Endocrine Disrupters

Author: Polyxeni Nicolopoulou-Stamati
Publisher: Springer Science & Business Media
ISBN: 9401597693
Format: PDF, ePub, Docs
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During recent decades, millions of tonnes of man-made chemicals have been produced and released into the environment, with very little safety testing. Many of these chemical substances have been found to interfere with the endocrine system and modulate its function. This book not only overviews the effects of endocrine/disrupting substances on human health, but also addresses the regulatory problems from the point of view of international organisations, including the WHO, the EU, and the European Chlorine Industry. This volume contains the proceedings of a workshop held at the International Hippocrates Foundation on Kos Island, Greece, in September 1999. The workshop was part of the activities of the ASPIS project, which aims at raising awareness of environmental health impacts among multidisciplinary groups. The contributions to this volume are the result of the interaction of participants at the workshop. As such, it addresses the issue of endocrine disrupters from many different points of view and allows the subject to be approached by a multidisciplinary readership, including: decision makers, medical doctors, environmental experts, post/and undergraduate students, lawyers, engineers, and journalists.

Reproductive Health and the Environment

Author: P. Nicolopoulou-Stamati
Publisher: Springer Science & Business Media
ISBN: 1402048297
Format: PDF, ePub
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This book reviews recent trends and developments in the study of the impact that the environment has on human reproduction. It thoroughly examines these issues, using the most modern techniques and methods available, to analyze the manner in which both male and female fertility can be affected and assessed. Coverage examines such diverse factors as toxic environmental contaminants, air pollution, and exposure to medical drugs.

Cancer as an Environmental Disease

Author: P. Nicolopoulou-Stamati
Publisher: Springer Science & Business Media
ISBN: 9781402020209
Format: PDF, Kindle
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These pages contain a number of chapters from specialists in the field who consider, from a number of different perspectives, the currently available evidence that supports the environmental cancer aetiology hypothesis. This constitutes the first part of the book. In the second part of the book, an examination of the policy implications of accepting that the cancer epidemic may essentially be preventable is presented. This will pose some difficult problems for politicians and decision-makers, who will have to consider adopting policies that may damage the economy in the short term in order to reap health benefits which will only become apparent several decades in the future.

Endocrine Disruptors in the Environment

Author: Sushil K. Khetan
Publisher: John Wiley & Sons
ISBN: 1118891155
Format: PDF, ePub, Mobi
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A concise and engaging overview of endocrine disruption phenomena that brings complex concepts within the reach of non-specialists For most of the last decade, the science of endocrine disruption has evolved with more definitive evidence of its damaging potential to health and environment. This book lists the major environmental chemicals of concern and their mechanism of endocrine disruption including remedial measures for them. Divided into three parts, Endocrine Disruptors in the Environment begins with an overview of the endocrine system and endocrine disruptors, discussing their salient features and presenting a historical perspective of endocrine disruption phenomena. It then goes on to cover hormone-signaling mechanisms, followed by various broad classes of putative endocrine disruptors, before introducing readers to environmental epigenetic modifications. Part two of the book focuses on removal processes of various EDCs by biotic and abiotic transformation/degradation. The last section consists of four chapters embracing themes on finding solutions to environmental EDCs—including their detection, regulation, replacement, and remediation. Endocrine Disruptors in the Environment is the first book to detail the endocrine effects of several known environmental contaminants and their mechanism of endocrine disruption. Additionally, it: Covers both the chemistry and biology of endocrine disruption and compiles almost all the known endocrine disrupting environmental chemicals and their mechanisms of toxicity Addresses policy and regulatory issues relevant to EDCs including scientific uncertainty and precautionary policy Brings forth the use of Green Chemistry principles in avoiding endocrine disruption in the designing and screening for safer chemicals and remediation of the EDCs in aquatic environment Includes a useful glossary of technical terms, a list of acronyms, topical references, and a subject index Endocrine Disruptors in the Environment is an ideal book for environmental chemists and endocrine toxicologists, developmental biologists, endocrinologists, epidemiologists, environmental health scientists and advocates, and regulatory officials tasked with risk assessment in environment and health areas.

Hormonal Chaos

Author: Sheldon Krimsky
Publisher: JHU Press
ISBN: 9780801872525
Format: PDF, Docs
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"Krimsky lays out a clear and thorough historical analysis of the development of the environmental endocrine hypothesis (sometimes called the endocrine disruption hypothesis), and then examines the larger scientific, political, and social ramifications of it." -- Archives of Sexual Behabior

Congenital Diseases and the Environment

Author: P. Nicolopoulou-Stamati
Publisher: Springer Science & Business Media
ISBN: 1402048319
Format: PDF, Mobi
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This book explores some further concepts that have arisen from more recent perceptions of environmental effects and their possible interactions with living systems. The book is written by international experts and numerous case studies are given. Discussion and presentation of old and novel ideas is targeted at developing a more holistic and united perception of the interaction between congenital diseases and the environment.

Environmental Contaminants

Author: Daniel Vallero
Publisher: Elsevier
ISBN: 0080470351
Format: PDF, ePub, Docs
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Environmental Contaminants serves as a tool for environmental professionals to produce technically sound and reproducible scientific evidence. It identifies ways to clean up environmental problems in air, water, soil, sediment and living systems. Ethical issues, environmental management, and professionalism, and environmental economic problems are illustrated to assist the reader in understanding and applying quantitative analysis of environmental problems. Real life solutions for practicing environmental professionals. Example problems, sidebars, and case studies to illustrate ethical issues, environmental economic problems, and environmental management. Explanation of scientific principles and concepts needed for risk assessment, waste management, contaminant transport, environmental hydrogeology, and environmental engineering & chemistry. A fully supportive glossary, appendices and tables throughout the text contain physical, chemical and biological resources necessary for all environmental practitioners.

Endocrine Disruptors Brain and Behaviors

Author: Heather B. Patisaul
Publisher: Oxford University Press
ISBN: 0199935734
Format: PDF, Docs
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Our world and bodies are becoming increasingly polluted with chemicals capable of interfering with our hormones and thus, possibly, our present and future neural and mental health. As authors Heather Patisaul and Scott Belcher outline, there is a large lack of data and evidence in this causal relationship, which begs a need for further study to accelerate progress in the endocrinology and neuroendocrinology fields. Endocrine Disruptors, Brain, and Behavior focuses on if and how these chemicals, known as endocrine disrupting compounds (EDCs), affect the development and function of the brain and might be contributing to neural disorders rapidly rising in prevalence. The book provides an overall synthesis of the EDC field, including its historical roots, major hypotheses, key findings, and research gaps. The authors explain why even the concept of endocrine disruption is controversial in some circles, how differing definitions of endocrine disruption and what constitutes an "adverse" outcome on the brain shape public policy, and where the current capacity by different stakeholders (industry, academia, regulatory agencies) to evaluate chemicals for safety in a regulatory context begins and ends. The book concludes with suggestions for future research needs and a summary of emerging technology which might prove capable of more effectively evaluating existing and emerging chemicals for endocrine disrupting properties. As such, it provides the context for interdisciplinary and innovative input from a broad spectrum of fields, including those well-schooled in neuroscience, evolutionary biology, brain, behavior, sex differences, and neuroendocrinology.

Hormonally Active Agents in the Environment

Author: Committee on Hormonally Active Agents in the Environment
Publisher: National Academies Press
ISBN: 0309064198
Format: PDF, ePub, Mobi
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Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decisionmakers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occurs--in diet, in pharmaceuticals, from industrial releases into the environment--and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Endocrine Disruption and Human Health

Author: Philippa D. Darbre
Publisher: Academic Press
ISBN: 0128011203
Format: PDF, Docs
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Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations