Neuroinflammatory Mechanisms in Alzheimer s Disease

Author: Joseph Rogers
Publisher: Springer Science & Business Media
ISBN: 9783764360740
Format: PDF
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There has been an increasing appreciation of the economic and human toll that age-related disorders take throughout the world. Unprecedented research efforts have followed, aiming at the understanding and treatment of Alzheimer's Disease (AD) in particular, and this effort has finally begun to bear fruit - sometimes in surprising ways: Twenty years ago, the idea that AD involved any sort of inflammatory or immune component seemed implausible, if considered at all. Now, there are hundreds of laboratories world-wide that are pursuing basic research in this area, and multi-site clinical trials are underway to test the therapeutic potential of common anti-inflammatory drugs in AD. How this dramatic sea-change came about is made clear in this book, both through overviews of the field and through focused papers on specific topics of recent interest. Complement, cytokines and the complex host of other acute phase reactants are covered, as are summaries of many epidemiologic and clinical-pathological findings...

Neuroinflammation

Author: Paul L. Wood
Publisher: Springer Science & Business Media
ISBN: 1592594735
Format: PDF, Mobi
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An unprecedented review of our current knowledge of the neuroinflammatory mediators and cells involved in neurodegenerative diseases. Beginning with a detailed review of our current concepts of which biochemical mediators are involved in neuronal loss and the mechanisms of cell death, the distinguished contributors critically examine those areas of current research involved in the design of specific pharmacological agents to inhibit at defined points in the neuroinflammatory cascade. They also address the molecular, cellular, and disease model actions of first-generation agents, as well as the potential clinical relevance to AIDS-related dementia, Alzheimer's disease, amyotropic lateral sclerosis (ALS), Down's syndrome, Huntington's disease, multiple sclerosis, Parkinson's disease, and stroke.

The CB2 Cannabinoid System A New Strategy in Neurodegenerative Disorder and Neuroinflammation

Author: Marialessandra Contino
Publisher: Frontiers Media SA
ISBN: 2889452239
Format: PDF, ePub
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The neurodegenerative disorders such as Parkinson’s disease (PD) or Alzheimer’s disease (AD) are the most common forms of dementia and no pharmacological treatments are to date available for these diseases. Indeed, the only used drugs are symptomatic and no useful to block the progression of the diseases. The lack of a therapeutic approach is also due to a lack of an early diagnosis. This Research Topic describes a new target that is involved in the firs step of these disorders and that can be useful for the treatment and the diagnosis of such pathologies: the cannabinoid receptor subtype 2 or CB2R. Indeed, CB2R is overexpressed in reactive microglia and activated astrocytes during neuroinflammation and thus their detection by PET probes can be an easily strategy for an early diagnosis of neurodegeneration. Moreover, CB2 agonists and inverse agonists displayed neuroprotective effects and they so can be candidated as new therapeutich drugs for the treatment of these pathologies. Therefore, the aim of this Research Topic is to show the great potential of CB2R ligands for the development of new tools/drugs for both the therapy and the diagnosis of neurodegeneration.

Frontiers in Anti Infective Drug Discovery

Author: Atta -ur- Rahman
Publisher: Bentham Science Publishers
ISBN: 1681084791
Format: PDF, Mobi
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This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the book series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships.

Recent Progress in Alzheimer s and Parkinson s Diseases

Author: Israel Hanin
Publisher: CRC Press
ISBN: 020302835X
Format: PDF, ePub, Mobi
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This book brings together the proceedings of Alzheimer's and Parkinson's Diseases: New Perspectives, the Sixth International Conference on Alzheimer's Disease and Parkinson's Disease, held recently in Seville, Spain, and discusses the latest developments in the basic science and therapy of Alzheimer's and Parkinson's diseases by leading specialists on the topic. Areas discussed include: mechanisms of degeneration of Parkinson's Disease; the interrelationships between gait and cognitive function; advances in gene transfer and pharmacological regulation of protein aggregation in the treatment of Alzheimer's and Parkinson's Diseases; Alzheimer pathology and ER stress; and stem cell strategies for Alzheimer's Disease.

Advances in Dementia Research and Treatment 2012 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 1464991723
Format: PDF, Mobi
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Advances in Dementia Research and Treatment / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Dementia. The editors have built Advances in Dementia Research and Treatment / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Dementia in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Dementia Research and Treatment / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Migraine A Neuroinflammatory Disease

Author: Egilius L.H. Spierings
Publisher: Springer
ISBN: 3034881312
Format: PDF, ePub, Mobi
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The potential involvement of neurogenic inflammation in the pathogenesis of the migraine headache and the inhibition of this mechanism as a possible mode of action of antimigraine medications are discussed in great depth in this volume. The topics are approached from a pathophysiological as well as a clinical experimental perspective by a renowned group of clinicians and scientists who carefully consider the current, future, and potential therapeutic approaches to migraine treatment. The first chapters of the book address the impact of migraine on a personal and societal level, the presentation, pathogenesis and treatment of migraine as well as the role of neurogenic inflammation. Subsequent chapters present models of neurogenic inflammation related to the pathogenesis of the migraine headache, focussing on the mediators and their receptors, as well as on the involvement of mast cells. The possibility of inhibition of neurogenic inflammation in abortive and preventive migraine treatment is also extensively discussed and a chapter on the question of whether migraine is a neuroinflammatory disease concludes this comprehensive analysis. Clinicians and scientists interested in inflammation from a physiological or pharmacological perspective and those interested in the pathogenesis of headache - migraine in particular - are the intended audience for this unique body of work.

Pharmacological Mechanisms in Alzheimer s Therapeutics

Author: A. Claudio Cuello
Publisher: Springer Science & Business Media
ISBN: 9780387715223
Format: PDF, Mobi
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The need for effective therapy to treat Alzheimer’s disease is greater than ever, but there is still no drug therapy that can stop or reverse the progression of the disease. There is, however, a great deal of anticipation over the imminent development of effective therapies as a result of the identification of promising targets for drug development. This book investigates these targets and examines ongoing strategies to develop effective therapies for this devastating neurodegenerative condition.

Neurochemical Mechanisms in Disease

Author: John P. Blass
Publisher: Springer Science & Business Media
ISBN: 9781441971043
Format: PDF, Kindle
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This newest volume of Advances in Neurobiology deals with the Neurochemistry of disease, with chapters covering both human diseases and animal “model” diseases.