Design and Analysis of Experiments in the Health Sciences

Author: Gerald van Belle
Publisher: John Wiley & Sons
ISBN: 1118279719
Format: PDF, ePub
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An accessible and practical approach to the design and analysis of experiments in the health sciences Design and Analysis of Experiments in the Health Sciences provides a balanced presentation of design and analysis issues relating to data in the health sciences and emphasizes new research areas, the crucial topic of clinical trials, and state-of-the- art applications. Advancing the idea that design drives analysis and analysis reveals the design, the book clearly explains how to apply design and analysis principles in animal, human, and laboratory experiments while illustrating topics with applications and examples from randomized clinical trials and the modern topic of microarrays. The authors outline the following five types of designs that form the basis of most experimental structures: Completely randomized designs Randomized block designs Factorial designs Multilevel experiments Repeated measures designs A related website features a wealth of data sets that are used throughout the book, allowing readers to work hands-on with the material. In addition, an extensive bibliography outlines additional resources for further study of the presented topics. Requiring only a basic background in statistics, Design and Analysis of Experiments in the Health Sciences is an excellent book for introductory courses on experimental design and analysis at the graduate level. The book also serves as a valuable resource for researchers in medicine, dentistry, nursing, epidemiology, statistical genetics, and public health.

Experimental Design and Analysis for Psychology

Author: Herve Abdi
Publisher: Oxford University Press
ISBN: 0199299889
Format: PDF, ePub
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A complete course in data collection and analysis for students who need to go beyond the basics. A true course companion, the engaging writing style takes readers through challenging topics, blending examples and exercises with careful explanations and custom-drawn figures ensuring the most daunting concepts can be fully understood.

Design and Analysis of Time Series Experiments

Author: Richard McCleary
Publisher: Oxford University Press
ISBN: 0190661569
Format: PDF, Docs
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Design and Analysis of Time Series Experiments presents the elements of statistical time series analysis while also addressing recent developments in research design and causal modeling. A distinguishing feature of the book is its integration of design and analysis of time series experiments.Drawing examples from criminology, economics, education, pharmacology, public policy, program evaluation, public health, and psychology, Design and Analysis of Time Series Experiments is addressed to researchers and graduate students in a wide range of behavioral, biomedical and social sciences.Readers learn not only how-to skills but, also the underlying rationales for the design features and the analytical methods. ARIMA algebra, Box-Jenkins-Tiao models and model-building strategies, forecasting, and Box-Tiao impact models are developed in separate chapters. The presentation of themodels and model-building assumes only exposure to an introductory statistics course, with more difficult mathematical material relegated to appendices. Separate chapters cover threats to statistical conclusion validity, internal validity, construct validity, and external validity with an emphasison how these threats arise in time series experiments. Design structures for controlling the threats are presented and illustrated through examples. The chapters on statistical conclusion validity and internal validity introduce Bayesian methods, counterfactual causality and synthetic control groupdesigns. Building on the earlier of the authors, Design and Analysis of Time Series Experiments includes more recent developments in modeling, and considers design issues in greater detail than any existing work. Additionally, the book appeals to those who want to conduct or interpret time seriesexperiments, as well as to those interested in research designs for causal inference.

Contemporary Multivariate Analysis and Design of Experiments

Author: Kaitai Fang
Publisher: World Scientific
ISBN: 9812567763
Format: PDF, Docs
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This book furthers new and exciting developments in experimental designs, multivariate analysis, biostatistics, model selection and related subjects. It features articles contributed by many prominent and active figures in their fields. These articles cover a wide array of important issues in modern statistical theory, methods and their applications. Distinctive features of the collections of articles are their coherence and advance in knowledge discoveries.

A First Course in the Design of Experiments

Author: John H. Skillings
Publisher: CRC Press
ISBN: 9780849396717
Format: PDF, Mobi
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Most texts on experimental design fall into one of two distinct categories. There are theoretical works with few applications and minimal discussion on design, and there are methods books with limited or no discussion of the underlying theory. Furthermore, most of these tend to either treat the analysis of each design separately with little attempt to unify procedures, or they will integrate the analysis for the designs into one general technique. A First Course in the Design of Experiments: A Linear Models Approach stands apart. It presents theory and methods, emphasizes both the design selection for an experiment and the analysis of data, and integrates the analysis for the various designs with the general theory for linear models. The authors begin with a general introduction then lead students through the theoretical results, the various design models, and the analytical concepts that will enable them to analyze virtually any design. Rife with examples and exercises, the text also encourages using computers to analyze data. The authors use the SAS software package throughout the book, but also demonstrate how any regression program can be used for analysis. With its balanced presentation of theory, methods, and applications and its highly readable style, A First Course in the Design of Experiments proves ideal as a text for a beginning graduate or upper-level undergraduate course in the design and analysis of experiments.

The Design and Statistical Analysis of Animal Experiments

Author: Simon T. Bate
Publisher: Cambridge University Press
ISBN: 1107030781
Format: PDF, Docs
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Written for animal researchers, this book provides a comprehensive guide to the design and statistical analysis of animal experiments. It has long been recognised that the proper implementation of these techniques helps reduce the number of animals needed. By using real-life examples to make them more accessible, this book explains the statistical tools employed by practitioners. A wide range of design types are considered, including block, factorial, nested, cross-over, dose-escalation and repeated measures and techniques are introduced to analyse the experimental data generated. Each analysis technique is described in non-mathematical terms, helping readers without a statistical background to understand key techniques such as t-tests, ANOVA, repeated measures, analysis of covariance, multiple comparison tests, non-parametric and survival analysis. This is also the first text to describe technical aspects of InVivoStat, a powerful open-source software package developed by the authors to enable animal researchers to analyse their data and obtain informative results.

Design and Analysis of Experiments with SAS

Author: John Lawson
Publisher: CRC Press
ISBN: 1420060600
Format: PDF, Docs
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A culmination of the author’s many years of consulting and teaching, Design and Analysis of Experiments with SAS provides practical guidance on the computer analysis of experimental data. It connects the objectives of research to the type of experimental design required, describes the actual process of creating the design and collecting the data, shows how to perform the proper analysis of the data, and illustrates the interpretation of results. Drawing on a variety of application areas, from pharmaceuticals to machinery, the book presents numerous examples of experiments and exercises that enable students to perform their own experiments. Harnessing the capabilities of SAS 9.2, it includes examples of SAS data step programming and IML, along with procedures from SAS Stat, SAS QC, and SAS OR. The text also shows how to display experimental results graphically using SAS ODS graphics. The author emphasizes how the sample size, the assignment of experimental units to combinations of treatment factor levels (error control), and the selection of treatment factor combinations (treatment design) affect the resulting variance and bias of estimates as well as the validity of conclusions. This textbook covers both classical ideas in experimental design and the latest research topics. It clearly discusses the objectives of a research project that lead to an appropriate design choice, the practical aspects of creating a design and performing experiments, and the interpretation of the results of computer data analysis. SAS code and ancillaries are available at http://lawson.mooo.com

An Introduction to the Design and Analysis of Experiments in Behavioral Research

Author: John J. Kennedy
Publisher: University Press of America
ISBN: 9780819148070
Format: PDF, Mobi
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This second edition is still designed for graduate students and researchers in the social, behavioral and health sciences who have modest backgrounds in mathematics and statistics. Also, priority is still given to the discussion of seminal ideas that underlie the analysis of variance. With respect to the first edition, the late Jum C. Nunnally of Vanderbilt University remarked, 'Overall, there is no better text on statistics in the behavioral sciences available, and I strongly recommend it.' A new feature is the optional availability of a microcomputer software package, MICRO-ANOVA, that will enable researchers to perform all analyses presented in the text on IBM PCs or equivalent computers. The software package is available through UPA.

Statistical Design

Author: George Casella
Publisher: Springer Science & Business Media
ISBN: 0387759646
Format: PDF, ePub
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Although statistical design is one of the oldest branches of statistics, its importance is ever increasing, especially in the face of the data flood that often faces statisticians. It is important to recognize the appropriate design, and to understand how to effectively implement it, being aware that the default settings from a computer package can easily provide an incorrect analysis. The goal of this book is to describe the principles that drive good design, paying attention to both the theoretical background and the problems arising from real experimental situations. Designs are motivated through actual experiments, ranging from the timeless agricultural randomized complete block, to microarray experiments, which naturally lead to split plot designs and balanced incomplete blocks. George Casella is Distinguished Professor in the Department of Statistics at the University of Florida. He is active in many aspects of statistics, having contributed to theoretical statistics in the areas of decision theory and statistical confidence, to environmental statistics, and has more recently concentrated efforts in statistical genomics. He also maintains active research interests in the theory and application of Monte Carlo and other computationally intensive methods. He is listed as an ISI "Highly Cited Researcher." In other capacities, Professor Casella has served as Theory and Methods Editor of the Journal of the American Statistical Association, 1996-1999, Executive Editor of Statistical Science, 2001-2004, and Co-Editor of the Journal of the Royal Statistical Society, Series B, 2009-2012. He has served on the Board of Mathematical Sciences of the National Research Council, 1999-2003, and many committees of both the American Statistical Association and the Institute of Mathematical Statistics. Professor Casella has co-authored five textbooks: Variance Components, 1992; Theory of Point Estimation, Second Edition, 1998; Monte Carlo Statistical Methods, Second Edition, 2004; Statistical Inference, Second Edition, 2001, and Statistical Genomics of Complex Traits, 2007.