Next Generation Sequencing and Sequence Assembly

Author: Ali Masoudi-Nejad
Publisher: Springer Science & Business Media
ISBN: 1461477263
Format: PDF, Kindle
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The goal of this book is to introduce the biological and technical aspects of next generation sequencing methods, as well as algorithms to assemble these sequences into whole genomes. The book is organized into two parts; part 1 introduces NGS methods and part 2 reviews assembly algorithms and gives a good insight to these methods for readers new to the field. Gathering information, about sequencing and assembly methods together, helps both biologists and computer scientists to get a clear idea about the field. Chapters will include information about new sequencing technologies such as ChIp-seq, ChIp-chip, and De Novo sequence assembly. ​

Big Data and Differential Privacy

Author: Nii O. Attoh-Okine
Publisher: John Wiley & Sons
ISBN: 1119229065
Format: PDF, Docs
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A comprehensive introduction to the theory and practice of contemporary data science analysis for railway track engineering Featuring a practical introduction to state-of-the-art data analysis for railway track engineering, Big Data and Differential Privacy: Analysis Strategies for Railway Track Engineering addresses common issues with the implementation of big data applications while exploring the limitations, advantages, and disadvantages of more conventional methods. In addition, the book provides a unifying approach to analyzing large volumes of data in railway track engineering using an array of proven methods and software technologies. Dr. Attoh-Okine considers some of today’s most notable applications and implementations and highlights when a particular method or algorithm is most appropriate. Throughout, the book presents numerous real-world examples to illustrate the latest railway engineering big data applications of predictive analytics, such as the Union Pacific Railroad’s use of big data to reduce train derailments, increase the velocity of shipments, and reduce emissions. In addition to providing an overview of the latest software tools used to analyze the large amount of data obtained by railways, Big Data and Differential Privacy: Analysis Strategies for Railway Track Engineering: • Features a unified framework for handling large volumes of data in railway track engineering using predictive analytics, machine learning, and data mining • Explores issues of big data and differential privacy and discusses the various advantages and disadvantages of more conventional data analysis techniques • Implements big data applications while addressing common issues in railway track maintenance • Explores the advantages and pitfalls of data analysis software such as R and Spark, as well as the ApacheTM Hadoop® data collection database and its popular implementation MapReduce Big Data and Differential Privacy is a valuable resource for researchers and professionals in transportation science, railway track engineering, design engineering, operations research, and railway planning and management. The book is also appropriate for graduate courses on data analysis and data mining, transportation science, operations research, and infrastructure management. NII ATTOH-OKINE, PhD, PE is Professor in the Department of Civil and Environmental Engineering at the University of Delaware. The author of over 70 journal articles, his main areas of research include big data and data science; computational intelligence; graphical models and belief functions; civil infrastructure systems; image and signal processing; resilience engineering; and railway track analysis. Dr. Attoh-Okine has edited five books in the areas of computational intelligence, infrastructure systems and has served as an Associate Editor of various ASCE and IEEE journals.

Next Generation Sequencing Technologies and Challenges in Sequence Assembly

Author: Sara El-Metwally, M.Sc
Publisher: Springer Science & Business
ISBN: 1493907158
Format: PDF, Mobi
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The introduction of Next Generation Sequencing (NGS) technologies resulted in a major transformation in the way scientists extract genetic information from biological systems, revealing limitless insight about the genome, transcriptome and epigenome of any species. However, with NGS, came its own challenges that require continuous development in the sequencing technologies and bioinformatics analysis of the resultant raw data and assembly of the full length genome and transcriptome. Such developments lead to outstanding improvements of the performance and coverage of sequencing and improved quality for the assembled sequences, nevertheless, challenges such as sequencing errors, expensive processing and memory usage for assembly and sequencer specific errors remains major challenges in the field. This book aims to provide brief overviews the NGS field with special focus on the challenges facing the NGS field, including information on different experimental platforms, assembly algorithms and software tools, assembly error correction approaches and the correlated challenges.

Next Generation Sequencing Technologies in Medical Genetics

Author: C. Alexander Valencia
Publisher: Springer Science & Business Media
ISBN: 1461490324
Format: PDF, Docs
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This book introduces readers to Next Generation Sequencing applications in medical genetics. The authors discuss the direct application of next-generation sequencing to medicine, specifically, laboratory medicine or molecular diagnostics. The first part of the book contains chapters on sanger sequencing, NGS technologies, targeted-amplification and capture, and exome sequencing. The second part of the book focuses on genetic disorders diagnoses by NGS, prenatal diagnosis, muscular dystrophies, mitochondrial disorders diagnosis, and challenges in molecular diagnosis. Recent developments and potential future trends in NGS sequencing applications are highlighted, as well.​

Industry Interactive Innovations in Science Engineering and Technology

Author: Swapan Bhattacharyya
Publisher: Springer
ISBN: 9811039534
Format: PDF, ePub, Docs
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The book is a collection of peer-reviewed scientific papers submitted by active researchers in the International Conference on Industry Interactive Innovation in Science, Engineering and Technology (I3SET 2016). The conference is a collective initiative of all departments and disciplines of JIS College of Engineering (an autonomous institution), Kalyani, West Bengal, India. The primary objective of the conference is to strengthen interdisciplinary research and encourage innovation in a demand-driven way as desired by the industry for escalating technology for mankind. A galaxy of academicians, professionals, scientists, industry people and researchers from different parts of the country and abroad shared and contributed their knowledge. The major areas of I3SET 2016 include nonconventional energy and advanced power systems; nanotechnology and applications; pattern recognition and machine intelligence; digital signal and image processing; modern instrumentation, control, robotics and automation; civil engineering and structural design; real-time and embedded systems, communication and devices; advanced optimization techniques; biotechnology, biomedical instrumentation and bioinformatics; and outcome based education.

Next Generation Genome Sequencing

Author: Michal Janitz
Publisher: John Wiley & Sons
ISBN: 3527644733
Format: PDF, Mobi
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Written by leading experts from industry and academia, this first single comprehensive resource addresses recent developments in next generation DNA sequencing technology and their impact on genome research, drug discovery and health care. As such, it presents a detailed comparative analysis of commercially available platforms as well as insights into alternative, emerging sequencing techniques. In addition, the book not only covers the principles of DNA sequencing techniques but also social, ethical and commercial aspects, the concept of personalized medicine and a five-year perspective of DNA sequencing.

Algorithms in Bioinformatics

Author: Wing-Kin Sung
Publisher: CRC Press
ISBN: 9781420070347
Format: PDF, ePub
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Thoroughly Describes Biological Applications, Computational Problems, and Various Algorithmic Solutions Developed from the author’s own teaching material, Algorithms in Bioinformatics: A Practical Introduction provides an in-depth introduction to the algorithmic techniques applied in bioinformatics. For each topic, the author clearly details the biological motivation and precisely defines the corresponding computational problems. He also includes detailed examples to illustrate each algorithm and end-of-chapter exercises for students to familiarize themselves with the topics. Supplementary material is available at http://www.comp.nus.edu.sg/~ksung/algo_in_bioinfo/ This classroom-tested textbook begins with basic molecular biology concepts. It then describes ways to measure sequence similarity, presents simple applications of the suffix tree, and discusses the problem of searching sequence databases. After introducing methods for aligning multiple biological sequences and genomes, the text explores applications of the phylogenetic tree, methods for comparing phylogenetic trees, the problem of genome rearrangement, and the problem of motif finding. It also covers methods for predicting the secondary structure of RNA and for reconstructing the peptide sequence using mass spectrometry. The final chapter examines the computational problem related to population genetics.

Computational Intelligence Techniques in Health Care

Author: P.V. Lakshmi
Publisher: Springer
ISBN: 9811003084
Format: PDF, Kindle
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This book presents research on emerging computational intelligence techniques and tools, with a particular focus on new trends and applications in health care. Healthcare is a multi-faceted domain, which incorporates advanced decision-making, remote monitoring, healthcare logistics, operational excellence and modern information systems. In recent years, the use of computational intelligence methods to address the scale and the complexity of the problems in healthcare has been investigated. This book discusses various computational intelligence methods that are implemented in applications in different areas of healthcare. It includes contributions by practitioners, technology developers and solution providers.

Computational Methods for Application in Industry 4 0

Author: Nikolaos E. Karkalos
Publisher: Springer
ISBN: 9783319923925
Format: PDF, Docs
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This book presents computational and statistical methods used by intelligent systems within the concept of Industry 4.0. The methods include among others evolution-based and swarm intelligence-based methods. Each method is explained in its fundamental aspects, while some notable bibliography is provided for further reading. This book describes each methods' principles and compares them. It is intended for researchers who are new in computational and statistical methods but also to experienced users.

Plant Stress Tolerance

Author: Kareem A. Mosa
Publisher: Springer
ISBN: 331959379X
Format: PDF, ePub, Docs
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Providing a comprehensive overview of cutting-edge research on Omics applications in plant sciences field,“Plant Stress Tolerance” focuses on different approaches towards plant stress tolerance including both biotic stresses and abiotic stresses. This book outlines the challenges facing this area of research, with solid, up-to-date information for graduate students, academic scientists and researchers on using the recent advances of Omics technologies on plant stresses.