Principles of Biochemical Toxicology Third Edition

Author: John Timbrell
Publisher: CRC Press
ISBN: 0748407367
Format: PDF, Mobi
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Research into the biochemical basis of toxicology has expanded rapidly over recent years, amidst concerns over the adverse effects of drugs, environmental pollution and occupational hazards. Following on from the acclaimed first two editions of Principles of Biochemical Toxicology, John Timbrell has expanded the text to include: summary sections questions and model answers thoroughly revised artwork These features, plus the new easy-to-read format will make biochemical toxicology more accessible to undergraduates and postgraduates coming across the subject for the first time, particularly when undertaking self-directed study. This comprehensive textbook provides a thorough explanation of dose-response relationships; disposition and metabolism; toxic responses to foreign compounds, and detailed examples to illustrate mechanisms of toxicity. There is also an expanded and updated bibliography, directing the reader to further reading if required. Students and lecturers will find the clear and concise approach, which established this book as the leading textbook in its field, an essential aid to learning and teaching.

Molecular and Biochemical Toxicology

Author: Robert C. Smart
Publisher: John Wiley & Sons
ISBN: 1118679725
Format: PDF, ePub, Mobi
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An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth Edition. Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style. Additional features of this new edition include: New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomics Increased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transporters Additional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicity Molecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects.

Principles of Ecotoxicology Fourth Edition

Author: C.H. Walker
Publisher: CRC Press
ISBN: 1439862664
Format: PDF
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Cutting across traditional subject boundaries, Principles of Ecotoxicology, Fourth Edition gives readers an integrated view of ecotoxicology, from molecules to ecosystems. This new edition of a bestselling textbook continues to emphasize principles rather than practice, providing the interdisciplinary perspective and grounding required for research. Organized into three sections, the book first describes the molecular structures, properties, and environmental fate of pollutants. It then deals with the effects of pollutants on living organisms at the molecular, cellular, and individual levels. Moving into population biology and population genetics, the third part of the book addresses a question of great interest to ecologists: What effects do pollutants have at the levels of population, community, and the whole ecosystem? The book also looks at how ecotoxicology is used in the biomonitoring of environmental pollution, the investigation of pollution problems, the conducting of field trials, the study of the development of resistance, and the growing area of environmental risk assessments. Throughout, examples and case studies illustrate the principles. This updated fourth edition includes new material on nanoparticle pollution, bioaccumulation, biomarkers, and chemical warfare in nature, as well as a new chapter on the future directions of ecotoxicology. A concise textbook that will also appeal to practicing ecotoxicologists, it provides a solid basis for understanding what happens to chemicals in the real world, where they go, how they ultimately degrade, and how they affect the individuals and populations that encounter them. What’s New in This Edition Revised and updated material throughout A chapter on future directions of ecotoxicology New material on nanoparticle pollution and chemical warfare in nature Expanded coverage of bioaccumulation, biomarkers, and risk assessment for affected populations More case studies, many from the United States Discussion of neurotoxic and behavioral effects of pollutants Recent research on the decline of vultures and effects of neonicotinoids on bees Organic Pollutants: An Ecotoxicological Perspective, Second Edition (CRC Press, 2008), a companion volume to this book, covers the mechanistic aspects of ecotoxicology in more depth.

Handbook on the Toxicology of Metals

Author: Monica Nordberg
Publisher: Elsevier
ISBN: 9780080546100
Format: PDF, ePub
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Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health. This new edition is a comprehensive review of the effects on biological systems from metallic elements and their compounds. An entirely new structure and illustrations represent the vast array of advancements made since the last edition. Special emphasis has been placed on the toxic effects in humans with chapters on the diagnosis, treatment and prevention of metal poisoning. This up-to-date reference provides easy access to a broad range of basic toxicological data and also gives a general introduction to the toxicology of metallic compounds. * Covers up-to-date toxicological information on 31 metallic elements and their compounds, each in a separate chapter * New chapters on general chemistry, biological monitoring and biomarkers, essential metals, principles for prevention of the toxic effects of metals, and more

An Introduction to Environmental Toxicology Second Edition

Author: Michael H. Dong
Publisher: Createspace Independent Pub
ISBN: 9781477666487
Format: PDF, ePub, Mobi
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An Introduction to Environmental Toxicology Second Edition, like the first (student) edition, provides a general introductory text on the basic concepts of and general principles for environmental toxicology. To this end, the book is organized into 23 chapters in four parts:I. Toxicologic Concepts and Environmental Concerns (Chapters 1 – 5);II. Bioaccumulation and Biodisposition of Toxicants (Chapters 6 – 10);III. Nature and Effects of Environmental Toxicants (Chapters 11 – 17); andIV. General Considerations and Special Foci (Chapters 18 – 23).The book is an introduction to the basic principles, concepts, and issues for and of environmental toxicology intended for undergraduates majoring in environmental toxicology, environmental sciences, or a related field, as well as for graduate students taking a course in environmental toxicology as an elective. The book is also intended as a supplementary reading material for students whose instructor prefers to use her/his own lecture notes as text materials for their course. Students using this book are expected to have already completed a course in general biology and a course in general chemistry.The book is written as a primer covering lecture materials for a course of 3 to 6 semester units. The 23 chapters, totaling more than 450 pages, are arranged in a way that the reader is provided with the best flow and mode of comprehension, with each chapter including a set of review questions. Listed below are the chapter titles: 1. Scope and Principles for Environmental Toxicology 2. Environmental Changes and Environmental Health 3. Environmental Pollution and Regulatory Agencies 4. Occurrence and Types of Environmental Toxicants 5. Fate and Transport of Toxicants in the Environment 6. Bioaccumulation of Persistent Environmental Toxicants 7. Uptake and Distribution of Toxicants 8. Metabolism/Biotransformation of Xenobiotics 9. Adverse Action/Toxic Response10. Factors and Conditions Affecting Toxicity11. Air Pollutants – I. Inorganic Gases12. Air Pollutants – II. Particulate Matter13. Volatile Organic Compounds14. Toxic and Radioactive Metals15. Pesticides and Pesticide Residues16. Persistent Toxic Substances17. Biological and Physical Toxic Agents18. Environmental Mutagenesis/Carcinogenesis19. Reproductive Toxicity and Endocrine Disruption20. Industrial Chemicals/Occupational Toxicology21. Food Toxicants/Toxic Household Substances22. Human Health Aspects of Ecotoxicology23. Environmental Health Risk Assessment

A Textbook of Modern Toxicology

Author: Ernest Hodgson
Publisher: John Wiley & Sons
ISBN: 1118211294
Format: PDF, Docs
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A Textbook of Modern Toxicology is a unique resource that provides both students and practitioners with a wide-ranging, accessible overview of the discipline. Suitable for courses in environmental, pharmacological, medical, and veterinary toxicology, this essential text features chapters written by experts who address a range of key topics. The Fourth Edition includes additional chapters on new approaches to toxicology - molecular methods (-omics: toxicogenomics, proteomics, and metabolomics), bioinformatics, and systems biology – and continues the legacy of its predecessors to provide up-to-date insights into acute toxicity and chemical carcinogenesis, organ toxicity, in vitro and in vivo toxicity testing, ecological risk assessment, and many other areas of toxicology that help foster a solid comprehension of the field. Also featured in the Fourth Edition are end-of-chapter questions and a Solutions Manual available separately for academic adopters.

Introduction to Toxicology Third Edition

Author: John Timbrell
Publisher: CRC Press
ISBN: 9780415247634
Format: PDF
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Since the publication of the first edition of Introduction to Toxicology , toxicology has become a more mature science, the number of undergraduate and postgraduate courses has increased and thus the need for a regularly updated introductory text has become more pressing. This third edition caters for this need in a clear and easy-to-read style, featuring: * Up-to-the-minute information * Relevant toxicological examples that reinforce principles * End-of-chapter essay questions * New and redrawn illustrations * Glossary of terms * Extensively revised bibliography The fundamental principles of absorption, distribution, metabolism and excretion are described in the introductory chapters, as are the types of exposure and response. In subsequent chapters these are clarified with the use of carefully chosen examples. Among the topics considered are the potential adverse effects of drugs, pesticides, food additives and industrial chemicals.

Information Resources in Toxicology

Author: Philip Wexler
Publisher: Academic Press
ISBN: 0127447709
Format: PDF, ePub, Mobi
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Information Resources in Toxicology, Third Edition is a sourcebook for anyone who needs to know where to find toxicology information. It provides an up-to-date selective guide to a large variety of sources--books, journals, organizations, audiovisuals, internet and electronic sources, and more. For the Third Edition, the editors have selected, organized, and updated the most relevant information available. New information on grants and other funding opportunities, physical hazards, patent literature, and technical reports have also been added. This comprehensive, time-saving tool is ideal for toxicologists, pharmacologists, drug companies, testing labs, libraries, poison control centers, physicians, legal and regulatory professionals, and chemists. Key Features * Serves as an all-in-one resource for toxicology information * New edition includes information on publishers, grants and other funding opportunities, physical hazards, patent literature, and technical reports * Updated to include the latest internet and electronic sources, e-mail addresses, etc. * Provides valuable data about the new fields that have emerged within toxicological research; namely, the biochemical, cellular, molecular, and genetic aspects

Principles and Methods of Toxicology Fifth Edition

Author: A. Wallace Hayes
Publisher: CRC Press
ISBN: 9780849337789
Format: PDF, ePub, Mobi
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Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.

Hayes Principles and Methods of Toxicology Sixth Edition

Author: A. Wallace Hayes
Publisher: CRC Press
ISBN: 1842145363
Format: PDF, Mobi
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Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk. The book begins with the four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field. New topics in this edition include: The importance of dose–response Systems toxicology Food safety The humane use and care of animals Neurotoxicology The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.