Genetic Models of Immune and Inflammatory Diseases

Author: Abul K. Abbas
Publisher: Springer Science & Business Media
ISBN: 1461223768
Format: PDF, ePub, Docs
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This book contains the proceedings of the Serono Symposia USA interna tional symposium on Genetic Models of Immune and Inflammatory Dis eases held on October 20 to 23, 1994, in Savannah, Georgia. The advent of methods for introducing genes into the germlines of mice, and for targeted disruption of particular genes by homologous recombination, has provided scientists in many disciplines with an extraordinarily powerful set of analyti cal tools. Some of the most informative applications of transgenic and gene knockout technology have been in studies of lymphocyte development and activation. The goal of this symposium was to bring together investigators using these genetic approaches for analyzing the immune system, with a view to defining common themes and novel directions. Transgenic mice have a wide variety of important applications in immu nology. Defined proteins can be expressed in selected tissues throughout development, thus acquiring the essential characteristic of "self" antigens. Such models have been used to study how immune responses to these artificially created "self" antigens are controlled. Antigen receptors of lym phocytes have been expressed as transgenes, and because lymphocytes are endowed with the unique property of allelic exclusion, such transgenic mice become essentially monospecific. Immunomodulatory agents have been expressed in defined tissues or throughout the body, providing tools for studying the functional consequences of dysregulated expression of biologi cal response modifiers.


Author: Rogerio A. Lobo
Publisher: Springer Science & Business Media
ISBN: 1461222885
Format: PDF, Kindle
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Here, the editor, Rogerio Lobo, has assembled an internationally recognized group of reproductive endocrinologists to address perimenopause -- the time both before and after the last menses -- and its attendant decline in ovarian function, as well as the clinical issues and therapeutic options for women during this period.

Therapeutic Outcome of Endocrine Disorders

Author: Brian Stabler
Publisher: Springer Science & Business Media
ISBN: 9780387989624
Format: PDF
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Therapeutic Outcome of Endocrine Disorders: Efficacy, Innovation and Quality of Life presents the proceedings of an international symposium held from November 13-16, 1997 in Palm Beach Gardens, Florida. The proceedings discuss scientific and clinical studies related to the treatment of endocrine disorders, including growth hormone deficiency, Turner Syndrome, constitutional delay of growth, treatment of diabetes, congenital adrenal hyperplasia, and congenital hypothyroidism.

Germ Cell Development Division Disruption and Death

Author: B. R. Zirkin
Publisher: Springer Verlag
Format: PDF, Docs
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An exploration of germ cell development, division, disruption and death, designed for reproductive endocrinologists, microbiologists and physiologists. Topics covered include: cloning and characterization of genes expressed in germ cell lines; spermatological transplantation; and testicular ageing.