Generalized Linear Mixed Models

Author: Walter W. Stroup
Publisher: CRC Press
ISBN: 1439815135
Format: PDF
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Generalized Linear Mixed Models: Modern Concepts, Methods and Applications presents an introduction to linear modeling using the generalized linear mixed model (GLMM) as an overarching conceptual framework. For readers new to linear models, the book helps them see the big picture. It shows how linear models fit with the rest of the core statistics curriculum and points out the major issues that statistical modelers must consider. Along with describing common applications of GLMMs, the text introduces the essential theory and main methodology associated with linear models that accommodate random model effects and non-Gaussian data. Unlike traditional linear model textbooks that focus on normally distributed data, this one adopts a generalized mixed model approach throughout: data for linear modeling need not be normally distributed and effects may be fixed or random. With numerous examples using SAS® PROC GLIMMIX, this book is ideal for graduate students in statistics, statistics professionals seeking to update their knowledge, and researchers new to the generalized linear model thought process. It focuses on data-driven processes and provides context for extending traditional linear model thinking to generalized linear mixed modeling. See Professor Stroup discuss the book.

Generalized Linear Mixed Models

Author: Walter W. Stroup
Publisher: CRC Press
ISBN: 1439815127
Format: PDF, ePub, Docs
Download Now
Generalized Linear Mixed Models: Modern Concepts, Methods and Applications presents an introduction to linear modeling using the generalized linear mixed model (GLMM) as an overarching conceptual framework. For readers new to linear models, the book helps them see the big picture. It shows how linear models fit with the rest of the core statistics curriculum and points out the major issues that statistical modelers must consider. Along with describing common applications of GLMMs, the text introduces the essential theory and main methodology associated with linear models that accommodate random model effects and non-Gaussian data. Unlike traditional linear model textbooks that focus on normally distributed data, this one adopts a generalized mixed model approach throughout: data for linear modeling need not be normally distributed and effects may be fixed or random. With numerous examples using SAS® PROC GLIMMIX, this book is ideal for graduate students in statistics, statistics professionals seeking to update their knowledge, and researchers new to the generalized linear model thought process. It focuses on data-driven processes and provides context for extending traditional linear model thinking to generalized linear mixed modeling. See Professor Stroup discuss the book.

Linear Models with R Second Edition

Author: Julian J. Faraway
Publisher: CRC Press
ISBN: 1439887349
Format: PDF, Mobi
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A Hands-On Way to Learning Data Analysis Part of the core of statistics, linear models are used to make predictions and explain the relationship between the response and the predictors. Understanding linear models is crucial to a broader competence in the practice of statistics. Linear Models with R, Second Edition explains how to use linear models in physical science, engineering, social science, and business applications. The book incorporates several improvements that reflect how the world of R has greatly expanded since the publication of the first edition. New to the Second Edition Reorganized material on interpreting linear models, which distinguishes the main applications of prediction and explanation and introduces elementary notions of causality Additional topics, including QR decomposition, splines, additive models, Lasso, multiple imputation, and false discovery rates Extensive use of the ggplot2 graphics package in addition to base graphics Like its widely praised, best-selling predecessor, this edition combines statistics and R to seamlessly give a coherent exposition of the practice of linear modeling. The text offers up-to-date insight on essential data analysis topics, from estimation, inference, and prediction to missing data, factorial models, and block designs. Numerous examples illustrate how to apply the different methods using R.

Linear Mixed Models

Author: Brady T. West
Publisher: CRC Press
ISBN: 1466560991
Format: PDF, ePub, Docs
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Highly recommended by JASA, Technometrics, and other journals, the first edition of this bestseller showed how to easily perform complex linear mixed model (LMM) analyses via a variety of software programs. Linear Mixed Models: A Practical Guide Using Statistical Software, Second Edition continues to lead readers step by step through the process of fitting LMMs. This second edition covers additional topics on the application of LMMs that are valuable for data analysts in all fields. It also updates the case studies using the latest versions of the software procedures and provides up-to-date information on the options and features of the software procedures available for fitting LMMs in SAS, SPSS, Stata, R/S-plus, and HLM. New to the Second Edition A new chapter on models with crossed random effects that uses a case study to illustrate software procedures capable of fitting these models Power analysis methods for longitudinal and clustered study designs, including software options for power analyses and suggested approaches to writing simulations Use of the lmer() function in the lme4 R package New sections on fitting LMMs to complex sample survey data and Bayesian approaches to making inferences based on LMMs Updated graphical procedures in the software packages Substantially revised index to enable more efficient reading and easier location of material on selected topics or software options More practical recommendations on using the software for analysis A new R package (WWGbook) that contains all of the data sets used in the examples Ideal for anyone who uses software for statistical modeling, this book eliminates the need to read multiple software-specific texts by covering the most popular software programs for fitting LMMs in one handy guide. The authors illustrate the models and methods through real-world examples that enable comparisons of model-fitting options and results across the software procedures.

Linear and Generalized Linear Mixed Models and Their Applications

Author: Jiming Jiang
Publisher: Springer Science & Business Media
ISBN: 0387479465
Format: PDF, Kindle
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This book covers two major classes of mixed effects models, linear mixed models and generalized linear mixed models. It presents an up-to-date account of theory and methods in analysis of these models as well as their applications in various fields. The book offers a systematic approach to inference about non-Gaussian linear mixed models. Furthermore, it includes recently developed methods, such as mixed model diagnostics, mixed model selection, and jackknife method in the context of mixed models. The book is aimed at students, researchers and other practitioners who are interested in using mixed models for statistical data analysis.

Analysis of Generalized Linear Mixed Models in the Agricultural and Natural Resources Sciences

Author: Edward Gbur
Publisher: ASA-CSSA-SSSA
ISBN: 9780891181828
Format: PDF
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Generalized Linear Mixed Models in the Agricultural and Natural Resources Sciences provides readers with an understanding and appreciation for the design and analysis of mixed models for non-normally distributed data. It is the only publication of its kind directed specifically toward the agricultural and natural resources sciences audience. Readers will especially benefit from the numerous worked examples based on actual experimental data and the discussion of pitfalls associated with incorrect analyses.

Mixed Effects Models for Complex Data

Author: Lang Wu
Publisher: CRC Press
ISBN: 9781420074086
Format: PDF, ePub
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Although standard mixed effects models are useful in a range of studies, other approaches must often be used in correlation with them when studying complex or incomplete data. Mixed Effects Models for Complex Data discusses commonly used mixed effects models and presents appropriate approaches to address dropouts, missing data, measurement errors, censoring, and outliers. For each class of mixed effects model, the author reviews the corresponding class of regression model for cross-sectional data. An overview of general models and methods, along with motivating examples After presenting real data examples and outlining general approaches to the analysis of longitudinal/clustered data and incomplete data, the book introduces linear mixed effects (LME) models, generalized linear mixed models (GLMMs), nonlinear mixed effects (NLME) models, and semiparametric and nonparametric mixed effects models. It also includes general approaches for the analysis of complex data with missing values, measurement errors, censoring, and outliers. Self-contained coverage of specific topics Subsequent chapters delve more deeply into missing data problems, covariate measurement errors, and censored responses in mixed effects models. Focusing on incomplete data, the book also covers survival and frailty models, joint models of survival and longitudinal data, robust methods for mixed effects models, marginal generalized estimating equation (GEE) models for longitudinal or clustered data, and Bayesian methods for mixed effects models. Background material In the appendix, the author provides background information, such as likelihood theory, the Gibbs sampler, rejection and importance sampling methods, numerical integration methods, optimization methods, bootstrap, and matrix algebra. Failure to properly address missing data, measurement errors, and other issues in statistical analyses can lead to severely biased or misleading results. This book explores the biases that arise when naïve methods are used and shows which approaches should be used to achieve accurate results in longitudinal data analysis.

Multiple Testing Problems in Pharmaceutical Statistics

Author: Alex Dmitrienko
Publisher: CRC Press
ISBN: 9781584889854
Format: PDF, ePub
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Useful Statistical Approaches for Addressing Multiplicity Issues Includes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple comparison research with an emphasis on pharmaceutical applications. In each chapter, the expert contributors describe important multiplicity problems encountered in pre-clinical and clinical trial settings. The book begins with a broad introduction from a regulatory perspective to different types of multiplicity problems that commonly arise in confirmatory controlled clinical trials, before giving an overview of the concepts, principles, and procedures of multiple testing. It then presents statistical methods for analyzing clinical dose response studies that compare several dose levels with a control as well as statistical methods for analyzing multiple endpoints in clinical trials. After covering gatekeeping procedures for testing hierarchically ordered hypotheses, the book discusses statistical approaches for the design and analysis of adaptive designs and related confirmatory hypothesis testing problems. The final chapter focuses on the design of pharmacogenomic studies based on established statistical principles. It also describes the analysis of data collected in these studies, taking into account the numerous multiplicity issues that occur. This volume explains how to solve critical issues in multiple testing encountered in pre-clinical and clinical trial applications. It presents the necessary statistical methodology, along with examples and software code to show how to use the methods in practice.

A Primer on Linear Models

Author: John F. Monahan
Publisher: CRC Press
ISBN: 9781420062045
Format: PDF, Kindle
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A Primer on Linear Models presents a unified, thorough, and rigorous development of the theory behind the statistical methodology of regression and analysis of variance (ANOVA). It seamlessly incorporates these concepts using non-full-rank design matrices and emphasizes the exact, finite sample theory supporting common statistical methods. With coverage steadily progressing in complexity, the text first provides examples of the general linear model, including multiple regression models, one-way ANOVA, mixed-effects models, and time series models. It then introduces the basic algebra and geometry of the linear least squares problem, before delving into estimability and the Gauss–Markov model. After presenting the statistical tools of hypothesis tests and confidence intervals, the author analyzes mixed models, such as two-way mixed ANOVA, and the multivariate linear model. The appendices review linear algebra fundamentals and results as well as Lagrange multipliers. This book enables complete comprehension of the material by taking a general, unifying approach to the theory, fundamentals, and exact results of linear models.