Human Ageing A Unique Experience Implications For The Disease Concept

Author: Singer Michael Alan
Publisher: World Scientific
ISBN: 9814619140
Format: PDF, Mobi
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Human Ageing: A Unique Experience explores the biology of human ageing focusing on the individual. The book begins with the premature ageing disorder Hutchinson-Gilford Progeria syndrome and spins a web of interconnected biological domains involving lamins, telomeres, alternative splicing, genetics, epigenetics, and molecular clocks. The profound influence of culture is explored since cultural inheritance and genetic inheritance are the two intertwined processes driving human evolution. An empirical framework is developed to describe human ageing at the individual level and the implications of this framework on the whole concept of diseases are discussed.

Human Ageing

Author: Michael A. Singer
Publisher: World Scientific Publishing Company Incorporated
ISBN: 9789814619127
Format: PDF, Kindle
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Human Ageing: A Unique Experience explores the biology of human ageing focusing on the individual. The book begins with the premature ageing disorder Hutchinson-Gilford Progeria syndrome and spins a web of interconnected biological domains involving lamins, telomeres, alternative splicing, genetics, epigenetics, and molecular clocks. The profound influence of culture is explored since cultural inheritance and genetic inheritance are the two intertwined processes driving human evolution. An empirical framework is developed to describe human ageing at the individual level and the implications of this framework on the whole concept of diseases are discussed.

Aging

Author: Shamim I. Ahmad
Publisher: CRC Press
ISBN: 1315283875
Format: PDF, Docs
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This book is a detailed and comprehensive synthesis of the scientific study of aging. Dozens of contributions from leading scholars review various theories of aging, and molecular, cellular, biochemical and microbial aspects of aging, among just a few of the topics included. Authoritative, wide ranging and thorough, this book will act as a source for experimental design, a comprehensive description of age related diseases, and provide information of the latest molecular theories underlying their causes. Additionally, it will target industries involved in developing anti-aging drugs, post-graduate medical students, and university libraries.

Conn s Handbook of Models for Human Aging

Author: Jeffrey L. Ram
Publisher: Academic Press
ISBN: 0128113545
Format: PDF, ePub, Mobi
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Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students. Combines both the methods of study for human aging and animal models Provides a historical overview and discussion of model availability, key methods and ethical issues Contains over 200 full color illustrations

The Demography and Epidemiology of Human Health and Aging

Author: Jacob S. Siegel
Publisher: Springer Science & Business Media
ISBN: 9789400713154
Format: PDF, ePub
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With this book, Siegel, an internationally known demographer and gerontologist, has made a unique contribution to the fledgling fields of health demography, and the demography and epidemiology of aging. The book represents a felicitous union of epidemiology, gerontology, and demography, and appears to be the first and only comprehensive text on this subject now available. Drawing on a wide range of sciences in addition to demography, gerontology, and epidemiology, including medical sociology, biostatistics, public policy, bioethics, and molecular biology, the author treats theoretical and applied issues, links methods and findings, covers the material internationally, nationally, and locally, and while focusing on the elderly, treats the entire life course. The methods, materials, and pespectives of demography and epidemiology are brought to bear on such topics as the prospects for future increases in human longevity, the relative contribution of life style, environment, genetics, and chance in human longevity, the measurement of the share of healthy years in total life expectancy, the role of population growth in the rising costs of health care, and the applications of health demography in serving the health needs of local communities. The separate chapters systematically develop the topics of the sources and quality of health data; mortality, life tables, and the measurement of health status; the interrelationships of health, on the one hand, and mortality, fertility, migration, and age structure, on the other; health conditions in the less developed countries; the concepts and theories of aging and projections of the aged population; and local health applications, public health policy, and bioethical issues in health demography. Given its comprehensiveness, clarity, interdisciplinary scope, and authencity, this book appeals to a wide range of users, from students and teachers of medical sociology, the demography of aging, and public health studies to practitioners in these areas, both as a text in health demography and the demography/epidemiology of aging, and as a reference work in these fields.

World Report on Ageing and Health

Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241565047
Format: PDF
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The WHO World report on ageing and health is not for the book shelf it is a living breathing testament to all older people who have fought for their voice to be heard at all levels of government across disciplines and sectors. - Mr Bjarne Hastrup President International Federation on Ageing and CEO DaneAge This report outlines a framework for action to foster Healthy Ageing built around the new concept of functional ability. This will require a transformation of health systems away from disease based curative models and towards the provision of older-person-centred and integrated care. It will require the development sometimes from nothing of comprehensive systems of long term care. It will require a coordinated response from many other sectors and multiple levels of government. And it will need to draw on better ways of measuring and monitoring the health and functioning of older populations. These actions are likely to be a sound investment in society's future. A future that gives older people the freedom to live lives that previous generations might never have imagined. The World report on ageing and health responds to these challenges by recommending equally profound changes in the way health policies for ageing populations are formulated and services are provided. As the foundation for its recommendations the report looks at what the latest evidence has to say about the ageing process noting that many common perceptions and assumptions about older people are based on outdated stereotypes. The report's recommendations are anchored in the evidence comprehensive and forward-looking yet eminently practical. Throughout examples of experiences from different countries are used to illustrate how specific problems can be addressed through innovation solutions. Topics explored range from strategies to deliver comprehensive and person-centred services to older populations to policies that enable older people to live in comfort and safety to ways to correct the problems and injustices inherent in current systems for long-term care.

Conn s Handbook of Models for Human Aging

Author: Jeffrey L. Ram
Publisher: Academic Press
ISBN: 0128113545
Format: PDF, ePub, Mobi
Download Now
Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students. Combines both the methods of study for human aging and animal models Provides a historical overview and discussion of model availability, key methods and ethical issues Contains over 200 full color illustrations

Preparing for an Aging World

Author: Committee on National Statistics
Publisher: National Academies Press
ISBN: 0309074215
Format: PDF, Mobi
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Aging is a process that encompasses virtually all aspects of life. Because the speed of population aging is accelerating, and because the data needed to study the aging process are complex and expensive to obtain, it is imperative that countries coordinate their research efforts to reap the most benefits from this important information. Preparing for an Aging World looks at the behavioral and socioeconomic aspects of aging, and focuses on work, retirement, and pensions; wealth and savings behavior; health and disability; intergenerational transfers; and concepts of well-being. It makes recommendations for a collection of new, cross-national data on aging populations-data that will allow nations to develop policies and programs for addressing the major shifts in population age structure now occurring. These efforts, if made internationally, would advance our understanding of the aging process around the world.

On Human Nature

Author: Michel Tibayrenc
Publisher: Academic Press
ISBN: 0127999159
Format: PDF, Mobi
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On Human Nature: Biology, Psychology, Ethics, Politics, and Religion covers the present state of knowledge on human diversity and its adaptative significance through a broad and eclectic selection of representative chapters. This transdisciplinary work brings together specialists from various fields who rarely interact, including geneticists, evolutionists, physicians, ethologists, psychoanalysts, anthropologists, sociologists, theologians, historians, linguists, and philosophers. Genomic diversity is covered in several chapters dealing with biology, including the differences in men and apes and the genetic diversity of mankind. Top specialists, known for their open mind and broad knowledge have been carefully selected to cover each topic. The book is therefore at the crossroads between biology and human sciences, going beyond classical science in the Popperian sense. The book is accessible not only to specialists, but also to students, professors, and the educated public. Glossaries of specialized terms and general public references help nonspecialists understand complex notions, with contributions avoiding technical jargon. Provides greater understanding of diversity and population structure and history, with crucial foundational knowledge needed to conduct research in a variety of fields, such as genetics and disease Includes three robust sections on biological, psychological, and ethical aspects, with cross-fertilization and reciprocal references between the three sections Contains contributions by leading experts in their respective fields working under the guidance of internationally recognized and highly respected editors

The Telomerase Revolution

Author: Michael Fossel
Publisher: BenBella Books, Inc.
ISBN: 1941631703
Format: PDF, ePub
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One of Wall Street Journal’s "Best Books for Science Lovers" in 2015 Science is on the cusp of a revolutionary breakthrough. We now understand more about aging—and how to prevent and reverse it—than ever before. In recent years, our understanding of the nature of aging has grown exponentially, and dramatic life extension—even age reversal—has moved from science fiction to real possibility. Dr. Michael Fossel has been in the forefront of aging research for decades and is the author of the definitive textbook on human aging. In The Telomerase Revolution, he takes us on a detailed but highly accessible scientific journey, providing startling insights into the nature of human aging. Twenty years ago, there was still considerable debate of the nature of human aging, with a variety of competing theories in play. But scientific consensus is forming around the telomere theory of aging. The essence of this theory is that human aging is the result of cellular aging. Every time a cell reproduces, its telomeres (the tips of the chromosomes) shorten. With every shortening of the telomeres, the cell’s ability to repair its molecules decreases. It ages. Human aging is the result of the aging of the body’s trillions of cells. But some of our cells don’t age. Sex cells and stem cells can reproduce indefinitely, without aging, because they create telomerase. Telomerase re-lengthens the telomeres, keeping these cells young. The Telomerase Revolution describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to dramatically extend life spans and even reverse human aging. Telomerase-based treatments are already available, and have shown early promise, but much more potent treatments will become available over the next decade. The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine.