Linear Mixed Models for Longitudinal Data

Author: Geert Verbeke
Publisher: Springer Science & Business Media
ISBN: 1441902996
Format: PDF, Docs
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This book provides a comprehensive treatment of linear mixed models for continuous longitudinal data. Next to model formulation, this edition puts major emphasis on exploratory data analysis for all aspects of the model, such as the marginal model, subject-specific profiles, and residual covariance structure. Further, model diagnostics and missing data receive extensive treatment. Sensitivity analysis for incomplete data is given a prominent place. Most analyses were done with the MIXED procedure of the SAS software package, but the data analyses are presented in a software-independent fashion.

Linear Mixed Models in Practice

Author: Geert Verbeke
Publisher: Springer Science & Business Media
ISBN: 146122294X
Format: PDF, Docs
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A comprehensive treatment of linear mixed models, focusing on examples from designed experiments and longitudinal studies. Aimed at applied statisticians and biomedical researchers in industry, public health organisations, contract research organisations, and academia, this book is explanatory rather than mathematical rigorous. Although most analyses were done with the MIXED procedure of the SAS software package, and many of its features are clearly elucidated, considerable effort was put into presenting the data analyses in a software-independent fashion.

Mixed Effects Models for Complex Data

Author: Lang Wu
Publisher: CRC Press
ISBN: 9781420074086
Format: PDF, Kindle
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Although standard mixed effects models are useful in a range of studies, other approaches must often be used in correlation with them when studying complex or incomplete data. Mixed Effects Models for Complex Data discusses commonly used mixed effects models and presents appropriate approaches to address dropouts, missing data, measurement errors, censoring, and outliers. For each class of mixed effects model, the author reviews the corresponding class of regression model for cross-sectional data. An overview of general models and methods, along with motivating examples After presenting real data examples and outlining general approaches to the analysis of longitudinal/clustered data and incomplete data, the book introduces linear mixed effects (LME) models, generalized linear mixed models (GLMMs), nonlinear mixed effects (NLME) models, and semiparametric and nonparametric mixed effects models. It also includes general approaches for the analysis of complex data with missing values, measurement errors, censoring, and outliers. Self-contained coverage of specific topics Subsequent chapters delve more deeply into missing data problems, covariate measurement errors, and censored responses in mixed effects models. Focusing on incomplete data, the book also covers survival and frailty models, joint models of survival and longitudinal data, robust methods for mixed effects models, marginal generalized estimating equation (GEE) models for longitudinal or clustered data, and Bayesian methods for mixed effects models. Background material In the appendix, the author provides background information, such as likelihood theory, the Gibbs sampler, rejection and importance sampling methods, numerical integration methods, optimization methods, bootstrap, and matrix algebra. Failure to properly address missing data, measurement errors, and other issues in statistical analyses can lead to severely biased or misleading results. This book explores the biases that arise when naïve methods are used and shows which approaches should be used to achieve accurate results in longitudinal data analysis.

Dynamic Mixed Models for Familial Longitudinal Data

Author: Brajendra C. Sutradhar
Publisher: Springer Science & Business Media
ISBN: 9781441983428
Format: PDF, Mobi
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This book provides a theoretical foundation for the analysis of discrete data such as count and binary data in the longitudinal setup. Unlike the existing books, this book uses a class of auto-correlation structures to model the longitudinal correlations for the repeated discrete data that accommodates all possible Gaussian type auto-correlation models as special cases including the equi-correlation models. This new dynamic modelling approach is utilized to develop theoretically sound inference techniques such as the generalized quasi-likelihood (GQL) technique for consistent and efficient estimation of the underlying regression effects involved in the model, whereas the existing ‘working’ correlations based GEE (generalized estimating equations) approach has serious theoretical limitations both for consistent and efficient estimation, and the existing random effects based correlations approach is not suitable to model the longitudinal correlations. The book has exploited the random effects carefully only to model the correlations of the familial data. Subsequently, this book has modelled the correlations of the longitudinal data collected from the members of a large number of independent families by using the class of auto-correlation structures conditional on the random effects. The book also provides models and inferences for discrete longitudinal data in the adaptive clinical trial set up. The book is mathematically rigorous and provides details for the development of estimation approaches under selected familial and longitudinal models. Further, while the book provides special cares for mathematics behind the correlation models, it also presents the illustrations of the statistical analysis of various real life data. This book will be of interest to the researchers including graduate students in biostatistics and econometrics, among other applied statistics research areas. Brajendra Sutradhar is a University Research Professor at Memorial University in St. John’s, Canada. He is an elected member of the International Statistical Institute and a fellow of the American Statistical Association. He has published about 110 papers in statistics journals in the area of multivariate analysis, time series analysis including forecasting, sampling, survival analysis for correlated failure times, robust inferences in generalized linear mixed models with outliers, and generalized linear longitudinal mixed models with bio-statistical and econometric applications. He has served as an associate editor for six years for Canadian Journal of Statistics and for four years for the Journal of Environmental and Ecological Statistics. He has served for 3 years as a member of the advisory committee on statistical methods in Statistics Canada. Professor Sutradhar was awarded 2007 distinguished service award of Statistics Society of Canada for his many years of services to the society including his special services for society’s annual meetings.

Models for Discrete Longitudinal Data

Author: Geert Molenberghs
Publisher: Springer Science & Business Media
ISBN: 0387289801
Format: PDF, Kindle
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The linear mixed model has become the main parametric tool for the analysis of continuous longitudinal data, as the authors discussed in their 2000 book. Without putting too much emphasis on software, the book shows how the different approaches can be implemented within the SAS software package. The authors received the American Statistical Association's Excellence in Continuing Education Award based on short courses on longitudinal and incomplete data at the Joint Statistical Meetings of 2002 and 2004.

Methods and Applications of Longitudinal Data Analysis

Author: Xian Liu
Publisher: Elsevier
ISBN: 0128014822
Format: PDF
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Methods and Applications of Longitudinal Data Analysis describes methods for the analysis of longitudinal data in the medical, biological and behavioral sciences. It introduces basic concepts and functions including a variety of regression models, and their practical applications across many areas of research. Statistical procedures featured within the text include: descriptive methods for delineating trends over time linear mixed regression models with both fixed and random effects covariance pattern models on correlated errors generalized estimating equations nonlinear regression models for categorical repeated measurements techniques for analyzing longitudinal data with non-ignorable missing observations Emphasis is given to applications of these methods, using substantial empirical illustrations, designed to help users of statistics better analyze and understand longitudinal data. Methods and Applications of Longitudinal Data Analysis equips both graduate students and professionals to confidently apply longitudinal data analysis to their particular discipline. It also provides a valuable reference source for applied statisticians, demographers and other quantitative methodologists. From novice to professional: this book starts with the introduction of basic models and ends with the description of some of the most advanced models in longitudinal data analysis Enables students to select the correct statistical methods to apply to their longitudinal data and avoid the pitfalls associated with incorrect selection Identifies the limitations of classical repeated measures models and describes newly developed techniques, along with real-world examples.

Longitudinal Data Analysis

Author: Garrett Fitzmaurice
Publisher: CRC Press
ISBN: 9781420011579
Format: PDF, ePub
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Although many books currently available describe statistical models and methods for analyzing longitudinal data, they do not highlight connections between various research threads in the statistical literature. Responding to this void, Longitudinal Data Analysis provides a clear, comprehensive, and unified overview of state-of-the-art theory and applications. It also focuses on the assorted challenges that arise in analyzing longitudinal data. After discussing historical aspects, leading researchers explore four broad themes: parametric modeling, nonparametric and semiparametric methods, joint models, and incomplete data. Each of these sections begins with an introductory chapter that provides useful background material and a broad outline to set the stage for subsequent chapters. Rather than focus on a narrowly defined topic, chapters integrate important research discussions from the statistical literature. They seamlessly blend theory with applications and include examples and case studies from various disciplines. Destined to become a landmark publication in the field, this carefully edited collection emphasizes statistical models and methods likely to endure in the future. Whether involved in the development of statistical methodology or the analysis of longitudinal data, readers will gain new perspectives on the field.

Modelling Longitudinal and Spatially Correlated Data

Author: Timothy G. Gregoire
Publisher: Springer Science & Business Media
ISBN: 1461206995
Format: PDF, Mobi
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Correlated data arise in numerous contexts across a wide spectrum of subject-matter disciplines. Modeling such data present special challenges and opportunities that have received increasing scrutiny by the statistical community in recent years. In October 1996 a group of 210 statisticians and other scientists assembled on the small island of Nantucket, U. S. A. , to present and discuss new developments relating to Modelling Longitudinal and Spatially Correlated Data: Methods, Applications, and Future Direc tions. Its purpose was to provide a cross-disciplinary forum to explore the commonalities and meaningful differences in the source and treatment of such data. This volume is a compilation of some of the important invited and volunteered presentations made during that conference. The three days and evenings of oral and displayed presentations were arranged into six broad thematic areas. The session themes, the invited speakers and the topics they addressed were as follows: • Generalized Linear Models: Peter McCullagh-"Residual Likelihood in Linear and Generalized Linear Models" • Longitudinal Data Analysis: Nan Laird-"Using the General Linear Mixed Model to Analyze Unbalanced Repeated Measures and Longi tudinal Data" • Spatio---Temporal Processes: David R. Brillinger-"Statistical Analy sis of the Tracks of Moving Particles" • Spatial Data Analysis: Noel A. Cressie-"Statistical Models for Lat tice Data" • Modelling Messy Data: Raymond J. Carroll-"Some Results on Gen eralized Linear Mixed Models with Measurement Error in Covariates" • Future Directions: Peter J.

Linear and Generalized Linear Mixed Models and Their Applications

Author: Jiming Jiang
Publisher: Springer Science & Business Media
ISBN: 0387479465
Format: PDF, ePub
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This book covers two major classes of mixed effects models, linear mixed models and generalized linear mixed models. It presents an up-to-date account of theory and methods in analysis of these models as well as their applications in various fields. The book offers a systematic approach to inference about non-Gaussian linear mixed models. Furthermore, it includes recently developed methods, such as mixed model diagnostics, mixed model selection, and jackknife method in the context of mixed models. The book is aimed at students, researchers and other practitioners who are interested in using mixed models for statistical data analysis.

Multivariate Generalized Linear Mixed Models Using R

Author: Damon Mark Berridge
Publisher: CRC Press
ISBN: 1439813264
Format: PDF, ePub, Mobi
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Multivariate Generalized Linear Mixed Models Using R presents robust and methodologically sound models for analyzing large and complex data sets, enabling readers to answer increasingly complex research questions. The book applies the principles of modeling to longitudinal data from panel and related studies via the Sabre software package in R. A Unified Framework for a Broad Class of Models The authors first discuss members of the family of generalized linear models, gradually adding complexity to the modeling framework by incorporating random effects. After reviewing the generalized linear model notation, they illustrate a range of random effects models, including three-level, multivariate, endpoint, event history, and state dependence models. They estimate the multivariate generalized linear mixed models (MGLMMs) using either standard or adaptive Gaussian quadrature. The authors also compare two-level fixed and random effects linear models. The appendices contain additional information on quadrature, model estimation, and endogenous variables, along with SabreR commands and examples. Improve Your Longitudinal Study In medical and social science research, MGLMMs help disentangle state dependence from incidental parameters. Focusing on these sophisticated data analysis techniques, this book explains the statistical theory and modeling involved in longitudinal studies. Many examples throughout the text illustrate the analysis of real-world data sets. Exercises, solutions, and other material are available on a supporting website.