Hazard Assessment of Chemicals

Author: Jitendra Saxena
Publisher: Elsevier
ISBN: 1483261859
Format: PDF, ePub, Docs
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Hazard Assessment of Chemicals: Current Developments, Volume 3 is a collection of expertly written articles that provide relevant and important information on the environmental and health hazard assessment of chemicals. The volume presents studies and expositions on such topics as hazard priority ranking system (or scoring system), a method to rank chemicals on the severity of their ill effects on the environment and human health. The book also tackles the effect of particulates on the toxic manifestations of chemicals; application of aquatic organisms as indicator systems for early detection of waterborne human carcinogens; techniques for metal speciation; and impact of fluorocarbons and other contaminants on stratospheric ozone. Environmentalists, ecologists, toxicologists, public safety officers and workers, and those concerned with the health effects of chemical agents in the environment will find this book very informative.

Chemicals in the Environment

Author: Ronald E. Hester
Publisher: Royal Society of Chemistry
ISBN: 0854042067
Format: PDF, Kindle
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Reviews the contemporary framework of legislation for the regulation of chemicals in the UK ...

Regulation for Chemical Safety in Europe Analysis Comment and Criticism

Author: D.M. Pugh
Publisher: Springer Science & Business Media
ISBN: 9401153167
Format: PDF, Kindle
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Many European Union Directives seek to minimize the potential for harm to humans and the environment arising from the use of chemicals. This book takes an interdisciplinary, selective look at the effector mechanisms employed in such directives. It covers the pre-marketing use of toxicology to identify the hazardous properties of chemicals, acknowledging its shortcomings, while contrasting the scientific method with the precautionary principle in developing risk-management practices. The book then goes on to describe the use of bio-indicators, chemical analyses and mathematical modelling for prediction, or to determine the adequacy of chemical safety legislation. The environmental risk assessment of priority chemicals is described and the impact of pesticides on sustainability in agriculture is discussed from the differing standpoints of agronomy and economics. Audience: All professionals concerned with the safe management of chemicals and their use, including teachers, practitioners, policy makers or legislators.

IPCS Risk Assessment Terminology

Author: International Program on Chemical Safety
Publisher: World Health Organization
ISBN: 9241562676
Format: PDF, ePub, Mobi
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A joint project of IPCS/OECD. In two parts: Part 1: IPCS/OECD Key Generic Terms used in Chemical Hazard/Risk Assessment. Part 2: IPCS Glossary of Key Exposure Assessment Terminology. IPCS project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals

Principles of Characterizing and Applying Human Exposure Models

Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241563117
Format: PDF
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The objective of this manual is to provide guidance to risk assessors on the use of quantitative toxicokinetic and toxicodynamic data to address interspecies and interindividual differences in dose/concentration-response assessment. Section 1 focuses on the relevance of this guidance in the context of the broader risk assessment paradigm and other initiatives of the International Programme on Chemical Safety (IPCS) project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals. Technical background material is presented in section 2, followed by generic guidance for the development of chemical-specific adjustment factors in section 3 and accompanying summary figures. Illustrative case-studies are included in an Appendix, and a glossary of terms is also provided.

The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals

Author: J. Krüse
Publisher: Springer Science & Business Media
ISBN: 9781402009341
Format: PDF, Docs
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In 2000 OpdenKamp Registration & Notification organized a two-day symposium in The Hague, The Netherlands, on `The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals'. Several speakers from Europe and the United States were invited to present the different aspects. A vast range of areas was discussed in relation to toxicological modeling and risk assessment, such as occupational toxicology and biomonitoring, exposure to organic solvents and crop protection products, dose-response relations in carcinogenicity, regulatory toxicology, estimation of dermal penetration, uptake and disposition of organic chemicals in fish, the possibilities of in vitro methods in hazard and risk assessment, and the extrapolation between animal and human species. Based on their presentations, the speakers prepared comprehensive papers for this symposium book, reflecting the state of the art of modeling and toxicological risk assessment at the beginning of the third millennium.

Practical Guide to Chemical Safety Testing

Author: Derek J. Knight
Publisher: iSmithers Rapra Publishing
ISBN: 9781859573723
Format: PDF, Kindle
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This book describes the different tests that must be performed on new chemicals and other materials to demonstrate to the regulatory authorities that they are safe for use. Tests vary from physico-chemical, measuring properties such as melting point and density, through genetic toxicity studies, to mammalian toxicology and studies to investigate effects on the environment. This book describes clearly the process of obtaining approval for use in a variety of global regions and across different applications. It also explains why different tests are performed and the implications of the results.