Single Channel Recording

Author: Bert Sakmann
Publisher: Springer Science & Business Media
ISBN: 1441912290
Format: PDF, Mobi
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Edited by the 1991 winners of the Nobel Prize in Physiology or Medicine, this Second Edition includes new chapters covering such applications as capacitance measurements; single-cell PCR measurements; whole-cell recording from brain slices in combination with imaging techniques; atomic force microscopy of cells and membranes attached to glass pipettes; and patch clamping.

Neurotoxicology

Author: Louis W. Chang
Publisher: Elsevier
ISBN: 0080537472
Format: PDF, Mobi
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Neurotoxicology: Approaches and Methods provides a unique and comprehensive presentation of the current concepts and state-of-the-art methods for the assessment of neurotoxicity. The book analyzes various techniques available and discusses their strengths and weaknesses. This volume will serve as an excellent desk companion and laboratory guide for all investigators, researchers, clinicians, and students interested in neurotoxicology. The internationally knowngroup of editors divide the book into seven sections: Neuromorphological and Neuropathological Approaches; Neurophysiological Approaches; Neurobehavioral Toxicology; Neurochemical and Biomolecular Approaches; In-Vitro Models; Clinical Neurotoxicology; and Risk Assessment of Neurotoxicity. Each section yields the most up-to-date information by experts in their fields. Meticulously organized and edited, Neurotoxicology: Approaches and Methods is the most authoritative and well-planned neurotoxicology book on the market. Discusses neurobehavioral testing methods for assessment of neural dysfunctions Explains state-of-the-art diagnostic methods, such as clinico-neuropsychological and neurophysiological methods, for patients confronted by neurotoxic problems Discusses In Vitro methods, including aggregating brain cell methods, organotypic cultures, and the use of human neuronal cell lines for the assessment of neurotoxicity Presents step-by-step procedures for many methods Provides state-of-the-art neuromorphological and biomolecular methods and approaches for neurotoxicity investigation

Off Screen Cinema

Author: Kaira M. Cabañas
Publisher: University of Chicago Press
ISBN: 022617459X
Format: PDF, Mobi
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One of the most important avant-garde movements of postwar Paris was Lettrism, which crucially built an interest in the relationship between writing and image into projects in poetry, painting, and especially cinema. Offering a full portrait of the avant-garde scene of 1950s Paris, this book focuses on the film works of key Lettrist figures like Gil J. Wolman, Maurice Lemaitre, Francois Dufrene, and especially the movement's founder, Isidore Isou, a Romanian immigrant whose 'discrepant editing' deliberately uncoupled image and sound.

Cambridge Handbook of Psychology Health and Medicine

Author: Andrew Baum
Publisher: Cambridge University Press
ISBN: 9780521436861
Format: PDF, Docs
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Health psychology is a rapidly expanding discipline combining psychology and clinical medicine. This important text collates international and interdisciplinary expertise to form a unique encyclopedic handbook to this field that will be valuable to medical practitioners as well as psychologists. To facilitate easy reference, the handbook's chapters are alphabetically organized with extensive crossreferencing. The first of three sections introduces the nonspecialist reader to broad areas of psychology relevant to the practice of medicine. The second and third sections examine behavioral factors in relation to practice by citing specific medical conditions. This book will prove to be an invaluable resource to all those with an interest in the psychological aspects of health care.

Epilepsy

Author: Jong Rho
Publisher: CRC Press
ISBN: 1420085603
Format: PDF, Kindle
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Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervous system, have led to a substantial reduction in the morbidity and mortality of patients with epilepsy. At the same time, remarkable developments in neuroscience have enhanced our understanding of brain structure and function. Epilepsy: Mechanisms, Models, and Translational Perspectives incorporates new translational advances that bring epilepsy therapies from the laboratory bench to the bedside and back again. It brings together the work of more than 70 of the field’s most respected and cutting-edge researchers and clinicians. In 24 chapters, this extraordinarily comprehensive and current work: Offers an overview of the basic anatomic and functional substrates of seizure genesis and considers novel pathogenic concepts that have both emerged and been validated experimentally Examines antiepileptic drug therapy, including the latest on molecular targets Looks at the state of surgical treatments for epilepsy and discusses advances in the fields of structural and functional neuroimaging Reviews the variety of nontraditional therapeutic options, such as the ketogenic diet, the vagus nerve stimulator, immunomodulators, neurosteroids, herbs, and botanicals Investigates neuroendocrine, hormonal, and biobehavioral factors that influence seizure susceptibility—information that can be incorporated into the design of treatment algorithms on an individualized basis Provides a glimpse of what future epilepsy therapies might look like, from novel mechanisms of drug delivery to gene and stem-cell therapies for epilepsy to seizure detection methods, to the ultimate goal of disease prevention. The idea for this book was inspired by the editors’ collective desire to promote bridging of the so-called translational divide—that is, covering innovative treatment strategies based on scientific principles that have yet to be tested rigorously in the clinical setting, but yet may provide practitioners with new and promising approaches toward epilepsy therapeutics.

Handbook of Ion Channels

Author: Jie Zheng
Publisher: CRC Press
ISBN: 1466551429
Format: PDF, Kindle
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The New Benchmark for Understanding the Latest Developments of Ion Channels Ion channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of cells. In nonexcitable tissues, they also help regulate basic salt balance critical for homeostasis. All of these features make ion channels important targets for pharmaceuticals. Handbook of Ion Channels illustrates the fundamental importance of these membrane proteins to human health and disease. Renowned researchers from around the world introduce the technical aspects of ion channel research, provide a modern guide to the properties of major ion channels, and present powerful methods for modeling ion channel diseases and performing clinical trials for ion channel drugs. Conveniently divided into five parts, the handbook first describes the basic concepts of permeation and gating mechanisms, balancing classic theories and the latest developments. The second part covers the principles and practical issues of both traditional and new ion channel techniques and their applications to channel research. The third part organizes the material to follow the superfamilies of ion channels. This part focuses on the classification, properties, gating mechanisms, function, and pharmacology of established and novel channel types. The fourth part addresses ion channel regulation as well as trafficking and distribution. The final part examines several ion channel-related diseases, discussing genetics, mechanisms, and pharmaceutical advances.

Basic Electrophysiological Methods

Author: Ellen Covey
Publisher: Oxford University Press
ISBN: 0199342547
Format: PDF, ePub, Docs
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Basic Electrophysiological Methods provides a concise and easy-to-read guide on a selection of the most important contemporary electrophysiological techniques, their implementation, applications, and ways in which they can be combined and integrated with neuroscientific techniques. Intended for students, postdocs, and faculty with a basic neuroscience background, this text will not obscure the relevant technical details with textbook neuroscience tutorials as many other books do. Instead, each chapter provides a conscientious overview of the underlying theory -- a comprehensive description of equipment, materials, methods, data management, and analysis -- a troubleshooting guide, and a list of frequently asked questions. No book or online resource can function as strictly a DIY set of instructions on how to implement a complex technique. However, this book provides a fundamental and accessible set of information intended to form a foundation prior to, during, and after hands-on experience and training, greatly facilitating the initial learning process and subsequent fine-tuning of technical details.

From Naked Ape to Superspecies

Author: David Suzuki
Publisher: Greystone Books Ltd
ISBN: 1926685199
Format: PDF, Docs
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For millennia, we lived in harmony with the Earth, taking only what we required to survive. But in just the past few centuries, we have used our powers to satisfy our obsession with consumption and new technology, without regard for the consequences. And in doing so, we have exploited our surroundings on an unprecedented scale. In this revised and updated edition of From Naked Ape to Superspecies, David Suzuki and Holly Dressel lucidly describe how we have evolved beyond our needs, trampling other species, believing that we can make the Earth work the way we want it to. And they introduce us to the people who are fighting back, those who are resisting the inexorable advance of the "global economy" juggernaut, the people whose voices are difficult to hear over the din of corporate public relations machines. We learn about how human arrogance—demonstrated by our disregard for the small and microscopic species that constitute the Earth’s engine and our reckless use of technological inventions like powerful herbicides or genetically engineered crops—is threatening the health of our children and the safety of our food supply.