Simulated Moving Bed Technology

Author: Alirio Rodrigues
Publisher: Butterworth-Heinemann
ISBN: 0128020512
Format: PDF, ePub, Docs
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Simulated Moving Bed Technology is one of only a few books solely dedicated to SMB. It aims to equip you with the tools and skills needed for SMB modelling, simulation, design and operation. The theory presented is supported by real-world examples from the petrochemical, sugar and pharma industries. The core of the book focuses on SMB process development and model validation. It explains basic process concepts and definitions, fundamental principles and equations, as well as typical applications and recent advances made to address challenges. Its specialist content makes it a must have book for people working with SMB technology, chemical engineering post-graduate students and process and R&D engineers in industry. Will provide you with the tools and predictive approaches for use in SMB design and performance assessment Covers SMB modelling, simulation, design and operation as applied to separation and reaction processes Discusses process intensification through coupling SMB and reaction in SMBR, membrane permeation and SMBR in PermSMBR and introduces the design of SCPC

Continuous Biopharmaceutical Processes

Author: David Pfister
Publisher: Cambridge University Press
ISBN: 1108420222
Format: PDF, Docs
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Provides a coherent and critical view on the potential benefits of various continuous processes in the biopharmaceutical industry.

Design Simulation and Optimization of Adsorptive and Chromatographic Separations A Hands On Approach

Author: Kevin R. Wood
Publisher: John Wiley & Sons
ISBN: 352781499X
Format: PDF, Docs
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This book allows the reader to effectively design, simulate and optimize adsorptive and chromatographic separations for industrial applications. To achieve this, a unified approach is presented, which develops the ideal and intermediate equations necessary, while simultaneously offering hands-on case studies employing the rigorous simulation packages Aspen Adsorption and Aspen Chromatography. The first part of the book deals with design strategies, detailed design considerations and the assumptions, which the models are allowed to make and covers shortcut design methods as well as mathematical tools to determine optimal operating conditions. These insights are used in Chapter 4 & 5 to estimate and optimize performance parameters, such as purity, recovery, etc. as well as the regression of these parameters.

Scale Up and Optimization in Preparative Chromatography

Author: Anurag Rathore
Publisher: CRC Press
ISBN: 9780203909287
Format: PDF, ePub, Mobi
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Presenting guidelines to predict and improve separation system performance, this book contains numerous case studies illustrating the practice of scale-up principles in process development. It offers solutions to limitations that occur in real-world purification schemes; methods to model, optimize, and characterize nonlinear separation processes; data comparisons from all stages of production; and industrial separation schemes for products such as synthetic molecules, antibody fragments, IgG, growth factors, and plasmid DNA. The book covers external constraints, separation economics, correlations for transport and kinetic phenomena, and the configuration and parameters of column design.

Separation and Purification Technologies in Biorefineries

Author: Shri Ramaswamy
Publisher: John Wiley & Sons
ISBN: 111849346X
Format: PDF, ePub, Mobi
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Separation and purification processes play a critical role in biorefineries and their optimal selection, design and operation to maximise product yields and improve overall process efficiency. Separations and purifications are necessary for upstream processes as well as in maximising and improving product recovery in downstream processes. These processes account for a significant fraction of the total capital and operating costs and also are highly energy intensive. Consequently, a better understanding of separation and purification processes, current and possible alternative and novel advanced methods is essential for achieving the overall techno-economic feasibility and commercial success of sustainable biorefineries. This book presents a comprehensive overview focused specifically on the present state, future challenges and opportunities for separation and purification methods and technologies in biorefineries. Topics covered include: Equilibrium Separations: Distillation, liquid-liquid extraction and supercritical fluid extraction. Affinity-Based Separations: Adsorption, ion exchange, and simulated moving bed technologies. Membrane Based Separations: Microfiltration, ultrafiltration and diafiltration, nanofiltration, membrane pervaporation, and membrane distillation. Solid-liquid Separations: Conventional filtration and solid-liquid extraction. Hybrid/Integrated Reaction-Separation Systems: Membrane bioreactors, extractive fermentation, reactive distillation and reactive absorption. For each of these processes, the fundamental principles and design aspects are presented, followed by a detailed discussion and specific examples of applications in biorefineries. Each chapter also considers the market needs, industrial challenges, future opportunities, and economic importance of the separation and purification methods. The book concludes with a series of detailed case studies including cellulosic bioethanol production, extraction of algae oil from microalgae, and production of biopolymers. Separation and Purification Technologies in Biorefineries is an essential resource for scientists and engineers, as well as researchers and academics working in the broader conventional and emerging bio-based products industry, including biomaterials, biochemicals, biofuels and bioenergy.

Real Time Simulation Technologies Principles Methodologies and Applications

Author: Katalin Popovici
Publisher: CRC Press
ISBN: 1351833391
Format: PDF, Docs
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Real-Time Simulation Technologies: Principles, Methodologies, and Applications is an edited compilation of work that explores fundamental concepts and basic techniques of real-time simulation for complex and diverse systems across a broad spectrum. Useful for both new entrants and experienced experts in the field, this book integrates coverage of detailed theory, acclaimed methodological approaches, entrenched technologies, and high-value applications of real-time simulation—all from the unique perspectives of renowned international contributors. Because it offers an accurate and otherwise unattainable assessment of how a system will behave over a particular time frame, real-time simulation is increasingly critical to the optimization of dynamic processes and adaptive systems in a variety of enterprises. These range in scope from the maintenance of the national power grid, to space exploration, to the development of virtual reality programs and cyber-physical systems. This book outlines how, for these and other undertakings, engineers must assimilate real-time data with computational tools for rapid decision making under uncertainty. Clarifying the central concepts behind real-time simulation tools and techniques, this one-of-a-kind resource: Discusses the state of the art, important challenges, and high-impact developments in simulation technologies Provides a basis for the study of real-time simulation as a fundamental and foundational technology Helps readers develop and refine principles that are applicable across a wide variety of application domains As science moves toward more advanced technologies, unconventional design approaches, and unproven regions of the design space, simulation tools are increasingly critical to successful design and operation of technical systems in a growing number of application domains. This must-have resource presents detailed coverage of real-time simulation for system design, parallel and distributed simulations, industry tools, and a large set of applications.

Preparative Chromatography

Author: H. Schmidt-Traub
Publisher: John Wiley & Sons
ISBN: 3527649301
Format: PDF, ePub, Mobi
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Completely revised and substantially extended to reflect the developments in this fast-changing field. It retains the interdisciplinary approach that elegantly combines the chemistry and engineering involved to describe the conception and improvement of chromatographic processes. It also covers recent advances in preparative chromatographic processes for the separation of "smaller" molecules using standard laboratory equipment as well as the detailed conception of industrial chemical plants. The increase in biopharmaceutical substances is reflected by new and revised chapters on different modifications of continuous chromatography as well as ion-exchange chromatography and other separation principles widely used in biochromatography. Following an introductory section on the history of chromatography, the current state of research and the design of chromatographic processes, the book goes on to define the general terminology. There then follow sections on stationary phases, selection of chromatographic systems and process concepts. A completely new chapter deals with engineering and operation of chromatographic equipment. Final chapters on modeling and determination of model parameters as well as model based design, optimization and control of preparative chromatographic processes allow for optimal selection of chromatographic processes. Essential for chemists and chemical engineers in the chemical, pharmaceutical, and food industries.

Innovative Food Processing Technologies

Author: Kai Knoerzer
Publisher: Woodhead Publishing
ISBN: 008100298X
Format: PDF, ePub, Docs
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Innovative Food Processing Technologies: Extraction, Separation, Component Modification and Process Intensification focuses on advances in new and novel non-thermal processing technologies which allow food producers to modify and process food with minimal damage to the foodstuffs. The book is highly focused on the application of new and novel technologies, beginning with an introductory chapter, and then detailing technologies which can be used to extract food components. Further sections on the use of technologies to modify the structure of food and the separation of food components are also included, with a final section focusing on process intensification and enhancement. Provides information on a variety of food processing technologies Focuses on advances in new and novel non-thermal processing technologies which allow food producers to modify and process food with minimal damage to the foodstuffs Presents a strong focus on the application of technologies in a variety of situations Created by editors who have a background in both the industry and academia

Separation and Purification Technologies in Biorefineries

Author: Shri Ramaswamy
Publisher: John Wiley & Sons
ISBN: 111849346X
Format: PDF, ePub, Docs
Download Now
Separation and purification processes play a critical role in biorefineries and their optimal selection, design and operation to maximise product yields and improve overall process efficiency. Separations and purifications are necessary for upstream processes as well as in maximising and improving product recovery in downstream processes. These processes account for a significant fraction of the total capital and operating costs and also are highly energy intensive. Consequently, a better understanding of separation and purification processes, current and possible alternative and novel advanced methods is essential for achieving the overall techno-economic feasibility and commercial success of sustainable biorefineries. This book presents a comprehensive overview focused specifically on the present state, future challenges and opportunities for separation and purification methods and technologies in biorefineries. Topics covered include: Equilibrium Separations: Distillation, liquid-liquid extraction and supercritical fluid extraction. Affinity-Based Separations: Adsorption, ion exchange, and simulated moving bed technologies. Membrane Based Separations: Microfiltration, ultrafiltration and diafiltration, nanofiltration, membrane pervaporation, and membrane distillation. Solid-liquid Separations: Conventional filtration and solid-liquid extraction. Hybrid/Integrated Reaction-Separation Systems: Membrane bioreactors, extractive fermentation, reactive distillation and reactive absorption. For each of these processes, the fundamental principles and design aspects are presented, followed by a detailed discussion and specific examples of applications in biorefineries. Each chapter also considers the market needs, industrial challenges, future opportunities, and economic importance of the separation and purification methods. The book concludes with a series of detailed case studies including cellulosic bioethanol production, extraction of algae oil from microalgae, and production of biopolymers. Separation and Purification Technologies in Biorefineries is an essential resource for scientists and engineers, as well as researchers and academics working in the broader conventional and emerging bio-based products industry, including biomaterials, biochemicals, biofuels and bioenergy.