Diagnostic Immunohistochemistry

Author: David J Dabbs
Publisher: Elsevier Health Sciences
ISBN: 145570010X
Format: PDF, ePub, Docs
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Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin’s lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. This concise and complete resource is today’s indispensable guide to the effective use of immunohistochemical diagnosis. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization. Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors. Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance. Features an expert author for each chapter to ensure coverage of the current state of the art. Provides guidance on the role of genomics in identifying genetic and molecular aspects of disease that may affect patient care and therapeutic approaches. Covers theranostic applications to enable you to evaluate therapeutic choices based on immunohistochemical results. Reflects the latest developments in the field through new chapters on molecular anatomic pathology and immunocytology, as well as updated chapters on immunohistology of the prostate, bladder, testis, and kidney and Non-Hodgkin’s lymphoma. Discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval. Presents key differential diagnoses boxes that provide tabular summaries of DDx and algorithms. Features discussions of ancillary anatomic molecular diagnostics as an adjunct to immunohistochemistry for a more well-rounded diagnostic approach.

Diagnostic Immunohistochemistry E Book

Author: David J Dabbs
Publisher: Elsevier Health Sciences
ISBN: 0323551602
Format: PDF, ePub, Docs
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User-friendly and concise, the new edition of this popular reference is your #1 guide for the appropriate use of immunohistochemical stains. Dr. David J. Dabbs and leading experts in the field use a consistent, organ system approach to cover all aspects of the field, with an emphasis on the role of genomics in diagnosis and theranostic applications that will better inform treatment options. Each well-written and well-researched chapter is enhanced with diagnostic algorithms, charts, tables, and superb, full-color histologic images, making this text a practical daily resource for all surgical pathologists. Features a systematic approach to the diagnostic entities of each organ system, including detailed differential diagnoses, diagnostic algorithms, and immunohistograms that depict immunostaining patterns of tumors. Covers many more antigens than other texts, and discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Contains new material on non-lymphoid malignancies, Hodgkin/non-Hodgkin lymphoma, and an expanded chapter on digital imaging and quantilative immunohistochemistry. Provides new grading schemes for several organs, along with new antibodies to cover more genomic immunohistochemistry applications. Offers more emphasis in the breast section of "eyes on" tissue for molecular/IHC prognostics compared to the current trend of gene-expression profiling of breast cancer.

Handbook of Practical Immunohistochemistry

Author: Fan Lin
Publisher: Springer
ISBN: 1493915789
Format: PDF, ePub
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In a conceptually current, quick-reference, Question & Answer format, the second edition of Handbook of Practical Immunohistochemistry: Frequently Asked Questions continues to provide a comprehensive and yet concise state-of-the-art overview of the major issues specific to the field of immunohistochemistry. With links to the authors Immunohistochemical Laboratory website, this volume creates a current and up-to-date information system on immunohistochemistry. This includes access to tissue microarrays (TMA) of over 10,000 tumors and normal tissue to validate common diagnostic panels and provide the best reproducible data for diagnostic purposes. Fully revised and updated from the first edition, the new features of the second edition include over 200 additional questions or revised questions with an IHC panel to answer each question; over 250 new color photos and illustrations; over 20 new useful biomarkers; hundreds of new references; several new chapters to cover phosphoproteins, rabbit monoclonal antibodies, multiplex IHC stains, overview of predictive biomarkers, and integration of IHC into molecular pathology; many new coauthors who are international experts in a related field; many updated IHC panels using Geisinger IHC data collected from over 10,000 tumors and normal tissues; and updated appendices containing detailed antibody information for both manual and automated staining procedures. Comprehensive yet practical and concise, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions, Second Edition will be of great value for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.

Immunohistochemistry in Tumor Diagnostics

Author: Muin S.A. Tuffaha
Publisher: Springer
ISBN: 3319535773
Format: PDF, ePub, Docs
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This book offers a comprehensive yet concise overview of immunoprofile of tumors and antibodies used in contemporary surgical pathology, and provides diagnostic algorithms for approaching tumor diagnostics. Immunohistochemistry has become the most important ancillary technique in diagnostic pathology in the last 20 years, and unlike most books on tumor diagnostics, this volume discusses in details immunohistochemical biomarkers, diagnostic approaches and their pitfalls, as well as the immunoprofile of common tumors throughout all systems of human body. With numerous color figures and detailed flowcharts, it appeals to all pathologists be they young residents in training who want a brief introduction to this technique, or specialists in need of a reliable and comprehensive reference resource in tumors diagnostics.

Antigen Retrieval Immunohistochemistry Based Research and Diagnostics

Author: Shan-Rong Shi
Publisher: John Wiley & Sons
ISBN: 9781118060308
Format: PDF
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The most complete, up-to-date reference on antigen retrieval and immunohistochemistry An antigen is a substance that prompts the generation of antibodies and can cause an immune response. The antigen retrieval (AR) technique is in wide use across the globe, and is a critical technique used in medical diagnosis of disease, particularly clinical targeted cancer treatment. Antigen Retrieval Immunohistochemistry Based Research and Diagnostics discusses several scientific approaches to the standardization of quantifiable immunohistochemistry (IHC). Based on the development and application of AR by the editors, this volume summarizes recent achievements in AR-IHC and analyzes numerous cutting-edge issues for future research projects. Featuring contributions from a worldwide group of leading experts and research scientists in the field, this important work: Summarizes the key problems in the four fields of antigen retrieval Discusses the advances of AR techniques and their applications Provides practical methods and protocols in AR-IHC, such as extraction of nucleic acids and proteins for molecular analysis, cell/tissue sample preparation, and standardization and development of various techniques to meet the future needs of¿clinical and research molecular analysis Encourages further research in AR and IHC, particularly how AR methods might be employed for improved test performance and the development of greater reliability and reproducibility of IHC Includes an appendix of related laboratory protocols Antigen Retrieval Immunohistochemistry Based Research and Diagnostics is intended for clinical pathologists, molecular cell biologists, basic research scientists, technicians, and graduate students who undertake tissue/cell morphologic and molecular analysis and wish to use and extend the power of immunohistochemistry. It is also pertinent for most biotechnology companies majoring in development of IHC products. Wiley Series in Biomedical Engineering and Multi-Disciplinary Integrated Systems / Kai Chang, Series Editor

Modern Immunohistochemistry

Author: Peiguo Chu
Publisher: Cambridge University Press
ISBN: 1316184455
Format: PDF, Kindle
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Since the publication of the first edition of this best-selling book in 2009, the field of immunohistochemistry has advanced significantly. Fully updated to reflect the latest developments in the field, Modern Immunohistochemistry, Second Edition, is a practical guide to all the important diagnostic markers in each organ system. Concise text is supplemented by over 1,100 high-quality colour images and algorithms. The new edition features even more summary tables, highlighting the key points of differential immunophenotypic panels. A new, expanded introduction explains the basic principles of immunohistochemistry, and chapters have been updated to incorporate predictive/prognostic markers and the latest WHO classifications. All chapters are written by the same expert authors, providing a consistent, engaging style throughout and avoiding contradictory advice. An essential text for residents, this is also an extremely valuable resource for practitioners in anatomic pathology wishing to familiarise themselves with diagnostic markers at a quick glance.

Immunohistochemistry Basics and Methods

Author: Igor B. Buchwalow
Publisher: Springer Science & Business Media
ISBN: 9783642046094
Format: PDF, ePub, Docs
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This concise yet comprehensive guide to the methods and protocols of immunohistochemistry covers established techniques and current developments in the field such as the use of epitope tags, multiple immunolabeling and diagnostic immunohistochemistry.

Practical Soft Tissue Pathology A Diagnostic Approach E Book

Author: Jason L. Hornick
Publisher: Elsevier Health Sciences
ISBN: 032355590X
Format: PDF, Docs
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Part of the in-depth and practical Pattern Recognition series, Practical Surgical Soft Tissue Pathology, 2nd Edition, helps you arrive at an accurate diagnosis by using a proven pattern-based approach. Leading diagnosticians guide you through the most common patterns seen in soft tissue pathology, applying appropriate immunohistochemistry and molecular testing, avoiding pitfalls, and making the best diagnosis. High-quality illustrations capture key morphologic patterns for a full range of common and rare tumor types, and a "visual index" at the beginning of the book directs you to the exact location of in-depth diagnostic guidance. A consistent chapter organization by histologic pattern considers soft tissue tumors the way you approach them in daily practice, helping you arrive at a quick and accurate diagnosis. A user-friendly design color-codes patterns to specific entities, and key points are summarized in tables and text boxes, so you can quickly and easily find what you are looking for. Sweeping content updates keep you at the forefront of recent findings regarding all major neoplastic and non-neoplastic diseases of the soft tissues. Improved pattern call-outs are now linked directly within the chapter, reinforcing the patterns for more efficient and complete understanding.