Migraine

Author: Joan Raymond
Publisher: Sterling Publishing Company
ISBN: 9780760739822
Format: PDF, ePub, Mobi
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It's not just another headache: when a migraine strikes, life stops while you deal with the blinding pain, sometimes accompanied by debilitating nausea, impaired sight, and sensitivity to light, sound, and smell. Unfortunately, many of the recommended cures just don't work. Find out exactly what a migraine is (and isn't) using the checklist of symptoms, and how to find relief. What are the newest remedies and who can they help? Does what you eat make a difference? Do hormone levels help cause migraines? And, why do women experience these killer headaches so much more than men? You'll see how to get the right diagnosis, and be your own best advocate. There's no need to suffer anymore, because this advice offers a variety of solutions to help you feel better.

Neuroinflammatory Mechanisms in Alzheimer s Disease

Author: Joseph Rogers
Publisher: Birkhäuser
ISBN: 3034883501
Format: PDF, ePub, Mobi
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Research into inflammatory mechanisms that may cause damage to the Alzheimer's disease (AD) brain has now been ongoing for nearly two decades. Some two dozen clinical studies have strongly suggested that conventional anti-inflammatory drugs may be useful to delay the onset or slow the progression of the disorder. Moreover, virtually all the major systems of the innate immune response appear to be present, and most are upregulated, in pathologically-vulnerable regions of the AD brain. These new findings are described in this volume - first in overview form, followed by chapters on topics of special interest. In many ways, to understand AD brain inflammation, one need only review a text on peripheral inflammation biology, leaving out the chapters on humoral medi ators and substituting microglia for macrophages. In several other key respects, however, AD brain inflammation is unique, due primarily to idiosyncratic interac tions of inflammatory mediators and mechanisms with classical AD pathology: amyloid ~ peptide(A~) deposits and neurofibrillary tangles (NFTs). For this reason, some key concepts about the inflammation that occurs in AD may warrant discus sion in preparation for the more detailed chapters that follow.

Cancer and Inflammation

Author: Douglas W. Morgan
Publisher: Springer Science & Business Media
ISBN: 9783764365929
Format: PDF, ePub, Docs
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How are cancer and inflammation interrelated mechanistically and clinically? Though extensive literature exists on the topic "Cancer and Inflammation", there are relatively few texts that have truly integrated the two in spite of the many common mechanisms shared by their processes. Certainly, areas such as cytokines, growth factors, proliferation, signal transduction and angiogenesis, for example, are found in both. Yet, the dynamics of how these common mechanisms are maybe interrelated in the pathologies of the two is not widely covered. Such coverage, as presented in this volume, may help further understanding and bring new approaches to therapeutics. The first section of the book discusses inflammatory mechanisms, studied in cellular and animal studies. The second part concentrates on clinical studies with antiinflammatory drugs in cancer treatment. The volume is written for biomedical researchers in the health care industry and in academia who are working in these areas.

Inflammation and Stroke

Author: Giora Z. Feuerstein
Publisher: Springer
ISBN: 3034882971
Format: PDF, Kindle
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Stroke is a leading cause of death in developed countries. However, current therapeutic strategies for stroke have been largely unsuccessful. One possible explanation is that research and pharmacological management have focused on very early events in brain ischemia. New research has shown that brain ischemia and trauma elicit strong inflammatory reactions driven by both external and brain cells. The recognition of inflammation as a fundamental response to brain ischemia provides novel opportunities for new anti-inflammatory therapies. For the first time, an international body of researchers presents the latest findings about the cellular and humoral aspects of immune and inflammatory reactions in the brain. The work may have an impact on the treatment of neuroinjuries and ancillary brain diseases, and increase the understanding of the roles infections and immune reactions play in the brain milieu.

The Blood Brain Barrier and Inflammation

Author: Ruth Lyck
Publisher: Springer
ISBN: 3319455141
Format: PDF, ePub, Mobi
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This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB. However, viruses, bacteria, parasites and auto-aggressive immune cells can penetrate the barrier and significantly contribute to CNS inflammation. The BBB can actively contribute to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alterations of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential to the development of new drugs to efficiently combat inflammatory diseases of the CNS.

Recent Advances in the Pathophysiology of COPD

Author: Trevor T. Hansel
Publisher: Springer
ISBN: 3034879393
Format: PDF
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Chronic obstructive pulmonary disease (COPD) ranges amongst the commonest diseases in the world. The relentless progression of the disease causes a pressing need for a better understanding of and therapies for COPD. This volume provides state-of-the-art information on the pathophysiology of COPD including an outlook on new therapies. It is of interest to researchers and clinicians in academia as well as in the pharmaceutical industry.

Disease modifying Therapy in Vasculitides

Author: Cees G.M. Kallenberg
Publisher: Springer
ISBN: 3034882351
Format: PDF, ePub, Mobi
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Especially the past two decades have seen renewed interest in the vasculitides. In this volume an international expert group presents the current state of knowledge and concentrates on principles of immune modulating therapy. Drawing from their work in rheumatology, nephrology, internal medicine, connective tissue disease and clinical immunology, they present new concepts in classificiation, diagnosis and pathophysiology of the vasculitides. Evidence from experimental and clinical trials is reviewed, as well as the outlook for further research.