Co and Posttranslational Proteolysis of Proteins

Author:
Publisher: Elsevier
ISBN: 0080542441
Format: PDF
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This volume examines a number of different proteases, a type of enzyme, that are required in order for the change to a biologically active mature protein to occur. The discussion of these various proteases is rarely undertaken in one volume and will serve as a great resource for scientists studying the group of proteases on signal peptide processing as well as those working on propeptide processing. These areas of research do not normally overlap, and yet they are each of common importance to the same cell processes.

Disease Markers of the Nervous System

Author: Michael G. Harrington
Publisher: IOS Press
ISBN: 9781586035679
Format: PDF, Kindle
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"The nervous system is important in controlling cognition and behaviors as well as bodily functions via the peripheral and autonomic pathways. A dysfunction in the nervous system results in diseases that are an increasing burden to modern medicine. Advances in the diagnosis, control and treatment of these diseases will require a comprehensive knowledge of the biochemical changes associated with specific brain functions. Brain functions are currently identified, and sometimes measured, by clinical structured interviews, coupled with imaging or neurophysiological procedures. Far fewer molecular based diagnostic methods, such as disease specific biomarkers, are available at this point to monitor biochemical changes for central nervous diseases. Fortunately, new technologies place medical research on the threshold of discovering a great deal about disease biochemistry, and future advances should be rapid. This volume provides a taste of the field and also highlights how much comprehensive work is needed towards the ultimate goal of understanding diseases of the nervous system on a molecular level. The editors believe the new technologies of the varied forms of array technologies, chromatography, mass spectrometry and analysis methods, when coupled with well-defined clinical experiments, have the opportunities to make real progress."

Handbook of Proteolytic Enzymes

Author: Alan J. Barrett
Publisher: Elsevier
ISBN: 0080984150
Format: PDF, ePub, Mobi
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Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.

Steroid Receptors in Health and Disease

Author: Virinder Moudgil
Publisher: Springer Science & Business Media
ISBN: 1468455419
Format: PDF
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During the last two decades, progress in steroid hormone research has resulted in the development of new approaches to contraception as well as diagnosis and treatment of endocrine disorders and cancers. Although significant advances have been made in the purification, characterization, immunochemistry and molecular biology of steroid receptors, the precise molecular mechanism of steroid hormone action has remained obscure. This book captures the detailed presentations made at the first conference on Steroid Receptors in Health and Disease held at Meadow Brook Hall, Oakland University in the fall of 1987. The purpose of this international con ference was to facilitate scientific exchange toward a better understand ing of the mode of action of steroid hormones. The scientific sessions consisted of poster presentations and state-of-the-art lectures, the latter of which make up this volume. The first chapter is meant to provide the reader with a more general background of the topics covered in the book, as well as to discuss certain theme-related issues that are either not yet well-established or accepted or are in the stage of infancy. It is hoped that this volume will serve as a useful treatise for students and investigators interested in basic and clinical aspects of biological regulation by steroid hormones. A task of this magnitude could not have been undertaken without the encouragement, advice and continued generous assistance of the members of the scientific committee. I am gratefully indebted to Drs.

Protein Misfolding Diseases

Author: Marina Ramirez-Alvarado
Publisher: John Wiley & Sons
ISBN: 9781118031810
Format: PDF, ePub, Docs
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An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.

Biopolymers Polyamides and Complex Proteinaceous Materials I

Author: A. Steinb├╝chel
Publisher: Wiley-Blackwell
ISBN:
Format: PDF, Kindle
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Biopolymers Online provides a comprehensive overview of the occurrence, metabolism, and applications of all important biopolymer classes. This reference work treats processes for biotechnological production, isolation from organisms and modification, material properties and technical uses in areas such as chemical and food industries, medicine, pharmacy, and materials science.

Posttranslational Modification of Proteins

Author: Christoph Kannicht
Publisher: Springer Science & Business Media
ISBN: 1592591817
Format: PDF
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Christoph Kannicht and a panel of highly experienced researchers describe readily reproducible methods for detecting and analyzing the posttranslational modifications of protein, particularly with regard to protein function, proteome research, and the characterization of pharmaceutical proteins.

Textbook of Biochemistry for Medical Students

Author: D M Vasudevan
Publisher: JP Medical Ltd
ISBN: 9385999745
Format: PDF, ePub
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Fully revised, new edition presenting students with latest advances in field of biochemistry. Features clinical case studies, MCQs, short questions, essays and viva voce questions for revision.

Protein Degradation

Author: R. John Mayer
Publisher: John Wiley & Sons
ISBN: 3527620362
Format: PDF
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The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, it also presents the latest results on novel members of the ubiquitin superfamily and their role in cellular regulation. Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.