Incretin Biology A Practical Guide

Author: Guy A Rutter
Publisher: World Scientific
ISBN: 1783267380
Format: PDF, Kindle
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Together, obesity and diabetes form a 21st century epidemic, the treatment of which consumes a substantial fraction of global health costs. New and improved therapies are therefore desperately needed. Incretins are short peptide hormones released from the gut in response to food transit. These hormones regulate a plethora of processes to control food intake, body weight and glucose homeostasis. This is one of the fastest areas of growth within diabetes research, and over the past decade, increasing numbers of novel diabetes drugs — many based on incretin action — have been added to the therapeutic armoury. Following an introduction detailing the historical perspective and discovery of incretin therapies and clinical applications, the book looks at the release of incretins at a cellular level from entero-endocrine cells, and actions on the pancreas (alpha and beta cells) and brain. It then looks at changes in incretins seen in diabetes and following bariatric surgery. Finally, the side effects of incretin therapy are discussed. Importantly, each chapter contains a methodology section aimed at providing a practical guide to key techniques in the field of incretin biology and ranges from basic laboratory research to clinical practice. Incretin Biology — A Practical Guide offers a unique perspective within this field of research by bringing together scientists, physicians and bariatric surgeons. Thus, it is a comprehensive text that offers a broad overview of the subject. Contents:History of Incretin Discovery and Clinical Application (S E K Zac-Varghese and S R Bloom)Synthesis and Secretion of Incretins from the Gut (A E Adriaenssens, F Reimann and Gribble)Studying Incretin Action on the Pancreatic β Cell (D J Hodson and G A Rutter)Action of Incretins on the Pancreatic α Cell: Control of Glucagon Secretion (L McCulloch, M Godazgar, P Rorsman and R Ramracheya)Role of Incretins in the Brain (J E Richards, S C Cork, M K Holt and S Trapp)Bariatric Surgery: Clinical Aspects (A Ahmed and C Tsironis)GLP-1 in Bariatric Surgery and Diabetes: Underlying Molecular Mechanisms (N B Jørgensen and J J Holst)GLP-1-Based Therapies: What are the Safety Implications? (A Mondragon, A Bertling, R Gomes-Faria, G A Rutter and G da Silva Xavier) Readership: Scientists and clinicians with an emphasis on translational research; biology students; medical students; physicians and bariatric surgeons; and those with an interest in the use of incretins in diabetes and obesity treatment with a view to undertake research within this field. Key Features:Broad overview of the field of incretin biology from a cellular level to clinical applicationDetailed protocols with extensive practical tipsChapters from prominent authors who are currently leading in this fieldKeywords:Incretin;Insulin Secretion;Entero-endocrine Cells;GLP-1;GIP;Dipeptidyl Peptidase-IV Inhibitors;Diabetes;Obesity;Pancreas;Beta Cell;Alpha Cell;Bariatric Surgery;Endocrinology

Practical Guide to Obesity Medicine

Author: Jolanta Weaver
Publisher: Elsevier Health Sciences
ISBN: 0323496008
Format: PDF
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Get a quick, expert overview of the many key facets of obesity management with this concise, practical resource by Dr. Jolanta Weaver. Ideal for any health care professional who cares for patients with a weight problem. This easy-to-read reference addresses a wide range of topics – including advice on how to "unpack" the behavioral causes of obesity in order to facilitate change, manage effective communication with patients suffering with weight problems and future directions in obesity medicine. Features a wealth of information on obesity, including hormones and weight problems, co-morbidities in obesity, genetics and the onset of obesity, behavioral aspects and psychosocial approaches to obesity management, energy and metabolism management, and more. Discusses pharmacotherapies and surgical approaches to obesity. Consolidates today’s available information and guidance in this timely area into one convenient resource.

Management of Diabetes Mellitus

Author: Dr. Diana W. Guthrie, PhD, BC-ADM, CDE, FAADE
Publisher: Springer Publishing Company
ISBN: 9780826119100
Format: PDF
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"I strongly recommend this text. Whether the reader is a relative novice or a seasoned veteran in diabetes care, the information will prove useful and concise and will likely stimulate further reading and study. House staff planning to rotate on my endocrine service should be forewarned: Management of Diabetes Mellitus: A Guide to Pattern Management is now required reading." --JAMA Praise for the previous edition "I recommend this book to nurses or physicians confronting patients afflicted with diabetes mellitus, as it presents a patterned approach to the understanding and management of this malady. Any patient with diabetes mellitus or health care professional using the information presented by these experts would be well prepared to manage this disease process" --Gloria K. Twilley, Lieutenant Colonel United States Air Force Nurse Corps The sixth edition of Management of Diabetes Mellitus fully reorganizes and expands upon the previous editions. While the new edition continues to set forth practical and easy-to-use guidelines for management, the newly expanded chapters contain detailed information on managing patients with different types of diabetes (type 1 and type 2), and further differentiates treatment and management strategies for various age groups. This edition also offers clear and concise explanations of the disease process, newly revised guidelines for the use of complementary and alternative therapies, and a guide for developing an educational program. Guthrie and Guthrie also stress the importance of self-management of diabetes, as much of this edition is dedicated to educating the diabetic patient on how to provide self-care, and control both acute and chronic complications of the disease. For the convenience of practitioners and diabetic patients themselves, this book contains reproducible forms, protocols, and guides that can be used for managing diabetes, including: Nutrition questionnaires Meal patterns comparing exchanges Carb Counting and Calorie Points Sample Calorie Point Distributions Exercise Log Intake Assessment Guide Clinical Practice Recommendations A guide to the "pattern approach"

Bariatric Surgery

Author: Francis A. Farraye
Publisher: SLACK Incorporated
ISBN: 9781556427367
Format: PDF, Mobi
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Obesity is a serious and rapidly increasing medical problem. Bariatric surgery is the only effective long-term treatment for morbid obesity and the performance of this surgery has increased dramatically over the years. Bariatric Surgery: A Primer for Your Medical Practice is a user-friendly, practical reference text that provides all the necessary information that the health care professional will need to assist in patient selection and preoperative assessment, as well as recommendations in dealing with complex postoperative care of the bariatric patient. Dr. Francis A. Farraye and Dr. R. Armour Forse, joined by leading experts, review what is required by today's practicing physician who will manage the care of obese adults. Inside the chapters of Bariatric Surgery, along with numerous tables, images, and charts, you will find many crucial elements of bariatric surgery extensively and practically covered. Bariatric Surgery is the perfect resource for the primary care physician, family practitioner, general internist, endocrinologist, nutritionist, gastroenterologist, radiologist, medical and surgical resident, and medical student. Long awaited, Bariatric Surgery is the answer many are searching for today. Some chapter topics: The medical management of obesity Types of bariatric surgery Assessments of patients prior to bariatric surgery Medical management of the patient after bariatric surgery Nutritional and psychological consequences of bariatric surgery Endoscopic and radiologic imaging

A Practical Guide to Diabetes Mellitus

Author: Nihal Thomas
Publisher: JAYPEE BROTHERS PUBLISHERS
ISBN: 9350905973
Format: PDF, Docs
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The Sixth Edition of A Practical Guide to Diabetes Mellitus offers a unique combination of rigorous pathophysiology with very practical approaches to diabetes prevention and control. This outstanding textbook will equip a cadre of doctors and other health care professionals to deliver high quality care to vulnerable populations around India and far beyond. Based on research as well as clinical practice, the text describes diabetes in relation to physiology, ocular, cardiovascular, neuropathy, pregnancy, emergencies, childhood diabetes, etc. Each chapter beings with a brief outline of the disease concerned followed by introduction, definition/terminology, classification, treatment, conclusion and ending with set of question for self-assessment. Covers step wise images describes insulin administration in subcutaneous and using pen devices in the chapter: Insulin therapy: practical aspects. Feet, Footcare and Neuroarthropathy chapter deals with etiology and pathophysiology and is divided into three parts: Ulceration, Neuroarthropathy and Peripheral Artery Occlusive(PAD) diseases. Infection in diabetes chapter focuses on infection related to head and neck, genitourinary, skin and soft tissue, pulmonology and abdominal. Recent advances includes application of new drugs like Taspoglutide, Albiglutide, Lixisenatide, Newer DPP-IV inhibitors, along with new insulin receptor activators, PPAR agonists, new hepatic targets for glycemic control in diabetes. This book contains more than 300 coloured images and illustrations, 40 clinical cases, 50 questions for quick revision along with answers to the self-assessments question given at the end of book."

Care of People with Diabetes

Author: Trisha Dunning
Publisher: John Wiley & Sons
ISBN: 1118697324
Format: PDF, Mobi
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‘This remarkably comprehensive book reflects the depth of knowledge and experience of its author and will assist nurses in the process of diabetes management. I wholeheartedly recommend this text to all health professionals whether working directly in, or on, the fringe of diabetes. ‘ From the foreword by Marg McGill, Chair, International Diabetes Federation Consultative Section on Diabetes Education Care of People with Diabetes is an essential guide to the care and management of people with diabetes mellitus, with particular emphasis on the acute care setting. It is written by an experienced clinical nurse specialist with extensive knowledge of evidence-based diabetes care. The book serves as an essential companion to clinical practice for nurses and health professionals. This third edition of Care of People with Diabetes has been extensively revised, and includes new information on smoking cessation, diabetes and driving, coeliac disease and Polycystic Ovarian Syndrome. Key features: Fully revised new edition of a successful text Provides the evidence for best practice Includes protocols for consistent care and improvement of patient outcomes Each chapter includes lists of key points, boxes highlighting key information, further reading, patient information, and patient care sheets.

Bariatric Surgical Practice Guide

Author: Rachel Maria Gomes
Publisher: Springer
ISBN: 9811027056
Format: PDF, ePub, Mobi
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This book provides a comprehensive review of literature of various aspects of bariatric surgery arriving at practical recommendations for simplifying day to day practice. This book is divided into 10 sections covering selection of patient, preoperative predictors of outcome, technical considerations, specific situations, post-operative pathways, management of complications, revisional surgery, and perioperative nutritional aspects. It covers specific situations in bariatric surgery such as GERD, hernia repair, gallstone disease, PCOD, NAFLD and end-organ disease. Bariatric Surgical Practice Guide is a quick resource for practicing bariatric surgeons, young and experienced, to understand all practical aspects of this surgery which is gaining importance worldwide at a rapid pace. Recommendations are based on existing literature as well as opinions of the authors who work at state-of-the-art clinical facilities.

The Physical Care of People with Mental Health Problems

Author: Eve Collins
Publisher: SAGE
ISBN: 1446291022
Format: PDF, ePub, Mobi
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This accessible, practical text provides mental health practitioners with the core knowledge and skills they need to be able to care effectively for the physical health of those who have been diagnosed with mental illness. Linked closely to professional standards, and with a clear values- and evidence-base, the book aims to raise awareness of the physical health needs of individuals with mental health problems, outline the physical health assessment process and suggest health enhancing interventions for use in clinical practice. Consideration will be given to the following aspects of physical wellbeing; - cardiovascular health - diabetes - sexual health - respiratory health - cancer - wound care - substance misuse - infection control - medicine management Further chapters on legal and ethical issues explain the need to practise appropriately within the Mental Health Act and the Mental Capacity Act, while a linking theme throughout the book stresses the importance of health promotion. Backed up by case examples and with a range of reflective exercises throughout, The Physical Care of People with Mental Health Problems is a key text for students and practitioners working in mental health services. It will also be useful reading for practice nurses, district nurses, midwives and all allied health practitioners.

Diabetes Associated with Single Gene Defects and Chromosomal Abnormalities

Author: F. Barbetti
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318060259
Format: PDF, ePub
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This volume, written by renowned experts, provides complete coverage of the main genetic conditions associated with diabetes. Divided into five sections, it offers insights into genetic defects involving the pancreatic beta cell, extreme insulin resistance, ciliopathies, obesity and glucose metabolism, chromosomal defects, and other genetic conditions associated with increased susceptibility to diabetes. Other topics include the various subtypes of monogenic diabetes, such as the neonatal form and the Wolfram syndrome, as well as chromosomal defects leading to complex conditions affiliated with diabetes, like Trisomy 21 or Prader-Willi syndrome. There are also chapters dedicated to the poorly explored relationships between metabolism and neurodegenerative disorders like Friedreich’s ataxia and muscular dystrophy. This book is a reference for every pediatric and adult endocrinologist and diabetologist, even experienced ones, with an interest in the intricacies and protean aspects of disorders of glucose metabolism secondary to genetic diseases.

Handbook of Diabetes

Author: Rudy Bilous
Publisher: John Wiley & Sons
ISBN: 9781444396188
Format: PDF, ePub, Mobi
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Over three editions the Handbook of Diabetes has built a reputation as an essential practical manual on the assessment and management of patients with diabetes. Previously written by Gareth Williams and John Pickup, the book has been completely revised by Rudy Bilous and Richard Donnelly to reflect recent changes in diabetes treatment and care. It contains information on the new IFCC units for measuring blood glucose and the latest drugs being used to combat diabetes, as well as alternative methods of insulin delivery. The book has been fully updated and redesigned to make it even more user-friendly, and contains case histories, practice points, and landmark clinical trials highlighted in color in each chapter where appropriate. It also features an entirely new set of clinical photographs, and all 250 images from the book can be downloaded from the companion CD for use in presentations. The Handbook of Diabetes is the ideal practical handbook for all health professionals with an interest in diabetes care.