Mouse Brain Development

Author: Andre M. Goffinet
Publisher: Springer Science & Business Media
ISBN: 3540480021
Format: PDF, ePub
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Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit nessed a quantum leap in our knowledge, due to technological improve ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno type. Nevertheless, the recent progress in genetics will allow us to contem plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop mental biology. The purpose of the present book is to provide an overview that syn thesizes up-to-date information on selected aspects of mouse brain devel opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.

Cell Cycle in Development

Author: Jacek Z. Kubiak
Publisher: Springer Science & Business Media
ISBN: 9783642190650
Format: PDF, ePub, Docs
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This book focuses on the intersection between cell cycle regulation and embryo development. Specific modifications of the canonical cell cycle occur throughout the whole period of development and are adapted to fulfil functions coded by the developmental program. Deciphering these adaptations is essential to comprehending how living organisms develop. The aim of this book is to review the best-known modifications and adaptations of the cell cycle during development. The first chapters cover the general problems of how the cell cycle evolves, while consecutive chapters guide readers through the plethora of such phenomena. The book closes with a description of specific changes in the cell cycle of neurons in the senescent human brain. Taken together, the chapters present a panorama of species - from worms to humans - and of developmental stages - from unfertilized oocyte to aged adult.

Oxford Textbook of Old Age Psychiatry

Author: Robin Jacoby
Publisher: Oxford University Press
Format: PDF
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The Oxford Textbook of Old Age Psychiatry is the new edition of the much loved and highly popular multi-author textbook previously published as Psychiatry in the Elderly. It has established itself as the standard textbook in its field due to its unique combination of comprehensive coverage, clear writing and authoritative and up-to-date information. This new edition maintains these strengths, with chapters covering the basic sciences underpinning old agepsychiatry, clinical practice, psychiatric services for older people, specific disorders and medico-legal and ethical issues.The text has been extensively updated, with several new chapters added reflecting developments in the speciality. These include chapters on: different psychotherapies, e.g. interpersonal therapy and cognitive behavioural therapy, and electroconvulsive therapy; memory clinics and liaison old age psychiatry; mild cognitive impairment and sleep disorders; and chapters by patients reflecting their experiences of their illnesses. The textbook has expanded to include 73 contributors from 8 differentcountries covering the panoply of relevant expertise. The editorial team has also grown with Robin Jacoby and Catherine Oppenheimer now being joined by Tom Dening and Alan Thomas.The breadth of authoritative coverage will continue to make this book one which all old age psychiatrists and trainees will want to have on their bookshelves. Geriatricians and other health professionals working with older people will also find in this book a handy resource to assist them when dealing with psychiatric disorders in older people.

Sex Chromosome Disorders Advances in Research and Treatment 2012 Edition

Publisher: ScholarlyEditions
ISBN: 1481618911
Format: PDF, ePub
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Sex Chromosome Disorders—Advances in Research and Treatment: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Sex Chromosome Disorders in a concise format. The editors have built Sex Chromosome Disorders—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Sex Chromosome Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Sex Chromosome Disorders—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

The Reeler Mouse as a Model of Brain Development

Author: Catherine Lambert de Rouvroit
Publisher: Springer Science & Business Media
ISBN: 3642722571
Format: PDF, Docs
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Only five years ago, nobody in his right mind would have consid ered publishing a book on reeler as a model for brain develop ment. Although this interesting mutation has been with us for half a century, it is fair to say that, in spite of a wave of enthusiasm in the late sixties and early seventies, generated primarily by Sidman, Caviness and colleagues, studies of reeler mice fell pro gressively out of fashion during the next two decades. All that changed almost overnight when the cloning of the reeler gene, dubbed reelin, was reported in Tom Curran's laboratory in 1995. The fact that the same gene was identified at the same time independently by two other groups using positional cloning sug gested strongly that reelin was the right candidate. Although the key experiments of transgenic rescue have not been made (and perhaps will never be), the equation "reeler is reelin" has been established beyond reasonable doubt, as alterations of the reelin gene and/or its expression have been found in at least five alleles of reeler and in the mutation Shaking Rat Kawasaki (SRK), an ortholog of reeler.

The Newborn Brain

Author: Hugo Lagercrantz
Publisher: Cambridge University Press
ISBN: 113948558X
Format: PDF, ePub
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Development of the brain and the emergence of the mind constitute some of the most important concerns of contemporary biology. Disturbances during fetal life may have profound implications for a child's future neurological and psychological development, which can in turn impact society. The new edition of this highly respected work presents a comprehensive review of the basic mechanisms of brain development and the pathophysiology of disorders of the infant brain, written by a team of distinguished neuroscientists, neonatologists, and neuropediatricians. The book follows the main milestones of brain development, from formation of the neural tube and wiring of the neurons in the brain. Neurotrophic factors, neurotransmitters, glial cell biology, cerebral circulation development of sensory functions are all described in detail. Furthermore, there are more philosophical chapters on the evolution of the brain and the emergence of consciousness. Clinical considerations are highlighted where relevant.