Development of Innovative Drugs via Modeling with MATLAB

Author: Ronald Gieschke
Publisher: Springer Science & Business Media
ISBN: 3642397654
Format: PDF, ePub, Mobi
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The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens? Written from the industry perspective and based on many years of experience, this book offers: - Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs - Guidance for exploration and modification of these programs to enhance the understanding of key principles - Usage of differential equations to pharmacokinetic, pharmacodynamic and (patho-) physiologic problems thereby acknowledging their dynamic nature - A range of topics from single exponential decay to adaptive dosing, from single subject exploration to clinical trial simulation, and from empirical to mechanistic disease modeling. Students with an undergraduate mathematical background or equivalent education, interest in life sciences and skills in a high-level programming language such as MATLAB, are encouraged to engage in model-based pharmaceutical research and development.

Laudato si

Author: Franziskus (Papst),
Publisher: Verlag Herder GmbH
ISBN: 345180736X
Format: PDF, ePub, Docs
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Mit großer Spannung wurde sie erwartet, auch von Nicht-Katholiken: Die Umwelt-Enzyklika von Papst Franziskus nimmt die heute entscheidenden Themen in den Blick; es geht um die geht um soziale, ökologische und politische Zusammenhänge. Wohl selten war ein päpstliches Schreiben so aktuell und brisant und vor allem relevant für alle Gesellschaftsschichten und Menschen weltweit. Mit "Laudato si" beweist Franziskus, dass die Kirche nach wie vor eine unverzichtbare Stimme im Diskurs zur Gestaltung der modernen Welt ist. Wer verstehen will, wie Papst und Kirche die großen Herausforderungen unserer Zeit bestehen wollen, kommt an diesem Werk nicht vorbei. Ein Muss für jeden, der an den drängenden Fragen unserer Zeit interessiert ist.

6th International Conference on the Development of Biomedical Engineering in Vietnam BME6

Author: Toi Vo Van
Publisher: Springer
ISBN: 9811043612
Format: PDF
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Under the motto “Healthcare Technology for Developing Countries” this book publishes many topics which are crucial for the health care systems in upcoming countries. The topics include Cyber Medical Systems Medical Instrumentation Nanomedicine and Drug Delivery Systems Public Health Entrepreneurship This proceedings volume offers the scientific results of the 6th International Conference on the Development of Biomedical Engineering in Vietnam, held in June 2016 at Ho Chi Minh City.

Operations Research and Health Care

Author: Margaret L. Brandeau
Publisher: Springer Science & Business Media
ISBN: 1402080662
Format: PDF
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In both rich and poor nations, public resources for health care are inadequate to meet demand. Policy makers and health care providers must determine how to provide the most effective health care to citizens using the limited resources that are available. This chapter describes current and future challenges in the delivery of health care, and outlines the role that operations research (OR) models can play in helping to solve those problems. The chapter concludes with an overview of this book – its intended audience, the areas covered, and a description of the subsequent chapters. KEY WORDS Health care delivery, Health care planning HEALTH CARE DELIVERY: PROBLEMS AND CHALLENGES 3 1.1 WORLDWIDE HEALTH: THE PAST 50 YEARS Human health has improved significantly in the last 50 years. In 1950, global life expectancy was 46 years [1]. That figure rose to 61 years by 1980 and to 67 years by 1998 [2]. Much of these gains occurred in low- and middle-income countries, and were due in large part to improved nutrition and sanitation, medical innovations, and improvements in public health infrastructure.