Comparative Genomics

Author: Xuhua Xia
Publisher: Springer Science & Business Media
ISBN: 3642371469
Format: PDF, ePub, Docs
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This book provides an evolutionary conceptual framework for comparative genomics, with the ultimate objective of understanding the loss and gain of genes during evolution, the interactions among gene products, and the relationship between genotype, phenotype and the environment. The many examples in the book have been carefully chosen from primary research literature based on two criteria: their biological insight and their pedagogical merit. The phylogeny-based comparative methods, involving both continuous and discrete variables, often represent a stumbling block for many students entering the field of comparative genomics. They are numerically illustrated and explained in great detail. The book is intended for researchers new to the field, i.e., advanced undergraduate students, postgraduates and postdoctoral fellows, although professional researchers who are not in the area of comparative genomics will also find the book informative.

Foundations of Comparative Genomics

Author: Arcady R. Mushegian
Publisher: Elsevier
ISBN: 9780080546094
Format: PDF
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This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics. Presents an historic overview of genome biology and its achievements Includes topics not covered in other books such as minimal and ancestral genomes Discusses the evolutionary resilience of protein-coding genes and frequent functional convergence at the molecular level Critically reviews horizontal gene transfer and other contentious issues Covers comparative virology as a somewhat overlooked foundation of modern genome science

Comparative Genomics

Author: Nicholas H. Bergman
Publisher: Humana Press
ISBN: 9781588296931
Format: PDF, Mobi
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This volume provides a collection of robust protocols for molecular biologists studying comparative genomics. Given the tremendous increase in available biosequence data over the past ten years, this volume is timely, comprehensive, and novel. The volume is intended for molecular biologists, biochemists and geneticists.

Comparative Genomics

Author: Per Sunnerhagen
Publisher: Springer Science & Business Media
ISBN: 9783540314806
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Fungal comparative genomics started in 2000 by the genome sequencing of several yeast species other than the canonical Saccharomyces cerevisiae. Since then, over 30 fungal genome sequences have become available. This set represents a total evolutionary divergence comparable to that between vertebrates and arthropods, but also contains closely related genomes. This volume describes how we can use this set of genomes to trace large and small-scale events in genome evolution, to extract information about highly conserved and less conserved sequence elements, and to develop novel methods in genomics that will have an impact on genomics at large.

Comparative Genomics

Author: James R. Brown
Publisher: CRC Press
ISBN: 9781420008876
Format: PDF, ePub
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When genomic research first came on the scene, much of the biomedical research community viewed it as a limited venture with limited potential. We now know that such an assessment was both highly premature and wonderfully inaccurate. In the last ten years, we’ve witnessed such remarkable acceleration in the merger of basic and applied genomic research that, among other things, genomic research is now thought of as being intrinsic to current drug research. Through rigorous comparative analysis, the genomes of cold-blooded vertebrate, avian, and other mammalian species are providing a deeper understanding of the human genome. Moreover, genomic sequences, which are becoming available for several species have proven to be highly relevant to drug research with regard to a number of otherwise intractable conditions. Rather than offering a comprehensive volume covering every aspect of comparative genomics, Comparative Genomics: Basic and Applied Research embodies the diverse interests of prominent researchers in the field. Compiling first hand descriptions of their pioneering work, the text focuses on commonalities and synergies across the broad field of comparative genomics. Among its many topics it covers— · Revolutionary advances in DNA-sequencing technology · Bold new approaches to the organization and analysis of large phylogenetic data sets · The impact of comparative genomics on our understanding of evolution · Efforts toward developing novel antimicrobial drugs, through the use of bacterial pathogen genomes Ultimately, future breakthroughs in comparative genomics will depend upon the continued interaction and interdependency of applied and basic research. This seminal volume demonstrates both the means and the fruits of that cooperation, and in doing so defines and lays the groundwork for continued progress.

Comparative Genomics

Author: Melody Clark
Publisher: Springer Science & Business Media
ISBN: 9780412830808
Format: PDF, Kindle
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Comparative genomics: an introduction: sequencing projects and model organisms (M. S. Clark). Drosophila melanogaster: a genetic tool (U. Schafer, H. Jackle). Tunicates: models for chordate evolution and development at low genomic complexity (W. R. Jeffrey). Fugu rubripes: a fish model genome (M. S. Clark, G. Elgar). The mouse and the genomic era (T. J. Wilson, F. Lazner, I. Kola, P. J. Hertzog). Quantitative Trait Loci in domestic animals - complex inheritance patterns (E. Lipkin, m. Soller). Comparative genomics of vertebrates and the evolution of sex chromosomes (J. A. M. Graves, S. Shetty). Insights into mammalian genome organization evolution by molecular cytogenetics (J. Wienberg, L. Froniecke, R. Stanyon). Index.

Comparative Genomics

Author: Francesca D. Ciccarelli
Publisher: Springer Science & Business Media
ISBN: 3642047432
Format: PDF, Kindle
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This book constitutes the proceedings of the 7th RECOMB International Satellite Workshop on Comparative Genomics, RECOMB-CG 2009, Budapest, Hungary, in September 2009. This workshop is devoted to bringing together scientists working on all aspects of comparative genomics, from computer scientists, mathematicians and statisticians working on novel computational approaches for genome analysis and comparison, to biologists applying these computational tools to study the structure and the evolution of prokaryotic and eukaryotic genomes. The 19 papers presented were carefully reviewed and selected from 31 submissions. The papers illustrate the crucial role of comparative genomics in understanding genome function and address a broad variety of aspects, ranging from the inference of evolution in genetic regulatory networks to the divergent fates of gene and genome duplication events and to the importance of new computational approaches to unraveling the structural evolution of genomes.

Comparative Genomics

Author: Guillaume Bourque
Publisher: Springer Science & Business Media
ISBN: 3540445293
Format: PDF, Kindle
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This book constitutes the refereed proceedings of the 4th RECOMB Comparative Genomics Satellite Workshop, RECOMB-CG 2006. The 17 revised full papers presented were carefully reviewed and selected from 34 initial submissions. The papers address a broad variety of aspects and components of the field of comparative genomics, ranging from new quantitative discoveries about genome structure and process to theorems on the complexity of computational problems inspired by genome comparison.