Relationship Inference with Familias and R

Author: Thore Egeland
Publisher: Academic Press
ISBN: 012802626X
Format: PDF, Docs
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Relationship Inference in Familias and R discusses the use of Familias and R software to understand genetic kinship of two or more DNA samples. This software is commonly used for forensic cases to establish paternity, identify victims or analyze genetic evidence at crime scenes when kinship is involved. The book explores utilizing Familias software and R packages for difficult situations including inbred families, mutations and missing data from degraded DNA. The book additionally addresses identification following mass disasters, familial searching, non-autosomal marker analysis and relationship inference using linked markers. The second part of the book focuses on more statistical issues such as estimation and uncertainty of model parameters. Although written for use with human DNA, the principles can be applied to non-human genetics for animal pedigrees and/or analysis of plants for agriculture purposes. The book contains necessary tools to evaluate any type of forensic case where kinship is an issue. This volume focuses on the core material and omits most general background material on probability, statistics and forensic genetics Each chapter includes exercises with available solutions The web page familias.name contains supporting material

Intelligence Genes and Success

Author: Bernie Devlin
Publisher: Springer Science & Business Media
ISBN: 1461206693
Format: PDF, ePub, Mobi
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A scientific response to the best-selling The Bell Curve which set off a hailstorm of controversy upon its publication in 1994. Much of the public reaction to the book was polemic and failed to analyse the details of the science and validity of the statistical arguments underlying the books conclusion. Here, at last, social scientists and statisticians reply to The Bell Curve and its conclusions about IQ, genetics and social outcomes.

Strengthening Forensic Science in the United States

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309142393
Format: PDF
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Scores of talented and dedicated people serve the forensic science community, performing vitally important work. However, they are often constrained by lack of adequate resources, sound policies, and national support. It is clear that change and advancements, both systematic and scientific, are needed in a number of forensic science disciplines to ensure the reliability of work, establish enforceable standards, and promote best practices with consistent application. Strengthening Forensic Science in the United States: A Path Forward provides a detailed plan for addressing these needs and suggests the creation of a new government entity, the National Institute of Forensic Science, to establish and enforce standards within the forensic science community. The benefits of improving and regulating the forensic science disciplines are clear: assisting law enforcement officials, enhancing homeland security, and reducing the risk of wrongful conviction and exoneration. Strengthening Forensic Science in the United States gives a full account of what is needed to advance the forensic science disciplines, including upgrading of systems and organizational structures, better training, widespread adoption of uniform and enforceable best practices, and mandatory certification and accreditation programs. While this book provides an essential call-to-action for congress and policy makers, it also serves as a vital tool for law enforcement agencies, criminal prosecutors and attorneys, and forensic science educators.

Interpreting DNA Evidence

Author: Ian Evett
Publisher: Sinauer Associates Incorporated
ISBN: 9780878931552
Format: PDF
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Interpretation of DNA profile matches depends on the use of statistical weights. This text provides the background information in statistics and genetics for the reader to arrive at these weights.

Mathematical and Statistical Methods for Genetic Analysis

Author: Kenneth Lange
Publisher: Springer Science & Business Media
ISBN: 1475727399
Format: PDF, ePub, Mobi
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Geneticists now stand on the threshold of sequencing the genome in its entirety. The unprecedented insights into human disease and evolution offered by mapping and sequencing are transforming medicine and agriculture. This revolution depends vitally on the contributions made by applied mathematicians, statisticians, and computer scientists. Kenneth Lange has written a book to enable graduate students in the mathematical sciences to understand and model the epidemiological and experimental data encountered in genetics research. Mathematical, statistical, and computational principles relevant to this task are developed hand-in-hand with applications to gene mapping, risk prediction, and the testing of epidemiological hypotheses. The book covers many topics previously only accessible in journal articles, such as pedigree analysis algorithms, Markov chain, Monte Carlo methods, reconstruction of evolutionary trees, radiation hybrid mapping, and models of recombination. The whole is backed by numerous exercise sets.

Common Errors in Statistics and How to Avoid Them

Author: Phillip I. Good
Publisher: John Wiley & Sons
ISBN: 1118360117
Format: PDF, Docs
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Praise for Common Errors in Statistics (and How to Avoid Them) "A very engaging and valuable book for all who use statistics in any setting." —CHOICE "Addresses popular mistakes often made in data collection and provides an indispensable guide to accurate statistical analysis and reporting. The authors' emphasis on careful practice, combined with a focus on the development of solutions, reveals the true value of statistics when applied correctly in any area of research." —MAA Reviews Common Errors in Statistics (and How to Avoid Them), Fourth Edition provides a mathematically rigorous, yet readily accessible foundation in statistics for experienced readers as well as students learning to design and complete experiments, surveys, and clinical trials. Providing a consistent level of coherency throughout, the highly readable Fourth Edition focuses on debunking popular myths, analyzing common mistakes, and instructing readers on how to choose the appropriate statistical technique to address their specific task. The authors begin with an introduction to the main sources of error and provide techniques for avoiding them. Subsequent chapters outline key methods and practices for accurate analysis, reporting, and model building. The Fourth Edition features newly added topics, including: Baseline data Detecting fraud Linear regression versus linear behavior Case control studies Minimum reporting requirements Non-random samples The book concludes with a glossary that outlines key terms, and an extensive bibliography with several hundred citations directing readers to resources for further study. Presented in an easy-to-follow style, Common Errors in Statistics, Fourth Edition is an excellent book for students and professionals in industry, government, medicine, and the social sciences.

Modern Multivariate Statistical Techniques

Author: Alan J. Izenman
Publisher: Springer Science & Business Media
ISBN: 9780387781891
Format: PDF
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This is the first book on multivariate analysis to look at large data sets which describes the state of the art in analyzing such data. Material such as database management systems is included that has never appeared in statistics books before.

Advanced Topics in Forensic DNA Typing Interpretation

Author: John M. Butler
Publisher: Academic Press
ISBN: 012405854X
Format: PDF, ePub, Docs
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Advanced Topics in Forensic DNA Typing: Interpretation builds upon the previous two editions of John Butler’s internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. Intended as a third-edition companion to the Fundamentals of Forensic DNA Typing volume published in 2010 and Advanced Topics in Forensic DNA Typing: Methodology published in 2012, this book contains 16 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field. Over 80 % of the content of this book is new compared to previous editions. Provides forensic DNA analysts coverage of the crucial topic of DNA mixture interpretation and statistical analysis of DNA evidence Worked mixture examples illustrate the impact of different statistical approaches for reporting results Includes allele frequencies for 24 commonly used autosomal STR loci, the revised Quality Assurance Standards which went into effect September 2011

Conservation and the Genetics of Populations

Author: Fred W. Allendorf
Publisher: John Wiley & Sons
ISBN: 1118408578
Format: PDF, Docs
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Loss of biodiversity is among the greatest problems facing the world today. Conservation and the Genetics of Populations gives a comprehensive overview of the essential background, concepts, and tools needed to understand how genetic information can be used to conserve species threatened with extinction, and to manage species of ecological or commercial importance. New molecular techniques, statistical methods, and computer programs, genetic principles, and methods are becoming increasingly useful in the conservation of biological diversity. Using a balance of data and theory, coupled with basic and applied research examples, this book examines genetic and phenotypic variation in natural populations, the principles and mechanisms of evolutionary change, the interpretation of genetic data from natural populations, and how these can be applied to conservation. The book includes examples from plants, animals, and microbes in wild and captive populations. This second edition contains new chapters on Climate Change and Exploited Populations as well as new sections on genomics, genetic monitoring, emerging diseases, metagenomics, and more. One-third of the references in this edition were published after the first edition. Each of the 22 chapters and the statistical appendix have a Guest Box written by an expert in that particular topic (including James Crow, Louis Bernatchez, Loren Rieseberg, Rick Shine, and Lisette Waits). This book is essential for advanced undergraduate and graduate students of conservation genetics, natural resource management, and conservation biology, as well as professional conservation biologists working for wildlife and habitat management agencies. Additional resources for this book can be found at: www.wiley.com/go/allendorf/populations.