Statistics in Human Genetics and Molecular Biology

Author: Cavan Reilly
Publisher: CRC Press
ISBN: 9781420072648
Format: PDF, ePub, Docs
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Focusing on the roles of different segments of DNA, Statistics in Human Genetics and Molecular Biology provides a basic understanding of problems arising in the analysis of genetics and genomics. It presents statistical applications in genetic mapping, DNA/protein sequence alignment, and analyses of gene expression data from microarray experiments. The text introduces a diverse set of problems and a number of approaches that have been used to address these problems. It discusses basic molecular biology and likelihood-based statistics, along with physical mapping, markers, linkage analysis, parametric and nonparametric linkage, sequence alignment, and feature recognition. The text illustrates the use of methods that are widespread among researchers who analyze genomic data, such as hidden Markov models and the extreme value distribution. It also covers differential gene expression detection as well as classification and cluster analysis using gene expression data sets. Ideal for graduate students in statistics, biostatistics, computer science, and related fields in applied mathematics, this text presents various approaches to help students solve problems at the interface of these areas.

Introduction to Computational Biology

Author: Michael S. Waterman
Publisher: CRC Press
ISBN: 1351437089
Format: PDF, Mobi
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Biology is in the midst of a era yielding many significant discoveries and promising many more. Unique to this era is the exponential growth in the size of information-packed databases. Inspired by a pressing need to analyze that data, Introduction to Computational Biology explores a new area of expertise that emerged from this fertile field- the combination of biological and information sciences. This introduction describes the mathematical structure of biological data, especially from sequences and chromosomes. After a brief survey of molecular biology, it studies restriction maps of DNA, rough landmark maps of the underlying sequences, and clones and clone maps. It examines problems associated with reading DNA sequences and comparing sequences to finding common patterns. The author then considers that statistics of pattern counts in sequences, RNA secondary structure, and the inference of evolutionary history of related sequences. Introduction to Computational Biology exposes the reader to the fascinating structure of biological data and explains how to treat related combinatorial and statistical problems. Written to describe mathematical formulation and development, this book helps set the stage for even more, truly interdisciplinary work in biology.

Statistical Modeling and Machine Learning for Molecular Biology

Author: Alan Moses
Publisher: CRC Press
ISBN: 1482258609
Format: PDF
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Molecular biologists are performing increasingly large and complicated experiments, but often have little background in data analysis. The book is devoted to teaching the statistical and computational techniques molecular biologists need to analyze their data. It explains the big-picture concepts in data analysis using a wide variety of real-world molecular biological examples such as eQTLs, ortholog identification, motif finding, inference of population structure, protein fold prediction and many more. The book takes a pragmatic approach, focusing on techniques that are based on elegant mathematics yet are the simplest to explain to scientists with little background in computers and statistics.

Computational Genome Analysis

Author: Richard C. Deonier
Publisher: Springer Science & Business Media
ISBN: 0387288074
Format: PDF, Kindle
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This book presents the foundations of key problems in computational molecular biology and bioinformatics. It focuses on computational and statistical principles applied to genomes, and introduces the mathematics and statistics that are crucial for understanding these applications. The book features a free download of the R software statistics package and the text provides great crossover material that is interesting and accessible to students in biology, mathematics, statistics and computer science. More than 100 illustrations and diagrams reinforce concepts and present key results from the primary literature. Exercises are given at the end of chapters.

Applied Statistical Genetics with R

Author: Andrea S. Foulkes
Publisher: Springer Science & Business Media
ISBN: 038789554X
Format: PDF, Docs
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Statistical genetics has become a core course in many graduate programs in public health and medicine. This book presents fundamental concepts and principles in this emerging field at a level that is accessible to students and researchers with a first course in biostatistics. Extensive examples are provided using publicly available data and the open source, statistical computing environment, R.

Ordered Data Analysis Modeling and Health Research Methods

Author: Pankaj K. Choudhary
Publisher: Springer
ISBN: 3319254332
Format: PDF
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This volume presents an eclectic mix of original research articles in areas covering the analysis of ordered data, stochastic modeling and biostatistics. These areas were featured in a conference held at the University of Texas at Dallas from March 7 to 9, 2014 in honor of Professor H. N. Nagaraja’s 60th birthday and his distinguished contributions to statistics. The articles were written by leading experts who were invited to contribute to the volume from among the conference participants. The volume is intended for all researchers with an interest in order statistics, distribution theory, analysis of censored data, stochastic modeling, time series analysis, and statistical methods for the health sciences, including statistical genetics.

Probabilistic Graphical Models for Genetics Genomics and Postgenomics

Author: Christine Sinoquet
Publisher: Oxford University Press, USA
ISBN: 0198709021
Format: PDF, Mobi
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At the crossroads between statistics and machine learning, probabilistic graphical models provide a powerful formal framework to model complex data. For instance, Bayesian networks and Markov random fields are two of the most popular probabilistic graphical models. With the rapid advance of high-throughput technologies and their ever decreasing costs, a fast-growing volume of biological data of various types - the so-called ''omics'' - is in need of accurate andefficient methods for modeling, prior to further downstream analysis. As probabilistic graphical models are able to deal with high-dimensional data, it is foreseeable that such models will have aprominent role to play in advances in genome-wide data analyses. Currently, few people are specialists in the design of cutting-edge methods using probabilistic graphical models for genetics, genomics and postgenomics. This seriously hinders the diffusion of such methods. The prime aim of the book is therefore to bring the concepts underlying these advanced models within reach of scientists who are not specialists of these models, but with no concession on theinformativeness of the book. The target readers include researchers and engineers who have to design novel methods for postgenomics data analysis, as well as graduate students starting a Masters or a PhD. Inaddition to an introductory chapter on probabilistic graphical models, a thorough review chapter focusing on selected domains in genetics and fourteen chapters illustrate the design of such advanced approaches in various domains: gene network inference, inference of causal phenotype networks, association genetics, epigenetics, detection of copy number variations, and prediction of outcomes from high-dimensional genomic data. Notably, most examples also illustrate that probabilistic graphicalmodels are well suited for integrative biology and systems biology, hot topics guaranteed to be of lasting interest.

Randomization Bootstrap and Monte Carlo Methods in Biology Third Edition

Author: Bryan F.J. Manly
Publisher: CRC Press
ISBN: 1482296411
Format: PDF
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Modern computer-intensive statistical methods play a key role in solving many problems across a wide range of scientific disciplines. This new edition of the bestselling Randomization, Bootstrap and Monte Carlo Methods in Biology illustrates the value of a number of these methods with an emphasis on biological applications. This textbook focuses on three related areas in computational statistics: randomization, bootstrapping, and Monte Carlo methods of inference. The author emphasizes the sampling approach within randomization testing and confidence intervals. Similar to randomization, the book shows how bootstrapping, or resampling, can be used for confidence intervals and tests of significance. It also explores how to use Monte Carlo methods to test hypotheses and construct confidence intervals. New to the Third Edition Updated information on regression and time series analysis, multivariate methods, survival and growth data as well as software for computational statistics References that reflect recent developments in methodology and computing techniques Additional references on new applications of computer-intensive methods in biology Providing comprehensive coverage of computer-intensive applications while also offering data sets online, Randomization, Bootstrap and Monte Carlo Methods in Biology, Third Edition supplies a solid foundation for the ever-expanding field of statistics and quantitative analysis in biology.