Illicit Drugs in the Environment

Author: Sara Castiglioni
Publisher: Wiley
ISBN: 9780470529546
Format: PDF, ePub, Docs
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Illicit drugs are an emerging class of environmental contaminants and mass spectrometry is the technique of choice for their analysis. This landmark reference discusses the analytical techniques used to detect illicit drugs in wastewater and surface water, details how to estimate the levels of contaminants in the environment, and explores the behavior, fate, and toxic effects of this new class of contaminants, now a ubiquitous presence in wastewater and surface water. The book details how an estimate of illicit drug consumption in a given population can be developed from an analysis of the residues of illicit drugs in wastewater. An important resource for analytical chemists, environmental researchers, forensic scientists, biologists, and toxicologists.

Mass Spectrometry for the Novice

Author: John Greaves
Publisher: CRC Press
ISBN: 1420094203
Format: PDF
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With usage of mass spectrometry continually expanding, an increasing number of scientists, technicians, students, and physicians are coming into contact with this valuable technique. Mass spectrometry has many uses, both qualitative and quantitative, from analyzing simple gases to environmental contaminants, pharmaceuticals, and complex biopolymers. The extraordinary versatility can make mass spectrometers daunting to novices. Consequently, new users would benefit greatly from an understanding of the basic concepts as well as the processes that occur in these instruments. Mass Spectrometry for the Novice provides exactly that, with detailed, straightforward descriptions and clear illustrations of principles of operations and techniques. The book begins with an overview that includes essential definitions and then provides information on the components of and the strategies used in the most common instruments. The authors discuss the methodologies available, classes of compounds analyzed, and the types of data that can be generated. A group of representative applications from published articles is summarized, demonstrating the diversity of mass spectrometry. The authors also condense the essentials of the topic into one invaluable chapter that provides a set of concise take-home messages on all aspects of mass spectrometry. The final section provides a collection of resources including books, reviews, and useful websites. Using simple language, new color figures, clever cartoons, and assuming no prior knowledge, this book provides a readily understandable entrée to mass spectrometry. A CD-ROM with selected figures and cartoons is included.

Interpretation of MS MS Mass Spectra of Drugs and Pesticides

Author: Wilfried M. A. Niessen
Publisher: John Wiley & Sons
ISBN: 111929424X
Format: PDF, Kindle
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Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns

Integration of Omics Approaches and Systems Biology for Clinical Applications

Author: Antonia Vlahou
Publisher: John Wiley & Sons
ISBN: 1119183979
Format: PDF
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Introduces readers to the state of the art of omics platforms and all aspects of omics approaches for clinical applications This book presents different high throughput omics platforms used to analyze tissue, plasma, and urine. The reader is introduced to state of the art analytical approaches (sample preparation and instrumentation) related to proteomics, peptidomics, transcriptomics, and metabolomics. In addition, the book highlights innovative approaches using bioinformatics, urine miRNAs, and MALDI tissue imaging in the context of clinical applications. Particular emphasis is put on integration of data generated from these different platforms in order to uncover the molecular landscape of diseases. The relevance of each approach to the clinical setting is explained and future applications for patient monitoring or treatment are discussed. Integration of omics Approaches and Systems Biology for Clinical Applications presents an overview of state of the art omics techniques. These methods are employed in order to obtain the comprehensive molecular profile of biological specimens. In addition, computational tools are used for organizing and integrating these multi-source data towards developing molecular models that reflect the pathophysiology of diseases. Investigation of chronic kidney disease (CKD) and bladder cancer are used as test cases. These represent multi-factorial, highly heterogeneous diseases, and are among the most significant health issues in developed countries with a rapidly aging population. The book presents novel insights on CKD and bladder cancer obtained by omics data integration as an example of the application of systems biology in the clinical setting. Describes a range of state of the art omics analytical platforms Covers all aspects of the systems biology approach—from sample preparation to data integration and bioinformatics analysis Contains specific examples of omics methods applied in the investigation of human diseases (Chronic Kidney Disease, Bladder Cancer) Integration of omics Approaches and Systems Biology for Clinical Applications will appeal to a wide spectrum of scientists including biologists, biotechnologists, biochemists, biophysicists, and bioinformaticians working on the different molecular platforms. It is also an excellent text for students interested in these fields.

The Llobregat

Author: Sergi Sabater
Publisher: Springer
ISBN: 3642309399
Format: PDF, Mobi
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The Llobregat belongs to the most thoroughly studied rivers in Europe and is a paradigm of the confluence of human and natural disturbances in a single basin. Because of its location in a very densely populated region and its Mediterranean character, the Llobregat supports a mixture of irregular flow, water abstraction, excess nutrients, mining debris, and a wide array of pollutants. The aquatic organisms strive to survive in a dramatically changing river that passes through a succession of dams, weirs and channels. The long-term river monitoring as well as the research that has been carried out in the river for a long time have provided an extensive knowledge of these disturbances and their effects on the biological communities. This book highlights the available information, with emphasis on the hydrological, chemical and biological elements interspersed in the river. Experts in the field discuss the main nutrient patterns and pollutant occurrence and the responses of the biological quality elements as well as the river ecosystem to the overall natural and man-made influences.

Mass Spectrometry in Structural Biology and Biophysics

Author: Igor A. Kaltashov
Publisher: John Wiley & Sons
ISBN: 0470937793
Format: PDF, Kindle
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With its detailed and systematic coverage of the current state of biophysical mass spectrometry (MS), here is one of the first systematic presentations of the full experimental array of MS-based techniques used in biophysics, covering both fundamental and practical issues. The book presents a discussion of general biophysical concepts and a brief overview of traditional biophysical techniques before outlining the more advanced concepts of mass spectrometry. The new edition gives an up-to-date and expanded coverage of experimental methodologies and a clear look at MS-based methods for studying higher order structures and biopolymers. A must for researchers in the field of biophysics, structural biology, and protein chemistry.

Mass Spectrometry and Stable Isotopes in Nutritional and Pediatric Research

Author: Henk Schierbeek
Publisher: John Wiley & Sons
ISBN: 1119341248
Format: PDF, ePub
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A guide for scientists, pediatricians and students involved in metabolic studies in pediatric research Addresses the availability of modern analytical techniques and how to apply these techniques in metabolic studies Covers the whole range of available mass spectrometric techniques used for metabolic studies including Stable Isotope Methodology Presents the relevance of mass spectrometry and stable isotope methodology in pediatric research covering applications in Nutrition, Obesity, Metabolic Disorders, and Kidney Disorders Focuses on the interactions between nutrients and the endogenous metabolism within the body and how these factors affect the health of a growing infant

Transformation Products of Emerging Contaminants in the Environment

Author: Dimitra A. Lambropoulou
Publisher: John Wiley & Sons
ISBN: 1118339576
Format: PDF, Mobi
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Over the last 15 years, the focus of chemical pollution has shifted from conventional pollutants to so-called “emerging” or “new” unregulated contaminants. These include pharmaceuticals and personal care products, hormones, UV filters, perfluorinated compounds, poylybrominated flame retardants (BFRs), pesticides, plasticizers, artificial sweeteners, illicit drugs, and endocrine disruptor compounds (EDCs). Despite the increasing number of published studies covering emerging contaminants, we know almost nothing about the effects of their transformation products and/or metabolites. This two-volume set provides a unique collection of research on transformation products, their occurrence, fate and risks in the environment. It contains 32 chapters, organised into 7 parts, each with a distinct focus: • General Considerations • Transformation Processes and Treatment Strategies • Analytical Strategies • Occurrence, Fate and Effects in the Environment • Global Speciality and Environmental Status • Risk Assessment, Management and Regulatory Framework • Outlook Transformation Products of Emerging Contaminants in the Environment is a valuable resource for researchers and industry professionals in environmental chemistry, analytical chemistry, ecotoxicology, environmental sciences, and hydrology, as well as environmental consultants and regulatory bodies.

Comprehensive Environmental Mass Spectrometry

Author: Albert Lebedev
Publisher: ILM Publications
ISBN: 1906799121
Format: PDF, Kindle
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This volume provides a wide-ranging and practical overview of all aspects of the use of mass spectrometry in envrionmental applications.

Metabolite Safety in Drug Development

Author: Suzanne L. Iverson
Publisher: John Wiley & Sons
ISBN: 111894965X
Format: PDF, Kindle
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A reference on drug metabolism and metabolite safety in the development phase, this book reviews the analytical techniques and experimental designs critical for metabolite studies. It features case studies of lessons learned and real world examples, along with regulatory perspectives from the US FDA and EMA. • Reviews the analytical techniques and experimental designs critical for metabolite studies • Covers methods including chirality, species differences, mass spectrometry, radiolabels, and in vitro / in vivo correlation • Discusses target pharmacology, in vitro systems aligned to toxicity tests, and drug-drug interactions • Includes perspectives from authors with firsthand involvement in industry and the study of drug metabolites, including viewpoints that have influenced regulatory guidelines