Applied Epidemiology and Biostatistics

Author: Giuseppe La Torre
Publisher: SEEd
ISBN: 9788889688564
Format: PDF
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This book provides not only the theory of biostatistics, but also the opportunity of applying it in practice. In fact, each chapter presents one or more specific examples on how to perform an epidemiological or statistical data analysis and includes download access to the software and databases, giving the reader the possibility of replicating the analyses described.

Small Clinical Trials

Author: Committee on Strategies for Small-Number-Participant Clinical Research Trials
Publisher: National Academies Press
ISBN: 0309073332
Format: PDF, ePub, Mobi
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Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.

Statistical Analysis of Epidemiologic Data

Author: S. Selvin
Publisher: Oxford University Press, USA
ISBN:
Format: PDF
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This book combines applied and theoretical approaches to the analysis of epidemiologic issues. It goes beyond elementary material to deal with real problems generated by disease data, and delves into less usual areas such as the analysis of spatial distributions, survival data, proportional hazards regression, and "computer-intensive" approaches to statistical estimation. Each method discussed in the text is illustrated with examples which include complete sets of data. Using actual data demonstrates the strengths and weaknesses of different analytic approaches in describing a disease process. The goal of the book is to allow the reader to develop a clear understanding of analytic approaches to problems in epidemiologic data analysis without relying on sophisticated mathematics and advanced statistical theory. For the Second Edition a new chapter on the analysis of matched data has been added. This covers both discrete and continuous outcomes and explains both the classic analytic approach and the conditional logistic regression model. New sections have also been added on contingency table data, misclassification, and additive models underlying tabular data. In all the chapters there are new applications and other revisions that make this Second Edition a clearer and more helpful exposition of the way statistical tools are used to analyze epidemiologic data.

EPA 630 R

Author: United States. Environmental Protection Agency. Risk Assessment Forum
Publisher:
ISBN:
Format: PDF, ePub, Mobi
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Cardiovascular Therapeutics

Author: Elliott M. Antman
Publisher: Saunders
ISBN: 9780721687339
Format: PDF, Mobi
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Building on the strong foundation provided by the 6th edition of Braunwald's Heart Disease, this thoroughly revised and updated reference is now more user-friendly and clinically useful than ever. Extensively cross-referenced with tables and figures, it facilitates the decision-making process clinicians face when choosing among various cardiovascular therapeutic options. This new edition of Cardiovascular Therapeutics covers the latest concepts in pathophysiology, evaluation, and management of patients with cardiovascular disorders*in partnership with the Braunwald text for a comprehensive yet focused clinical resource.