NF B Related Genetic Diseases

Author: Gilles Courtois
Publisher: Springer
ISBN: 3319258508
Format: PDF
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This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases. It shows that studying patient-related pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand the various functions of NF-KB in humans, complementing studies performed with mouse models. In addition, people treating those patients acquire a deeper understanding of the molecular basis of the pathophysiological processes.

Synthetic Biology

Author: Manuel Porcar
Publisher: Springer
ISBN: 9401793824
Format: PDF, ePub
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Synthetic Biology (SB) is a revolutionary discipline with a vast range of practical applications, but is SB research really based on engineering principles? Does it contributing to the artificial synthesis of life or does it utilise approaches sufficiently advanced to fall outside the scope of biotechnology or metabolic engineering? This volume reviews the development of SB and includes the major milestones of the discipline, the ‘top-down’ and ‘bottom-up’ approaches towards the construction of an artificial cell and the development of the “iGEM” competition. We conclude that SB is an emerging field with extraordinary technological potential, but that most research projects actually are an extension of metabolic engineering since the complexity of living organisms, their tight dependence on evolution and our limited knowledge of the interactions between the molecules, actually make life difficult to engineer.

Drought Stress in Maize Zea mays L

Author: Muhammad Aslam
Publisher: Springer
ISBN: 3319254421
Format: PDF, ePub
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This book focuses on early germination, one of maize germplasm most important strategies for adapting to drought-induced stress. Some genotypes have the ability to adapt by either reducing water losses or by increasing water uptake. Drought tolerance is also an adaptive strategy that enables crop plants to maintain their normal physiological processes and deliver higher economical yield despite drought stress. Several processes are involved in conferring drought tolerance in maize: the accumulation of osmolytes or antioxidants, plant growth regulators, stress proteins and water channel proteins, transcription factors and signal transduction pathways. Drought is one of the most detrimental forms of abiotic stress around the world and seriously limits the productivity of agricultural crops. Maize, one of the leading cereal crops in the world, is sensitive to drought stress. Maize harvests are affected by drought stress at different growth stages in different regions. Numerous events in the life of maize crops can be affected by drought stress: germination potential, seedling growth, seedling stand establishment, overall growth and development, pollen and silk development, anthesis silking interval, pollination, and embryo, endosperm and kernel development. Though every maize genotype has the ability to avoid or withstand drought stress, there is a concrete need to improve the level of adaptability to drought stress to address the global issue of food security. The most common biological strategies for improving drought stress resistance include screening available maize germplasm for drought tolerance, conventional breeding strategies, and marker-assisted and genomic-assisted breeding and development of transgenic maize. As a comprehensive understanding of the effects of drought stress, adaptive strategies and potential breeding tools is the prerequisite for any sound breeding plan, this brief addresses these aspects.

Molecular Biology and Pathogenesis of Peste des Petits Ruminants Virus

Author: Muhammad Munir
Publisher: Springer Science & Business Media
ISBN: 3642314511
Format: PDF, ePub, Docs
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Peste de Petits Ruminants (PPR) is a highly contagious viral disease of domestic and wild small ruminants that can significantly affect economies. The authors are experts in the field and provide an up-to-date and comprehensive review covering all aspects of the disease. The book is divided into seven chapters highlighting genome organization, virus replication and the determinants of virulence, pathophysiology and clinical disease, immunology and immunopathogenesis, epidemiology, diagnostic assays and vaccines, and the challenges concerning global eradication. It is an invaluable reference work, presenting the latest information for virologists, microbiologists, immunologists, veterinarians, and scientists working in PPR research.

The Chaperonopathies

Author: Alberto J.L. Macario
Publisher: Springer Science & Business Media
ISBN: 9400746679
Format: PDF
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This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments.

Biological Physical and Technical Basics of Cell Engineering

Author: Gerhard M. Artmann
Publisher: Springer
ISBN: 9811079048
Format: PDF, Kindle
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This book presents and discusses recent scientific progress on Cell and Stem Cell Engineering. It predominantly focuses on Biological, Physical and Technical Basics, and features new trends of research reaching far into the 21st century.

Human Physical Fitness and Activity

Author: Ann E. Caldwell
Publisher: Springer
ISBN: 3319304097
Format: PDF, ePub
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​The science of human physical activity and fitness is ripe for a novel theoretical framework that can integrate the ecological, genetic, physiological and psychological factors that influence physical activity in humans. Physical inactivity dominates most developed nations around the world, and is among the leading causes of disease burden and death worldwide. Despite the wide array of physical and mental health benefits, few people get the recommended level of physical activity to achieve these benefits. Current research on physical activity has not, as of yet, been successful for the development of effective exercise interventions. Several researchers have advocated a more integrative approach that takes evolutionary history into account, but such a framework has yet to be advanced. To that aim, the first goal of this book is to present a comprehensive evolutionary and life history framework that highlights the domain-specific aspects of the evolved psychology and physiology that can lead to a more integrated and complete understanding of physical activity across the lifespan. It summarizes and extends previous work that has been done to understand the ways natural selection has shaped physical activity in humans in traditional and modern economies and environments. In many ways, humans are adapted to be physically active. Overall, however, natural selection has shaped a flexible, but energy conscious system that responds to environmental and individual costs and benefits of physical activity to optimally allocate a finite energetic budget across the lifespan. This system is adapted to respond to cues of resource scarcity and high levels of obligatory physical activity, and conserves energy to favor allocation in ways that increase the likelihood of reproductive success and survival. This nuanced application leads to a more thorough understanding of the circumstances that natural selection is predicted to favor both sedentary and active behaviors in predictable ways across the lifespan. The second goal of this book is to synthesize and interpret cross-disciplinary research (from biological and evolutionary anthropology and psychology; epidemiology; health psychology; and exercise physiology) that can illuminate original approaches to increase physical activity in modern, primarily sedentary contexts. This includes a breakdown of the human lifespan to discuss the predicted costs and benefits of physical activity at each stage of life in order to differentiate the obstacles to physical activity and exercise that are functionally adaptive—or were in the environments that they evolved—and identifying which factors are more modifiable than others in order to develop interventions and environments that are more conducive to physical activity. Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

Gamma Glutamyl Transpeptidases

Author: Immacolata Castellano
Publisher: Springer Science & Business Media
ISBN: 3034806825
Format: PDF, ePub, Mobi
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Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.γ-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson’s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of γ-GTs and gives information about applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.​

Biomedical Applications of Natural Proteins

Author: Dhiraj Kumar
Publisher: Springer
ISBN: 8132224914
Format: PDF
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This book is intended as a reference guide for graduate students, postgraduate students and researchers with a basic knowledge of protein chemistry who would like to know more about the biomedical applications of natural proteins to promote healthier lives. The book is divided into ten chapters, each of which explains different natural proteins and their established biomedical applications. The first chapter extensively deals with protein based natural fibers and provides an overview of all protein based fibers currently available. In turn, chapter two mainly focuses on the biomedical applications of a special class of proteins called Heat Shock Proteins; the biomedical applications of silkworm pupae proteins are dealt in chapter three. Chapter four examines an interesting use of Eri silk fibroin as a biomaterial for Tissue Engineering, while chapter five discusses the key experimental details involved in converting Tasar silk sericin into self-assembled nanoparticles. Chapter six offers brief descriptions of bioactive proteins with respect to their sources, synthesis and applications. Chapter seven is dedicated to Interleukine-8 and its role in human life, while chapter eight addresses the importance of natural proteins in infectious diseases. Chapter nine explores the issue of excess intake of dietary proteins and its adverse effects, and finally, chapter ten discusses the efficiency of drug delivery systems made up of gelatin nanocomposites. The book is above all intended as a valuable resource for students and researchers alike, sparking their curiosity with regard to the applications of natural proteins and motivating them to focus their own energies on the discovery or identification of additional natural proteins for diverse biomedical uses.

The Evolution of Mammalian Sociality in an Ecological Perspective

Author: Clara B. Jones
Publisher: Springer Science & Business Media
ISBN: 3319039318
Format: PDF
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This brief discusses factors associated with group formation, group maintenance, group population structure, and other events and processes (e.g., physiology, behavior) related to mammalian social evolution. Within- and between-lineages, features of prehistoric and extant social mammals, patterns and linkages are discussed as components of a possible social “tool-kit”. "Top-down” (predators to nutrients), as well as “bottom-up” (nutrients to predators) effects are assessed. The present synthesis also emphasizes outcomes of Hebbian (synaptic) decisions on Malthusian parameters (growth rates of populations) and their consequences for (shifting) mean fitnesses of populations. Ecology and evolution (EcoEvo) are connected via the organism’s “norms of reaction” (genotype x environment interactions; life-history tradeoffs of reproduction, survival, and growth) exposed to selection, with the success of genotypes influenced by intensities of selection as well as neutral (e.g. mutation rates) and stochastic effects. At every turn, life history trajectories are assumed to arise from “decisions” made by types responding to competition for limiting resources constrained by Hamilton’s rule (inclusive fitness operations).