Drug Drug Interactions for Therapeutic Biologics

Author: Honghui Zhou
Publisher: John Wiley & Sons
ISBN: 1118630211
Format: PDF, Docs
Download Now
Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologics Offering both theory and practical guidance, this book fully explores drug-drug interaction assessments for therapeutic biologics during the drug development process. It draws together and analyzes all the latest findings and practices in order to present our current understanding of the topic and point the way to new research. Case studies and examples, coupled with expert advice, enable readers to better understand the complex mechanisms of biologic drug-drug interactions. Drug-Drug Interactions for Therapeutic Biologics features contributions from leading international experts in all areas of therapeutic biologics drug development and drug-drug interactions. The authors' contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience. Coverage includes such essential topics as: Drug-drug interaction risks in combination with small molecules and other biologics Pharmacokinetic and pharmacodynamic drug-drug interactions In vitro methods for drug-drug interaction assessment and prediction Risk-based strategies for evaluating biologic drug-drug interactions Strategies to minimize drug-drug interaction risk and mitigate toxic interactions Key regulations governing drug-drug interaction assessments for therapeutic biologics. Drug-Drug Interactions for Therapeutic Biologics is recommended for pharmaceutical and biotechnology scientists, clinical pharmacologists, medicinal chemists, and toxicologists. By enabling these readers to understand how therapeutic biologics may interact with other drugs, the book will help them develop safer, more effective therapeutic biologics.

ADME and Translational Pharmacokinetics Pharmacodynamics of Therapeutic Proteins

Author: Honghui Zhou
Publisher: John Wiley & Sons
ISBN: 111889880X
Format: PDF, ePub, Mobi
Download Now
With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain

Proteins and Peptides

Author: Randall J. Mrsny
Publisher: CRC Press
ISBN: 1420078070
Format: PDF, Docs
Download Now
Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is an invaluable source for drug discovery and development scientists in the biopharmaceutical industry who frequently navigate the maze of protein and peptide pharmacokinetics, pharmacodynamics, and metabolism. Key features include:

Medical Pharmacology and Therapeutics E Book

Author: Derek G. Waller
Publisher: Elsevier Health Sciences
ISBN: 0702071900
Format: PDF
Download Now
Medical Pharmacology & Therapeutics, now in its fifth edition, offers medical students all they need to know to become safe and effective prescribers. It forms a complete, integrated resource for basic pharmaceutical science, pathophysiology, clinical pharmacology, and therapeutics. The fifth edition has been extensively revised and updated throughout. Key features include: Clear, disease-based approach. Presentation of how drugs are used in clinical practice. Succinct explanations of the major pathogenic mechanisms of each disease and consequent clinical signs and symptoms. Comprehensive reviews of major drug classes relevant to each disease. Structured approach to the principles of disease management – outlining core principles of drug choice and planning a therapeutic regimen for common diseases. Quick-reference drug compendia illustrating key similarities and differences among all BNF-listed drugs in each class. Comes with free e-book on StudentConsult. New sections on key and evolving topics, including prescribing safety and pharmacovigilance. Updated figures to further clarify complex areas. Revised multiple-choice and case-based questions for self-assessment.

Drug Interactions in Infectious Diseases

Author: Stephen C. Piscitelli
Publisher: Springer Science & Business Media
ISBN: 1592599249
Format: PDF, ePub, Mobi
Download Now
Over the past 25 years, the world’s population has witnessed an explosion in kno- edge about infectious diseases. The global population is coming to the realization that diseases long recognized to cause substantial suffering, such as malaria, tuberculosis, schistosomiasis, and hepatitis, can be diagnosed and treated, and that transmission can be prevented using tools that are available, and which may be becoming increasingly affordable. The global population is recognizing that few infections are local: the travel of humans, other animals, insects, and food transport pathogens around the world, often with astonishing rapidity. New pathogens are appearing, either newly recognized or newly developing, such as severe acute respiratory syndrome (SARS), avian inf- enza, metapneumovirus, or hepatitis C, which are causing human morbidity and m- tality. Finally, there is growing fear that dangerous pathogens may be intentionally introduced into human populations by deranged individuals or terrorist organizations. The potential to use drugs or biologic agents to treat and prevent infectious diseases has increased dramatically over the past quarter century as we have learned more about the biology of many of these agents, and as we have developed techniques to discover new agents by high throughput screening programs and by sophisticated drug design and synthesis.

Pharmacology and Therapeutics for Dentistry E Book

Author: John A. Yagiela
Publisher: Elsevier Health Sciences
ISBN: 0323078249
Format: PDF, ePub, Docs
Download Now
Use your knowledge of pharmacology to enhance oral care! Pharmacology and Therapeutics for Dentistry, 6th Edition describes how to evaluate a patient’s health and optimize dental treatment by factoring in the drugs they take. It explores the basic fundamentals of pharmacology, special topics such as pain control, fear and anxiety, and oral complications of cancer therapy, and most importantly, the actions of specific drug groups on the human body. Whether you’re concerned about the drugs a patient is already taking or the drugs you prescribe for treatment, this book helps you reduce risk and provide effective dental care. An emphasis on the dental applications of pharmacology relates drugs to dental considerations in clinical practice. Dental aspects of many drug classes are expanded to include antibiotics, analgesics, and anesthetics. The Alternative Medicine in Dentistry chapter discusses chemicals used as alternative medicines and assesses their potential benefits and risks. The Nonopioid Analgesics chapter groups together non-opioid analgesics, nonsterioidal anti-inflammatory drugs, and antirheumatic and antigout drugs, making these easier to locate and study. Coverage of the endocrine system includes four separate chapters for the most comprehensive coverage. Drug Interactions in Clinical Dentistry appendix lists potential interactions between drugs a patient is taking for nondental conditions and drugs that may be used or prescribed during dental treatment, including effects and recommendations. Glossary of Abbreviations appendix includes the most common abbreviations used for drugs or conditions. New Pharmacogenetics and Pharmacogenomics chapter covers the effects of genetic traits of patients on their responses to drugs. A NEW introductory section offers tips for the study of dental pharmacology and relates pharmacology to dental considerations. An updated discussion of drug-drug interactions covers the harmful effects of mixing medications. Coverage of adverse effects and mechanisms of COX-2 inhibitors, antibiotic prophylaxis, and antiplaque agents explains the dental risks relating to common drug treatments.

Rheumatology E Book

Author: Marc C. Hochberg
Publisher: Elsevier Health Sciences
ISBN: 0702063037
Format: PDF, ePub, Mobi
Download Now
Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg’s Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics. Remain up to date on the latest information in rheumatology through 13 brand-new chapters covering biomedical and translation science, disease and outcome assessment, new imaging modalities, early emerging disease, clinical therapeutics, patient management, and rehabilitation. Take advantage of expanded coverage of small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies. Focus on the core knowledge needed for successful results with each chapter co-authored by an internationally-renowned specialist in the field. Easily find the information you need thanks to a consistent, user-friendly format with templated content and large-scale images.

Psoriasis

Author: Wolfram Sterry
Publisher: John Wiley & Sons
ISBN: 1118661818
Format: PDF, ePub
Download Now
Practical and user-friendly, this is the ideal guide to the diagnosis and treatment of psoriasis, helping you navigate a logical management pathway through a complex maze of possibilities. Psoriasis is a cruel disease that can seriously affect the sufferer’s quality and length of life. It is also highly idiosyncratic, with features that vary greatly from patient to patient; this being mirrored in the highly variable response to treatment. It is increasingly recognized that psoriasis is not a discrete disease and that many patients suffer two or three comorbid conditions that can complicate the efforts of doctors treating patients. Psoriasis: Diagnosis and Management will provide dermatologists of all levels with a practical, well-illustrated approach to fully understanding the disease, including clear, clinical guidance to enable best-practice and effective management of patients. In full color throughout and excellently illustrated, key highlights include: easily understandable description of the psoriasis pathogenesis; a strong emphasis on the clinical features of psoriasis; careful consideration of comorbid conditions as part of the psoriatic spectrum to be managed; coverage of both traditional and contemporary management approaches; plenty of diagnostic algorithms and management protocols to aid the daily practical care of patients. Brought to you by several of the world’s leading authorities on the subject, Psoriasis: Diagnosis and Management is an essential purchase for the dermatologist.

Monoclonal Antibodies

Author: Kresina
Publisher: CRC Press
ISBN: 9780824781163
Format: PDF, ePub, Docs
Download Now
Presents a sampling of new and novel approaches to the amelioration of musculoskeletal disease pathology, emphasizing prevention and therapy. Where applicable, these new technologies are focused on their application to human autoimmune diseases, but the volume mainly discusses and details the use of

All In One Care Planning Resource

Author: Pamela L. Swearingen
Publisher: Elsevier Health Sciences
ISBN: 032339244X
Format: PDF, Kindle
Download Now
The only book featuring nursing care plans for all core clinical areas, Swearingen's All-In-One Nursing Care Planning Resource, 4th Edition provides 100 care plans with the nursing diagnoses and interventions you need to know to care for patients in all settings. It includes care plans for medical-surgical, maternity/OB, pediatrics, and psychiatric-mental health, so you can use just one book throughout your entire nursing curriculum. This edition includes a new care plan addressing normal labor and birth, a new full-color design, new QSEN safety icons, new quick-reference color tabs, and updates reflecting the latest NANDA-I nursing diagnoses and collaborative problems. Edited by nursing expert Pamela L. Swearingen, this book is known for its clear approach, easy-to-use format, and straightforward rationales. NANDA-I nursing diagnoses are incorporated throughout the text to keep you current with NANDA-I terminology and the latest diagnoses. Color-coded sections for medical-surgical, maternity, pediatric, and psychiatric-mental health nursing care plans make it easier to find information quickly. A consistent format for each care plan allows faster lookup of topics, with headings for Overview/Pathophysiology, Health Care Setting, Assessment, Diagnostic Tests, Nursing Diagnoses, Desired Outcomes, Interventions with Rationales, and Patient-Family Teaching and Discharge Planning. Prioritized nursing diagnoses are listed in order of importance and physiologic patient needs. A two-column format for nursing assessments/interventions and rationales makes it easier to scan information. Detailed rationales for each nursing intervention help you to apply concepts to specific patient situations in clinical practice. Outcome criteria with specific timelines help you to set realistic goals for nursing outcomes and provide quality, cost-effective care. NEW! Care plan for normal labor and birth addresses nursing care for the client experiencing normal labor and delivery. UPDATED content is written by practicing clinicians and covers the latest clinical developments, new pharmacologic treatments, patient safety considerations, and evidence-based practice guidelines. NEW full-color design makes the text more user friendly, and includes NEW color-coded tabs and improved cross-referencing and navigation aids for faster lookup of information. NEW! Leaf icon highlights coverage of complementary and alternative therapies including information on over-the-counter herbal and other therapies and how these can interact with conventional medications.