Incretin Biology A Practical Guide

Author: Guy A Rutter
Publisher: World Scientific
ISBN: 1783267380
Format: PDF, Kindle
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Together, obesity and diabetes form a 21st century epidemic, the treatment of which consumes a substantial fraction of global health costs. New and improved therapies are therefore desperately needed. Incretins are short peptide hormones released from the gut in response to food transit. These hormones regulate a plethora of processes to control food intake, body weight and glucose homeostasis. This is one of the fastest areas of growth within diabetes research, and over the past decade, increasing numbers of novel diabetes drugs — many based on incretin action — have been added to the therapeutic armoury. Following an introduction detailing the historical perspective and discovery of incretin therapies and clinical applications, the book looks at the release of incretins at a cellular level from entero-endocrine cells, and actions on the pancreas (alpha and beta cells) and brain. It then looks at changes in incretins seen in diabetes and following bariatric surgery. Finally, the side effects of incretin therapy are discussed. Importantly, each chapter contains a methodology section aimed at providing a practical guide to key techniques in the field of incretin biology and ranges from basic laboratory research to clinical practice. Incretin Biology — A Practical Guide offers a unique perspective within this field of research by bringing together scientists, physicians and bariatric surgeons. Thus, it is a comprehensive text that offers a broad overview of the subject. Contents:History of Incretin Discovery and Clinical Application (S E K Zac-Varghese and S R Bloom)Synthesis and Secretion of Incretins from the Gut (A E Adriaenssens, F Reimann and Gribble)Studying Incretin Action on the Pancreatic β Cell (D J Hodson and G A Rutter)Action of Incretins on the Pancreatic α Cell: Control of Glucagon Secretion (L McCulloch, M Godazgar, P Rorsman and R Ramracheya)Role of Incretins in the Brain (J E Richards, S C Cork, M K Holt and S Trapp)Bariatric Surgery: Clinical Aspects (A Ahmed and C Tsironis)GLP-1 in Bariatric Surgery and Diabetes: Underlying Molecular Mechanisms (N B Jørgensen and J J Holst)GLP-1-Based Therapies: What are the Safety Implications? (A Mondragon, A Bertling, R Gomes-Faria, G A Rutter and G da Silva Xavier) Readership: Scientists and clinicians with an emphasis on translational research; biology students; medical students; physicians and bariatric surgeons; and those with an interest in the use of incretins in diabetes and obesity treatment with a view to undertake research within this field. Key Features:Broad overview of the field of incretin biology from a cellular level to clinical applicationDetailed protocols with extensive practical tipsChapters from prominent authors who are currently leading in this fieldKeywords:Incretin;Insulin Secretion;Entero-endocrine Cells;GLP-1;GIP;Dipeptidyl Peptidase-IV Inhibitors;Diabetes;Obesity;Pancreas;Beta Cell;Alpha Cell;Bariatric Surgery;Endocrinology

Practical Guide to Obesity Medicine

Author: Jolanta Weaver
Publisher: Elsevier Health Sciences
ISBN: 0323496008
Format: PDF, Docs
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Get a quick, expert overview of the many key facets of obesity management with this concise, practical resource by Dr. Jolanta Weaver. Ideal for any health care professional who cares for patients with a weight problem. This easy-to-read reference addresses a wide range of topics – including advice on how to "unpack" the behavioral causes of obesity in order to facilitate change, manage effective communication with patients suffering with weight problems and future directions in obesity medicine. Features a wealth of information on obesity, including hormones and weight problems, co-morbidities in obesity, genetics and the onset of obesity, behavioral aspects and psychosocial approaches to obesity management, energy and metabolism management, and more. Discusses pharmacotherapies and surgical approaches to obesity. Consolidates today’s available information and guidance in this timely area into one convenient resource.

Calcium Signalling and Disease

Author: Ernesto Carafoli
Publisher: Springer Science & Business Media
ISBN: 1402061919
Format: PDF
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Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.

Diabetes For Dummies

Author: Alan L. Rubin
Publisher: John Wiley & Sons
ISBN: 1119090768
Format: PDF, Docs
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The straight facts on treating diabetes successfully With diabetes now considered pandemic throughout the world, there have been enormous advances in the field. Now significantly revised and updated, this new edition of Diabetes For Dummies includes the latest information on diabetes medications and monitoring equipment, new findings about treating diabetes in the young and elderly, new ways to diagnose and treat long- and short-term complications, updated nutritional guidelines, new tools for measuring blood sugar and delivering insulin to the body, and much more. There's no question that the burden of diabetes is increasing globally: it's estimated that 387 million people worldwide are living with diabetes, and that staggering number is expected to increase an additional 205 million+ by 2035. If you or a loved one is part of this overwhelming statistic, you can take comfort in the sensitive and authoritative information provided in this hands-on guide. From monitoring and maintaining your glucose to understanding the importance of exercising and eating right—and everything in between—Diabetes For Dummies takes the guesswork out of living with diabetes and empowers you to take control and keep your life on a healthy track. Reduce your risk of diabetes complications Discover the latest and the tried-and-true options for monitoring blood sugar Get up to speed on the various diabetes medications and lifestyle strategies Improve diabetes control and overall health If you're one of the millions of diabetics or pre-diabetics in search of an accessible and up-to-date resource to help you manage this disease, Diabetes For Dummies is the trusted guide you'll turn to again and again.

Diabetes Associated with Single Gene Defects and Chromosomal Abnormalities

Author: F. Barbetti
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318060259
Format: PDF, ePub
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This volume, written by renowned experts, provides complete coverage of the main genetic conditions associated with diabetes. Divided into five sections, it offers insights into genetic defects involving the pancreatic beta cell, extreme insulin resistance, ciliopathies, obesity and glucose metabolism, chromosomal defects, and other genetic conditions associated with increased susceptibility to diabetes. Other topics include the various subtypes of monogenic diabetes, such as the neonatal form and the Wolfram syndrome, as well as chromosomal defects leading to complex conditions affiliated with diabetes, like Trisomy 21 or Prader-Willi syndrome. There are also chapters dedicated to the poorly explored relationships between metabolism and neurodegenerative disorders like Friedreich’s ataxia and muscular dystrophy. This book is a reference for every pediatric and adult endocrinologist and diabetologist, even experienced ones, with an interest in the intricacies and protean aspects of disorders of glucose metabolism secondary to genetic diseases.

5th International Conference on Biomedical Engineering in Vietnam

Author: Vo Van Toi
Publisher: Springer
ISBN: 3319117769
Format: PDF
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This volume presents the proceedings of the Fifth International Conference on the Development of Biomedical Engineering in Vietnam which was held from June 16-18, 2014 in Ho Chi Minh City. The volume reflects the progress of Biomedical Engineering and discusses problems and solutions. I aims identifying new challenges, and shaping future directions for research in biomedical engineering fields including medical instrumentation, bioinformatics, biomechanics, medical imaging, drug delivery therapy, regenerative medicine and entrepreneurship in medical devices.

The Handbook of Endocrine Surgery

Author: Herbert Chen
Publisher: World Scientific
ISBN: 9814293202
Format: PDF, ePub, Docs
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This pocket handbook is geared towards surgical endocrinologists in training but will also be useful as a quick reference to the practicing endocrine surgeon or the resident in training during their surgical endocrinology rotation. It provides the essential information physicians need to aid them in the evaluation and management of patients with both straightforward and complex endocrine problems. This book contains practical information about how to order, perform, and interpret laboratory assessments, diagnostic tests and imaging tests, as well as useful treatment algorithms to aid in the care of patients with endocrine disorders.

Ramadan Diabetes Care

Author: Abdul Hamid Zargar
Publisher: JP Medical Ltd
ISBN: 9350907003
Format: PDF, ePub, Docs
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Fasting during the holy month of Ramadan is an important spiritual practice for many Muslims. This involves going without food, liquids and even medication between the hours of dawn until sunset, putting people with diabetes at significant risk of hypoglycaemia (low blood glucose), hyperglycaemia (high blood glucose), or dehydration. This book is a guide to the management of patients with diabetes during Ramadan. Beginning with an introduction to the physiology and endocrinology of fasting, the following chapters examine both pharmacological and non-pharmacological treatment options. The final sections are dedicated to management of the condition in different population groups (children, adolescents, the elderly); and management of complications, including hypoglycaemic and hyperglycaemic emergencies, and co-morbid conditions such as hypertension, high cholesterol and cardiovascular disease. Key points Guide to the management of diabetes during Ramadan Discusses both pharmacological and non-pharmacological treatment options Examines management of diabetes for different population groups Includes comprehensive section on complications and their management

Textbook of Diabetes

Author: Richard I. G. Holt
Publisher: John Wiley & Sons
ISBN: 1118924878
Format: PDF
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Now in its fifth edition, the Textbook of Diabetes has established itself as the modern, well-illustrated, international guide to diabetes. Sensibly organized and easy to navigate, with exceptional illustrations, the Textbook hosts an unrivalled blend of clinical and scientific content. Highly-experienced editors from across the globe assemble an outstanding set of international contributors who provide insight on new developments in diabetes care and information on the latest treatment modalities used around the world. The fifth edition features an array of brand new chapters, on topics including: Ischaemic Heart Disease Glucagon in Islet Regulation Microbiome and Diabetes Diabetes and Non-Alcoholic Fatty Liver Disease Diabetes and Cancer End of Life Care in Diabetes as well as a new section on Psychosocial aspects of diabetes. In addition, all existing chapters are fully revised with the very latest developments, including the most recent guidelines from the ADA, EASD, DUK and NICE. Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates Via the companion website, readers can access a host of additional online materials such as: 200 interactive MCQ's to allow readers to self-assess their clinical knowledge every figure from the book, available to download into presentations fully searchable chapter pdfs Once again, Textbook of Diabetes provides endocrinologists and diabetologists with a fresh, comprehensive and multi-media clinical resource to consult time and time again.

Biologically Optimized Radiation Therapy

Author: Anders Brahme
Publisher: World Scientific Publishing Company
ISBN: 9814602507
Format: PDF
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Radiation therapy has developed and advanced dramatically in the last few decades. However, very little has been published or done in the area of biologically optimized treatment planning. Development of Biologically Optimized Radiation Therapy aims to fill and close an important gap in the literature with a well-focused and in-depth content. The book covers the biological, physical and clinical background of advanced biologically based radiation therapy optimization with focus on modern radiation therapy modalities such as electron, photon and light ion therapy. Highly recommended for its strong interdisciplinary profile, the book contains a meritorious compilation of previously unpublished materials in many areas of modern science. Undergraduates, researchers and practitioners such as oncologists, medical physicists and radiation biologists alike should find the book immensely informative and comprehensively thorough.