Relaxin and Related Peptides

Author: Alexander I. Agoulnik
Publisher: Springer Science & Business Media
ISBN: 9780387746722
Format: PDF, ePub, Docs
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This comprehensive book contains the latest information on diverse biological functions of relaxin and related peptide found since the recent discovery of relaxin receptors. It also describes the evolution of relaxin family peptides and their receptors, molecular mechanisms of ligand/receptor interaction and the analysis of activated signaling pathways.

Relaxin and Related Peptides

Author: Gillian D. Bryant-Greenwood
Publisher: Wiley-Blackwell
ISBN:
Format: PDF, ePub, Docs
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Relaxin is a protein hormone, produced and secreted during pregnancy in mammalian species, having superficial structural features resembling those of insulin. Since its initial isolation from the ovaries of pregnant pigs in 1976, increasing interest in relaxin has led to increased understanding of the chemistry, synthesis, secretion, biological roles, mechanisms of action, and potential clinical applications of relaxin in humans and domestic animals. In pigs, rats, and mice, relaxin promotes growth and softening of the cervix, enabling rapid and safe delivery of the fetuses. In these species relaxin also promotes growth and development of the mammary apparatus. Recently, biological effects of relaxin in the heart, kidney, liver, and brain have been identified, and these discoveries have triggered additional interest in possible clinical applications for relaxin. In 2002, a second form of relaxin, which is found primarily in the brain, was discovered. Relaxin-like factor (also called insulin 3), which was discovered in 1993, is produced in the fetal testis and plays a major role in testicular descent during development. The recent identification of the receptors for both relaxin and relaxin-like factor has enabled more rigorous studies of the target tissues and mechanisms of action of these hormones. This volume contains a description of recent advances and future research and clinical possibilities in the field of relaxin and related peptides. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Relaxin and Related Peptides

Author: O. David Sherwood
Publisher: Wiley-Blackwell
ISBN: 9781573314855
Format: PDF, ePub, Docs
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Relaxin is a protein hormone, produced and secreted duringpregnancy in mammalian species, having superficial structuralfeatures resembling those of insulin. Since its initial isolationfrom the ovaries of pregnant pigs in 1976, increasing interest inrelaxin has led to increased understanding of the chemistry,synthesis, secretion, biological roles, mechanisms of action, andpotential clinical applications of relaxin in humans and domesticanimals. In pigs, rats, and mice, relaxin promotes growth and softeningof the cervix, enabling rapid and safe delivery of the fetuses. Inthese species relaxin also promotes growth and development of themammary apparatus. Recently, biological effects of relaxin in the heart, kidney,liver, and brain have been identified, and these discoveries havetriggered additional interest in possible clinical applications forrelaxin. In 2002, a second form of relaxin, which is foundprimarily in the brain, was discovered. Relaxin-like factor (also called insulin 3), which wasdiscovered in 1993, is produced in the fetal testis and plays amajor role in testicular descent during development. The recentidentification of the receptors for both relaxin and relaxin-likefactor has enabled more rigorous studies of the target tissues andmechanisms of action of these hormones. This volume contains a description of recent advances and futureresearch and clinical possibilities in the field of relaxin andrelated peptides. NOTE: Annals volumes are available for sale asindividual books or as a journal. For information on institutionaljournal subscriptions, please visit ahref="http://www.blackwellpublishing.com/nyas"www.blackwellpublishing.com/nyas/a. ACADEMY MEMBERS: Please contact the New York Academyof Sciences directly to place your order (ahref="http://www.nyas.org/"www.nyas.org/a). Members ofthe New York Academy of Science receive full-text access to theAnnals online and discounts on print volumes. Please visit ahref="http://www.nyas.org/MemberCenter/Join.aspx"http://www.nyas.org/MemberCenter/Join.aspx/afor more information about becoming a member.

Relaxin 2000

Author: Geoffrey W. Tregear
Publisher: Springer Science & Business Media
ISBN: 9401728771
Format: PDF, Kindle
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The first international forum on relaxin was a workshop held in Hawaii in 1980. This was followed by the Kroc Foundation conference in Santa Ynes, California in 1981 and then the First International Congress on the Hormone Relaxin in Florence in 1982. After a hiatus of several years, the Second International Congress on the Hormone Relaxin was held in Adelaide in 1994. Since that time, the enormous advances in molecular biology and protein chemistry have led to a stellar growth in relaxin research. Novel sites of action of the hormone have been elucidated, numerous new mammalian primary structures determined, more detailed mechanisms of action postulated, the control of relaxin secretion better understood, non-pregnant roles of the hormone identified, and, importantly, relaxin-related peptides (particularly INSL 3 and 5) identified and possible synergistic actions with relaxin proposed. A raft of novel clinical applications of relaxin has also been explored. Together, these exciting developments made the time ripe for a third international conference. We were therefore delighted to welcome many colleagues, old and new, at Relaxin 2000, the first international forum on relaxin and related peptides in the new Millennium. This conference, which we hope will now be held every four to five years, was held at the Cable Beach Inter-Continental Resort at the delightful old pearling town of Broome in the far north-west of Australia from 22-27 October, 2000.

Peptides for the New Millennium

Author: Gregg B. Fields
Publisher: Springer Science & Business Media
ISBN: 0306468816
Format: PDF, Kindle
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“Have you tried peptides? Small proteins, the best in the land! Won’t you try peptides? Keep all your body processes in hand! For labor and lactation oxytocin you must buy! Enkephalin always gives a good runner’s high! So won’t you try peptides? Small proteins, the best in the land!” The above words [1], penned by Gary Gisselman to open Peptide Ångst: La Triviata, the opera which made its world premiere on July 1, 1999, also serve as a fitting charge to the th 16 American Peptide Symposium. This latest edition of a premier biennial series was held under the auspices of the American Peptide Society, June 26–July 1, 1999, at the Minneapolis Convention Center, Minneapolis,Minnesota, with the undersigned serving as Co-Chairs. The fortunate coincidence of the calendar allowed us to set as the theme “Peptides for the New Millennium”, and in our judgment, the approximately 1200 participants [2] who converged in the Twin Cities from academic and industrial institutions in 36 countries were treated to an exciting and stimulating conference that left most everyone with an enthusiastic vision for the future of our field. The present Proceedings volume should serve as a handy reference source and succinct snapshot of peptide science at essentially its century mark – the clock having started with the initial contributions of Emil Fischer and Th. Curtius.

Handbook of Hormones

Author: Yoshio Takei
Publisher: Academic Press
ISBN: 0128010673
Format: PDF, ePub, Mobi
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Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research collates fundamental information about the structure and function of hormones from basic biology to clinical use. The handbook offers a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors and signalling pathways, and the biological activities they regulate. The evolution of hormones and gene families is also covered both in the text and in online ancillaries. Users will find simple and visual ways to learn key molecular information. Chapters and online ancillary resources integrate additional sections, providing a comparative molecular, functional, and evolutionary consideration. Provides the only single resource available with concise, yet informative descriptions of hormones in vertebrates, invertebrates, and plants Presents hormones in groups according to their origin, so that readers can easily understand their inter-relation Includes comparative information on the structures and functions of hormones enabling readers to understand both general and specific actions in and across species Ancillary website hosts additional information, including sequence data, comparative data, figures, and tables

Insulin and IGFs

Author:
Publisher: Academic Press
ISBN: 9780080922157
Format: PDF, Docs
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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on insulin and IGFs. *Longest running series published by Academic Press *Contributions by leading international authorities

Knobil and Neill s Physiology of Reproduction

Author: Tony M. Plant
Publisher: Academic Press
ISBN: 012397769X
Format: PDF, ePub
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The Fourth Edition of Knobil & Neill continues to serve as a reference aid for research, to provide the historical context to current research, and most importantly as an aid for graduate teaching on a broad range of topics in human and comparative reproduction. In the decade since the publication of the last edition, the study of reproductive physiology has undergone monumental changes. Chief among these advances are in the areas of stem cell development, signaling pathways, the role of inflammation in the regulatory processes in the various tissues, and the integration of new animal models which have led to a greater understanding of human disease. The new edition synthesizes all of this new information at the molecular, cellular, and organismal levels of organization and present modern physiology a more understandable and comparative context. The Fourth Edition has been extensively revised, reflecting new fundamental advancements in this rapidly advancing field. Provides a common language for researchers across the fields of physiology, endocrinology, and biology to discuss their understanding of reproduction. Saves academic researchers time in quickly accessing the very latest details on reproductive physiology, as opposed to searching through thousands of journal articles.

Amino Acids Peptide and Proteins

Author: E Farkas
Publisher: Royal Society of Chemistry
ISBN: 1849735859
Format: PDF, ePub, Docs
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Amino Acids, Peptides and Proteins comprises a comprehensive review of significant developments at this biology/chemistry interface. Each volume of this Specialist Periodical Report opens with an overview of amino acids and their applications. In keeping with the preceeding volumes in the series, this volume presents contributions from across the globe addressing the hot topics in the field. Disulfide-containing peptides and proteins are investigated by NMR, and mass spectrometry is used to determine inter-peptide distant constraints. Further chapters review the latest literature on antimicrbial peptides, modifications by Cytochrome P450 and the relaxin-family neuropeptides. Self-assembly and the moleculatr recognition of designed peptides are also discussed, and the latest in peptide and protein-based pharmaceuticals are reviewed. Volume editor Max Ryadnov also contributes a chapter on biofunctional peptide design. As the published literature in the field continues to grow, researchers in academia and industry will find this comprehensive review of the current research and thought an essential first point of reference.