New Trends in Genetic Risk Assessment

Author: G. Jolles
Publisher: Academic Press
ISBN: 1483265676
Format: PDF, ePub, Mobi
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New Trends in Genetic Risk Assessment is based on the Fifth International Round Table of the Rhône-Poulenc Santé Foundation, held in Nice 1987. The conference was an attempt to review the latest theories and mechanisms stipulated for the various aspects of genotoxicity; it was above all an open forum to discuss the new trends, the new tests, and the new battery of tests for assessing the genetic risk of chemicals and especially drugs. This volume is actually not a proceedings of the meeting but a monograph specially edited to report the reviews which were presented and the discussions which took place; it was designed to provide a better understanding of the knowledge obtained in the most recent years and to help in the practical choice of approaches or tests for the prediction of the various forms of genotoxicity. The main subjects of this review concern molecular analysis of mutagenesis, detection of DNA damage, gene mutation, clastogenesis, aneuploidy, and germ cells. Each theme is preceded by a short overview summarizing the state of the art and the contributions of each author. Finally, special attention was given to the personal views of some leading toxicologists as to the battery of tests presently available or recommended.

Genetic Toxicology

Author: Albert P. Li
Publisher: CRC Press
ISBN: 9780849388156
Format: PDF, ePub
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Genetic Toxicology is a comprehensive book covering the historical perspective of genetic toxicology; basic mechanisms of mutations and chromosomal effects; health consequences of genetic damage, including cancer and inheritable mutations; properties of physical, chemical, and biological mutagens; risk assessment of human exposure to genotoxicants; and the current position of some government regulatory agencies in the United States on the issues of genetic toxicology. The book will be a useful reference for students and researchers in toxicology, genetics, cancer biology, and medicine who are interested in the basic and applied principles of genetic toxicology. It will also benefit industrial toxicologists, products registration specialists, and government regulatory specialists with responsibility for the safety evaluation of industrial and environmental agents.

Biomarkers

Author: Mortimer L. Mendelsohn
Publisher: Joseph Henry Press
ISBN: 0309517869
Format: PDF, ePub, Mobi
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A 38-year-old man who works in a factory applying coatings reports progressive breathing difficulties. A 45-year-old woman attributes her cough to copier "fumes." What are the prospects that compound-specific or diagnostically useful biomarkers can be developed and used for the benefit of workers like these and their employers? What promise do biomarkers of susceptibility offer for reducing risk to occupational exposures? What are the legal and ethical issues associated with the use of such biomarkers? These questions are explored in detail in this volume, which provides a comprehensive report on current and anticipated development in the application of biomarkers. Leading investigators present data, provide expert analyses, and make recommendations in the areas of: Dosimetry and physical measurement of exposure. Use of chromosome aberrations, adducts, and gene mutations as measurement of exposure and response. Metabolic susceptibility. Organ- and system-specific biomarkers. What biomarkers may reveal about carcinogenesis. The book also explores the societal and ethical issues of using biomarkers in the workplace, military, courtroom, and other settings.

Cancer Risk Evaluation

Author: Günter Obe
Publisher: John Wiley & Sons
ISBN: 3527634630
Format: PDF, Docs
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An overview of the different approaches to cancer risk assessment of environmental factors - including "-omics" technologies, discussing the strengths and weaknesses of the methods in different fields. The main focus is on the carcinogenic effects of ionizing and non-ionizing radiation, demonstrating the difficulties in accurately assessing those factors that may or may not pose a significant cancer risk. The book extends the view to a broader context of risk assessment, highlighting various aspects of risk management. Written by leading experts in the field, this is a resource for policy makers and professionals in health risk assessment, and public health workers, as well as oncologists and researchers in academia. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from Google Play or the MedHand Store.

Human Gene Therapy Current Opportunities and Future Trends

Author: G. M. Rubanyi
Publisher: Springer Science & Business Media
ISBN: 9783540004134
Format: PDF, Mobi
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Advances in genetics, molecular biology and gene delivery technologies in recent years have led to new gene therapy strategies for treatment of a variety of diseases. This book gives a comprehensive overview of the present status and future directions of gene delivery systems and therapeutic strategies for the clinical application of gene therapy in cancer, cardiovascular and central nervous system diseases. Stem cell-based therapies and gene expression regulatory systems as novel platform technologies for various gene therapy applications are also discussed. Leading experts give excellent overviews of basic molecular aspects and clinical applications in this new emerging biomedical field.

Risk Assessment and Decision Making Using Test Results

Author: V. Chankong
Publisher: Springer Science & Business Media
ISBN: 1468455958
Format: PDF, ePub, Docs
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The difficulties associated with making risk assessments on the basis of experimental results are familiar to practitioners in many fields engineering, epidemiology, chemistry, etc. These difficulties are particularly common in problems that have dynamic and stochastic characteristics driven by multiple purposes and goals, with complex interconnections and inter dependencies. Acquiring an appropriate data base, processing and analyzing model results, and transmitting these results at an appropriate technical, social, political, and institutional level are additional difficulties that must be addressed. This book is grounded on the premise that risks are best assessed on the basis of experimental results and sound mathematical analyses, coupled with the knowledge of experts. The carcinogenicity prediction and battery selection (ePBS) approach described herein provides a systematic mechan ism-a synthesis of systems and statistical and decision analyses-to aid researchers and decision makers in the critical field of carcinogenicity prediction in selecting an appropriate battery of tests to use and in translating experimental results into information that can be used as an aid to decision making.

Assessing Genetic Risks

Author: Lori B. Andrews
Publisher: National Academies
ISBN:
Format: PDF, ePub, Docs
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This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and policy recommendations on key issues in genetic testing and screening. Among the important issues covered are quality control in genetic gesting; appropriate roles for public agencies, private health practitioners, research laboratories and centers, and companies involved in testing; value-neutral education and counseling for persons considering testing; use of test results in insurance, employment, and other settings; and more.

Methods for Risk Assessment of Transgenic Plants

Author: Klaus Ammann
Publisher: Springer
ISBN: 3034880332
Format: PDF, Kindle
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For centuries, TK has been used almost exclusively by its creators, that is, indigenous and local communities. Access to, use of and handing down of TK has been regulated by local laws, customs and tmditions. Some TK has been freely accessible by all members of an indigenous or local community and has been freely exchanged with other communities; other TK has only been known to particular individuals within these communities such as shamans, and has been handed down only to particular individuals of thc next generation. Over many generations, indigenous and local communities have accumulated a great deal of TK which has generally been adapted, developed and improved by the generations that followed. For a long time, Western anthropologists and other scientists have generally been able to freely access TK and have documented it in their works. Still, this TK was only seldom used outside the indigenous and local communities that created it. More recently, however, Western scientists have become aware that TK is neither outdated nor valueless knowledge, but, instead, 1 can be useful to solve some of the problems facing today's world. Modem science, for example, has shown an increased interest in some fornls ofTK as knowledge that can be used in 4 research and development (R&D) activities and be integrated in modem innovations. This holds especially true for TK regarding genetic resources, which has been integrated in modem 6 phannaceuticals,s agro-chemicals and seed.