Genes Environment and Alzheimer s Disease

Author: Orly Lazarov
Publisher: Academic Press
ISBN: 0128028858
Format: PDF, ePub
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Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. Provides the first volume to link genetic and environmental risk factors for Alzheimer’s disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer’s disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists

Alzheimer s Disease A Century of Scientific and Clinical Research

Author: G. Perry
Publisher: IOS Press
ISBN: 1607501759
Format: PDF, Docs
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This publication is a landmark work commemorating the centennial of Alois Alzheimer's discovery of what would be known as Alzheimer's disease (AD). The centennial of Alois Alzheimer’s original description of the disease that would come to bear his name offers a vantage point from which to commemorate the seminal discoveries in the field. It traces how the true importance of AD as the major cause of late life dementia ultimately came to light and narrates the evolution of the concepts related to AD throughout the years and its recognition as a major public health problem, with an estimated 30-40 million people affected by AD today. To identify the breakthroughs, the editors have used citation analysis, landmark papers identified by current researchers, and drew upon their own experience and insights. This process took into account the perspectives of individuals who recall the impact of findings at the time they were made, as well as of scientists today who have the advantage of hindsight in weighing the lasting influence of these findings. Because modern AD research was triggered by the seminal work of Tomlinson, Blessed, and Roth some four decades ago, it is particularly fortunate that the vast majority of these milestone authors are still with us.

Gene Environment Interactions

Author: Lucio G. Costa
Publisher: John Wiley & Sons
ISBN: 0471758035
Format: PDF, Docs
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Understanding the play between heredity and environment, and relating it to disease causation, is the task of ecogenetics. Gene-Environment Interactions: Fundamentals of Ecogenetics presents the first comprehensive survey of this discipline, reflecting its relationship with toxicology, epidemiology, pharmacology, public health, and other medical and biological fields. Divided into four sections, the text elucidates key basic and advanced topics: * Section 1 covers fundamentals, including the history of the discipline, a discussion of the molecular laboratory tools currently available to assess genotypes, using such measurements in molecular epidemiology studies, and the statistical issues involved in their analysis. * Section 2 focuses on a number of key genetic polymorphisms relevant for ecogenetics, including enzymes of phase I and phase II metabolism, enzymes involved in DNA repair, as well as receptors and ion channels. This highlights characteristics of selected, widely studied genotypic/phenotypic differences, and allows discussion of how given genetic variations can influence responses to exogenous chemicals. * Section 3 examines gene-environment interactions through a disease-based approach, addressing how genetic polymorphisms can influence susceptibility to various diseases. Chapters cover important disease conditions such as various types of cancer, neurodegenerative diseases, cardiovascular disease, chronic pulmonary diseases, infectious diseases, diabetes, and obesity. * The final section discusses the ethical, legal, and social issues that arise when investigating and evaluating genetic polymorphisms in human populations, as well as the impact of ecogenetics on risk assessment, regulatory policies, and medicine and public health. Packed with clear examples illustrating concepts, as well as numerous tables and figures, Gene-Environment Interactions: Fundamentals of Ecogenetics is a unique resource for a wide range of physicians, students, and other specialists.

Alzheimer Disease New Insights for the Healthcare Professional 2013 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 1481663054
Format: PDF, ePub
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Alzheimer Disease: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Alzheimer Disease: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Alzheimer Disease: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Life Span Human Development

Author: Carol K. Sigelman
Publisher: Cengage Learning
ISBN: 1285454316
Format: PDF
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Known for its clear, straightforward writing style, comprehensive coverage, strong and current research-based approach, and excellent visuals and tables, this life-span development text offers a topical organization at the chapter level and a consistent chronological presentation within each chapter. Each chapter focuses on a domain of development such as physical growth, cognition, or personality, and traces developmental trends and influences in that domain from infancy to old age. Within each chapter, you will find sections on four life stages: infancy, childhood, adolescence, and adulthood. This unique organization enables students to comprehend the processes of transformation that occur in key areas of human development. Another staple of the text is its emphasis on theories and how they apply to specific topics in each chapter. This new edition also asks students to engage more actively with the content, and includes a clear focus on the complex interactions of nature and nurture in development, more integrated coverage of culture and diversity, and an exciting new media package for both students and instructors. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Genetic Variants in Alzheimer s Disease

Author: Kevin Morgan
Publisher: Springer Science & Business Media
ISBN: 1461473098
Format: PDF, ePub, Docs
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Alzheimer’s Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex and certain subcortical regions. In the last three years, the genetics of Alzheimer’s Disease has made significant advances; in fact, one could argue more than in the previous two decades. This has resulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimer’s. These new pathways are now legitimate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure. The aim of this book is to put all of the recent genetic data on these new genes into context. Different genetic variants will be discussed, as well as biomarkers and future possibilities. ​

The Key Facts on Alzheimer s Disease

Author: Patrick W. Nee
Publisher: The Internationalist
ISBN: 1484867777
Format: PDF, ePub
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The Key Facts on Alzheimer’s Disease provides readers with essential, easy-to-read information on Alzheimer’s Disease. Compiled in a simplified manner, this guide helps patients navigate this painful and debilitating diseases without enduring the complicated nature of medical terminology. By making a patient-friendly manual to the causes, symptoms, treatment, and ongoing research of Alzheimer’s Disease, one can easily determine what they are facing and how to live their life to the fullest.

Inside the Brain

Author: Ronald Kotulak
Publisher: Andrews McMeel Publishing
ISBN: 9780836232899
Format: PDF, ePub
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Explores how the brain learns, how it controls behavior, how it sustains damage and heals itself, and how scientists are searching for ways to keep it young and healthy.

Investigating Neurological Disease

Author: Albert Hofman
Publisher: Cambridge University Press
ISBN: 9780521000093
Format: PDF, ePub
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This invaluable handbook for clinicians reviews the epidemiology, treatment and prognosis of all major diseases of the nervous system.

Molecular Neurobiology of Alzheimer Disease and Related Disorders

Author: Masatoshi Takeda
Publisher: Karger Medical and Scientific Publishers
ISBN: 380557603X
Format: PDF, ePub, Mobi
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Alzheimers disease affects 6-10% of the elderly population, causing impairment in cognitive functions and significant disability in daily living for more than ten years. Neurofibrillary tangles, amyloid deposits and neuronal loss are the three hallmarks of Alzheimers disease. Due to insolubility of these unique structures in Alzheimer brain tissue, they were very difficult to study by usual biochemical methods in the past. Active research is now going on to elucidate the pathogenesis of Alzheimers disease. Major topics of neurobiological study of Alzheimers disease include the unraveling of the molecular mechanism of neurofibrillary tangle formation in neuronal and glial cells, the molecular processing of amyloid precursor protein in intracellular organella and in extra-cellular space, and the molecular mechanism of neuronal loss. The articles in this book were selected from contributions presented by leading scientists in this field at the international symposium which took place in Osaka in 2002. This publication is essential reading for all researchers, clinicians, basic and social scientists, neurologists and psychiatrists to promote the understanding of this formidable disease.