Lentiviral Vectors

Author: Didier Trono
Publisher: Springer Science & Business Media
ISBN: 3642561144
Format: PDF, ePub, Mobi
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For the first time a compilation of chapters that depict the biological bases underlying the development of lentiviral vectors, the techniques involved in the manufacture of this new gene delivery tool, and its most promising applications.

Lentiviral Vectors

Author: Didier Trono
Publisher: Springer Science & Business Media
ISBN: 3642561144
Format: PDF
Download Now
For the first time a compilation of chapters that depict the biological bases underlying the development of lentiviral vectors, the techniques involved in the manufacture of this new gene delivery tool, and its most promising applications.

Encyclopedia of Neuroscience

Author: Larry R. Squire
Publisher: Academic Press
ISBN: 0080963935
Format: PDF, ePub
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The Encyclopedia of the Neuroscience explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. Each article is written by an expert in that specific domain and peer reviewed by the advisory board before acceptance into the encyclopedia. Each article contains a glossary, introduction, a reference section, and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields.

Genes and Resistance to Disease

Author: V. Boulyjenkov
Publisher: Springer Science & Business Media
ISBN: 3642569471
Format: PDF, ePub, Docs
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The advances in human genetics that have ocurred during the past 20 years have revolutionized our knowledge of the role played by inheritance in health and disase. It is clear that our DNA determines not only the emergence of catastrophic single-gene disorders, which affect millions of persons worldwide, but also interacts with environments to predispose individuals to cancer, allergy, hypertension, heart disease, diabetes, psychiatric disorders and even to some infectious diseases. Overall, the study of longevity and the demonstration of genes favouring a long lifespan suggest that such protective systems exist. In recent years, the study of genetic polymorphisms has made clear that some alleles have beneficial effects. These discoveries can substantially improve our understanding of the interactions between genetics and the environment, between pathogenetic mechanisms and new treatments.

Desk Encyclopedia of General Virology

Author: Marc H.V. van Regenmortel
Publisher: Academic Press
ISBN: 9780123751621
Format: PDF, ePub, Docs
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This volume, derived from Encyclopedia of Virology, provides an overview of the development of virology during the last ten years. Entries detail the nature, origin, phylogeny and evolution of viruses. It then moves into a summary of our understanding of the structure and assembly of virus particles and describes how this knowledge was obtained. Genetic material of viruses and the different mechanisms used by viruses to infect and replicate in their host cells are highlighted. The volume is rounded out with an overview of some major groups of viruses with particular attention being given to our current knowledge of their molecular biology. The most comprehensive single-volume source providing an overview of virology to non-specialists Bridges the gap between basic undergraduate texts and specialized reviews Concise and general overviews of important topics within the field will help when preparing for lectures, writing reports, or drafting grant applications

Adeno Associated Virus AAV Vectors in Gene Therapy

Author: Kenneth I. Berns
Publisher: Springer Science & Business Media
ISBN: 3642802079
Format: PDF, ePub
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Human gene therapy holds great promise for the cure of many genetic diseases. In order to achieve such a cure there are two requirements. First, the affected gene must be cloned, its se quence determined and its regulation adequately characterized. Second, a suitable vector for the delivery of a good copy of the affected gene must be available. For a vector to be of use several attributes are highly desirable: these include ability to carry the intact gene (although this may be either the genomic or the cDNA form) in a stable form, ability to introduce the gene into the desired cell type, ability to express the introduced gene in an appropriately regulated manner for an extended period of time, and a lack of toxicity for the recipient. Also of concern is the frequency of cell transformation and, in some cases, the ability to introduce the gene into nondividing stem cells. Sev eral animal viruses have been tested as potential vectors, but none has proven to have all the desired properties described above. For example, retroviruses are difficult to propagate in sufficient titers, do not integrate into nondividing cells, and are of concern because of their oncogenic properties in some hosts and because they integrate at many sites in the genome and, thus, are potentially insertional mutagens. Additionally, genes introduced by retroviral vectors are frequently expressed for relatively short periods of time. A second virus used as a vector in model systems has been adenovirus (Ad).

Microbicides for Prevention of HIV Infection

Author: Jeremy Nuttall
Publisher: Springer
ISBN: 3662445964
Format: PDF, Docs
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One of the most promising new approaches for the prevention of HIV transmission, particularly for developing countries, involves topical, self-administered products known as microbicides. The development of microbicides is a long and complicated process, and this volume provides an overview of all the critical areas, from the selection of appropriate candidate molecules and their formulation, preclinical and clinical testing for safety and efficacy, strategies for product registration and finally, issues associated with product launch, distribution and access. The book will prove valuable to both those working in the field and all others who are interested in learning more about this product class, which has the potential to significantly impact the future of this devastating epidemic.