrifuges; selection and sizing centrifuges; scale-up of equipment, performance prediction and analysis of test results using numerical simulation. A comprehensive guide to centrifuges, their optimal development and operation in the biotechnology industry Applications for the separation of proteins, DNA, mitochondria, ribosomes, lysosomes and other cellular elements Provides detailed process information and data to assist in the development of particular processes from existing systems Explores the commercial applications of centrifuges in biotechnology Guidance on troubleshooting and optimizing centrifuges

Food Processing Technology

Author: P J Fellows
Publisher: Woodhead Publishing
ISBN: 0081005237
Format: PDF, ePub
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Food Processing Technology: Principles and Practice, Fourth Edition, has been updated and extended to include the many developments that have taken place since the third edition was published. The new edition includes an overview of the component subjects in food science and technology, processing stages, important aspects of food industry management not otherwise considered (e.g. financial management, marketing, food laws and food industry regulation), value chains, the global food industry, and over-arching considerations (e.g. environmental issues and sustainability). In addition, there are new chapters on industrial cooking, heat removal, storage, and distribution, along with updates on all the remaining chapters. This updated edition consolidates the position of this foundational book as the best single-volume introduction to food manufacturing technologies available, remaining as the most adopted standard text for many food science and technology courses. Updated edition completely revised with new developments on all the processing stages and aspects of food industry management not otherwise considered (e.g. financial management, marketing, food laws, and food industry regulation), and more Introduces a range of processing techniques that are used in food manufacturing Explains the key principles of each process, including the equipment used and the effects of processing on micro-organisms that contaminate foods Describes post-processing operations, including packaging and distribution logistics Includes extra textbook elements, such as videos and calculations slides, in addition to summaries of key points in each chapter

Process Validation in Manufacturing of Biopharmaceuticals Third Edition

Author: Anurag S. Rathore
Publisher: CRC Press
ISBN: 1439850933
Format: PDF, Docs
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Process Validation in Manufacturing of Biopharmaceuticals, Third Edition delves into the key aspects and current practices of process validation. It includes discussion on the final version of the FDA 2011 Guidance for Industry on Process Validation Principles and Practices, commonly referred to as the Process Validation Guidance or PVG, issued in final form on January 24, 2011. The book also provides guidelines and current practices, as well as industrial case studies illustrating the different approaches that can be taken for successful validation of biopharmaceutical processes. Case studies include Process validation for membrane chromatography Leveraging multivariate analysis tools to qualify scale-down models A matrix approach for process validation of a multivalent bacterial vaccine Purification validation for a therapeutic monoclonal antibody expressed and secreted by Chinese Hamster Ovary (CHO) cells Viral clearance validation studies for a product produced in a human cell line A much-needed resource, this book presents process characterization techniques for scaling down unit operations in biopharmaceutical manufacturing, including chromatography, chemical modification reactions, ultrafiltration, and microfiltration. It also provides practical methods to test raw materials and in-process samples. Stressing the importance of taking a risk-based approach towards computerized system compliance, this book will help you and your team ascertain process validation is carried out and exceeds expectations.

Principles and Practice of Clinical Research

Author: John I. Gallin
Publisher: Academic Press
ISBN: 0128499044
Format: PDF
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Principles and Practice of Clinical Research, Fourth Edition has been thoroughly revised to provide a comprehensive look at both the fundamental principles and expanding practice of clinical research. New to this edition of this highly regarded reference, authors have focused on examples that broadly reflect clinical research on a global scale while including a discussion of international regulations, studies, and implications. In addition to key topics such as bioethics, clinical outcome data, cultural diversity, protocol guidelines, and “omic platforms, this edition contains new chapters devoted to electronic health records and information resources for clinical researchers, as well as the many opportunities associated with big data. Covering a vast number of topics and practical advice for both novice and advanced clinical investigators, this book is a highly relevant and essential resource for all those involved in conducting research. Features input from experts in the field dedicated to translating scientific research from bench to bedside and back Provides expanded coverage of global clinical research Contains hands-on, practical suggestions, illustrations, and examples throughout Includes new chapters on the international regulation of drugs and biologics, the emergence of the important role of comparative effectiveness research and how to identify clinical risks and manage patient safety in a clinical research setting

Federal Regulatory Directory

Author: CQ Press
Publisher: CQ Press
ISBN: 1483384799
Format: PDF, ePub, Docs
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The Federal Regulatory Directory, Seventeenth Edition continues to offer a clear path through the maze of complex federal agencies and regulations, providing to-the-point analysis of regulations. Information-packed profiles of more than 100 federal agencies and departments detail the history, structure, purpose, actions, and key contacts for every regulatory agency in the U.S. government. Now updated with an improved searching structure, the Federal Regulatory Directory continues to be the leading reference for understanding federal regulations, providing a richer, more targeted exploration than is possible by cobbling together electronic and print sources.

Biotechnology of Metals

Author: K. A. Natarajan
Publisher:
ISBN: 9780128040225
Format: PDF, Mobi
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Biotechnology of Metals: Principles, Recovery Methods and Environmental Concerns deals with all aspects of metal biotechnology in different areas, such as biogenesis, biomaterials, biomimetic strategies, biohydrometallurgy, mineral biobeneficiation, electrobioleaching, microbial corrosion, human implants, concrete biocorrosion, microbiology of environment pollution, and bioremediation. As the technology of this interdisciplinary science has diversified over the last five years, this book provides a valuable source for scientists and students in a number of disciplines, including geology, chemistry, metallurgy, microbiology, chemical engineering, environment, civil engineering, and biomedical engineering. Offers comprehensive coverage of an interdisciplinary subject Outlines the role of microbiology and biotechnology in mining, metallurgy, waste disposal and environmental control Covers new topics, such as biogenesis, biomaterials processing, the role of micro-organisms in causing corrosion, and much more Presents scientifically illustrated experimental research methods in metals biotechnology

Introduction to Petroleum Biotechnology

Author: James G. Speight
Publisher: Gulf Professional Publishing
ISBN: 0128052880
Format: PDF, Docs
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Introduction to Petroleum Biotechnology introduces the petroleum engineer to biotechnology, bringing together the various biotechnology methods that are applied to recovery, refining and remediation in the uses of petroleum and petroleum products. A significant amount of petroleum is undiscoverable in reservoirs today using conventional and secondary methods. This reference explains how microbial enhanced oil recovery is aiding to produce more economical and environmentally-friendly metabolic events that lead to improved oil recovery. Meanwhile, in the downstream side of the industry, petroleum refining operators are facing the highest levels of environmental regulations while struggling to process more of the heavier crude oils since conventional physical and chemical refining techniques may not be applicable to heavier crudes. This reference proposes to the engineer and refining manager the concepts of bio-refining applications to not only render heavier crudes as lighter crudes through microbial degradation, but also through biodenitrogenation, biodemetallization and biodesulfurization, making more petroleum derivatives purified and upgraded without the release of more pollutants. Equipped for both upstream and downstream to learn the basics, this book is a necessary primer for today’s petroleum engineer. Presents the fundamentals behind petroleum biotechnology for both upstream and downstream oil and gas operations Provides the latest technology in reservoir recovery using microbial enhanced oil recovery methods Helps readers gain insight into the current and future application of using biotechnology as a refining and fuel blending method for heavy oil and tar sands