Handbook of Statistics in Clinical Oncology Third Edition

Author: John Crowley
Publisher: CRC Press
ISBN: 143986201X
Format: PDF, ePub, Mobi
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Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice, and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research, this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research. Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials, incorporating updates to all four parts: Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches, along with new chapters on phase 0 trials and phase I trial design for targeted agents. Phase II trials: Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs. Phase III trials: Many new chapters include interim analyses and early stopping considerations, phase III trial designs for targeted agents and for testing the ability of markers, adaptive trial designs, cure rate survival models, statistical methods of imaging, as well as a thorough review of software for the design and analysis of clinical trials. Exploratory and high-dimensional data analyses: All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition, chapters on risk calculators and forensic bioinformatics have been added. Accessible to statisticians and oncologists interested in clinical trial methodology, the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.

Introduction to Statistical Methods for Clinical Trials

Author: Thomas D. Cook
Publisher: CRC Press
ISBN: 1584880279
Format: PDF, ePub
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Clinical trials have become essential research tools for evaluating the benefits and risks of new interventions for the treatment and prevention of diseases, from cardiovascular disease to cancer to AIDS. Based on the authors’ collective experiences in this field, Introduction to Statistical Methods for Clinical Trials presents various statistical topics relevant to the design, monitoring, and analysis of a clinical trial. After reviewing the history, ethics, protocol, and regulatory issues of clinical trials, the book provides guidelines for formulating primary and secondary questions and translating clinical questions into statistical ones. It examines designs used in clinical trials, presents methods for determining sample size, and introduces constrained randomization procedures. The authors also discuss how various types of data must be collected to answer key questions in a trial. In addition, they explore common analysis methods, describe statistical methods that determine what an emerging trend represents, and present issues that arise in the analysis of data. The book concludes with suggestions for reporting trial results that are consistent with universal guidelines recommended by medical journals. Developed from a course taught at the University of Wisconsin for the past 25 years, this textbook provides a solid understanding of the statistical approaches used in the design, conduct, and analysis of clinical trials.

Statistical Design and Analysis of Clinical Trials

Author: Weichung Joe Shih
Publisher: CRC Press
ISBN: 1482250500
Format: PDF, ePub, Mobi
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Statistical Design and Analysis of Clinical Trials: Principles and Methods concentrates on the biostatistics component of clinical trials. Developed from the authors’ courses taught to public health and medical students, residents, and fellows during the past 15 years, the text shows how biostatistics in clinical trials is an integration of many fundamental scientific principles and statistical methods. Teach Your Students How to Design, Monitor, and Analyze Clinical Trials The book begins with ethical and safety principles, core trial design concepts, the principles and methods of sample size and power calculation, and analysis of covariance and stratified analysis. It then focuses on sequential designs and methods for two-stage Phase II cancer trials to Phase III group sequential trials, covering monitoring safety, futility, and efficacy. The authors also discuss the development of sample size reestimation and adaptive group sequential procedures, explain the concept of different missing data processes, and describe how to analyze incomplete data by proper multiple imputations. Turn Your Students into Better Clinical Trial Investigators This text reflects the academic research, commercial development, and public health aspects of clinical trials. It gives students a multidisciplinary understanding of the concepts and techniques involved in designing and analyzing various types of trials. The book’s balanced set of homework assignments and in-class exercises are appropriate for students in (bio)statistics, epidemiology, medicine, pharmacy, and public health.

Occupational Outlook Handbook 2009

Author: U. S. Department of Labor
Publisher: Skyhorse Publishing Inc.
ISBN: 1602393206
Format: PDF, Kindle
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A directory for up-and-coming jobs in the near-future employment market includes recommendations for finding or advancing a career and draws on statistics from the U.S. Department of Labor, in a guide that includes coverage of more than 250 occupations. Original.

Cancer Management in Small Animal Practice E Book

Author: Carolyn J. Henry
Publisher: Elsevier Health Sciences
ISBN: 1437701981
Format: PDF, Kindle
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Cancer Management in Small Animal Practice provides you with all the tools needed to diagnose, stage, and manage the many different disease entities known as "cancer." This manual is designed to provide you with easy-to-access, clinically relevant details for complete care of the small animal cancer patient, while considering the needs, concerns, and capabilities of the client. It provides quick reference sections for information not included in current oncology texts, including drug interactions and resources for participation in clinical trials. All information is well referenced and the reference section on the accompanying website includes links to the original and related articles. The latest information including diagnostic procedures, treatment modalities, and outcome predictions to help clients make the best decisions for their pets. Expert contributors, renowned for clinical, as well as academic and research expertise, offer a wide breadth and depth of expertise. Full-color format provides accurate visual depictions of specific diseases and procedures to enhance your diagnostic capabilities. Key Points highlight critical information, enabling quick, easy access. Systems approach to diagnosis and management offers logical, systematic, head-to-tail procedure for accurate diagnosis, treatment, and prognosis. Extensive discussions of supportive care limit adverse events and increase patient survival and puts emergency information at the practitioner’s fingertips. Suggested readings highlight the latest information for further investigation and research. Comprehensive drug safety guidelines thoroughly discuss all information required to safely handle and administer cancer drugs. Helpful drug formularies offer available formulations, recommended dosages, toxicities, and relative costs. Chapter on how to access clinical trials provides helpful information and hope for patients and their caregivers.

Gynecologic Oncology Handbook

Author: Michelle Benoit, MD
Publisher: Demos Medical
ISBN: 1620700050
Format: PDF, Kindle
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Gynecologic Oncology Handbook provides a comprehensive yet concise, practical guide for fellows, residents, specialist trainees, and clinicians in the diagnosis and management of gynecologic cancers. The book addresses the fundamentals of gynecologic oncology, including staging, surgical therapies, comorbidity diagnosis and management, adjuvant therapies including chemotherapy and radiation, and survival and palliative care. With a focus on specific management decision-making, the book provides the basic information needed to guide the clinician on the ward or in the clinic, including clinical study references, medical comorbidity algorithms, and directed gynecologic cancer workups and treatments. In a bullet point format, the book provides the resources you need to meet the demands of clinical management in gynecologic cancer care. Gynecologic Oncology Handbook features: Covers all fundamentals of gynecologic oncology including, staging, surgical therapies, comorbidity diagnosis and management, adjuvant therapies, and background study data Examines survivor care and palliative care practices Includes clinical study references, medical comorbidity algorithms, and directed workups and treatments Written in bullet-point format for quick reference

Associations Publications in Print

Author:
Publisher:
ISBN:
Format: PDF
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1981- in 2 v.: v.1, Subject index; v.2, Title index, Publisher/title index, Association name index, Acronym index, Key to publishers' and distributors' abbreviations.

The Complete Recovery Room Book

Author: Anthea Hatfield
Publisher: OUP Oxford
ISBN: 0191644145
Format: PDF, ePub
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The care that a patient receives in the first hours after surgery is crucial to minimizing the risk of complications such as heart attacks, pneumonia, and blood clots. As the patient awakes from their drug-induced coma, it takes time for them to metabolize and excrete these drugs, during which period they remain unable to care for themselves, and at increased risk of harm. The recovery room staff must manage both comatose and physiologically unstable patients, and deal with the immediate post-operative care of surgical patients. The fifth edition of this popular book provides nurses, surgeons and anaesthetists with clear guidance on how to manage day-to-day problems and how to make difficult decisions. Previous editions of this book have established it as the definitive guide to setting-up, equipping, staffing, and administering an acute care unit. It includes basic science such as physiology and pharmacology, specific symptoms including pain and vomiting, and has chapters devoted to the unique post-operative needs of individual types of surgery. This new edition brings this important text up to date and new drugs and techniques for monitoring are described. A new section looks ahead to the future development and design of recovery rooms and how they can contribute to patient well being.

Radiation Oncology Review for Boards and MOC

Author: Tithi Biswas, MD
Publisher: Springer Publishing Company
ISBN: 1617052280
Format: PDF, ePub, Docs
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Radiation Oncology Review for Boards and MOC is a singular study guide, written for those who are preparing for the American Board of Radiology certification exam or maintenance exam. The authors provide a concise, targeted overview of the key knowledge within each clinical area of radiation oncology practice, as well as to related topics that are relevant to practice and are covered on examinations. Chapters span the relevant disease site and subspecialty areas including gastrointestinal, gynecologic, genitourinary, breast, soft tissue and bone, pediatric, central nervous system, head and neck, skin, lung/ thoracic, and hematologic malignancies. The chapters detail the latest research and statistics, along with essential clinical knowledge on staging, management considerations, treatment planning and simulation, toxicity, follow up and outcomes that will be tested during the certification and recertification exams. Each chapter includes a focused practice test with multiple-choice questions and answers, which contain rationales and references. Two full practice exams appear at the end of the book. Ideal for first-time test-takers and recertification candidates alike, the bulleted, straightforward format will help anyone preparing for the boards or MOC recall their existing, specialized knowledge, and sharpen their skills in other areas of radiation oncology. KEY FEATURES: Includes two comprehensive practice tests that assess your knowledge of all disease sites and subtopics Reviews palliative care in several site-specific chapters Presents other related topics crucial to the exam, including biostatistics