Pediatric Brain Stimulation

Author: Adam Kirton
Publisher: Academic Press
ISBN: 0128020385
Format: PDF, ePub, Docs
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Pediatric Brain Stimulation: Mapping and Modulating the Developing Brain presents the latest on this rapidly expanding field that has seen an exponential growth in publications over the past 10 years. Non-invasive modalities like TMS can painlessly map and measure complex neurophysiology in real patients. Neuromodulatory applications like rTMS and tDCS carry increasingly proven therapeutic applications. Rapidly advancing technological methodologies are increasing opportunities and indications. Despite all these benefits, applications in the more plastic developing brains of children are only just emerging. This book provides a comprehensive overview of brain stimulation in children. Chapters include Transcranial Magnetic Stimulation (TMS) fundamentals, brain stimulation in pediatric neurological conditions, and invasive brain stimulation. The main audience for this research will be those interested in applying brain stimulation technologies to advance clinical research and patient care, although a wide variety of clinicians and scientist will find this to be a valuable reference on brain stimulation with specific chapters on a variety of conditions. Provides an overview of recent findings and knowledge of pediatric brain stimulation and the developing brain Edited by renowned leaders in the field of pediatric brain stimulation Presents a great resource for basic and clinical scientists and practitioners in neuroscience, neurology, neurosurgery, and psychiatry

The Safety and Efficacy of Noninvasive Brain Stimulation in Development and Neurodevelopmental Disorders

Author: Lindsay M. Oberman
Publisher: Frontiers Media SA
ISBN: 2889196992
Format: PDF, ePub, Mobi
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Noninvasive brain stimulation (including Transcranial Magnetic Stimulation (TMS) and Transcranial Current Brain Stimulation (TCS)) can be used both experimentally and therapeutically. In the experimental domain TMS can be applied in single pulses to depolarize a small population of neurons in a targeted brain region. This protocol can be used, for example, to map cortical motor outputs, study central motor conduction time, or evaluate the cortical silent period (a measure of intracortical inhibition) all of which are relevant to neurodevelopment. TMS can also be applied in pairs of pulses (paired pulse stimulation, ppTMS) where two pulses are presented in rapid succession to study intracortical inhibition and facilitation. Trains of repeated TMS (rTMS) pulses can be applied at various stimulation frequencies and patterns to modulate local cortical excitability beyond the duration of the stimulation itself. Depending on the parameters of stimulation the excitability can be either facilitated or suppressed. TCS (including Transcranial Direct Current Stimulation (tDCS), alternating current (tACS), and random noise current stimulation (tRNS) also have the potential to modulate cortical excitability and have also been used to study and modulate cortical activity in healthy and patient populations. The after-effects of rTMS and TCS are thought to be related to changes in efficacy (in either the positive or negative direction) of synaptic connections of the neurons being stimulated, thus these techniques have been used to study and modulate cortical plasticity mechanisms in a number of populations. Recently, researchers have begun to apply these techniques to the study of neurodevelopmental mechanisms as well as the pathophysiology and development of novel treatments for neurodevelopmental disorders. Though there is much promise, caution is warranted given the vulnerability of pediatric and clinical populations and the potential that these techniques have to modify circuit development in a cortex that is in a very dynamic state. This Research Topic hopes to provide an opportunity to share ideas across areas (human and animal researchers, clinicians and basic scientists). We are particularly interested in papers that address issues of choosing a protocol (intensity, frequency, location, coil geometry etc.), populations where noninvasive brain stimulation may have direct impact on diagnostics and treatment, as well as the safety and ethics of applying these techniques in pediatric populations. As many may not be aware of the potential and limitations of noninvasive brain stimulation and its use for research and treatment in this area, this Research Topic promises to have broad appeal. Submissions for all Frontiers article types are encouraged.

Oxford Handbook of Transcranial Stimulation

Author: Eric Wassermann
Publisher: Oxford University Press
ISBN: 0198568924
Format: PDF
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Transcranial stimulation comprises an important set of techniques for investigating brain function, some of which are showing the promise of treating disease. This book provides the definitive review of the scientific and technical background required to understand transcranial stimulation, for neuroscientists, neurologists, and psychiatrists.

The Stimulated Brain

Author: Roi Cohen Kadosh
Publisher: Elsevier
ISBN: 0124047122
Format: PDF, Kindle
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The Stimulated Brain—which garnered an Honorable Mention for Biomedicine & Neuroscience at the 2015 PROSE Awards from the Association of American Publishers—presents the first integration of findings on brain stimulation from different research fields with a primary focus on Transcranial Electrical Stimulation (tES), one of the most frequently used noninvasive stimulation methods. The last decade has witnessed a significant increase in the amount of research exploring how noninvasive brain stimulation can not only modulate but also enhance cognition and brain functions. However, although Transcranial Magnetic Stimulation (TMS) and particularly tES have the potential to become more widely applicable techniques (as they come with none of the risks associated with deep brain stimulation) the reference literature on these neurotechnologies has been sparse. This resource provides a broad survey of current knowledge, and also marks future directions in cognitive and neuro-enhancement. It expands our understanding of basic research findings from animals and humans, including clear translational benefits for applied research and the therapeutic use of noninvasive brain stimulation methods. The book's coverage includes a primer that paves the way to a more advanced knowledge of tES and its physiological basis; current research findings on cognitive and neuro-enhancement in animals and typical and atypical human populations, such as neurological patients; and discussions of future directions, including specific neuroethical issues and pathways for collaboration and entrepreneurialism. The Stimulated Brain is the first book to provide a comprehensive understanding of different aspects of noninvasive brain stimulation that are critical for scientists, clinicians, and those who are interested in “stimulating their minds by exploring this fascinating field of research. Honorable Mention for Biomedicine & Neuroscience in the 2015 PROSE Awards from the Association of American Publishers The only reference on the market to focus on transcranial electrical stimulation (tES) Coverage across technical, historical, and application topics makes this the single, comprehensive resource for researchers and students Edited book with chapters authored by international leaders in the fields of medicine, neuroscience, psychology, and philosophy—providing the broadest, most expert coverage available

Brain Stimulation

Author: Irving Reti
Publisher: John Wiley & Sons
ISBN: 111856829X
Format: PDF
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Brain stimulation technologies are both tools to probe brain function and to provide therapeutic options for patients with neuropsychiatric disease where pharmacological options are not viable. Although the field has been in existence for over seventy years, research interest in brain stimulation has been on the rise particularly in the last two decades. Brain Stimulation: Methodologies and Interventions is an introduction to the field of brain stimulation technology and its applications. The book explores how brain stimulating technologies work in the context of brain pathways that mediate normal and abnormal brain function. Chapters cover neuroanatomy and activitydependent changes in neuronal function triggered by brain stimulation, as well as applications of brain stimulation technologies themselves, including noninvasive procedures that rely on convulsive or seizure therapeutics, and non-convulsive therapies such as magnetic and electrical brain stimulation. Authored by an international group of leaders in the field, Brain Stimulation is a valuable resource for both neuroscience researchers and clinicians. KEY POINTS • Includes introductory chapters on relevant neuroanatomy • Covers both invasive and noninvasive brain stimulation techniques • Explains basic mechanisms and therapeutic applications • Written by an international team of leaders in the field • Illustrated in full color

Current Concepts in Movement Disorder Management

Author: A. Niranjan
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318062022
Format: PDF, Mobi
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This book summarizes the current state of movement disorder management and the role of surgical therapies as an alternative to medication. Following a chapter on the history of movement disorder surgery, leaders in their fields describe the pathophysiology, functional neuroanatomy, clinical presentation, and medical management of Parkinson’s disease, dystonia, and essential tremor. This is followed by chapters on the spectrum of movement disorder surgery itself, from the lesioning procedures of radiofrequency ablation, stereotactic radiosurgery, and high-frequency ultrasound to the modulatory procedures of “asleep”, image-guided deep brain stimulation (DBS) and “awake”, microelectrode-guided DBS. The final chapters focus on closed-loop DBS, drug-delivery, gene therapy, and other emerging neurosurgical therapies, highlighting long-standing experimental strategies that are reaching exciting phases of clinical translation. This volume is a valuable tool for accessing the wide spectrum of concepts that currently define this dynamic field.

Sociolinguistic Research

Author: Robert Lawson
Publisher: Routledge
ISBN: 1317371100
Format: PDF, Mobi
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Shortlisted for the LSA Leonard Bloomfield Book Award 2017 Sociolinguistic Research: Application and Impact provides a unique overview of international research projects, showcasing their positive outcomes and offering critical insights and constructive critiques into the meaning of ‘impact’ in contemporary research. The book includes: original findings from cutting-edge research from scholars such as Mary Bucholtz, Walt Wolfram and Peter Patrick; coverage of organisational contexts including education, government, justice, heritage, and the workplace; activities including after-school programmes, workplace training courses, social media campaigns, and video productions; application of research to professional practice including teaching (primary school to university), adjudication, police interviewing, and governmental policymaking; contributors’ personal reflections on the research process and its outcomes, including constructive critiques of institutional definitions of impact. With chapters spanning research across five continents, Sociolinguistic Research: Application and Impact is essential reading for sociolinguistic researchers, students embarking on sociolinguistic research, and anyone interested in the practical application of research on language and society.

Rhythms of the Brain

Author: Gyorgy Buzsaki
Publisher: Oxford University Press
ISBN: 019804125X
Format: PDF
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This book provides eloquent support for the idea that spontaneous neuron activity, far from being mere noise, is actually the source of our cognitive abilities. In a sequence of "cycles," György Buzsáki guides the reader from the physics of oscillations through neuronal assembly organization to complex cognitive processing and memory storage. His clear, fluid writing-accessible to any reader with some scientific knowledge-is supplemented by extensive footnotes and references that make it just as gratifying and instructive a read for the specialist. The coherent view of a single author who has been at the forefront of research in this exciting field, this volume is essential reading for anyone interested in our rapidly evolving understanding of the brain.

Brain Mapping

Author:
Publisher: Academic Press
ISBN: 0123973163
Format: PDF, Mobi
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Brain Mapping: A Comprehensive Reference offers foundational information for students and researchers across neuroscience. With over 300 articles and a media rich environment, this resource provides exhaustive coverage of the methods and systems involved in brain mapping, fully links the data to disease (presenting side by side maps of healthy and diseased brains for direct comparisons), and offers data sets and fully annotated color images. Each entry is built on a layered approach of the content – basic information for those new to the area and more detailed material for experienced readers. Edited and authored by the leading experts in the field, this work offers the most reputable, easily searchable content with cross referencing across articles, a one-stop reference for students, researchers and teaching faculty. Broad overview of neuroimaging concepts with applications across the neurosciences and biomedical research Fully annotated color images and videos for best comprehension of concepts Layered content for readers of different levels of expertise Easily searchable entries for quick access of reputable information Live reference links to ScienceDirect, Scopus and PubMed

Pediatric Epilepsy

Author: Blaise F. Bourgeois, MD
Publisher: Demos Medical Publishing
ISBN: 9781934559864
Format: PDF, ePub
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The extensively updated third edition of Pediatric Epilepsy: Diagnosis and Therapy continues to be the definitive volume on the diagnosis, treatment, classification, and management of the childhood epilepsies. Written by nearly 100 international leaders in the field, this new edition progresses logically with major sections on the basic mechanisms of the disease, classification, epidemiology, etiology, diagnosis, and age-related syndromes of epilepsy. The core of the new third edition is its completely updated section on antiepileptic drugs, including an in-depth discussion of dosage considerations, drug toxicity, teratogenicity, and drug interactions, with recommendations for optimal combinations when multiple drug therapy is required. Features unique to the third edition include: Expanded section on the basic science and mechanism of epilepsy Completely updated drug chapters, including newly released drugs and those in development Expanded chapters on vagus nerve stimulation and surgical treatment Expanded section on co-morbidities The third edition includes 21 new chapters, including discussions of: epileptic channelopathies; epileptogenic cerebral cortical malformation; epilepsy genes; etiologies and workup; evidence-based medicine issues related to drug selection; Levetiracetam; Sulthiame; Pregabalin; herbal medications; basic and advanced imaging; immunotherapy issues; vagus nerve stimulation therapy; cognitive and psychiatric co-morbidities and educational placement; and psychosocial aspects of epilepsy.