Relationship Inference with Familias and R

Author: Thore Egeland
Publisher: Academic Press
ISBN: 012802626X
Format: PDF, ePub, Mobi
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Relationship Inference in Familias and R discusses the use of Familias and R software to understand genetic kinship of two or more DNA samples. This software is commonly used for forensic cases to establish paternity, identify victims or analyze genetic evidence at crime scenes when kinship is involved. The book explores utilizing Familias software and R packages for difficult situations including inbred families, mutations and missing data from degraded DNA. The book additionally addresses identification following mass disasters, familial searching, non-autosomal marker analysis and relationship inference using linked markers. The second part of the book focuses on more statistical issues such as estimation and uncertainty of model parameters. Although written for use with human DNA, the principles can be applied to non-human genetics for animal pedigrees and/or analysis of plants for agriculture purposes. The book contains necessary tools to evaluate any type of forensic case where kinship is an issue. This volume focuses on the core material and omits most general background material on probability, statistics and forensic genetics Each chapter includes exercises with available solutions The web page familias.name contains supporting material

The R Book

Author: Michael J. Crawley
Publisher: John Wiley & Sons
ISBN: 1118448960
Format: PDF, Mobi
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Hugely successful and popular text presenting an extensive and comprehensive guide for all R users The R language is recognized as one of the most powerful and flexible statistical software packages, enabling users to apply many statistical techniques that would be impossible without such software to help implement such large data sets. R has become an essential tool for understanding and carrying out research. This edition: Features full colour text and extensive graphics throughout. Introduces a clear structure with numbered section headings to help readers locate information more efficiently. Looks at the evolution of R over the past five years. Features a new chapter on Bayesian Analysis and Meta-Analysis. Presents a fully revised and updated bibliography and reference section. Is supported by an accompanying website allowing examples from the text to be run by the user. Praise for the first edition: ‘…if you are an R user or wannabe R user, this text is the one that should be on your shelf. The breadth of topics covered is unsurpassed when it comes to texts on data analysis in R.’ (The American Statistician, August 2008) ‘The High-level software language of R is setting standards in quantitative analysis. And now anybody can get to grips with it thanks to The R Book…’ (Professional Pensions, July 2007)

Intelligence Genes and Success

Author: Bernie Devlin
Publisher: Springer Science & Business Media
ISBN: 1461206693
Format: PDF, Docs
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A scientific response to the best-selling The Bell Curve which set off a hailstorm of controversy upon its publication in 1994. Much of the public reaction to the book was polemic and failed to analyse the details of the science and validity of the statistical arguments underlying the books conclusion. Here, at last, social scientists and statisticians reply to The Bell Curve and its conclusions about IQ, genetics and social outcomes.

Strengthening Forensic Science in the United States

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309142393
Format: PDF, ePub, Mobi
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Scores of talented and dedicated people serve the forensic science community, performing vitally important work. However, they are often constrained by lack of adequate resources, sound policies, and national support. It is clear that change and advancements, both systematic and scientific, are needed in a number of forensic science disciplines to ensure the reliability of work, establish enforceable standards, and promote best practices with consistent application. Strengthening Forensic Science in the United States: A Path Forward provides a detailed plan for addressing these needs and suggests the creation of a new government entity, the National Institute of Forensic Science, to establish and enforce standards within the forensic science community. The benefits of improving and regulating the forensic science disciplines are clear: assisting law enforcement officials, enhancing homeland security, and reducing the risk of wrongful conviction and exoneration. Strengthening Forensic Science in the United States gives a full account of what is needed to advance the forensic science disciplines, including upgrading of systems and organizational structures, better training, widespread adoption of uniform and enforceable best practices, and mandatory certification and accreditation programs. While this book provides an essential call-to-action for congress and policy makers, it also serves as a vital tool for law enforcement agencies, criminal prosecutors and attorneys, and forensic science educators.

Interpreting DNA Evidence

Author: Ian Evett
Publisher: Sinauer Associates Incorporated
ISBN: 9780878931552
Format: PDF
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Interpretation of DNA profile matches depends on the use of statistical weights. This text provides the background information in statistics and genetics for the reader to arrive at these weights.

Mathematical and Statistical Methods for Genetic Analysis

Author: Kenneth Lange
Publisher: Springer Science & Business Media
ISBN: 1475727399
Format: PDF, Docs
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Geneticists now stand on the threshold of sequencing the genome in its entirety. The unprecedented insights into human disease and evolution offered by mapping and sequencing are transforming medicine and agriculture. This revolution depends vitally on the contributions made by applied mathematicians, statisticians, and computer scientists. Kenneth Lange has written a book to enable graduate students in the mathematical sciences to understand and model the epidemiological and experimental data encountered in genetics research. Mathematical, statistical, and computational principles relevant to this task are developed hand-in-hand with applications to gene mapping, risk prediction, and the testing of epidemiological hypotheses. The book covers many topics previously only accessible in journal articles, such as pedigree analysis algorithms, Markov chain, Monte Carlo methods, reconstruction of evolutionary trees, radiation hybrid mapping, and models of recombination. The whole is backed by numerous exercise sets.

Advanced Topics in Forensic DNA Typing Interpretation

Author: John M. Butler
Publisher: Academic Press
ISBN: 012405854X
Format: PDF, Docs
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Advanced Topics in Forensic DNA Typing: Interpretation builds upon the previous two editions of John Butler’s internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. Intended as a third-edition companion to the Fundamentals of Forensic DNA Typing volume published in 2010 and Advanced Topics in Forensic DNA Typing: Methodology published in 2012, this book contains 16 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field. Over 80 % of the content of this book is new compared to previous editions. Provides forensic DNA analysts coverage of the crucial topic of DNA mixture interpretation and statistical analysis of DNA evidence Worked mixture examples illustrate the impact of different statistical approaches for reporting results Includes allele frequencies for 24 commonly used autosomal STR loci, the revised Quality Assurance Standards which went into effect September 2011

Introduction to Computational Genomics

Author: Nello Cristianini
Publisher: Cambridge University Press
ISBN: 1139460153
Format: PDF
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Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.

Data Analysis and Graphics Using R

Author: John Maindonald
Publisher: Cambridge University Press
ISBN: 1139486675
Format: PDF, Docs
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Discover what you can do with R! Introducing the R system, covering standard regression methods, then tackling more advanced topics, this book guides users through the practical, powerful tools that the R system provides. The emphasis is on hands-on analysis, graphical display, and interpretation of data. The many worked examples, from real-world research, are accompanied by commentary on what is done and why. The companion website has code and datasets, allowing readers to reproduce all analyses, along with solutions to selected exercises and updates. Assuming basic statistical knowledge and some experience with data analysis (but not R), the book is ideal for research scientists, final-year undergraduate or graduate-level students of applied statistics, and practising statisticians. It is both for learning and for reference. This third edition expands upon topics such as Bayesian inference for regression, errors in variables, generalized linear mixed models, and random forests.