Neuronal and Glial Proteins

Author: Paul Marangos
Publisher: Elsevier
ISBN: 0323151566
Format: PDF, Mobi
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Neuronal and Glial Proteins: Structure, Function, and Clinical Application focuses on the basic and clinical information relating to a number of proteins that are either enriched in or unique to nervous tissue. This book discusses the structural and functional characteristics of cell-specific proteins, which provide a better understanding of the molecular mechanisms involved in processes that are specific to glia or neurons. Organized into three sections encompassing 15 chapters, this book starts with an overview of the fundamental principles and strategies involved in studying the anatomical, structural, functional, and immunological aspects of brain protein. This text then discusses the techniques, including the preparation of brain tissues as well as the preparation of neural and glial cells in purified form. Other chapters review the two-dimensional gel electrophoresis, which is recognized as a significant technique for discovering brain molecules. The final chapter deals with the membrane-associated nervous system proteins. Neurochemists and clinical researchers will find this book useful.

The Role of Glia in Neurotoxicity

Author: Michael Aschner
Publisher: CRC Press
ISBN: 9780849347924
Format: PDF, ePub
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It is well established that glial cells represent more than mere passive cytoskeletal support elements of the central and peripheral nervous system. A reciprocal relationship exists between neurons and glia that is vital for mutual differentiation, development, and functioning of both cell types. It also has become apparent that perturbations in glial function may lead to deleterious consequences in juxtaposed neurons. It is therefore possible that neuronal damage induced by chemicals or neuropathic disease involves dissociation of glial-neuronal interactions. The Role of Glia in Neurotoxicity brings together experts in the neurosciences to provide a more complete understanding of the effects of chemicals on nervous system function. This book explores potential sites of glial-neuronal interactions both in the central and peripheral nervous system, focusing on potential sites of neurotoxicant actions. Text introduces basic aspects of neuroscience, the first step toward understanding the mechanisms at work in normal physiology. The ways in which these processes are disturbed in pathological conditions are discussed. Distinguished authors examine the functional interactions between glial cells and neurons during development, adulthood, and senescence. The roles of glia in the normal CNS and PNS are described. The book offers specific, in-depth examples of directly (via diffusive and cell surface signals) or indirectly (via effects on the extracellular fluid or the blood-brain barrier) mediated glial neurotoxicity. This reference includes different techniques, conceptual frameworks, and approaches that are currently used in the study of the role of glia in neurotoxicity. This timely review not only presents an excellent overview of the state of the science but also provides direction for future research into the consequences of an altered glial-neuronal unit.

Gene Expression in the Central Nervous System

Author: A.C.H. Yu
Publisher: Elsevier
ISBN: 0080862306
Format: PDF, ePub
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Gene expression is an active ongoing process that maintains a functional CNS, as proteins are being made on a continual basis. Processes such as learning and memory, nerve cell repair and regeneration and its response to stress are critically dependent on gene expression. This volume highlights the role of gene expression in normal CNS function, and presents many research methods at the cutting edge of neuroscience, which will provide insight into therapeutic approaches through which the control of gene expression may be used in the treatment of many nervous system diseases.

Astrocytes

Author: Gerard Meurant
Publisher: Academic Press
ISBN: 0323139876
Format: PDF, Docs
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Interest in the functional roles of astrocytes in the nervous system has grown significantly as it is recognized that these cells not only have their own pharmacology but also release neuro- and vaso-active factors. This book relates astrocyte pharmacology to cell function for the first time, making it an attractive text across the neuroscience community. * Discusses the pharmacological regulation of specific astrocyte functions * Covers functional interactions between these and adjacent CNS cell types * Examines regional heterogeneity of astrocytes with respect to receptor expression * Compares in vitro and in vivo approaches

Cerebral Reorganization of Function after Brain Damage

Author: Harvey S. Levin
Publisher: Oxford University Press
ISBN: 9780198028208
Format: PDF, ePub, Mobi
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Cerebral Reorganization of Function After Brain Damage integrates basic research on neuroplasticity and clinical research on reorganization of function after brain injury, with a view toward translating the findings to rehabilitation. Historical foundations of research on neuroplasticity are presented to provide a perspective on recent findings. Leading investigators synthesize their work with results from other laboratories to provide a current update on neuroanatomic features that enhance neuroplasticity and provide a substrate for reorganization of function. The capacity for recovery from brain injury associated with focal lesions as compared to diffuse cerebral insult is discussed. Interventions such as environmental enrichment and drugs to enhance reorganization of function after brain injury have been studied in animal models and in human studies. Methodologies to study neuroplasticity are discussed including functional magnetic resonance imaging, neurophysiological measures, transcranial magnetic stimulation, and computational modeling. Implications of neuroplasticity research for innovations in rehabilitation of persons with brain injury are critically reviewed. This text will be particularly appealing to neuropsychologists, neurologists, psychologists, neuroscientists, psychiatrists, speech scientists, and other health professionals engaged in rehabilitation-related research.

Basic Neurosciences with Clinical Applications

Author: Eduardo E. Benarroch
Publisher: Elsevier Health Sciences
ISBN: 0750675365
Format: PDF, Mobi
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This single-author book covers basic aspects of neuroscience, including concepts of molecular biology, neurochemistry, and electrophysiology, and makes direct clinical correlations in a concise and coherent manner. This concise, coherent text provides a link between basic science and clinical correlations. Readers will benefit from the author's expertise as an academic clinical neurologist. This text provides a concise review of basic neuroscience concepts that are included in several qualifying examinations, including the National Boards.

Myelin

Author: Russell E. Martenson
Publisher: CRC Press
ISBN: 9780849388491
Format: PDF, ePub, Docs
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Myelin: Biology and Chemistry provides in-depth reviews and discussions regarding recent findings in the biology and chemistry of myelin. Topics are interdisciplinary and carry readers from the cellular level to that of the gene. Research in demyelinating diseases (naturally occurring and experimentally produced) is described and emphasizes autoimmune and virally induced mechanisms. Advances in molecular biology, such as those that provide details of the structures of the major myelin proteins, demonstrate the control of their synthesis, and explore the mutations within their genes that disrupt the process of myelination, are discussed in depth. Myelin: Biology and Chemistry will be an important addition to the libraries of molecular biologists, biochemists, cell biologists, physical chemists, immunologists, virologists, and pathologists involved in the study of myelin.