Disorders of Synaptic Plasticity and Schizophrenia

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Publisher: Academic Press
ISBN: 0080548628
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Schizophrenia is a severe brain disorder that affects 1% of the population. Its cause is due to the interaction of a number of abnormal genes with environmental factors. This book summarizes new advances schizophrenia research that focus on the field of neural and synaptic plasticity. Synapses in the brain in schizophrenia show a wide range of disorders, both structural and functional. This volume covers the most active and promising of these new developments, and opens up new avenues for the treatment of schizophrenia. * Addresses new areas of research in neurotransmitters, receptors, vitamin transport, metabolism, and signaling. * Reviews the growing field of synaptic plasticity research * Provides links with other diseases of the Central Nervous System (CNS)

Synaptic Plasticity

Author: Michael R. Kreutz
Publisher: Springer Science & Business Media
ISBN: 3709109329
Format: PDF, ePub, Docs
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This book introduces the current concepts of molecular mechanisms in synaptic plasticity and provides a comprehensive overview of cutting-edge research technology used to investigate the molecular dynamics of the synapses. It explores current concepts on activity-dependent remodeling of the synaptic cytoskeleton and presents the latest ideas on the different forms of plasticity in synapses and dendrites. Synaptic Plasticity in Health and Disease not only supplies readers with extensive knowledge on the latest developments in research, but also with important information on clinical and applied aspects. Changes in spine synapses in different brain disease states, so-called synaptopathies, are explained and described by experts in the field. By outlining basic research findings as well as physiological and pathophysiological impacts on synaptic plasticity, the book represents an essential state-of-the-art work for scientists in the fields of biochemistry, molecular biology and the neurosciences, as well as for doctors in neurology and psychiatry alike.

International Review of Neurobiology

Author: Ronald J. Bradley
Publisher: Elsevier
ISBN: 0080495524
Format: PDF, Kindle
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Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

Brain Evolution Language and Psychopathology in Schizophrenia

Author: Paolo Brambilla
Publisher: Routledge
ISBN: 1134694423
Format: PDF, Kindle
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This book provides a comprehensive review of new developments in the study of language processing and related neural networks in schizophrenia by addressing the complex link between psychopathology, language and evolution at different levels of analysis. Psychopathological symptoms in schizophrenia are mainly characterized by thought and language disorders, which are strictly intertwined. In particular, language is the distinctive dimension of human beings and is ontologically related to brain development. Although normal at the levels of segmental phonology and morphological organization, the speech of patients suffering from schizophrenia is often characterized by flattened intonation and word-finding difficulties. Furthermore, research suggests that the superior temporal gyrus and specific prefrontal areas which support language in humans are altered in people with schizophrenia. Brambilla and Marini bring together international contributors to explore the link between brain evolution and the psychopathological features of schizophrenia, with a focus on language and its neural underpinnings. Divided into three sections the book covers: • brain evolution and language phylogenesis • brain abnormalities in schizophrenia • psychopathology and schizophrenia. This theoretical approach will appeal to professionals including clinical psychologists, cognitive neuroscientists, neuropsychiatrists, neuropsychologists, neurolinguists, and researchers considering the links between brain evolution, language and psychopathology in schizophrenia.

Handbuch Psychoaktive Substanzen

Author: Maximilian von Heyden
Publisher: Springer-Verlag
ISBN: 3642551254
Format: PDF, Mobi
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Das Handbuch Psychoaktive Substanzen bietet einen fundierten Überblick und vereint das aktuelle Grundlagenwissen einer neu entstehenden Drogenwissenschaft, die psychoaktive Substanzen mehrdimensional betrachtet, Chancen und Risiken bilanziert und gegenwärtige Debatten mit Fakten fundiert. Das Handbuch ist ein wichtiges Referenzdokument für verschiedene Disziplinen und Professionen; von Medizinern, Psychologen, Suchttherapeuten, Pharmakologen und Neurowissenschaftlern zu Sozialwissenschaftlern, (Sozial-)Pädagogen, Kriminologen, Juristen und Polizisten. Es ist außerdem für jene Personen von Interesse, die sich mit den soziokulturellen und historischen Aspekten des Ge- und Missbrauchs von psychoaktiven Substanzen beschäftigen – einschließlich Lehrern, Journalisten und Politikern. Basierend auf einem interdisziplinären Ansatz wird in den Kapiteln das komplexe Wirkungsgefüge zwischen Mensch und psychoaktiven Substanzen untersucht und in strukturierter und übersichtlicher Weise zugänglich gemacht. Aktuelle Entwicklungen wie das Erscheinen neuer psychoaktiver Substanzen (NPS) sowie die kulturellen und politischen Veränderungen der letzten Jahre werden ebenfalls beleuchtet. The Handbook of Psychoactive Substances integrates the current knowledge base of the evolving field of drug science that views psychoactive substances from an interdisciplinary perspective. Opportunities and risks are balanced alongside objective facts in order to add to current debates. The Handbook is an important reference document, with relevance to many disciplines and professions; from medical doctors, psychologists, addiction therapists, pharmacologists and neuroscientists to criminologists, police officers, lawyers and attorneys. It will also be of interest to those involved in the socio-cultural and historical aspects of drug use and misuse, including teachers, journalists and politicians. In a helpful structured form the handbook offers user-friendly and trustworthy information concerning classes of psychoactive substances. Chapters explore psychoactive drugs as therapeutic tools, their benefits for medicine and research and the problems associated with their harmful use. Current developments, including the recent appearance of Novel Psychoactive Substances (NPS) and the associated political and cultural changes in recent years are also explored in the book.

Integrating the Neurobiology of Schizophrenia

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Publisher: Elsevier
ISBN: 9780080475080
Format: PDF, ePub, Mobi
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This book examines the role that dopamine plays in schizophrenia, examining its role in not only the symptoms of the disease but also in its treatment. It also reviews all neurotransmitters that have been implicated in schizophrenia, exploring the genetic data, clinical data implicating the transmitter, and the preclinical data exploring how a transmitter may interact with dopamine and contribute to the dopaminergic phenotype observed in the illness. This book will serve as an educational tool for instructors, a guide for clinicians, and be of interest to researchers. It is a good reference for researchers specialized in one particular area and interested in learning about other areas of pathology in schizophrenia and how they may all feed into each other. The book concludes with an overall integrative model assembling as many of these elements as possible.

Diet and Exercise in Cognitive Function and Neurological Diseases

Author: Akhlaq A. Farooqui
Publisher: John Wiley & Sons
ISBN: 1118840569
Format: PDF, Docs
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Diet and exercise have long been recognized as important components of a healthy lifestyle, as they have a great impact on improving cardiovascular and cerebrovascular functions, lowering the risk of metabolic disorders, and contributing to healthy aging. As a greater proportion of the world’s population is living longer, there has been increased interest in understanding the role of nutrition and exercise in long-term neurological health and cognitive function. Diet and Exercise in Cognitive Function and Neurological Diseases discusses the role and impact that nutrition and activity have on cognitive function and neurological health. The book is divided into two sections. The first section focuses on diet and its impact on neurobiological processes. Chapters focus on the impacts of specific diets, such as the Mediterranean, ketogenic and vegan diets, as well as the role of specific nutrients, fats, fatty acids, and calorie restriction on neurological health and cognitive function. The second section of the book focuses on exercise, and its role in maintaining cognitive function, reducing neuroinflammatory responses, regulating adult neurogenesis, and healthy brain aging. Other chapters look at the impact of exercise in the management of specific neurological disorders such Multiple Sclerosis and Parkinson’s Disease. Diet and Exercise in Cognitive Function and Neurological Diseases is a timely reference on the neurobiological interplay between diet and exercise on long-term brain health and cognitive function.

Amines and Schizophrenia

Author: Harold E. Himwich
Publisher: Elsevier
ISBN: 1483157091
Format: PDF, ePub, Mobi
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Amines and Schizophrenia is a collection of articles that survey and discuss the biochemical basis present, if any, in schizophrenia, focusing on the role of certain amines. The book discusses certain hypotheses dealing with the field of bio-chemistry as the basis for diseases such as schizophrenia, manic-depressive psychosis, and related diseases. Discussions start with the properties of mescaline, because the psychotic effect of the drug has some aspects similar to that of a schizophrenic syndrome. One paper examines the presence of certain amines, such as norepinephrine, dopamine, and serotonin in the brain, including their role in the synaptic transmission of nerve impulses in the central nervous system. Other papers review the role of derangements of tryptophan metabolism in psychotic behavior; the metabolic interrelationships of tryptophan and methionine in mental illness; and the results obtained with psychomimetic and non-psychomimetic congeners of three classes of indoleamines including LSD. The book gives more details on the actions of various biological amines on single neurons in the limbic system of the brain. The text also evaluates the use of hallucinogenic drugs in considering their heuristic value in the study of the biochemical basis of mental function. The selection will prove relevant for psychologists, psychiatrists, drug researchers, pharmacologists, and chemical laboratory workers and technicians.

Small Molecule Therapeutics for Schizophrenia

Author: Sylvain Celanire
Publisher: Springer
ISBN: 3319115022
Format: PDF, ePub, Docs
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The topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drug ability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine.