Incretin Biology A Practical Guide

Author: Guy A Rutter
Publisher: World Scientific
ISBN: 1783267380
Format: PDF
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Together, obesity and diabetes form a 21st century epidemic, the treatment of which consumes a substantial fraction of global health costs. New and improved therapies are therefore desperately needed. Incretins are short peptide hormones released from the gut in response to food transit. These hormones regulate a plethora of processes to control food intake, body weight and glucose homeostasis. This is one of the fastest areas of growth within diabetes research, and over the past decade, increasing numbers of novel diabetes drugs — many based on incretin action — have been added to the therapeutic armoury. Following an introduction detailing the historical perspective and discovery of incretin therapies and clinical applications, the book looks at the release of incretins at a cellular level from entero-endocrine cells, and actions on the pancreas (alpha and beta cells) and brain. It then looks at changes in incretins seen in diabetes and following bariatric surgery. Finally, the side effects of incretin therapy are discussed. Importantly, each chapter contains a methodology section aimed at providing a practical guide to key techniques in the field of incretin biology and ranges from basic laboratory research to clinical practice. Incretin Biology — A Practical Guide offers a unique perspective within this field of research by bringing together scientists, physicians and bariatric surgeons. Thus, it is a comprehensive text that offers a broad overview of the subject. Contents:History of Incretin Discovery and Clinical Application (S E K Zac-Varghese and S R Bloom)Synthesis and Secretion of Incretins from the Gut (A E Adriaenssens, F Reimann and Gribble)Studying Incretin Action on the Pancreatic β Cell (D J Hodson and G A Rutter)Action of Incretins on the Pancreatic α Cell: Control of Glucagon Secretion (L McCulloch, M Godazgar, P Rorsman and R Ramracheya)Role of Incretins in the Brain (J E Richards, S C Cork, M K Holt and S Trapp)Bariatric Surgery: Clinical Aspects (A Ahmed and C Tsironis)GLP-1 in Bariatric Surgery and Diabetes: Underlying Molecular Mechanisms (N B Jørgensen and J J Holst)GLP-1-Based Therapies: What are the Safety Implications? (A Mondragon, A Bertling, R Gomes-Faria, G A Rutter and G da Silva Xavier) Readership: Scientists and clinicians with an emphasis on translational research; biology students; medical students; physicians and bariatric surgeons; and those with an interest in the use of incretins in diabetes and obesity treatment with a view to undertake research within this field. Key Features:Broad overview of the field of incretin biology from a cellular level to clinical applicationDetailed protocols with extensive practical tipsChapters from prominent authors who are currently leading in this fieldKeywords:Incretin;Insulin Secretion;Entero-endocrine Cells;GLP-1;GIP;Dipeptidyl Peptidase-IV Inhibitors;Diabetes;Obesity;Pancreas;Beta Cell;Alpha Cell;Bariatric Surgery;Endocrinology

Practical Guide to Obesity Medicine

Author: Jolanta Weaver
Publisher: Elsevier Health Sciences
ISBN: 0323496008
Format: PDF, Docs
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Get a quick, expert overview of the many key facets of obesity management with this concise, practical resource by Dr. Jolanta Weaver. Ideal for any health care professional who cares for patients with a weight problem. This easy-to-read reference addresses a wide range of topics – including advice on how to "unpack" the behavioral causes of obesity in order to facilitate change, manage effective communication with patients suffering with weight problems and future directions in obesity medicine. Features a wealth of information on obesity, including hormones and weight problems, co-morbidities in obesity, genetics and the onset of obesity, behavioral aspects and psychosocial approaches to obesity management, energy and metabolism management, and more. Discusses pharmacotherapies and surgical approaches to obesity. Consolidates today’s available information and guidance in this timely area into one convenient resource.

The Handbook of Endocrine Surgery

Author: Herbert Chen
Publisher: World Scientific
ISBN: 9814293202
Format: PDF, ePub, Mobi
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This pocket handbook is geared towards surgical endocrinologists in training but will also be useful as a quick reference to the practicing endocrine surgeon or the resident in training during their surgical endocrinology rotation. It provides the essential information physicians need to aid them in the evaluation and management of patients with both straightforward and complex endocrine problems. This book contains practical information about how to order, perform, and interpret laboratory assessments, diagnostic tests and imaging tests, as well as useful treatment algorithms to aid in the care of patients with endocrine disorders.

Clinical Examination

Author: Balakrishnan Kichu R. Nair
Publisher: World Scientific
ISBN: 9814273910
Format: PDF, Docs
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Contrary to conventional clinical skill textbooks written in a routine, system based approach, ?Clinical Examination: A Problem Based Approach? breaks that mould by presenting clinical cases in a problem solving manner. The book is composed of in-depth dissections of case scenarios and their appropriate investigations. Written by experts from Australia, New Zealand, US and the UK, this book brings an international perspective to a wide variety of specialties including, gastroenterology, neurology, rheumatology, respiratory and the cardiovascular system. Another unique feature of the book is the chapters on examining the older patient, the joints and the vascular system. This publication is a must-have for all medical undergraduates and postgraduates.The author is a distinguished clinician and educator. He is the recipient of the Order of Australia (AM) 2009 for ?service to medicine and to medical education through the development of undergraduate and professional development programs?.

Lysosomal Storage Disorders

Author: Gregory M. Pastores
Publisher: World Scientific
ISBN: 9814271322
Format: PDF, ePub, Mobi
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This book presents an overview of lysosomal storage disorders, and provides the reader with an understanding of clinical features, associated complications, and diagnosis and management approaches. It also describes historical developments in the field and current thinking relating to pathophysiology and prospective therapeutic strategies. The book is written by an expert in the field who has been engaged in both basic and clinical research, in addition to having extensive practical experience in patient care. It is written from the perspective of someone who entered the field just as treatment was being introduced, and who has been engaged in the seminal clinical trials and the development of therapeutic guidelines. It offers a broad perspective and should appeal to both novices and experts in the field who seek a single resource that provides a comprehensive picture of relevant topics on this subject. A multi-faceted volume, the author addresses the issue of diagnosis and patient management, underlying mechanisms of disease, sources of morbidity and treatment options, covering issues of interest to both the basic scientist and the clinician. Sample Chapter(s). Foreword (34 KB). Chapter 1: Introduction (1,266 KB). Contents: Clinical Perspectives; Diagnostic Confirmation and Screening Protocols; Assessment of Disease Burden and Assignment of Disease Severity; Pathophysiology and Biomarkers; Current and Emerging Therapies; Future Prospects. Readership: Graduate medical students, nurses, genetic counselors and physicians.

Radiation Protection in the Health Sciences

Author: Marilyn E Noz
Publisher: World Scientific Publishing Company
ISBN: 9813101598
Format: PDF, Kindle
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This book takes a very practical approach to radiation protection and presents very readable information for anyone working in the radiation field or with radioactive material. Offering information rarely found elsewhere, the authors describe in detail both the basic principles and practical implementation recommendations of radiation protection. Each chapter includes self-assessment review questions and problems, with answers provided, to help readers master important information. Coupled with a teacher's manual, this book is highly suitable as an undergraduate text for students preparing for careers as X-ray, radiation oncology, or nuclear medicine technologists. It can also be used as a reference for residents in radiology and radiation oncology, medical personnel, or anyone working with radioactive materials such as those involved in homeland security/emergency services, or employed at a nuclear power plant.

Multidisciplinary Management of Gastrointestinal Cancers

Author: Weijing Sun
Publisher: World Scientific
ISBN: 9814651885
Format: PDF, ePub, Docs
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This invaluable book provides an introduction to the development and application of molecular biology with a focus on translational research development in a variety of gastrointestinal cancers. Multidisciplinary Management of Gastrointestinal Cancers will emphasize the multidisciplinary aspects of GI cancer diagnosis, treatment and management, introduce the application of new techniques in GI cancer therapy; guide clinicians/experts to use newly developed evidence-based information and knowledge in patient care. This book with also discuss the role of supportive care and quality of life issues in patients with GI malignancies.

Emerging Therapeutic Ultrasound

Author: Junru Wu
Publisher: World Scientific
ISBN: 9812566856
Format: PDF, ePub
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With contributions by internationally re-knowned authorities and experts in the field of ultrasonic imaging, this book provides comprehensive reviews on basic physical principles and applications of emerging and rapidly developing therapeutic techniques.In specific, reviews of mechanisms for bioeffects of ultrasound relevant to therapeutic applications, high intensity focused ultrasound and its application in surgery, ultrasound assisted target drug and gene delivery, as well as transdermal drug delivery are discussed.The book will be a useful reference source for graduate students, academics and researchers.

Handbook of Nuclear Medicine and Molecular Imaging

Author: E. Edmund Kim
Publisher: World Scientific
ISBN: 9814366234
Format: PDF, ePub, Mobi
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This handbook will provide updated information on nuclear medicine and molecular imaging techniques as well as its clinical applications, including radionuclide therapy, to trainees and practitioners of nuclear medicine, radiology and general medicine. Updated information on nuclear medicine and molecular imaging are vitally important and useful to both trainees and existing practitioners. Imaging techniques and agents are advancing and changing so rapidly that concise and pertinent information are absolutely necessary and helpful. It is hoped that this handbook will help readers be better equipped for the utilization of new imaging methods and treatments using radiopharmaceuticals.