Molecular Biology of the Cell

Author: Bruce Alberts
Publisher: Garland Science
ISBN: 9780815341116
Format: PDF, Kindle
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Ideal for libraries, laboratories, and researchers, this Reference Edition provides the complete text of Chapters 1-25 in printed format. The Media DVD contains PowerPoint presentations and more than 125 animations, videos, and molecular models.

Molecular Biology of the Cell 5th Ed 2008

Author: Garland Science
Publisher: Bukupedia
ISBN:
Format: PDF, ePub
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In many respects,w e understand the structure of the universeb etter than the workings of living cells. Scientists can calculate the age of the Sun and predict when it will cease to shine, but we cannot explain how it is that a human being may live for eighty years but a mouse for only two. We know the complete genomes equenceso f thesea nd many other speciesb, ut we still cannot predict how a cell will behave if we mutate a previously unstudied gene. Stars may be l0a3 times bigger, but cells are more complex, more intricately structured, and more astonishingp roducts of the laws of physicsa nd chemistry.T hrough heredity and natural selection, operating from the beginnings of life on Earth to the presentd ay-that is, for about 20Voo f the ageo f the universe-living cellsh ave been progressively refining and extending their molecular machinery and recording the results of their experiments in the genetic instructions they pass on to their progeny. With each edition of this book, we marvel at the new information that cell biologists have gathered in just a few years. But we are even more amazed and daunted at the sophistication of the mechanisms that we encounter. The deeper we probe into the cell,t he more we reafizeh ow much remainst o be understood. In the days of our innocence, working on the first edition, we hailed the identification of a single protein-a signal receptol say-as a great step forward' Now we appreciate that each protein is generally part of a complexwith many others, working together as a system, regulating one another's activities in subtle ways, and held in specific positions by binding to scaffold proteins that give the chemical factory a definite spatial structure. Genome sequencing has given us virtually complete molecular parts-lists for many different organisms; genetics and biochemistry have told us a great deal about what those parts are capable of individually and which ones interact with which others; but we have only the most primitive grasp of the dynamics of these biochemical systems, with all their interlocking control loops. Therefore, although there are great achievements to report, cell biologistsf ace eveng reaterc hallengesf or the future. In this edition, we have included new material on many topics, ranging from epigeneticsh, istonem odificationss, mall RNAs,a nd comparativeg enomicst,o geneticn oise,c ytoskeletadl lmamics,c ell-cyclec ontrol, apoptosis,s tem cells, and novel cancer therapies. As in previous editions, we have tried above all to give readers a conceptual framework for the mass of information that we now have about cells. This means going beyond the recitation of facts. The goal is to learn how to put the facts to use-to reason, to predict, and to control the behavior of living systems. To help readers on the way to an active understanding, we have for the first time incorporatede nd-of-chapterp roblems,w ritten by Iohn Wilson and Tim Hunt. These emphasize a quantitative approach and the art of reasoning from experiments.A companion volume, MolecularB iologyo f the CelI,F ifth Edition: TheP roblemsB ook0 SBN9 78-0-8153-4110-9b)y, t he samea uthors,g ivesc omplete answerst o thesep roblemsa nd alsoc ontainsm ore than 1700a dditional problems and solutions. A further major adjunct to the main book is the attached Media DVD-ROM disc. This provides hundreds of movies and animations, including manythat are new in this edition, showing cells and cellular processesin action and bringing the text to life; the disc also now includes all the figures and tables from the main book,p re-loadedin to [email protected] esentationsO. thera ncillariesa vailablefo r the book include a bank of test questions and lecture outlines, available to qualified instructors,a nd a seto f 200f ull-coloro verheadtr ansparencies. Perhaps the biggest change is in the physical structure of the book. In an effort to make the standard Student Edition somewhat more portable, we are providing chapters 2r-25, covering multicellular systems, in electronic (pDF) form on the accompanying disc, while retaining in the printed volume chapters l-20, covering the core of the usual cell biology curriculum. But we should emphasize that the final chapters have been revised and updated as thoroughly as the rest of the book and we sincerely hope that they will be read! A Reference Edition (ISBN9 7s-0-8153-4r11-6c)o, ntainingt he full seto f chaptersa sp rinred pages, is also available for those who prefer it. Full details of the conventions adopted in the book are given in the Note to the Readert hat follows this PrefaceA. s explainedt here,w e have taken a drastic approach in confronting the different rules for the writing of gene names in different species: throughout this book, we use the same style, regardless of speciesa, nd often in defianceo fthe usuals pecies-specifcico nventions. As always,w e are indebted to many people. Full acknowledgmentsfo r scientific help are given separatelyb, ut we must here singleo ut somee xceptionally important contributions: Iulie Theriot is almost entirely responsible for chapters 16 (cytoskeleton)a nd 24 (PathogensI,n fection, and Innate Immunity), and David Morgan likewise for chapter 17 (cell cycle). wallace Marshall and Laura Attardi provided substantialh elp with chapters 8 and 20, respectively,a s did Maynardo lson for the genomicss ectiono f chapter4 ,X iaodongwangf or chapter 18, and Nicholas Harberd for the plant section of Chapter 15. we also owe a huge debt to the staff of Garland science and others who helped convert writers' efforts into a polished final product. Denise schanck directed the whole enterprise and shepherded the wayward authors along the road with wisdom, skill, and kindness. Nigel orme put the artwork into its final form and supervisedt he visuala spectso f the book,i ncluding the backc over,w ith his usual flair. Matthew Mcclements designed the book and its front cover. Emma Jeffcockla id out its pagesw ith extraordinarys peeda nd unflappablee fficiency, d ealingi mpeccablywith innumerablec orrections.M ichaelM oralesm anaged the transformation of a mass of animations, video clips, and other materials into a user-friendly DVD-ROM. Eleanor Lawrence and sherry Granum updatedand enlargedt he glossaryJ. ackieH arbor and SigridM assonk ept us organized. Adam Sendroffkept us aware ofour readers and their needs and reactions. Marjorie Anderson, Bruce Goatly, and sherry Granum combed the text for obscurities, infelicities, and errors. we thank them all, not only for their professional skill and dedication and for efficiency far surpassing our own, but also for their unfailing helpftrlnessa nd friendship:t hey havem adei t a pleasuret o work on the book. Lastly, and with no less gratitude, we thank our spouses, families, friends and colleaguesw. ithout their patient,e ndurings upport,w e couldn ot havep roduced any of the editions of this book. MolecularB iologyo f the Cell BruceA lberts AlexandeJro hnson JulianL ewis Martin Raff Keith Roberts PeteWr alter Withp roblemsb y John Wilson Tim Hunt GarlandS cience Taylo&r FranciGs roup

Molecular Biology of the Cell

Author: John H. Wilson
Publisher: Garland Pub
ISBN:
Format: PDF, ePub, Docs
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Designed to correspond with the first 20 chapters of the fifth edition of "Molecular Biology of the Cell," this workbook contains more than 2,000 problems and their solutions, which also appear on the accompanying CD-ROM.

Immunologie

Author: Charles A. Janeway
Publisher: Spektrum Akademischer Verlag
ISBN: 9783827410795
Format: PDF, Docs
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Das Standardlehrbuch der Immunologie im deutschen Raum liegt nun erneut in einer vollstAndig A1/4berarbeiteten und aktualisierten Form vor. Der "Janeway" bleibt damit ein hochaktueller und verlAsslicher Begleiter im unverAndert rasant fortschreitenden Fachgebiet der Immunologie. ”Dieses Buch setzt eindeutig neue MaAstAbe.Immunology Today" ”... so aktuell, wie ein Lehrbuch nur sein kann.The New England Journal of Medicine" ”... eine anschauliche, lebendige und verlAAliche EinfA1/4hrung in das gesamte Gebiet der Immunbiologie.Cell" ”Unter den Immunologie-LehrbA1/4chern nimmt dieses sicher heute den vorderen Rang ein. Es macht VergnA1/4gen, sich von ihm bilden zu lassen.Biospektrum" ”Die Texte erklAren die komplizierte Materie in einer klaren und anschaulichen Sprache ... Das Buch eignet sich hervorragend als Lehrbuch und als Nachschlagewerk fA1/4r jeden, der sich mit Fragen der Immunologie beschAftigt.Deutsche Apotheker Zeitung" ”Dieses neue Lehrbuch aus dem Spektrum-Verlag ist sicherlich das zur Zeit umfassendste, aktuellste und didaktisch sinnvollste Werk zum Thema Immunologie, das in deutscher Sprache auf dem Markt und zu einem vernA1/4nftigen Preis zu erwerben ist.Curare" ”Kann uneingeschrAnkt jedem Medizinstudenten und jedem klinisch tAtigen Kollegen empfohlen werden.Prof. M. Seyfarth, UniversitAt LA1/4beck"”Das Buch deckt die moderne Immunologie in ihrer ganzen Vielfalt ab. Trotzdem wirken Text und Darstellungen wie aus einem GuA.Prof. Th. HA1/4nig, UniversitAt WA1/4rzburg" ”Das Lehrbuch "Immunologie" von Janeway und Travers ist hochaktuell und A1/4berdies exzellent illustriert. Das Gesamtkonzept ist ... sehr gut auf die BedA1/4rfnisse von Biologie- und Medizinstudenten zugeschnitten.Prof. W. DrAge, DKFZ Heidelberg" ”Dieses Buch zeigt, wie man das komplexe Wissensgebiet der Immunologie klar und verstAndlich beschreiben kann und den Leser gleichzeitig zur kritischen Beurteilung der aktuellen Forschung befAhigt.Prof. Dr. N. Koch, UniversitAt Bonn" ”Das Buch ersetzt in hervorragender Weise eine leider noch nicht etablierte Pflichtvorlesung fA1/4r Mediziner und Biologen.Prof. G. Uhlenbruck, UniversitAt KAln" ” ... ein modernes und kompaktes Lehrbuch, das man bedenkenlos allen jungen Medizinern und Biologen, Studenten, Doktoranden und Post-Docs, die sich mit Fragen der Immunologie beschAftigen wollen oder beschAftigen, empfehlen kann.Prof. Klaus Rajewsky im Vorwort zur deutschen Ausgabe"

Cell and Molecular Biology

Author: Gerald Karp
Publisher:
ISBN: 9780470293584
Format: PDF, Docs
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This title is intended for sophomore/junior-level courses in cell biology offered out of molecular and/or cell biology departments. Cell and Molecular Biology gives students the tools they need to understand the science behind cell biology. Karp explores core concepts in considerable depth, and presents experimental detail when it helps to explain and reinforce the concept being explained. This fifth edition continues to offer an exceedingly clear presentation and excellent art program, both of which have received high praise in prior editions.

Molekulare Humangenetik

Author: Tom Strachan
Publisher: Spektrum Akademischer Verlag
ISBN: 9783827414939
Format: PDF, Docs
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Die vorliegende 3. Auflage der Molekularen Humangenetik ist völlig neu überarbeitet - unter Berücksichtigung der Entdeckungen, die im Zuge und in der Folge des Human Genome Project gemacht wurden. Die einführenden Kapitel (Teil I) beschreiben die Grundlagen wie DNA-Struktur und -Funktion, Chromosomen, Zellen und Entwicklung, Stammbaumanalysen und grundlegende Techniken im Labor. In Teil II werden die verschiedenen Genomsequenzierungsprojekte und die dadurch ermöglichten Einblicke in Organisation, Expression, Variabilität und Evolution des menschlichen Genoms gezeigt. Die Kartierung, Identifizierung und Diagnose der Ursachen von mendelnden und komplexen Krankheiten sowie Krebs ist Schwerpunkt von Teil III. Der letzte Teil gibt Ausblicke auf die funktionelle Genomik und Bioinformatik, auf Tiermodelle und Therapien. Das Buch soll eine Brücke bilden zwischen den grundlegenden Lehrbüchern und der Forschungsliteratur, sodass auch Interessierte mit relativ wenig Hintergrundwissen zum Thema die neuesten Forschungsergebnisse lesen und beurteilen können.

Heikle Gespr che

Author: Kerry Patterson
Publisher: Linde Verlag GmbH
ISBN: 3709402522
Format: PDF
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Der New-York-Times-Bestseller in der 2. Auflage Ob am Arbeitsplatz, in der Partnerschaft, der Familie oder im Freundeskreis, wir alle kommen hin und wieder in die Lage, heikle Dinge offen ansprechen zu müssen. Aber wer führt schon gern Gespräche, bei denen Meinungsverschiedenheiten, Einwände und Ärger vorprogrammiert sind? Viele Menschen schrecken davor zurück, weil sie nicht wissen, wie sie sich in solchen Situationen richtig verhalten sollen. Genau dabei hilft dieses Buch. Der Bestseller liefert praktische Tipps und Techniken und zeigt nun bereits in der zweiten, überarbeiteten Auflage, wie man schwierige Gespräche konstruktiv meistert und auch über unangenehme Themen gelassen diskutiert.