Industrial Bioseparations

Author: Daniel Forciniti
Publisher: Wiley-Blackwell
ISBN: 0813820855
Format: PDF, Kindle
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Industrial Bioseparations offers comprehensive coverage of bioseparations including all unit operations. This new book offers a careful balance between the fundamentals of bioseparations processing and the practical applications in industry today. It is laid out in a methodical way with preliminary chapters covering general approaches to bioseparations for commercially important biomacromolecules, thermodynamics and mass transfer principles, and following chapters addressing unit operations such as filtration and chromatography. Lab experiments are included which emphasize obtaining scale up parameters as well as commonly used operating conditions are included.

Bioseparations engineering

Author: Michael R. Ladisch
Publisher: Wiley-Interscience
Format: PDF, ePub, Docs
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Multidisciplinary resource for graduate studies and the biotechnology industry Knowledge of the genetic basis of biological functioning continues to grow at an astronomical rate, as do the challenges and opportunities of applying this information to the production of therapeutic compounds, specialty biochemicals, functional food ingredients, environmentally friendly biocatalysts, and new bioproducts from renewable resources. While genetic engineering of living organisms transforms the science of genomics into treatments for cancer, diabetes, and heart disease, or products for industry and agriculture, the science and technology of bioseparations are the keys to delivering these products in a purified form suitable for use by people. The methods, theory, and materials that reduce the science of bioseparations to practice, whether in the laboratory or the plant, are the subjects of Bioseparations Engineering. Examples address purification of biomolecules ranging from recombinant proteins to gene therapy products, with footnotes detailing economics of the products. Mechanistic analysis and engineering design methods are given for: * Isocratic and gradient chromatography * Sedimentation, centrifugation, and filtration * Membrane systems * Precipitation and crystallization Topics addressed within this framework are: stationary phase selection; separations development; modeling of ion exchange, size exclusion, reversed phase, hydrophobic interaction, and affinity chromatography; the impact of regulatory issues on chromatography process design; organization of separation strategies into logical sequences of purification steps; and bridges between molecular biology, combinatorial methods, and separations science. A result of teaching and developing the subject matter over ten years, Bioseparations Engineering is an ideal text for graduate students, as well as a timely desk book for process engineers, process scientists, researchers, and research associates in the pharmaceutical, food, and life sciences industries.

Manufacturing of Pharmaceutical Proteins

Author: Stefan Behme
Publisher: John Wiley & Sons
ISBN: 3527683097
Format: PDF, ePub, Mobi
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Structured like a textbook, the second edition of this reference covers all aspects of biopharmaceutical manufacturing, including legal and regulatory issues, production facility design, and quality assurance, with a focus on supply chain management and regulations in emerging markets and cost control. The author has longstanding industrial expertise in biopharmaceutical production and years of experience teaching at universities. As such, this practical book is ideal for use in academia as well as for internal training within companies.

Protein Purification Protocols

Author: Paul Cutler
Publisher: Springer Science & Business Media
ISBN: 159259655X
Format: PDF, ePub, Docs
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This new edition of Protein Purification Protocols completely updates the existing protocols to reflect recent advances and adds the enormous new array of proteomic techniques for protein isolation and analysis. These cutting-edge techniques include not only two-dimensional gel electrophoresis for analysis and characterization, but also analytical chromatography for multidimensional separations of proteins and peptides, and mass spectrometry for isolating proteins.

Bioseparations Science and Engineering

Author: Roger G. Harrison
Publisher: Oxford University Press
ISBN: 0190213744
Format: PDF
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Designed for undergraduates, graduate students, and industry practitioners, Bioseparations Science and Engineering fills a critical need in the field of bioseparations. Current, comprehensive, and concise, it covers bioseparations unit operations in unprecedented depth. In each of the chapters, the authors use a consistent method of explaining unit operations, starting with a qualitative description noting the significance and general application of the unit operation. They then illustrate the scientific application of the operation, develop the required mathematical theory, and finally, describe the applications of the theory in engineering practice, with an emphasis on design and scaleup. Unique to this text is a chapter dedicated to bioseparations process design and economics, in which a process simular, SuperPro Designer? is used to analyze and evaluate the production of three important biological products. New to this second edition are updated discussions of moment analysis, computer simulation, membrane chromatography, and evaporation, among others, as well as revised problem sets. Unique features include basic information about bioproducts and engineering analysis and a chapter with bioseparations laboratory exercises. Bioseparations Science and Engineering is ideal for students and professionals working in or studying bioseparations, and is the premier text in the field.

Separation Process Principles 3rd Edition

Author: J. D. Seader
Publisher: Wiley Global Education
ISBN: 1118139623
Format: PDF, Mobi
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Separation Process Principles, 3rd Edition is the most comprehensive and up-to-date treatment of the major separation operations in the chemical industry. This third edition is renamed Separation Process Principles -- Chemical and Biochemical Operations to reflect the inclusion of bioseparations in several chapters. Extraordinary advances that are being made in the biological fields could significantly help solve world problems in the energy, environmental, and health areas. To help provide instruction in the important bioseparations area, a new author has been added for this edition, D. Keith Roper, who has extensive industrial and academic experience in bioseparations. Separation Process Principles, 3rd Edition provides review chapters on thermo and mass transfer, comprehensive discussion of many separation processes, photos, diagrams, and descriptions of process equipment, and challenging, realistic problems. Improved clarity, study questions, and boxed equations and examples in this 3rd edition are especially helpful for students encountering separation processes for the first time. Separation Process Principles, 3rd Edition prepares students for professional practice, and is a reference they'll value as practicing engineers.

Principles of Bioseparations Engineering

Author: Raja Ghosh
Publisher: World Scientific Publishing Company Incorporated
ISBN: 9789812568922
Format: PDF, ePub, Docs
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Bioseparations engineering deals with the scientific and engineering principles involved in large-scale separation and purification of biological products. This book discusses the underlying principles of bioseparations engineering written from the perspective of an undergraduate course. It covers membrane based bioseparations.

Centrifugal Separations in Biotechnology

Author: Wallace Woon-Fong Leung
Publisher: Academic Press
Format: PDF, ePub
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The biotechnology industry is growing rapidly and requires the successful separation of proteins, DNA, mitochondria, ribosomes, lysosomes and other cellular elements. Centrifugation is an increasingly-important technique to achieve such separations, and this practical book gives a broad but detailed account of principles, types of centrifuge, applications, testing, selection, sizing, troubleshooting, numerical simulation and membrane use. No other book aimed at the biotech industry achieves this coverage, making this a well-timed and vital book for biotech professionals. * First book to cover this area in depth * Experienced author of international status * Growth area world-wide


Author: S. C. Rastogi
Publisher: Alpha Science International Limited
Format: PDF, Kindle
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Biotechnology: Principles and Applications covers broad vistas of biotechnology, for students providing a sound basis of understanding of various aspects of this ever-growing field. This comprehensive book includes a wide coverage of topics needed to appreciate the principles and applied aspects of biotechnology.