Mesenchymal Stem Cell Derived Exosomes

Author: Yaoliang Tang
Publisher: Academic Press
ISBN: 0128004975
Format: PDF, Kindle
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Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

Exosomes Stem Cells and MicroRNA

Author: Karl L. Mettinger
Publisher: Springer
ISBN: 3319744704
Format: PDF, ePub
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This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.

Stem Cells and Progenitor Cells in Ischemic Stroke Fashion or Future

Author: Thorsten R. Doeppner
Publisher: Frontiers Media SA
ISBN: 2889197247
Format: PDF, Docs
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Stroke remains one of the most devastating diseases in industrialized countries. Recanalization of the occluded arterial vessel using thrombolysis is the only causal therapy available. However, thrombolysis is limited due to severe side effects and a limited time window. As such, only a minority of patients receives this kind of therapy, showing a need for new and innovative treatment strategies. Although neuroprotective drugs have been shown to be beneficial in a variety of experimental stroke models, they ultimately failed in clinical trials. Consequently, recent scientific focus has been put on modulation of post-ischemic neuroregeneration, either via stimulation of endogenous neurogenesis or via application of exogenous stem cells or progenitor cells. Neurogenesis persists within the adult brain of both rodents and primates. As such, neural progenitor cells (NPCs) are found within distinct niches like the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone of the dentate gyrus. Cerebral ischemia stimulates these astrocyte-like progenitor cells, upon which NPCs proliferate and migrate towards the site of lesion. There, NPCs partly differentiate into mature neurons, without significantly being integrated into the residing neural network. Rather, the majority of new-born cells dies within the first weeks post-stroke, leaving post-ischemic neurogenesis a phenomenon of unknown biological significance. Since NPCs do not replace lost brain tissue, beneficial effects observed in some studies after either stimulated or protected neurogenesis are generally contributed to indirect effects of these new-born cells. The precise identification of appropriated cellular mediators, however, is still elusive. How do these mediators work? Are they soluble factors or maybe even vesicular structures emanating from NPCs? What are the cues that guide NPCs towards the ischemic lesion site? How can post-ischemic neurogenesis be stimulated? How can the poor survival of NPCs be increased? In order to support post-ischemic neurogenesis, a variety of research groups have focused on application of exogenous stem/progenitor cells from various tissue sources. Among these, cultivated NPCs from the SVZ and mesenchymal stem cells (MSCs) from the bone marrow are frequently administered after induction of stroke. Although neuroprotection after delivery of stem/progenitor cells has been shown in various experimental stroke models, transplanted cells are usually not integrated in the neural network. Again, the vast amount of grafted cells dies or does not reach its target despite profound neuroprotection, also suggesting indirect paracrine effects as the cause of neuroprotection. Yet, the factors being responsible for these observations are under debate and still have to be addressed. Is there any “optimal” cell type for transplantation? How can the resistance of grafted cells against a non-favorable extracellular milieu be increased? What are the molecules that are vital for interaction between grafted cells and endogenous NPCs? The present research topic seeks to answer - at least in part - some of the aforementioned questions. Although the research topic predominantly focuses on experimental studies (and reviews alike), a current outlook towards clinical relevance is given as well.

Radionanomedicine

Author: Dong Soo Lee
Publisher: Springer
ISBN: 3319677209
Format: PDF, Mobi
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This book describes radionanomedicine as an integrated medicine using exogenous and endogenous This book describes radionanomedicine as an integrated approach that uses exogenous and endogenous nanomaterials for in vivo and human applications. It comprehensively explains radionanomedicine comprising nuclear and nanomedicine, demonstrating that it is more than radionanodrugs and that radionanomedicine also takes advantage of nuclear medicine using trace technology, in which miniscule amounts of materials and tracer kinetic elucidate in vivo biodistribution. It also discusses exogenous nanomaterials such as inorganic silica, iron oxide, upconversion nanoparticles and quantum dots or organic liposomes labelled with radioisotopes, and radionanomaterials used for targeted delivery and imaging for theranostic purposes. Further, it examines endogenous nanomaterials i.e. extracellular vesicles labelled with radioisotopes, known as radiolabelled extracellular vesicles, as well as positron emission tomography (PET) and single photon emission computed tomography (SPECT), which elucidate the biodistribution and potential for therapeutic success.

Neuroimmune Pharmacology

Author: Tsuneya Ikezu
Publisher: Springer
ISBN: 3319440225
Format: PDF, ePub
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The second edition of Neuroimmune Pharmacology bridges the disciplines of neuroscience, immunology and pharmacology from the molecular to clinical levels with particular thought made to engage new research directives and clinical modalities. Bringing together the foremost field authorities from around the world, Neuroimmune Pharmacology will serve as an invaluable resource for the basic and applied scientists of the current decade and beyond.

Zellul re Diagnostik und Therapie

Author: Ulrich Sack
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110383683
Format: PDF, Mobi
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Today’s cellular therapies enable individualized treatment for hematological diseases, inborn immunodeficiency, as well as other illnesses. Procedures for detecting specific cell populations play a critical role in diagnosis, the quality control of cell therapy products, and the evaluation of therapeutic success. For the first time, this book presents the latest scientific understanding of these procedures in context.

An diesem Tage lasen wir nicht weiter

Author: Will Schwalbe
Publisher: Ullstein eBooks
ISBN: 3843703914
Format: PDF, ePub, Docs
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„Was liest du gerade?“ So beginnt das Gespräch zwischen Will Schwalbe und seiner Mutter Mary Anne. Sie ist todkrank, doch anstatt zu verzweifeln, widmet sie sich ihrer großen Leidenschaft, dem Lesen. Über ein Jahr begleitet Will seine Mutter bis zum Ende ihres Lebens – und durch eine Welt von Büchern, die sie gemeinsam erkunden: Joseph und seine Brüder, Die Eleganz des Igels, Der Vorleser ... Am Ende erkennt Will: Lesen ist nicht das Gegenteil von handeln – es ist das Gegenteil von sterben. Will Schwalbe erzählt die Geschichte jenes Jahres. Er erzählt von den Büchern, die ihrer beider Leben geprägt haben. Und er erzählt von Trauer, Angst und der Erkenntnis, dass das Glück ganz unerwartet aus dem Moment heraus entsteht.