Quantum Dots for DNA Biosensing

Author: Jun-Jie Zhu
Publisher: Springer Science & Business Media
ISBN: 3642449107
Format: PDF, ePub, Mobi
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This book provides a broad introduction to all major aspects of quantum dot properties including fluorescence, electrochemical, photochemical and electroluminescence. Such properties have been produced for applications in biosensing, cell tracking, in vivo animal imaging and so on. It focuses on their special applications in DNA biosensing and provides readers with detailed information on the preparation and functionalization of quantum dots and the fabrication of DNA biosensors, using examples to show how these properties can be used in DNA biosensor design and the advantages of quantum dots in DNA biosensing. Further new emerging quantum dots such as metal nanoclusters and graphene dots and their applications in DNA biosensing have also been included.

Cellular and Molecular Toxicology of Nanoparticles

Author: Quaiser Saquib
Publisher: Springer
ISBN: 3319720414
Format: PDF, ePub, Docs
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This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and passive penetration, which can affect varied cell types. Readers will be benefited with the compilations on basic and molecular facet of NPs toxicity. The chapters will provide a comprehensive information on the state-of-the-art methodologies. The application of toxicogenomic approaches, which is already established in nanotoxicology, has been given special consideration to unravel the toxicodynamics of nanomaterials. Among these approaches, the high-throughput RNA sequencing (RNA-Seq), which is able to build a complete map of transcriptome across different cell types and perturbations upon NPs exposure has been included. The readers are also introduced to the less studied topic on the adsorption of biomolecules (mainly proteins) on the NPs surface, constituting the so-called “biomolecular corona”. The book has been designed for scientists engaged in NPs toxicity research. Nonetheless, it should be of interest to a variety of scientific disciplines including marine biology, environmental pollution, genetics, pharmacology, medicine, drug and food material sciences, consumer products. Also, the compilations will be of interest to the environmental watchdogs, federal regulators, risk assessors and the policy makers.

Biocompatible Graphene for Bioanalytical Applications

Author: Yuwei Hu
Publisher: Springer
ISBN: 3662456958
Format: PDF, ePub
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This book highlights the latest advances in the use of graphene and bio-compatible-material-decorated graphene to detect various targets (e.g. DNA, RNA, amino acids, peptides, proteins, enzymes, antigens, glucose, DA, AA, UA, ATP, NADH, gas, ions, etc.). It focuses on the specific interaction of these substances with graphene (or modified graphene) and the efficient transduction of the target recognition event into detectable signals via various techniques. Particular emphasis is given to well-designed strategies for constructing graphene-based platforms and target determination. It also covers other bio-analytical applications including cellular imaging, drug delivery and bacteria inhibition, before turning to a discussion of future challenges and prospects of graphene in bio-analytical applications. This book is intended for researchers working in the fields of analytical chemistry, nanomaterials and biomedical engineering. Li Niu is a Professor at the State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences.

Novel Optical Nanoprobes for Chemical and Biological Analysis

Author: Lingxin Chen
Publisher: Springer
ISBN: 3662436248
Format: PDF
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Novel Optical Nanoprobes for Chemical and Biological Analysis starts with a brief introduction to several kinds of versatile nanomaterials with novel optical properties, such as gold/silver nanoparticles, quantum dots, upconversion nanoparticles and graphene. It mainly focuses on the latest sensor design strategies, which apply the optical properties of nanomaterials to various detection techniques including colorimetry, fluorescence, and surface-enhanced Raman scattering (SERS). These sensors are attractive owing to their high sensitivity, high specificity, and potential for easy quantification of targets in many applications, such as conventional chemical and biological analysis, clinical diagnosis, and intracellular system sensing as well as single-molecule detection. The challenges and future perspectives for optical nanoprobes are also presented, such as the increase in sensitivity for real environmental and clinical samples, the design and application of multifunctional nanoplatforms, and biocompatibility of nanomaterials.

Nanozymes Next Wave of Artificial Enzymes

Author: Xiaoyu Wang
Publisher: Springer
ISBN: 3662530686
Format: PDF, ePub, Docs
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This book describes the fundamental concepts, the latest developments and the outlook of the field of nanozymes (i.e., the catalytic nanomaterials with enzymatic characteristics). As one of today’s most exciting fields, nanozyme research lies at the interface of chemistry, biology, materials science and nanotechnology. Each of the book’s six chapters explores advances in nanozymes. Following an introduction to the rise of nanozymes research in the course of research on natural enzymes and artificial enzymes in Chapter 1, Chapters 2 through 5 discuss different nanomaterials used to mimic various natural enzymes, from carbon-based and metal-based nanomaterials to metal oxide-based nanomaterials and other nanomaterials. In each of these chapters, the nanomaterials’ enzyme mimetic activities, catalytic mechanisms and key applications are covered. In closing, Chapter 6 addresses the current challenges and outlines further directions for nanozymes. Presenting extensive information on nanozymes and supplemented with a wealth of color illustrations and tables, the book offers an ideal guide for readers from disparate areas, including analytical chemistry, materials science, nanoscience and nanotechnology, biomedical and clinical engineering, environmental science and engineering, green chemistry, and novel catalysis.

Nanoparticles in Lung Cancer Therapy Recent Trends

Author: Abhijit Bandyopadhyay
Publisher: Springer
ISBN: 8132221753
Format: PDF, ePub, Docs
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This brief provides an insight into the present scenario of the role of nanotechnology in the diagnosis and treatment of lung cancer at an early stage. Currently, lung cancer is the subject of major concern owing to the very high mortality rate throughout the world. Most of the conventional treatment methods such as surgery, chemotherapy, radiotherapy, etc., fail to prolong life of the patients. Incidents of recurrence are also very common in case of lung cancer. Researchers have shown that nanoparticles may act as a powerful anti cancer tool, especially for lung cancer. Unique surface properties and easy surface functionalization of nanoparticles enable early detection, diagnosis, imaging and treatment of lung cancer. The authors have elaborately presented how various nanoparticles (natural, semi synthetic and synthetic) may help in the treatment of lung cancer. They have also detailed works of various scientists who succeeded in developing effective nanoparticles and enabled very specific lung cancer therapy without any undesirable side effects and minimized death.

Silicon Nano biotechnology

Author: Yao He
Publisher: Springer Science & Business Media
ISBN: 3642546684
Format: PDF, ePub
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This book reviews the latest advances in the development of silicon nano-biotechnology for biological and biomedical applications, which include biosensing, bioimaging, and cancer therapy. In this book, newly developed silicon nano-biotechnology and its biomedical applications are systematically introduced. For instance, fluorescent silicon nanoparticles, serving as novel high-performance biological nanoprobes, are superbly suited to real-time and long-term bioimaging. Silicon nanowire-based sensing platform is especially capable of sensitive, specific, and multiplexed detection of various biological species. Silicon-based nanocarriers with ultra-high drug-loading capacity are highly efficacious for in vitro and in vivo cancer therapies. This book is intended for readers who are interested in the design of functional silicon nanostructures and their biological and biomedical applications. It uses silicon nanoparticles and silicon nanowires as models and discusses topics ranging from their synthesis to their biological applications, the goal being to highlight these exciting achievements as starting points in the field of silicon nano-biotechnology. Yao He is a Professor at Institute of Functional Nano&Soft Materials (FUNSOM), Soochow University, China. Yuanyuan Su is an Associate Professor at Institute of Functional Nano&Soft Materials (FUNSOM), Soochow University, China.

Electrogenerated Chemiluminescence

Author: Saima Parveen
Publisher: Springer Science & Business Media
ISBN: 3642395554
Format: PDF, ePub, Docs
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This book primarily focuses on the fundamentals of and new developments in electrochemiluminescence (ECL), presenting high-quality content and explicitly aiming to summarize and disseminate the current state-of-the-art. The topics covered include the fundamental theory, mechanism, types of reactions involved, and the instrumental techniques. The book also examines the applications of ECL in many of the emerging fields of science, such as bioanalytical, analytical, clinical, pharmaceutical, forensic, military, microchip, μTAS, and LED. It will be invaluable to bioanalysts, drug analysts, pharmaceutical researchers and other professionals worldwide, as well as to other interested readers.

Nanobiomaterials

Author: Xiumei Wang
Publisher: John Wiley & Sons
ISBN: 3527698655
Format: PDF, Mobi
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Written by an international team of editors and contributors from renowned universities and institutes, this book addresses the latest research in the field of nanobiomaterials, covering nanotechnologies for their fabrication, developments in biomedical applications, and the challenges of biosafety in clinic uses. Clearly structured, the volume defines the scope and classification of the field, resulting in a broad overview from fundamental principles to current technological advances, and from materials synthesis to biomedical applications along with future trends.

Nano Bio Probe Design and Its Application for Biochemical Analysis

Author: Bang-Ce Ye
Publisher: Springer Science & Business Media
ISBN: 3642295436
Format: PDF, ePub
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In this volume, Prof. Ye and his coworkers propose and review the concept of nano-bio probe design for biochemical analysis on the basis of their recent published works. A unique biochemical analysis technology based on fluorescence polarization enhanced by nanoparticles is described here with successful applications in environmental monitoring, rapid and sensitive sensing protease activity and high-throughput screening of inhibitors. Furthermore, they introduce a versatile molecular beacon (MB)-like probe for the multiplex sensing of targets such as sequence-specific DNA, protein, metal ions and small molecule compounds based on the self-assembled biomolecule-graphene conjugates. Besides, some colorimetric and luminescence probes utilizing metal nanoparticles for biochemical applications are also presented, such as chiral enantiomer discrimination and separation, environmental monitoring, clinic diagnosis and etc.