Mouse Brain Development

Author: Andre M. Goffinet
Publisher: Springer Science & Business Media
ISBN: 3540480021
Format: PDF
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Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit nessed a quantum leap in our knowledge, due to technological improve ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno type. Nevertheless, the recent progress in genetics will allow us to contem plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop mental biology. The purpose of the present book is to provide an overview that syn thesizes up-to-date information on selected aspects of mouse brain devel opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.

Cell Cycle in Development

Author: Jacek Z. Kubiak
Publisher: Springer Science & Business Media
ISBN: 9783642190650
Format: PDF, ePub, Docs
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This book focuses on the intersection between cell cycle regulation and embryo development. Specific modifications of the canonical cell cycle occur throughout the whole period of development and are adapted to fulfil functions coded by the developmental program. Deciphering these adaptations is essential to comprehending how living organisms develop. The aim of this book is to review the best-known modifications and adaptations of the cell cycle during development. The first chapters cover the general problems of how the cell cycle evolves, while consecutive chapters guide readers through the plethora of such phenomena. The book closes with a description of specific changes in the cell cycle of neurons in the senescent human brain. Taken together, the chapters present a panorama of species - from worms to humans - and of developmental stages - from unfertilized oocyte to aged adult.

Cortical Development

Author: Christine F. Hohmann
Publisher: Springer Science & Business Media
ISBN: 9783540434368
Format: PDF, ePub, Mobi
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The cerebral neocortex, a structure unique to the mammalian brain and prerequisite for higher cognitive functions, has since decades attracted the curiosity of neurobiologists and developmental biologists alike. This volume gives a comprehensive and up-to-date overview of early cortical development. It provides concise information on the birth, specification, migration and terminal differentiation of neocortical cells. Both the cellular and molecular events leading to the establishment of a functional neocortex are presented in considerable detail, and possible implications for neurodegenerative diseases are discussed.

Oxford Textbook of Old Age Psychiatry

Author: Robin Jacoby
Publisher: Oxford University Press
ISBN:
Format: PDF, Kindle
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The Oxford Textbook of Old Age Psychiatry is the new edition of the much loved and highly popular multi-author textbook previously published as Psychiatry in the Elderly. It has established itself as the standard textbook in its field due to its unique combination of comprehensive coverage, clear writing and authoritative and up-to-date information. This new edition maintains these strengths, with chapters covering the basic sciences underpinning old agepsychiatry, clinical practice, psychiatric services for older people, specific disorders and medico-legal and ethical issues.The text has been extensively updated, with several new chapters added reflecting developments in the speciality. These include chapters on: different psychotherapies, e.g. interpersonal therapy and cognitive behavioural therapy, and electroconvulsive therapy; memory clinics and liaison old age psychiatry; mild cognitive impairment and sleep disorders; and chapters by patients reflecting their experiences of their illnesses. The textbook has expanded to include 73 contributors from 8 differentcountries covering the panoply of relevant expertise. The editorial team has also grown with Robin Jacoby and Catherine Oppenheimer now being joined by Tom Dening and Alan Thomas.The breadth of authoritative coverage will continue to make this book one which all old age psychiatrists and trainees will want to have on their bookshelves. Geriatricians and other health professionals working with older people will also find in this book a handy resource to assist them when dealing with psychiatric disorders in older people.

Sex Chromosome Disorders Advances in Research and Treatment 2012 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 1481618911
Format: PDF, ePub, Mobi
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Sex Chromosome Disorders—Advances in Research and Treatment: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Sex Chromosome Disorders in a concise format. The editors have built Sex Chromosome Disorders—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Sex Chromosome Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Sex Chromosome Disorders—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Cell Polarity and Subcellular RNA Localization

Author: Dietmar Richter
Publisher: Springer Science & Business Media
ISBN: 3540400257
Format: PDF, Mobi
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Selective cytoplasmic organelle and protein targeting has long been thought to constitute the sole determinant of cell polarity and complexity. This view has been changed, however, by the discovery of differential subcellular RNA distribution patterns. Over the past decade it has become clear that selective mRNA sorting and translation contributes to an accumulation of cognate proteins at discrete cellular sites. In this book, various systems are discussed (e.g. Xenopus oocytes, mammalian brain, invertebrate nervous system) in terms of RNA trafficking, RNA-targeting sequences (cis-elements) and RNA-transporting proteins (trans-factors), activity-dependent translational regulation and the significance of the cytoskeleton for neuronal function and plasticity. It also discusses nucleocytoplasmic export of mRNA and viral RNA as another example of subcellular RNA kinesis.

Vertebrate Eye Development

Author: M. Elizabeth Fini
Publisher: Springer Science & Business Media
ISBN: 3540468269
Format: PDF, Docs
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"Who would believe that so small a space could contain the images of all the universe?" Leonardo da Vinci The last years of the 20th century have found the discipline of Developmental Biology returning to its original position at the forefront of biological re search. This progress can be attributed to the burgeoning knowledge base on molecules and gene families, and to the power of the molecular genetic ap proach. Topping the list of organ systems which have provided the most significant advances would have to be the eye. The vertebrate eye was one of the classic embryologic models, used to demonstrate many important prin ciples, including the concepts of inductive tissue interactions first put forth in the early 1900s. Within the last decade of this century, a return to some of the old questions with the new approaches has put eye development back into the limelight. I find this a highly appropriate topic for a book which aims to spark research for the new millennium. We begin with a chapter that discusses the anatomy of eye development, providing the basic reference information for the chapters that follow. A novel aspect of this introduction is the connection made between develop mental strategies and the eye's optical function. What also emerges from this chapter is the number of important eye structures that have barely been touched by the modern developmental biologist. Work on cornea and ante rior chamber development has lagged behind lens and retina.

The Mouse Nervous System

Author: Charles Watson
Publisher: Academic Press
ISBN: 0123694973
Format: PDF, Docs
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The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. * Visualization of brain white matter anatomy via 3D diffusion tensor imaging contrasts enhances relationship of anatomy to function * Systematic consideration of the anatomy and connections of all regions of brain and spinal cord by the authors of the most cited rodent brain atlases * A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states, * Full segmentation of 170120+ brain regions more clearly defines structure boundaries than previous point-and-annotate anatomical labeling, and connectivity is mapped in a way not provided by traditional atlasesA detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area. * Full coverage of the role of gene expression during development, and the new field of genetic neuroantomy using site-specific recombinases * Examples of the use of mouse models in the study of neurological illness