Data Warehousing for Biomedical Informatics

Author: Richard E. Biehl
Publisher: CRC Press
ISBN: 1482215225
Format: PDF, ePub, Docs
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Data Warehousing for Biomedical Informatics is a step-by-step how-to guide for designing and building an enterprise-wide data warehouse across a biomedical or healthcare institution, using a four-iteration lifecycle and standardized design pattern. It enables you to quickly implement a fully-scalable generic data architecture that supports your organization’s clinical, operational, administrative, financial, and research data. By following the guidelines in this book, you will be able to successfully progress through the Alpha, Beta, and Gamma versions, plus fully implement your first production release in about a year. The Alpha version allows you to implement just enough of the basic design pattern to illustrate its core capabilities while loading a small sampling of limited data for demonstration purposes. This provides an easy way for everyone involved to visualize the new warehouse paradigm by actually examining a core subset of the working system. You can finish the Alpha version, also referred to as the proof-of-concept, in as little as 3-4 weeks. The Beta version, which can be completed in about 2-3 months, adds required functionality and much more data. It allows you to get the full warehouse up and running quickly, in order to facilitate longer-term planning, user and support team training, and setup of the operational environment. The Gamma version, which is a fully-functional system–though still lacking data–can be implemented in about 3-4 months. About one year after starting, you will be ready to launch Release 1.0 as a complete and secure data warehouse.

Pediatric Biomedical Informatics

Author: John J. Hutton
Publisher: Springer Science & Business Media
ISBN: 9400751494
Format: PDF, ePub
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Advances in the biomedical sciences, especially genomics, proteomics, and metabolomics, taken together with the expanding use of electronic health records, are radically changing the IT infrastructure and software applications needed to support the transfer of knowledge from bench to bedside. Pediatric Biomedical Informatics: Computer Applications in Pediatric Research describes the core resources in informatics necessary to support biomedical research programs and how these can best be integrated with hospital systems to receive clinical information that is necessary to conduct translational research.The focus is on the authors’ recent practical experiences in establishing an informatics infrastructure in a large research-intensive children’s hospital. This book is intended for translational researchers and informaticians in pediatrics, but can also serve as a guide to all institutions facing the challenges of developing and strengthening informatics support for biomedical research. The first section of the book discusses important technical challenges underlying computer-based pediatric research, while subsequent sections discuss informatics applications that support biobanking and a broad range of research programs. Pediatric Biomedical Informatics provides practical insights into the design, implementation, and utilization of informatics infrastructures to optimize care and research to benefit children. Dr. John Hutton is the Vice President and Director of Biomedical Informatics at Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA. He is also Professor of Pediatrics and Associate Dean for Information Services at the University of Cincinnati College of Medicine.

Biomedical Informatics in Translational Research

Author: Hai Hu
Publisher: Artech House
ISBN: 159693039X
Format: PDF, Mobi
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This trailblazing resource on biomedical informatics provides medical researchers with innovative techniques for integrating and federating data from clinical and molecular studies. This volume helps researchers manage data, expedite their efforts, and make the most of targeted basic research.

Medical Informatics Europe 99

Author: Peter Kokol
Publisher: IOS Press
ISBN: 9780967335513
Format: PDF, Docs
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This volume seeks to reflect the state of the art on medical informatics. It presents ideas that will guide the process of medical informatics. Topics in the book include: information systems in health care and medicine; telemedicine and telematics; security; biomedical processing, data mining and knowledge discovery; training and education; Internet/intranet; resources management; intelligent medical systems; health guidelines and protocols; electronic patient encounter, card technology, electronic data interchange; terminology; nursing informatics.

Biomedical Informatics for Cancer Research

Author: Michael F. Ochs
Publisher: Springer Science & Business Media
ISBN: 1441957146
Format: PDF, ePub
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view, showing that multiple molecular pathways must be affected for cancer to develop, but with different specific proteins in each pathway mutated or differentially expressed in a given tumor (The Cancer Genome Atlas Research Network 2008; Parsons et al. 2008). Different studies demonstrated that while widespread mutations exist in cancer, not all mutations drive cancer development (Lin et al. 2007). This suggests a need to target only a deleterious subset of aberrant proteins, since any tre- ment must aim to improve health to justify its potential side effects. Treatment for cancer must become highly individualized, focusing on the specific aberrant driver proteins in an individual. This drives a need for informatics in cancer far beyond the need in other diseases. For instance, routine treatment with statins has become widespread for minimizing heart disease, with most patients responding to standard doses (Wilt et al. 2004). In contrast, standard treatment for cancer must become tailored to the molecular phenotype of an individual tumor, with each patient receiving a different combination of therapeutics aimed at the specific aberrant proteins driving the cancer. Tracking the aberrations that drive cancers, identifying biomarkers unique to each individual for molecular-level di- nosis and treatment response, monitoring adverse events and complex dosing schedules, and providing annotated molecular data for ongoing research to improve treatments comprise a major biomedical informatics need.

Medical Informatics in a United and Healthy Europe

Author: Klaus-Peter Adlassnig
Publisher: IOS Press
ISBN: 1607500442
Format: PDF
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This volume contains the proceedings of the 22nd International Conference on Medical Informatics Europe 2009 (MIE) in Sarajevo, Bosnia and Herzegovina, September 2009. The scientific topics presented in these proceedings range from national and transnational ehealth roadmaps, health information and electronic health record systems, systems interoperability and communication standards, medical terminology and ontology approaches, and social networks to web, web 2.0, and semantic web solutions for patients, health personnel and researchers.

Data Mining in Biomedical Imaging Signaling and Systems

Author: Sumeet Dua
Publisher: CRC Press
ISBN: 1439839395
Format: PDF, ePub, Mobi
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Data mining can help pinpoint hidden information in medical data and accurately differentiate pathological from normal data. It can help to extract hidden features from patient groups and disease states and can aid in automated decision making. Data Mining in Biomedical Imaging, Signaling, and Systems provides an in-depth examination of the biomedical and clinical applications of data mining. It supplies examples of frequently encountered heterogeneous data modalities and details the applicability of data mining approaches used to address the computational challenges in analyzing complex data. The book details feature extraction techniques and covers several critical feature descriptors. As machine learning is employed in many diagnostic applications, it covers the fundamentals, evaluation measures, and challenges of supervised and unsupervised learning methods. Both feature extraction and supervised learning are discussed as they apply to seizure-related patterns in epilepsy patients. Other specific disorders are also examined with regard to the value of data mining for refining clinical diagnoses, including depression and recurring migraines. The diagnosis and grading of the world’s fourth most serious health threat, depression, and analysis of acoustic properties that can distinguish depressed speech from normal are also described. Although a migraine is a complex neurological disorder, the text demonstrates how metabonomics can be effectively applied to clinical practice. The authors review alignment-based clustering approaches, techniques for automatic analysis of biofilm images, and applications of medical text mining, including text classification applied to medical reports. The identification and classification of two life-threatening heart abnormalities, arrhythmia and ischemia, are addressed, and a unique segmentation method for mining a 3-D imaging biomarker, exemplified by evaluation of osteoarthritis, is also presented. Given the widespread deployment of complex biomedical systems, the authors discuss system-engineering principles in a proposal for a design of reliable systems. This comprehensive volume demonstrates the broad scope of uses for data mining and includes detailed strategies and methodologies for analyzing data from biomedical images, signals, and systems.

Data Mining and Machine Learning in Cybersecurity

Author: Sumeet Dua
Publisher: CRC Press
ISBN: 9781439839430
Format: PDF, Docs
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With the rapid advancement of information discovery techniques, machine learning and data mining continue to play a significant role in cybersecurity. Although several conferences, workshops, and journals focus on the fragmented research topics in this area, there has been no single interdisciplinary resource on past and current works and possible paths for future research in this area. This book fills this need. From basic concepts in machine learning and data mining to advanced problems in the machine learning domain, Data Mining and Machine Learning in Cybersecurity provides a unified reference for specific machine learning solutions to cybersecurity problems. It supplies a foundation in cybersecurity fundamentals and surveys contemporary challenges—detailing cutting-edge machine learning and data mining techniques. It also: Unveils cutting-edge techniques for detecting new attacks Contains in-depth discussions of machine learning solutions to detection problems Categorizes methods for detecting, scanning, and profiling intrusions and anomalies Surveys contemporary cybersecurity problems and unveils state-of-the-art machine learning and data mining solutions Details privacy-preserving data mining methods This interdisciplinary resource includes technique review tables that allow for speedy access to common cybersecurity problems and associated data mining methods. Numerous illustrative figures help readers visualize the workflow of complex techniques and more than forty case studies provide a clear understanding of the design and application of data mining and machine learning techniques in cybersecurity.

Medical Infobahn for Europe

Author: Arie Hasman
Publisher: Ios PressInc
ISBN: 9781586030636
Format: PDF, ePub
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The challenge of this century is to develop and introduce information technology for the improvement of quality and efficiency of health care. Telematics applications will focus on the patient and support evidence-based health informatics, will provide generic medical information for health care professionals and citizens, and support disease management as well as case management. Biometry and epidemiology continuously contribute to the progress in medicine by focussing on risk assessment, prevention, improvements in therapy, drug surveillance and safety, and by providing a rational synthesis for evidence. Presentations, demonstrations, tutorials and other contributions of medical informatics as well as the methodological contributions of biometry and epidemiology are covering an important number of topics.