Redox Proteomics

Author: Isabella Dalle-Donne
Publisher: John Wiley & Sons
ISBN: 0471973114
Format: PDF, ePub
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Methodology and applications of redox proteomics The relatively new and rapidly changing field of redox proteomicshas the potential to revolutionize how we diagnose disease, assessrisks, determine prognoses, and target therapeutic strategies forpeople with inflammatory and aging-associated diseases. Thiscollection brings together, in one comprehensive volume, a broadarray of information and insights into normal and alteredphysiology, molecular mechanisms of disease states, and newapplications of the rapidly evolving techniques ofproteomics. Written by some of the finest investigators in this area, RedoxProteomics: From Protein Modifications to Cellular Dysfunction andDiseases examines the key topics of redox proteomics and redoxcontrol of cellular function, including: * The role of oxidized proteins in various disorders * Pioneering studies on the development of redox proteomics * Analytical methodologies for identification and structuralcharacterization of proteins affected by oxidative/nitrosativemodifications * The response and regulation of protein oxidation in differentcell types * The pathological implications of protein oxidation forconditions, including asthma, cardiovascular disease, diabetes,preeclampsia, and Alzheimer's disease Distinguished by its in-depth discussions, balanced methodologicalapproach, and emphasis on medical applications and diagnosisdevelopment, Redox Proteomics is a rich resource for allprofessionals with an interest in proteomics, cellular physiologyand its alterations in disease states, and related fields.

Applications of Advanced Omics Technologies From Genes to Metabolites

Author:
Publisher: Elsevier
ISBN: 0444626697
Format: PDF, Mobi
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The book contains contributions concerning the application of the new instrumental and methodological developments in omics technologies, including those related to Genomics, Transcriptomics, Proteomics, Peptidomics and Metabolomics, Lipidomics and Foodomics. The16 chapters discuss in detail: innovative applications of functional gene microarrays for profiling microbial communities, microRNA profiling, novel genotyping applications using microarray technology in cancer research, next-generation sequencing applied to the study of human microbiome, emerging RNA-SEQ applications in food science, recent progress in plant proteomics, applications of gel-free proteomic approaches, the challenges and applications of proteomics tools for food authenticity, the role of salivary peptidomics in clinical applications, metabolomic approaches to the study of degenerative, cardiovascular and renal diseases, and neonatal medicine. Also covered are other omics applications such as profiling of genetically modified organisms, the fundamentals, applications and challenges of foodomics, and MS-based lipidomics. Moreover, this volume includes relevant and updated aspects on bioinformatics, data treatment, data integration and systems biology. This book complements the previous volume "Fundamentals of Advanced Omics Technologies: New Advances from Genes to Metabolites" that covered the fundamental aspects of these new omics technologies. Describes the latest applications of omics technologies Provides an excellent reference for applications of advanced omics techniques Includes advanced tools and methodologies for dealing with the data generated

Nutrigenomics and Proteomics in Health and Disease

Author: Martin Kussmann
Publisher: John Wiley & Sons
ISBN: 1119101263
Format: PDF, ePub
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Now in a revised second edition, Nutrigenomics and Proteomics in Health and Disease brings together the very latest science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals and their impact on gene interaction and health. Authored by an international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date. Thoroughly updated to reflect the most current developments in the field, the second edition includes six new chapters covering gut health and the personal microbiome; gut microbe-derived bioactive metabolites; proteomics and peptidomics in nutrition; gene selection for nutrigenomic studies; gene-nutrient network analysis, and nutrigenomics to nutritional systems biology. An additional five chapters have also been significantly remodelled. The new text includes a rethinking of in vitro and in vivo models with regard to their translatability into human phenotypes, and normative science methods and approaches have been complemented by more comprehensive systems biology-based investigations, deploying a multitude of omic platforms in an integrated fashion. Innovative tools and methods for statistical treatment and biological network analysis are also now included.

Yeast Gene Analysis

Author:
Publisher: Academic Press
ISBN: 9780080919133
Format: PDF, Kindle
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Focusing on Saccharomyces cerevisiae, the second edition of Yeast Gene Analysis represents a major reworking of the original edition, with many completely new chapters and major revisions to all previous chapters. Originally published shortly after completion of the yeast genome sequence, the new edition covers many of the major genome-wide strategies that have been developed since then such as microarray analysis of transcription, synthetic gene array studies, protein microarrays and chemical genetic approaches. It represents a valuable resource for any research laboratory using budding yeast as their experimental system in which to identify new yeast gene functions. The chapters are written in a readable style with useful background information, technical tips and specific experimental protocols included as appropriate, enabling both the novice and the experienced yeast researcher to adopt new procedures with confidence. New chapters on: * strain construction * genome-wide two-hybrid approaches * use of microarrays for transcript analysis * real-time analysis of chromosome behaviour and FRET * synthetic gene array technology and protein arrays * chemical genomics and yeast prions * RNA gene analysis and mitochondrial gene function analysis * phylogenetic footprinting * discovering human gene function and predicting yeast gene function

Genomics and Proteomics Engineering in Medicine and Biology

Author: Metin Akay
Publisher: Wiley-IEEE Press
ISBN:
Format: PDF, ePub, Mobi
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Current applications and recent advances in genomics and proteomics Genomics and Proteomics Engineering in Medicine and Biology presents a well-rounded, interdisciplinary discussion of a topic that is at the cutting edge of both molecular biology and bioengineering. Compiling contributions by established experts, this book highlights up-to-date applications of biomedical informatics, as well as advancements in genomics-proteomics areas. Structures and algorithms are used to analyze genomic data and develop computational solutions for pathological understanding. Topics discussed include: Qualitative knowledge models Interpreting micro-array data Gene regulation bioinformatics Methods to analyze micro-array Cancer behavior and radiation therapy Error-control codes and the genome Complex life science multi-database queries Computational protein analysis Tumor and tumor suppressor proteins interactions

A Companion to the Philosophy of Biology

Author: Sahotra Sarkar
Publisher: Wiley-Blackwell
ISBN:
Format: PDF, Mobi
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Comprised of essays by top scholars in the field, this volume offers detailed overviews of philosophical issues raised by biology. Brings together a team of eminent scholars to explore the philosophical issues raised by biology Addresses traditional and emerging topics, spanning molecular biology and genetics, evolution, developmental biology, immunology, ecology, mind and behaviour, neuroscience, and experimentation Begins with a thorough introduction to the field Goes beyond previous treatments that focused only on evolution to give equal attention to other areas, such as molecular and developmental biology Represents both an authoritative guide to philosophy of biology, and an accessible reference work for anyone seeking to learn about this rapidly-changing field

Biomedical Informatics in Translational Research

Author: Hai Hu
Publisher: Artech House
ISBN: 159693039X
Format: PDF, Kindle
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This trailblazing resource on biomedical informatics provides medical researchers with innovative techniques for integrating and federating data from clinical and molecular studies. This volume helps researchers manage data, expedite their efforts, and make the most of targeted basic research.

The Oncogenomics Handbook

Author: William J. LaRochelle
Publisher: Springer Science & Business Media
ISBN: 1588294250
Format: PDF, ePub, Docs
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An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.