Advances in Cancer Stem Cell Biology

Author: Roberto Scatena
Publisher: Springer Science & Business Media
ISBN: 9781461408093
Format: PDF, Mobi
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In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours- seem to show intriguing relationships with physiological stem cells. Specifically, these cancer cells show significant similarities in the mechanisms that regulate self-renewal of normal stem cells. Moreover, tumour cells might directly arise from normal stem cells. Further, the cellular biology of cancer stem cells show a lot of similarities with normal stem cells.

On the Power of Fuzzy Markup Language

Author: Giovanni Acampora
Publisher: Springer
ISBN: 3642354882
Format: PDF, ePub, Docs
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One of the most successful methodology that arose from the worldwide diffusion of Fuzzy Logic is Fuzzy Control. After the first attempts dated in the seventies, this methodology has been widely exploited for controlling many industrial components and systems. At the same time, and very independently from Fuzzy Logic or Fuzzy Control, the birth of the Web has impacted upon almost all aspects of computing discipline. Evolution of Web, Web2.0 and Web 3.0 has been making scenarios of ubiquitous computing much more feasible; consequently information technology has been thoroughly integrated into everyday objects and activities. What happens when Fuzzy Logic meets Web technology? Interesting results might come out, as you will discover in this book. Fuzzy Mark-up Language is a son of this synergistic view, where some technological issues of Web are re-interpreted taking into account the transparent notion of Fuzzy Control, as discussed here. The concept of a Fuzzy Control that is conceived and modeled in terms of a native web wisdom represents another step towards the last picture of Pervasive Web Intelligence.

Health and Social Care Act 2012

Author: Great Britain
Publisher: The Stationery Office
ISBN: 9780105407126
Format: PDF, ePub, Docs
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Royal assent, 27 March 2012. An Act to establish and make provision about a National Health Service Commissioning Board and clinical commissioning groups and to make other provision about the National Health Service in England; to make provision about public health in the United Kingdom; to make provision about regulating health and adult social care services; to make provision about public involvement in health and social care matters, scrutiny of health matters by local authorities and co-operation between local authorities and commissioners of health care services; to make provision about regulating health and social care workers; to establish and make provision about a National Institute for Health and Care Excellence; to establish and make provision about a Health and Social Care Information Centre and to make other provision about information relating to health or social care matters; to abolish certain public bodies involved in health or social care; to make other provision about health care. Explanatory notes have been produced to assist in the understanding of this Act and will be available separately

Gutshot Straight

Author: Lou Berney
Publisher: Harper Collins
ISBN: 0061963461
Format: PDF, Mobi
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“Lou Berney’s novel is so energetic, so droll, and so wheezingly funny that it accomplished what no book ever has before: it made me forget to eat lunch.” —Stephen Harrigan, New York Times bestselling author of Challenger Park A fast and funny caper in the tradition of Elmore Leonard, Carl Hiaasen, and the Coen Brothers, Gutshot Straight brings a fresh new talent into the crime fiction fold: Louis Berney. He’s already won raves for his short fiction collection The Road to Bobby Joe and Other Stories (“Rivals the work of contemporary hotshots T.C. Boyle and Ralph Lombreglia” —Chicago Tribune). With Gutshot Straight, Berney is “all in”—sure to win a fervent following with the story of “Shake” Bouchon, fresh out of prison and on the straight and narrow path…after maybe just one last job.

Another Mother s Life

Author: Rowan Coleman
Publisher: Simon and Schuster
ISBN: 9781416584230
Format: PDF, ePub, Docs
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Can you ever mend a shattered friendship? From Rowan Coleman, author of the acclaimed bestseller The Accidental Mother, comes a deeply moving novel for every woman who was ever a teenager in love, a mother, or made a heartbreaking decision. For wealthy Alison James, moving with her family to her hometown of Farmington presents more than a case of relocation jitters. Fifteen years ago, she fled town, eloping with her best friend's boyfriend. Now, blessed with three children, but uneasy in her marriage, she wonders if that decision led her away from the life she was meant to lead. Catherine Ashley, broke, the mother of two and almost divorced, can't help but wonder the same thing. Although she's content with her children, she finds herself returning again and again to those few weeks fifteen years ago when she fell deeply in love, only to be betrayed by her most trusted friend. Now, once more living in the same town, Alison and Catherine are about to find out just how different their lives could still be. But this time around they are adults, and while their own happiness is at stake, so is their children's. Wise and warmhearted, Another Mother's Life will make you laugh and cry -- and think about what you would do when confronted by some of life's most difficult choices.

Geographic Information Systems

Author: Michael G. Wing
Publisher: Oxford University Press, USA
ISBN: 9780195426106
Format: PDF, ePub
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An introduction to natural resource management, Geographic Information Systems provides students with a look at Geographic Information Systems (GIS) and the GIS applications they are likely to encounter in the field. Covering topics such as querying, buffering, clipping, and overlay analysis, Geographic Information Systems also delivers background information on the history of GIS, database creation, editing and acquisition, and map development. It is important to note that this text is not about how to do GIS, but is instead about the potential application of GIS to natural resources management. The applications provided can be extended to any region of the world, although the primary emphasis is on the U.S. and Canada.

Cases and Materials on State and Local Government Law

Author: Richard Briffault
Publisher: West Academic Publishing
ISBN: 9780314285010
Format: PDF, ePub
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The 8th Edition continues earlier editionsâe(tm) focus on the critical roles played by states and local governments and the complex structure of our state-local system. It challenges students to understand the competing models of local government that frame the field. It then takes that theoretical analysis to the hands-on questions of local government formation and boundary chan≥ home rule and state-local disputes; interlocal conflict and regional governance; spending, tax and debt limits; and service delivery. This Edition contains a new treatment of fiscal distress and municipal bankruptcy, and examines the state and local roles in such cutting edge issues as fracking, school finance, promoting social and economic equity, and economic development.