Cancer Clinical Trials

Author: Stephen L. George
Publisher: CRC Press
ISBN: 1498706908
Format: PDF, Mobi
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Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis provides statisticians with an understanding of the critical challenges currently encountered in oncology trials. Well-known statisticians from academic institutions, regulatory and government agencies (such as the U.S. FDA and National Cancer Institute), and the pharmaceutical industry share their extensive experiences in cancer clinical trials and present examples taken from actual trials. The book covers topics that are often perplexing and sometimes controversial in cancer clinical trials. Most of the issues addressed are also important for clinical trials in other settings. After discussing general topics, the book focuses on aspects of early and late phase clinical trials. It also explores personalized medicine, including biomarker-based clinical trials, adaptive clinical trial designs, and dynamic treatment regimes.

Biopharmaceutical Applied Statistics Symposium

Author: Karl E. Peace
Publisher: Springer
ISBN: 9811078297
Format: PDF, ePub, Mobi
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This BASS book Series publishes selected high-quality papers reflecting recent advances in the design and biostatistical analysis of biopharmaceutical experiments – particularly biopharmaceutical clinical trials. The papers were selected from invited presentations at the Biopharmaceutical Applied Statistics Symposium (BASS), which was founded by the first Editor in 1994 and has since become the premier international conference in biopharmaceutical statistics. The primary aims of the BASS are: 1) to raise funding to support graduate students in biostatistics programs, and 2) to provide an opportunity for professionals engaged in pharmaceutical drug research and development to share insights into solving the problems they encounter.The BASS book series is initially divided into three volumes addressing: 1) Design of Clinical Trials; 2) Biostatistical Analysis of Clinical Trials; and 3) Pharmaceutical Applications. This book is the first of the 3-volume book series. The topics covered include: A Statistical Approach to Clinical Trial Simulations, Comparison of Statistical Analysis Methods Using Modeling and Simulation for Optimal Protocol Design, Adaptive Trial Design in Clinical Research, Best Practices and Recommendations for Trial Simulations in the Context of Designing Adaptive Clinical Trials, Designing and Analyzing Recurrent Event Data Trials, Bayesian Methodologies for Response-Adaptive Allocation, Addressing High Placebo Response in Neuroscience Clinical Trials, Phase I Cancer Clinical Trial Design: Single and Combination Agents, Sample Size and Power for the Mixed Linear Model, Crossover Designs in Clinical Trials, Data Monitoring: Structure for Clinical Trials and Sequential Monitoring Procedures, Design and Data Analysis for Multiregional Clinical Trials – Theory and Practice, Adaptive Group-Sequential Multi-regional Outcome Studies in Vaccines, Development and Validation of Patient-reported Outcomes, Interim Analysis of Survival Trials: Group Sequential Analyses, and Conditional Power – A Non-proportional Hazards Perspective.

Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research

Author: Chul Ahn
Publisher: CRC Press
ISBN: 1466556269
Format: PDF, ePub, Docs
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Accurate sample size calculation ensures that clinical studies have adequate power to detect clinically meaningful effects. This results in the efficient use of resources and avoids exposing a disproportionate number of patients to experimental treatments caused by an overpowered study. Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research explains how to determine sample size for studies with correlated outcomes, which are widely implemented in medical, epidemiological, and behavioral studies. The book focuses on issues specific to the two types of correlated outcomes: longitudinal and clustered. For clustered studies, the authors provide sample size formulas that accommodate variable cluster sizes and within-cluster correlation. For longitudinal studies, they present sample size formulas to account for within-subject correlation among repeated measurements and various missing data patterns. For multiple levels of clustering, the level at which to perform randomization actually becomes a design parameter. The authors show how this can greatly impact trial administration, analysis, and sample size requirement. Addressing the overarching theme of sample size determination for correlated outcomes, this book provides a useful resource for biostatisticians, clinical investigators, epidemiologists, and social scientists whose research involves trials with correlated outcomes. Each chapter is self-contained so readers can explore topics relevant to their research projects without having to refer to other chapters.

Statistik f r Dummies

Author: Deborah J. Rumsey
Publisher: John Wiley & Sons
ISBN: 3527692762
Format: PDF, ePub, Mobi
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Von A wie Ausreißer bis Z wie Z-Verteilung Entdecken Sie mit Statistik für Dummies Ihren Spaß an der Statistik und werfen Sie einen Blick hinter die Kulissen dieser komplizierten, aber hilfreichen Wissenschaft! Deborah Rumsey zeigt Ihnen das nötige statistische Handwerkszeug wie Stichprobe, Wahrscheinlichkeit, Bias, Median, Durchschnitt und Korrelation. Sie lernen die verschiedenen grafischen Darstellungsmöglichkeiten von statistischem Material kennen und werden über die unterschiedlichen Methoden der Auswertung erstaunt sein. Schärfen Sie mit diesem Buch Ihr Bewusstsein für Zahlen und deren Interpretation, sodass Ihnen keiner mehr etwas vormachen kann!

SPSS 16

Author: Achim Bühl
Publisher: Pearson Deutschland GmbH
ISBN: 9783827373328
Format: PDF, ePub
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Die Standardeinführung für SPSS ist auf der Basis zahlreicher neuer Datensätze für die Version 16 vollständig überarbeitet und erweitert worden. Ausgehend von Problemstellungen aus der Praxis wird gezeigt, wie Sie mit SPSS arbeiten können. Die Beispiele basieren meist auf Fallstudien und sind vor allem dem sozialwissenschaftlichen und dem psychologisch-medizinischen Bereich entnommen. Der Autor beschreibt ausführlich den kompletten statistischen Inhalt der Module Base, Regression Models und Advanced Models. In der 11. Auflage des Werks nimmt erstmals auch die Korrespondenzanalyse einen breiten Raum ein; ein Verfahren, das immer häufiger eingesetzt wird und Zusammenhänge von Variablen optisch als Punkte eines geometrischen Raums aufbereitet.