Neurodegenerative Disorders as Systemic Diseases

Author: Keiji Wada
Publisher: Springer
ISBN: 4431545417
Format: PDF, ePub, Mobi
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This book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients.

Neurological Disorders due to Systemic Disease

Author: Steven L. Lewis
Publisher: John Wiley & Sons
ISBN: 1118414020
Format: PDF, ePub
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Edited by Steven L Lewis, MD, Department of Neurological Sciences, RushUniversity Medical Center, Chicago, Illinois, USA How do you identify which neurologic syndromes occur due tosystemic disease? Neurological problems commonly occur in the context ofunderlying systemic disease, and may even be the presenting symptomof a medical condition that has not yet been diagnosed.Consequently neurologists need to be aware when a neurologicalpresentation might indicate an underlying systemic disorder. Neurological Disorders due to SystemicDisease provides the tools you need to make theseconnections. The unique neurologic presentation-based approachrelates to the common clinical situations you encounter,including: Headache Stroke Movement disorders Neuromuscular disorders Encephalopathies, seizures, myelopathies, neuro-ophthalmologicand neuro-otologic disorders, sleep disorders, and others Major categories of systemic illness are explored for eachpresentation to guide you towards a likely cause. Theseinclude: Endocrine, electrolyte, and metabolic disorders Systemic autoimmune disorders Organ dysfunction and failure, and critical medicalillness Systemic cancer and paraneoplastic disorders Systemic infectious disease Complications due to drugs and alcohol Vitamin and mineral deficiencies Written by a leading cast of experts, with a practical approachincluding ‘things to remember’ for each presentation,Neurological Disorders due to Systemic Disease shouldbe on every neurologist’s desk.

Metal Ions and Neurodegenerative Disorders

Author: Paolo Zatta
Publisher: World Scientific
ISBN: 9789812796691
Format: PDF, Kindle
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Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer''s disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer''s, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena. Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on OC Metals and the Brain: From Neurochemistry to NeurodegenerationOCO (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa. This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy. Contents: Metal-Catalyzed Redox Activity in Neurodegenerative Disease (M A Taddeo et al.); Aluminum and Central Nervous System Morphology in Hemodialysis (E Reusche); Transition Metals, Oxidation, Lipoproteins, and Amyloid-: Major Players in Alzheimer''s Disease (A Kontush); Molecular Basis of Copper Transport: Cellular and Physiological Functions of Menkes and Wilson Disease Proteins (ATP7A and ATP7B) (D R Kramer et al.); Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis (M B Yim et al.); Copper and Prion Disease (J Sasson & D Brown); Metallothioneins in Neurodegeneration (M Aschner et al.); Iron and Neurodegeneration (S L Grab & J R Connor); Iron, Neuromelanin, and -Synuclein in Neuropathogenesis of Parkinson''s Disease (K L Double et al.); Iron and Epilepsy (W-Y Ong et al.); Role of Iron Metabolism in Multiple Sclerosis (M J Kotze et al.); Neuroprotective Effects of Lithium (S Ermidiou-Pollet & S Pollet); and other articles. Readership: Academics, graduate students and researchers in neurology, psychiatry, neuroscience and environmental health."

Movement Disorders in Neurologic and Systemic Disease

Author: Werner Poewe
Publisher: Cambridge University Press
ISBN: 1139867628
Format: PDF, ePub
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Movement disorders - ranging from parkinsonism to a variety of hyperkinetic disorders, such as tremors, dystonic, chorea and myoclonus - can be the presenting or a prominent clinical feature in a broad spectrum of systemic conditions such as endocrine and metabolic disorders, autoimmune diseases, infections, intoxications, tumors and pareneoplastic syndromes, stroke and multiple sclerosis. The resulting clinical scenarios can be confusing and difficult to interpret by internists, generalists and neurologists. Movement Disorders in Neurologic and Systemic Disease provides comprehensive coverage of the most common movement disorders seen in systemic and general neurologic disease, as well as differential diagnostic and therapeutic algorithms. The chapters are written by internationally recognized experts and more than 50 illustrative videos highlight the phenomenology of some of the movement disorders and provide a useful 'bed-side' diagnostic tool. This book is a valuable resource for neurologists, physiatrists, psychiatrists, internists, primary care physicians and trainees in medicine and neurology.

Neurologic Aspects of Systemic Disease

Author: José Biller
Publisher: Newnes
ISBN: 0702044334
Format: PDF, ePub
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Systemic disease involves several parts of the body or the complete system. Neurologic Aspects of Systemic Disease, a two-part volume in the Handbook of Clinical Neurology series, focuses on the specific neurologic aspects of systemic disease. Part 2 includes coverage of gastrointestinal and hepatobiliary, endocrinologic, and metabolic diseases, as well as nutritional, environmental, and hematologic disorders. Each chapter provides a complete introduction to the neurologic aspect and provides the best known diagnostic and treatment practices. The collection is a valuable and trusted resource for clinical neurologists, research neurologists, neuroscientists, and general medical professionals: a first stop for a focused review of the state of the art for understanding the neurologic impact of each covered disease. A comprehensive introduction and overview of the neurologic aspects of systemic disease Part 2 covers of gastrointestinal/hepatobiliary, endocrinologic, and metabolic diseases and nutritional, environmental, and hematologic disorders Each chapter focuses on the neurologic aspects related to a specific disease presentation

Movement Disorders An Issue of Neurologic Clinics

Author: Joseph Jankovic
Publisher: Elsevier Health Sciences
ISBN: 0323354645
Format: PDF, ePub
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The daily life impact of movement disorders on people affected ranges from the inconvenient to major quality of life issues, depending upon the disorder and its progression. Topics in this issue of Neurologic Clinics address: Pathogenic Nechanisms of Neurodegeneration in Parkinson’s Disease; Treatment Strategies in Early and Advanced Parkinson’s Disease; Atypical Parkinsonism; Medical and Surgical Treatment of Tremors; Diagnosis and Treatment of Dystonia; Huntington’s Disease: Pathogenesis and Treatment; Tics and Tourette Syndrome; Paroxysmal Movement Disorders; Drug-induced Movement Disorders; Wilson Disease and other Neurodegenerations with Metal Accumulations; Psychogenic Movement Disorders; Ataxia; Gait Disorders; and Movement Disorders in Systemic Diseases. Videos are planned for the majority of the presentations and each article presents an Overview, Imaging, Pathology, and Diagnostic Dilemmas. The editor of this issue of Neurologic Clinics, Dr. Joseph Jankovic, is well known as expert in the pathophysiology, diganosis, and management of movement disorders - he has served as president of the international Movement Disorder Society and is recipient of numerous research awards related to these disorders. Dr Jankovic has involved world renown experts as authors in this publication.

Imaging in Neurodegenerative Disorders

Author: Luca Saba
Publisher: OUP Oxford
ISBN: 0191651400
Format: PDF, Mobi
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Diagnosing neurodegenerative diseases can prove particularly intimidating to clinicians, because many times the diagnosis cannot be critically "confirmed" by a simple test. New imaging modalities have advanced to the point of high resolution, morphological, metabolic and functional analysis. Computed tomography, magnetic resonance, nuclear medicine and molecular imaging have recently emerged as outstanding non-invasive techniques for the study of the neurodegenerative disorders. Imaging in Neurodegenerative Disorders covers all the imaging techniques and new exciting methods like new tracers, biomarker, metabolomic and gene-array profiling, potential for applying such techniques clinically, and offers present and future applications as applied to the neurodegenerative disorders with the most world renowned scientists in these fields. This book is an invaluable resource for researchers, clinicians, and trainees in neuroscience, neurology, psychiatry, and radiology.

Prion Diseases New Insights for the Healthcare Professional 2011 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 1464920192
Format: PDF, ePub, Mobi
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Prion Diseases: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Prion Diseases in a compact format. The editors have built Prion Diseases: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Prion Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Prion Diseases: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Pediatric Neuro Ophthalmology

Author: Michael C. Brodsky
Publisher: Springer Science & Business Media
ISBN: 9780387690698
Format: PDF, Docs
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"Due to the generous representation of the afferent visual system within the brain, neurological disease may disrupt vision as a presenting symptom or as a secondary effect of the disease. Conversely, early developmental disturbances of vision often disrupt ocular motor control systems, giving rise to complex disorders such as nystagmus, strabismus, and torticollis. The signs and symptoms of neurological disease are elusive by their very nature, presenting a confounding diagnostic challenge. Neurological medications and neurosurgical treatments can produce neuro-ophthalmological dysfunction that can be difficult to distinguish from disease progression. Affected patients may experience substantial delays in diagnosis, and are often subjected to extensive (and expensive) diagnostic testing. Scientific articles pertaining to specific disorders are scattered throughout medical subspecialty journals. These children continue to "fall through the cracks" of our medical education system. The increasing recognition that pediatric neuro-ophthalmology comprises a distinct set of diseases from those seen in adults has led to its emergence as a dedicated field of study. "Since the original publication of Pediatric Neuro-Ophthalmology nearly fourteen years ago, interest in the field has burgeoned. Pediatric ophthalmology and pediatric neurology subspecialty conferences often include symposia dedicated to recent advances in pediatric neuro-ophthalmology. Technical advances in neuroimaging have given rise to a more integrated mechanistic classification of neuro-ophthalmological disease in children. Our understanding of neurodevelopmental disorders of the visual system has expanded, longstanding monoliths have been dissembled into component parts, basic molecular mechanisms have taken center stage, and genetic underpinnings have become definitional. Evolutionary alterations can now be observed at the level of the gene, adding a new dimension to our understanding of disease pathogenesis. New classifications now encompass clinically disparate conditions. Descriptive definitions have been supplanted by mechanistic ones, and clinical definitions superseded by genetic ones. Our concept of disease pathogenesis has been revised and in some cases overturned. Bearing witness to these remarkable advancements has compelled me to enhance and expand the first edition of Pediatric Neuro-Ophthalmology into this new and revised one. "In the first edition of this book, our goal was to present the clinical characteristics, diagnostic evaluation, and therapeutic options for the common neuro-ophthalmologic disorders of childhood. In so doing, we designed the book to be provide a narrative journey through the thought processes involved in the clinical management of these disorders. In this edition, I have retained the basic narrative format of original book, while expanding the exploration of these complex visual disorders in the context of the many new scientific advancements and discoveries that have come to light. These conditions are fun to diagnose, fascinating to understand, and gratifying to manage." --from the Preface to the 2nd Edition.

Movement Disorders 4 E Book

Author: Anthony H. V. Schapira
Publisher: Elsevier Health Sciences
ISBN: 1437719759
Format: PDF, ePub, Mobi
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Movement Disorders 4, the newest volume in the Blue Books in Neurology series provides you with rapid access to practical, clinical guidance on the diagnosis and pharmacologic treatment on the full range of movement disorders. Emphasizes the vast array of pharmacologic therapeutics, backed by clinical trials of the past 15 years to help you determine the best and most up-to-date drug therapy. Provides the latest on hot topics such as frontotemporal dementia and Tourette’s and related disorders, keeping you up to date on today’s issues. Presents the surgical management of Parkinson’s Disease to help you determine when to recommend surgery and for which patients. Includes extensive comprehensive information on Parkinson’s so you can better diagnose and treat PD patients. Offers more clinical details on tremors, differentiating between PD and other movement disorders and the genetics of movement disorders so you can determine which movement disorder is present.