Estrogens and Antiestrogens I

Author: Michael Oettel
Publisher: Springer Science & Business Media
ISBN: 3642586163
Format: PDF, Mobi
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For many years, Springer has been publishing an impressive series of textbooks of pharmacology which have set standards in medical science. Surprisingly, an extensive overview of the current state of the art in research on estrogens and anti estrogens was still lacking. The present two volumes on estrogens and antiestrogens provide a comprehensive review of a field of research in which remarkable progress has been made over the past few years. New insights into the mechanisms of steroid hormone action resulted in a tremendous number of publications from which new principles of preventive and therapeutic appli cations of estrogens and antiestrogens emerged. Although various electronic data bases provide easy access to this copious information, there was a clear necessity for a monograph-style textbook which assesses and summarizes current knowledge in this rapidly expanding field of research. It should be noted, however, that, due to this dynamic development, it is barely possible to comprehensively update every aspect of basic and clinical knowledge on estro gens and antiestrogens. Thus, the intention of the editors was to provide the reader with an overview of the "classic" and most recently explored areas of research and stimulate future interests in basic and applied endocrinology. Estrogens were among the first steroid hormones described in the scientific literature. Since they were first isolated, since the chemical, synthesic and pharmacological characterization of naturally occurring estrogens and, later on, of orally active derivatives, estrogen research has produced continu ously hallmark results in reproductive endocrinology worldwide.

Estrogens and Antiestrogens II

Author: Michael Oettel
Publisher: Springer Science & Business Media
ISBN: 3642601073
Format: PDF, ePub, Docs
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For many years, Springer has been publishing an impressive series of textbooks of pharmacology which have set standards in medical science. Surprisingly, an extensive overview of the current state of the art in research on estrogens and anti estrogens was still lacking. The present two volumes on estrogens and anti estrogens provide a comprehensive review of a field of research in which remarkable progress has been made over the past few years. New insights into the mechanisms of steroid hormone action resulted in a tremendous number of pUblications from which new principles of preventive and therapeutic appli cations of estrogens and anti estrogens emerged. Although various electronic data bases provide easy access to this copious information, there was a clear necessity for a monograph-style textbook which assesses and summarizes current knowledge in this rapidly expanding field of research. It should be noted, however, that, due to this dynamic development, it is barely possible to comprehensively update every aspect of basic and clinical knowledge on estro gens and antiestrogens. Thus, the intention of the editors was to provide the reader with an overview of the "classic" and most recently explored areas of research and stimulate future interests in basic and applied endocrinology. Estrogens were among the first steroid hormones described in the scientific literature. Since they were first isolated, since the chemical, synthesic and pharmacological characterization of naturally occurring estrogens and, later on, of orally active derivatives, estrogen research has produced continu ously hallmark results in reproductive endocrinology worldwide.

Color Atlas of Pharmacology

Author: Heinz Lüllmann
Publisher: Thieme
ISBN: 3132411434
Format: PDF, ePub, Mobi
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The Fifth Edition of Luellmann's Color Atlas of Pharmacology has been extensively revised to include all recent advances and new drugs, and the illustrations have been optimized and updated. Each two-page spread presents concise text on the left complemented by detailed full-color illustrations on the right to help users quickly digest important facts and concepts. Color-coded sections provide readers with a helpful framework with which to approach the latest developments in pharmacology. Part 1, General Pharmacology, explains basic aspects, such as drug absorption, distribution, and elimination, along with the molecular mechanisms of drug actions Part 2, Systems Pharmacology, presents the different groups of drugs, emphasizing their functional and therapeutic aspects Part 3, Therapy of Selected Diseases, provides all the relevant information regarding the pharmacological treatment of a large number of conditions Key features: User-friendly format ideal for study and review, self-assessment, and quick reference Completely revised and updated, with 174 color plates New glossary of important and interesting pharmacological terms Updated detailed drug indexes containing current information on drugs listed by both generic and brand names The Fifth Edition of Color Atlas of Pharmacology is an essential study guide and reference for every student, nurse, and practicing physician needing to keep up to date with recent advances in the field.

Endocrinology

Author: Shlomo Melmed
Publisher: Springer Science & Business Media
ISBN: 1592598293
Format: PDF, ePub
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Maintaining the original goal of the first edition to integrate the basic science of endocrinology with its physiological and clinical principles, this new edition succinctly summarizes in 450 pages the latest findings on hormone secretion and hormone action, as well as all the most recent insights into the physiology and pathophysiology of hormonal disorders. Coverage extends across the entire spectrum of endocrinology-from mammalian cells, plants, and insects to animal models and human diseases-with much increased coverage of diabetes and metabolism. Highlights include cutting-edge discussions of appetite disorders, obesity, reproductive failure, control of thyroid function, hormone action in man and the lower species, and the mechanisms subserving hormone secretion.

Flavonoids in the Living System

Author: John Manthey
Publisher: Springer Science & Business Media
ISBN: 1461553350
Format: PDF, Docs
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The presence of contaminant flavonoids in vitamin C preparations from citrus fruits initially led Szent-Gyorgyi and his collaborators to suggest that a flavonoid compound, with biological activity for the prevention of capillary fragility, was vitamin P. Later re search, although not disproving biological activity, discontinued the use of the vitamin classification for these compounds. However, the ubiquitous distribution of flavonoids in living organisms, and the continued discovery of various activity in biological systems makes these compounds targets of wide ranging investigation. This volume is primarily based on a Symposium on Flavonoids and related com pounds held during the 212th National Meeting of the American Chemical Society held in Orlando, Florida on August 28-29, 1996 under the sponsorship of the Division of Agricul tural and Food Chemistry. While the book is not intended to be a comprehensive volume on flavonoid research, the papers provide various approaches to exploring the biological functions of flavonoids in plants and animals, their chemical modifications for enhanced activity, some analytical techniques, as well as their use in food classification. A signifi cant portion is devoted to medicinal implications of these compounds. The organizers would like to express their appreciation to Tropicana Products, Inc., Bradenton, Florida, Coca-Cola Foods Division, Plymouth, Florida and the American Chemical Society's Division of Agricultural and Food Chemistry for financial support. Of course, the book could not be produced without the authors, whose cooperation and pa tience is greatly appreciated.

Essentials of Medical Pharmacology

Author: KD Tripathi
Publisher: JP Medical Ltd
ISBN: 9350259370
Format: PDF, ePub, Mobi
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This new edition has been fully revised to bring pharmacologists and trainees fully up to date with the latest developments in the field of medical pharmacology. Beginning with an introduction to general pharmacological principles, the following sections discuss drugs for common and less common disorders found in different regions of the body. The seventh edition includes new drugs, as well as the latest therapeutic guidelines from authoritative sources such as the World Health Organisation (WHO) and the British National Formulary (BNF). Each topic includes key point summary boxes as well as illustrations, flowcharts and tables to enhance learning. A ‘problem-directed study’ question at the end of each chapter helps trainees test their knowledge. An extensive appendices section includes a list of essential medicines, drugs that should/shouldn’t be prescribed in pregnancy and lactation, and suggestions for further reading. Key points Fully revised, new edition presenting latest developments in medical pharmacology Includes therapeutic guidelines from WHO and BNF Problem-directed study questions and key point summary boxes enhance learning Previous edition published in 2008

Medicinal Chemistry

Author: Thomas Nogrady
Publisher: Oxford University Press
ISBN: 0190282967
Format: PDF
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Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

Clinical Toxicology

Author: Frank A. Barile
Publisher: CRC Press
ISBN: 142009226X
Format: PDF, Kindle
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Examining the complex interactions associated with clinical toxicological events and chemical exposure of drug administration, this updated and revised Second Edition functions as a stand-alone text or reference of clinical toxicology for professionals, students of toxicology and pharmacy, as well as forensic toxicologists, occupational healthcare workers, industrial hygienists, and safety engineers. This all-inclusive source has been updated to include the latest issues and the most current research in clinical toxicology. Key features in Clinical Toxicology: Principles and Mechanisms include: Convenient and organized categorization of compounds into therapeutic and non-therapeutic agents Tables, drawings, and figures that provide readily accessible, precise data Tables for easy usage and cross-reference to names, indications, effects, adverse reactions, and drug interactions for over 70 common herbal products The brand, generic, and street names of therapeutic agents Topics covered in the Second Edition include: Symptoms of diseases and pathology caused by toxins and clinical drugs Biological and chemical toxins, changes in protocols for managing toxic ingestions, new antidotes, changes in treatments, and the pharmacology and toxicology of herbal products The effects of biological and chemical agents cited by the U.S. and U.N. as potential bioterrorist weapons General physiology and pharmacology principles The widely distributed chemical agents and currently used therapeutic drugs that have hazardous effects

Medical Parasitology

Author: Rohela Mahmud
Publisher: Springer
ISBN: 3319687956
Format: PDF, Docs
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This textbook will provide a systematic comprehension of the various medically important human parasites; their distribution, habitat, morphology and life cycle, pathogenesis and clinical features, laboratory diagnosis, treatment, prevention and control. The main emphasis is on the protozoan and helminthic diseases, also medical entomology covering vectors relevant to these diseases. The book aims to promote an easy yet comprehensive way of learning parasitology. It attempts to break down the complexity of medical parasitology into parts that are easy to understand yet integrating the essential information of parasitic infections. The integration of knowledge of parasites will be achieved through student friendly illustrations, inclusion of a collection of recent case reports, examples of test questions and scenarios, and the images of human parasites. Essentially, it provides a “one-stop learning package” for medical parasitology.