Discovery of Novel Natural Products with Therapeutic Potential

Author: Vincent P. Gullo
Publisher: Newnes
ISBN: 1483292134
Format: PDF, Docs
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Although science has discovered effective drugs for many of the diseases that afflict mankind, many human health problems remain untreatable. The search for novel therapeutic agents is always ongoing. This book will describe some of the diverse sources of natural products, such as terrestrial and marine environments; and will review how research has increased knowledge of biological systems and human disease, leading to the design of targeted asssays, amenable to high volume screening.

Natural Products

Author: Lixin Zhang
Publisher: Springer Science & Business Media
ISBN: 1592599761
Format: PDF, Docs
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A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

Natural Products in the New Millennium Prospects and Industrial Application

Author: Amelia Rauter
Publisher: Springer Science & Business Media
ISBN: 9401598762
Format: PDF, Docs
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This book deals with a variety of aspects of natural product research. It includes review articles and revised original contributions involving analysis, isolation and structure elucidation, synthesis and bioactivity of terrestrial and marine natural products. Plant cell biotechnology for the production of secondary metabolites is discussed. This volume provides also outstanding information about the industrial application of natural products for medicinal purposes. The broad interdisciplinary approach found in this book, which comprises 50 papers, makes it interesting to the scientists, whose work is in any way related to the research or use of natural products.

Anticancer Plants Natural Products and Biotechnological Implements

Author: Mohd Sayeed Akhtar
Publisher: Springer
ISBN: 981108064X
Format: PDF, Docs
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This volume provides summarized scientific evidence of the different classes of plant-derived phytocompounds, their sources, chemical structures, anticancer properties, mechanisms of action, methods of extraction, and their applications in cancer therapy. It also discusses endophyte-derived compounds as chemopreventives to treat various cancer types. In addition, it provides detailed information on the enhanced production of therapeutically valuable anticancer metabolites using biotechnological interventions such as plant cell and tissue culture approaches, including in vitro-, hairy root- and cell-suspension culture; and metabolic engineering of biosynthetic pathways. Anticancer Plants: Natural Products and Biotechnological Implements – Volume 2” explores the natural bioactive compounds isolated from plants as well as fungal endophytes, their chemistry, and preventive effects to reduce the risk of cancer. Moreover, it highlights the genomics/proteomics approaches and biotechnological implementations. Providing solutions to deal with the challenges involved in cancer therapy, the book benefits a wide range of readers including academics, students, and industrial experts working in the area of natural products, medicinal plant chemistry, pharmacology, and biotechnology.

Ethnomedicine and Drug Discovery

Author: M.M. Iwu
Publisher: Elsevier
ISBN: 9780080531250
Format: PDF, ePub, Mobi
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The emergence of new infectious, chronic and drug resistant diseases have prompted scientists to look towards medicinal plants as agents for treatment and prevention. This book provides an interphase between ethnomedical and ethnobotanical approaches to new drug discovery and advances in biotechnology and molecular science that has made it increasingly feasible to transform traditional medicines into modern drugs. These novel approaches also raise new issues and the volume explores economic, ethical and policy considerations of drug development based on indigenous knowledge or traditional medicine. This work also features standardization and development of phytomedicines for major therapeutic indications, including emerging infectious diseases affecting developing and developed countries. The publication provides state-of-the-art information on the most innovative science, the research, the industry, the market, and the future of ethnomedicine and drug discovery.

Marine Bioprocess Engineering

Author: J.G. Burgess
Publisher: Elsevier
ISBN: 9780080535807
Format: PDF
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This book contains full papers of both oral and poster presentations of the international symposium 'Marine Bioprocess Engineering' which was held in Noordwijkerhout, The Netherlands, 1998. The symposium focused on the bioprocessing of marine natural products. Bioprocess engineering has been the key to success in the commercialization of biotechnology, especially with respect to biopharmaceuticals. In marine biotechnology, both new and existing biotechnological techniques are developed an applied to organisms from marine sources. For marine biotechnology, bioprocess engineering represents the link between discovery and commercialization. The diversity of marine life points to a myriad of new bioproducts waiting to be discovered and developed commercially. The volume begins to bridge the gap between the isolation of products from marine organisms in the laboratory and industrial applications by focusing on the bioprocess-engineering aspects. Reviews and recent developments in product discovery, bio-energy production, cultivation of marine organisms, scale up and product recovery are presented. This publication should ensure that the engineering aspects of marine biotechnology will receive further attention in the future. Exploration of new bioproducts from the ocean should be followed up by a sustainable exploitation of these valuable resources.

Bioactive Natural Products

Author: Goutam Brahmachari
Publisher: John Wiley & Sons
ISBN: 3527337946
Format: PDF, Kindle
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A multi-disciplinary survey of current topics and future trends in natural products research, with a focus on pharmaceutical and medical applications.

Biotechnological Production of Plant Secondary Metabolites

Author: Ilkay Orhan
Publisher: Bentham Science Publishers
ISBN: 1608051145
Format: PDF
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Modern techniques have been developed to overcome problems associated with the extraction of natural products from plants. These techniques include production of secondary metabolites by biotechnological methods such as plant tissue culture and microbial

Bio exploitation of Filamentous Fungi

Author: Stephen B. Pointing
Publisher:
ISBN: 9789628567720
Format: PDF, ePub
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The focus of this exciting new book is on identifying existing and potential applications for filamentous fungi. Selected topics at the forefront of current fungal biotechnology research, namely bioactive compounds and agricultural applications, are covered in depth by acknowledged experts in their field. Other emerging fungal technologies such as bioremediation are also reviewed, together with associated subjects such as the ownership of genetic resources.

Discovery and Development of Antidiabetic Agents from Natural Products

Author: Goutam Brahmachari
Publisher: Elsevier
ISBN: 0128096926
Format: PDF, ePub
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Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab