Breast Cancer Cellular and Molecular Biology

Author: Marc E. Lippman
Publisher: Springer Science & Business Media
ISBN: 1461317339
Format: PDF, ePub, Mobi
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Where do you begin to look for a recent, authoritative article on the diagnosis or management of particular malignancy? The few general oncology text books are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals fre quently publish good in-depth reviews of cancer topics, and published sym posium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by divid ing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Cell and Molecular Biology of Breast Cancer

Author: Heide Schatten
Publisher: Springer Science & Business Media
ISBN: 1627036342
Format: PDF, ePub
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Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book. Included are reviews of genetics, epigenetics, various aspects of cell and molecular biology, and several other areas of breast cancer that are aimed at determining new intervention sites for treatments and cures of the disease. The chapters are written by internationally recognized experts and include reviews of key topics in breast cancer research. Each chapter highlights the new aspects of specific research topics and the various impacts of designing new strategies as well as identifies new targets for therapeutic intervention. The topics addressed are selected to be of interest to patients, scientists, students, teachers, and anyone else interested in expanding their knowledge of breast cancer imaging, diagnostics, therapeutics, or basic biomedical research on breast cancer.

Regulatory Mechanisms in Breast Cancer

Author: Marc E. Lippman
Publisher: Springer Science & Business Media
ISBN: 1461539404
Format: PDF, Kindle
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In Breast Cancer: Cellular and Molecular Biology [Kluwer Academic Pub lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres sion. In the two years since its publication, much new and exciting in formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho logists to establish prognostic outcome. Of particular interest is a new proto oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto oncogene and antioncogene expression.

Genes Oncogenes and Hormones

Author: Robert B. Dickson
Publisher: Springer Science & Business Media
ISBN: 146153500X
Format: PDF, ePub
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Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current di agnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Mammary Tumor Cell Cycle Differentiation and Metastasis

Author: Robert B. Dickson
Publisher: Springer Science & Business Media
ISBN: 1461312590
Format: PDF, Docs
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Mammary Tumor Cell Cycle, Differentiation and Metastasis is the fifth volume since 1988 in a series designed to broadly examine current advances in the cellular and molecular biology of breast cancer. As in previous volumes, the editors have invited recognized experts in cutting-edge topics to provide a chapter focused on their area of research. The editors have turned to the researchers who study rodent models of the disease and to those who study the cellular and molecular basis of human breast cancer. The first section of the book is devoted to new mouse models of mammary development and tumorigenesis. The second section moves to studies of human breast cancer and focuses on receptors, signalling, and the cell cycle. The final section deals with defective tissue interactions in human breast cancer. We are now in a period of extremely rapid accumulation of data on the molecular and cellular biology of breast cancer. These findings are highlighted in chapters from Mammary Tumor Cell Cycle, Differentiation and Metastasis: Advances in Cellular and Molecular Biology of Breast Cancer.

Introduction to the Cellular and Molecular Biology of Cancer

Author: Leonard Maurice Franks
Publisher: Oxford University Press, USA
ISBN: 9780198548546
Format: PDF, ePub
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The third edition of this repected textbook has been extensively revised and updated by the authors and editors to achieve the same objectives as the two earlier editions -- to provide a relatively brief but comprehensive introduction to the initiation, development, and treatment of cancer.After an introduction describing the pathology and natural history of the disease, subsequent chapters survey particular areas of research, concentrating on the principles involved and recent developments. Each topic is reviewed authoritatively by acknowledged experts, in a way that will beunderstood by non-experts in the field.The chapters on epidemiology, genetic and chromosome changes, oncogenes, chemical and radiation carcinogenesis, growth factors, the biology of human leukaemia, and hormones and cancer have been rewritten and/or extensively revised and new developments resulting from the wide application of currenttechniques in cellular and molecular biology to the study of cancer are included. Other chapters have been revised and brought up to date, and new chapters are inclueed on cytokines and cancer, the molecular pathology of cancer, and cancer prevention and screening.Introduction to the Molecular and Celluar Bilogy of Cancer provides a general survey of the whole field of cancer as a basis for research and will serve as a valuable introduction to students and scientists new to the field.

Cell Molecular Biology of Prostate Cancer

Author: Heide Schatten
Publisher: Springer
ISBN: 3319956930
Format: PDF, Docs
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This volume covers classic and modern cell and molecular biology of prostate cancer, as well as novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation and genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis and progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Cell & Molecular Biology of Prostate Cancer is one of two companion books comprehensively addressing the biology and clinical aspects of prostate cancer. Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, the companion volume, discusses both classic and the most recent imaging approaches including analysis of needle biopsies, applications of nanoparticle probes and peptide-based radiopharmaceuticals for detection, early diagnosis and treatment of prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature.

Molecular Biology of Cancer

Author: Fiona Macdonald
Publisher: Garland Science
ISBN: 0203503449
Format: PDF, ePub
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Molecular Biology of Cancer has been extensively revised and covers heredity cancer, microarray technology and increased study of childhood cancers. It continues to provide a detailed overview of the process which lead to the development and proliferation of cancer cells, including the techniques available for their study. It also describes the means by which tumor suppressor genes and oncogenes may be used in the diagnosis and in determining the prognosis of a wide variety of cancers, including breast, genitourinary, lung and gastrointestinal cancer.

Cancer Biology

Author: R. J. B. King
Publisher: Addison-Wesley Longman Limited
ISBN: 9780582404328
Format: PDF
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Cancer Biology provides a clear, concise and authoritative introduction to the biological principles that underlie the causes and treatment of cancer, drawing on the author's extensive research and teaching experience to guide students through this complex subject. The study of cancer encompasses cell and molecular biology, biochemistry, epidemiology and medical sciences and this text brings together these diverse areas. The emphasis is on human aspects, with underlying principles illustrated by specific examples which are supplemented with data from other species where appropriate. The new edition has been updated throughout with new material on chemoprevention, DNA repair, telomerase, apoptosis, signal transduction, cell adhesion, angiogenesis and new treatments. A new appendix provides descriptions of 15 selected cancers, with data on cancer risks and survival rates, and notes on risk factors and metastasis. Features * Comprehensive up-to-date coverage of key topics in cancer biology * A human emphasis including principles of cancer treatment * Accessible single author text, with boxes, chapter summaries and clear two-colour diagrams * Updated coverage of diet and prevention, DNA repair, telomerase, apoptosis, signal transduction, cell adhesion, angiogenesis and new treatments * Extended and updated references, a new list of abbreviations and improved glossary * New appendix on features of 15 selected cancers, including breast cancer and leukaemia Cancer Biology is an essential text for students of cell biology, biochemistry, molecular biology, genetics and biomedical sciences. It will also be valuable to postgraduate students moving into cancerresearch. Roger King is Honorary Professor in Cellular Oncology at Surrey University, UK. He was formerly Chairman of the International Society for Hormones and Cancer, Head of the Hormone Biochemistry Department at the Imperial Cancer Research Fund Laboratories and a consultant to the World Health Organisation.

The Molecular Biology of Cancer

Author: Stella Pelengaris
Publisher: John Wiley & Sons
ISBN: 1118430859
Format: PDF, ePub, Docs
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The Molecular Biology of Cancer, Stella Pelengaris& Michael Khan This capturing, comprehensive text, extensively revisedand updated for its second edition, provides a detailed overview ofthe molecular mechanisms underpinning the development of cancer andits treatment. “Bench to Bedside”: A key strength of thisbook that sets it apart from general cancer biology references isthe interweaving of all aspects of cancer biology from the causes,development and diagnosis through to the treatment and care ofcancer patients – essential for providing a broader view ofcancer and its impact. The highly readable presentation of a complex field,written by an international panel of researchers, specialists andpractitioners, would provide an excellent text for graduate andundergraduate courses in the biology of cancer, medical studentsand qualified practitioners in the field preparing for higherexams, and for researchers and teachers in the field. For the teaching of cancer biology, special features havebeen included to facilitate this use: bullet points at thebeginning of each chapter explaining key concepts and controversialareas; each chapter builds on concepts learned in previouschapters, with a list of key outstanding questions remaining in thefield, suggestions for further reading, and questions for studentreview. All chapters contain text boxes that provide additional andrelevant information. Key highlights are listed below: An overview of the cancer cell and important newconcepts. Selected human cancers: lung, breast, colorectal, prostate,renal, skin, cervix, and hematological malignancies. Key cellular processes in cancer biology including (a)traditionally important areas such as cell cycle control, growthregulation, oncogenes and tumour suppressors apoptosis, as well as(b) more highly topical areas of apoptosis, telomeres, DNA damageand repair, cell adhesion, angiogenesis, immunity, epigenetics, andthe proteasome. Clinical oncology: In-depth coverage of important concepts suchas screening, risk of cancer and prevention, diagnoses, managingcancer patients from start to palliative care and end-of-lifepathways. Chapters highlighting the direct links between cancer researchand clinical applications. New coverage on how cancer drugs are actually used inspecific cancer patients, and how therapies are developed andtested. Systems Biology and cutting edge research areas covered such asRNA interference (RNAi). Each chapter includes key points, chapter summaries, textboxes, and topical references for added comprehension andreview. Quotations have been used in each chapter to introduce basicconcepts in an entertaining way. Supported by a dedicated website at ahref="http://www.blackwellpublishing.com/pelengaris"www.blackwellpublishing.com/pelengaris/a We should list the great reviews we got for first editionwhich are on the back of the 2nd edition: “A capturing, comprehensive, clearly written andabsolutely accurate introduction into cancer biology…..Thisbook deserves great praise for the readable presentation of thiscomplex field….the true synthesis of bench and bedsideapproaches is marvelously achieved.” Christian Schmidt,Molecular Cell “Chapters address the issues of cancer diagnosis,treatment, and patient care and set the book apart from generalmolecular biology references….This book is applicable to bothgraduate and undergraduate students, and in the context of aresearch laboratory, this book would be an excellent resource as areference guide for scientists at all levels.” V.Emuss,Institute of Cancer Research, London. Also, from the first edition: “Pelengaris, Khan, and the contributing authors are to beapplauded. The Molecular Biology of Cancer is acomprehensive and readable presentation of the many faces of cancerfrom molecular mechanisms to clinical therapies and diagnostics.This book will be welcomed by neophyte students, establishedscientists in other fields, and curious physicians.” -DeanFelsher, Stanford University